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HIV CASCADE TOOLKIT: A USERS GUIDE for constructing, presenting , interpreting and using HIV cascades in Vietnam
TABLE OF CONTENTS
ABBREVIATIONS 3
ACKNOWLEDGEMENTS 4
I. Overview and Purpose
Guiding Principles
10
III.
1:1 rule
13
Numbers first
15
Data limitations
17
IV.
Preparatory steps
18
19
Adjusting data
20
V.
21
22
24
VI.
Interpretation tips
26
VII. Supporting others to generate, present and use simple HIV CoPC cascades 27
Key resources
27
VIII. Summary 28
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HIV CASCADE TOOLKIT: A USERS GUIDE for constructing, presenting , interpreting and using HIV cascades in Vietnam
Abbreviations
AIDS
ART
ARV
CDC
CoPC
D28
FSW
HIV
HTC
KP
LTFU
M&E
MMT
MSM
NGI
OPC
PEPFAR
PLHIV
PWID
TB
U.S.
VAAC
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HIV CASCADE TOOLKIT: A USERS GUIDE for constructing, presenting , interpreting and using HIV cascades in Vietnam
Acknowledgements
The U.S. Presidents Emergency Plan for AIDS Relief (PEPFAR) through
the United States Agency for International Development (USAID)
has provided financial support for development of the HIV Cascade
Toolkit: A Users Guide for Constructing, Presenting, Analyzing and Using
HIV Cascades in Vietnam. The contents of the guidelines are the
responsibility of the authors and do not necessarily reflect the views
of USAID or the United States Government.
FHI 360 Vietnam would like to thank to all our colleagues and partners
who provided invaluable inputs for this document.
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HIV CASCADE TOOLKIT: A USERS GUIDE for constructing, presenting , interpreting and using HIV cascades in Vietnam
I.
Although HIV may continue to be an important public heath threat for years to come, strong evidence in
support of the benefits of anti-retroviral therapy (ART) has ushered in an era in which we can envision an end
to the AIDS epidemic. Focusing outreach efforts on individuals at greatest risk; increasing uptake of HIV testing
and counseling (HTC) among key populations; facilitating early diagnosis of HIV infection and initiation on
ART; and retaining people living with HIV (PLHIV) on treatment are the hallmarks of a strong HIV response that
ultimately lowers viral suppression and achieves population-level impact.
To achieve ambitious AIDS-free goals, however, requires that implementers have tools that discern service
system gaps, help focus or prioritize programmatic interventions, and make the most strategic use of available
resources.
The continuum of HIV prevention to care (CoPC) cascade is a way to show, in visual form, the numbers of
individuals who are actually accessing CoPC services and receiving the services they need. At each step of the
continuum, the CoPC cascade illustrates engagement in an HIV service system. It powerfully identifies leaks
in the system, so that implementers at site, district, provincial or national levels can target limited resources
on effective interventions that improve the health of HIV positive individuals, lower the amount of virus in
vulnerable communities, and prevent new infections in the long term. Knowing where the drop-offs are most
pronounced is vital for knowing where, when and how to intervene to break the cycle of HIV transmission in
Vietnam.
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HIV CASCADE TOOLKIT: A USERS GUIDE for constructing, presenting , interpreting and using HIV cascades in Vietnam
II.
HIV cascades commonly begin at HIV diagnosis and consist of six bars or steps that illustrate the continuum
of care (Figure 1).
1. HIV infected
2. HIV diagnosed
4. Retained in
HIV care
5. On ART
6. Suppressed
viral load
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HIV CASCADE TOOLKIT: A USERS GUIDE for constructing, presenting , interpreting and using HIV cascades in Vietnam
Key indicators, or metrics, are linked to each bar or step of HIV cascade. These indicators are used to generate a
visual representation of HIV service system performance. They help implementers to:
Identify loss of client engagement expressed as gaps, leakages or missed opportunities in the
continuum of HIV prevention to care
Taken together, utilization of the cascade assists countries like Vietnam to provide the highest standard of care
that is feasible within available resources.
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HIV CASCADE TOOLKIT: A USERS GUIDE for constructing, presenting , interpreting and using HIV cascades in Vietnam
Guiding Principles
Five key principles guide the construction and use of HIV CoPC cascades in Vietnam. Simply put, cascades
should be:
1. Simple to generate, by relying on a minimal set of core indicators that exist in the HIV service system
and are routinely collected as part of national reporting procedures.
2. Easy to use and interpret by a variety of implementers, with minimal outside technical assistance.
3. Adaptable, according to the data needs at program, site, provincial or national-levels.
4. Consistent, by using the same set of recommended indicators and clearly outlining the location, time
period and population represented in the analysis.
These four principles support the fifth one that utilization of the cascade
5. Fosters a culture of data use, that strives to continually improve the HIV service system in Vietnam.
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HIV CASCADE TOOLKIT: A USERS GUIDE for constructing, presenting , interpreting and using HIV cascades in Vietnam
VL
Prioritize key
populations
approach
target
Populations
Identify
HIV positive
Individuals
Diagnose
PLHIV
Enrol
in care
Initiate
ART
Sustain
on ART
Suppress
viral loads
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HIV CASCADE TOOLKIT: A USERS GUIDE for constructing, presenting , interpreting and using HIV cascades in Vietnam
The first three bars of the cascade focus on HIV prevention, or outreach. Cascade analysis across these bars
helps implementers better understand:
Who is being reached, and how many members of key populations are being reached, in HIV prevention
or outreach efforts
Who is testing for HIV and how many of these individuals are testing positive for the virus
The use of consistent unique identifier codes (UIC) in routine monitoring data efforts can improve the validity
of outreach data and enable program implementers to graph the progress of individuals through the cascade
of services. Figure 3 illustrates an HIV CoPC cascade that monitors overall cascade performance in outreach and
testing services without the application of UIC across one Vietnamese province. Figure 4 uses HIV prevention
UIC monitoring to track clients reached to testing, diagnosis, and to enrollment in care and treatment services
across nine provinces implementing USAID/SMART TAs enhanced outreach approach.
Figure 3 | HIV CoPC cascade (bars 1-4), Quang Ninh province, 2013
8000
9360
8000
6748
6357
7448
94%
Persons
Persons
6000
4000
6000
80%
4000
2000
19%
0
Identified KPs
Reached KPs
1218
Tested KPs
20%
248
Newly diagnosed
PLHIV
Source: Quang Ninh PAC, 6/2014
2000
3%
Reached KPs
Tested KPs
232
100%
Newly diagnosed
PLHIV
232
Enrolled in
Care
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Figure 6 illustrates the same care and treatment cascade that now includes bar
7, or sustain on ART, which measures the number or proportion of PLHIV who
are registered at HIV care and treatment facilities 12 months after ART initiation.
Vietnam is unable to reliably collect population-level viral load data, as viral load
testing is not yet a routine part of the care and treatment monitoring system.
Figure 5 | HIV CoPC cascade (bars 4-6), Province A, January - December 2013
Figure 6 | HIV CoPC cascade (bars 4-7), Province A, January - December 2013
Persons
500
700
319
200
Female
Male
514
79%
400
85%
134
300
200
415
86%
356
88%
100
0
Newly diagnosed
PLHIV
500
488
158
Newly enrolled
in care
314
Newly initiated
ART
319
Female
600
Persons
700
200
Male
514
79%
400
488
158
85%
134
300
200
415
86%
356
88%
94%
314
100
0
Newly initiated
ART
Sustained
on ART
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HIV CASCADE TOOLKIT: A USERS GUIDE for constructing, presenting , interpreting and using HIV cascades in Vietnam
Detailed descriptions
for each CoPC cascade
indicator are found here
Reach KP
Test KP
Diagnose PLHIV
Initiate ART
Sustain on ART
Suppress viral
load
Enroll in care
NUMBER of new patients registered at HIV
outpatient clinics during the reporting period
Data Source:
D28 (adjusted)/facility ART register
UNAIDS, UNICEF, World Health Organization. Global AIDS response progress reporting 2014: Construction of core indicators for monitoring the 2011 United Nations political declaration on HIV and AIDS.
Geneva: UNAIDS; 2014 (http://www.unaids.org/en/media/unaids/contentassets/documents/document/2014/GARPR_2014_guidelines_en.pdf )
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HIV CASCADE TOOLKIT: A USERS GUIDE for constructing, presenting , interpreting and using HIV cascades in Vietnam
Identify PLHIV
Enroll in care
Initiate ART
UNAIDS, UNICEF, World Health Organization. Global AIDS response progress reporting 2014: Construction of core indicators for monitoring the 2011 United Nations political declaration on HIV and AIDS.
Geneva: UNAIDS; 2014 (http://www.unaids.org/en/media/unaids/contentassets/documents/document/2014/GARPR_2014_guidelines_en.pdf )
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HIV CASCADE TOOLKIT: A USERS GUIDE for constructing, presenting , interpreting and using HIV cascades in Vietnam
Numbers first
All core indicators are first expressed as numbers. Implementers who prepare cascades using numerical core indicators will find it easy to convert the cascade data into
proportional or percentage figures, which are typically expressed as arrows between cascade bars.
Proportion indicators for periodic cascades are illustrated in Table 1. At each step of the periodic cascade, implementers can measure the uptake of services relative to
the previous stage. Here, the highlighted cascade step becomes the numerator and is divided against the value in the previous step (the denominator).
Table 1 | Calculating proportional or percentage data for periodic cascades
Cascade bars
Proportion/Percentage
Numerator/Denominator
Numerator: NUMBER of KPs reached by community outreach workers during the reporting period
Diagnose PLHIV
Enroll in care
Enroll in care
Initiate ART
Initiate ART
Sustain on ART
Suppress viral load
Denominator: NUMBER of persons in KP groups estimated by the end of the last reporting period
Numerator: NUMBER of KPs who received test results and post-test counseling during the reporting
period
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Table 2 outlines proportion indicators for cross-sectional cascades. In cross-sectional cascades, two cascade steps are highlighted: (1) enroll in care and (2) initiate ART.
The denominator for both cascade steps is the first cascade stage: Identify PLHIV. This allows implementers to calculate the total numbers of PLHIV who are accessing
care and treatment services at a particular point of time.
Table 2 | Calculating proportional or percentage data for cross-sectional cascades
Cascade bars
Proportion/Percentage
Numerator/Denominator
Enroll in care
Identify PLHIV
Numerator: NUMBER of patients CURRENTLY registered at HIV outpatient clinics by the end of the
reporting period
Initiate ART
Identify PLHIV
Denominator: Total NUMBER of PLHIV reported from HIV INFO by the end of the reporting period
Numerator: NUMBER of PLHIV with advanced HIV infection who are CURRENTLY enrolled on ART
by the end of the reporting period
Denominator: NUMBER of patients CURRENTLY registered at HIV outpatient clinics by the end of the
reporting period
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Data limitations
Like any tool, there are limitations associated with the utility and application of the HIV CoPC cascade.
Implementers must be cognizant that:
1. The usefulness of the CoPC cascade is heavily influenced by the quality of available data.
Routine data quality assurance procedures are important for ensuring accurate reporting. Its crucial
for implementers to know the source of data and how data are reported when calculating the
indicators. Missing information such as the numbers of PLHIV loss to follow up or dead from AIDS
can skew bar totals and under- or overestimate the impact of a CoPC program. Over-reporting
counting outreach contacts instead of outreach individuals for instance will accentuate the size
of the reach-testing gap. The lack of disaggregated HIV testing figures for key populations means
that implementers will need to adjust the data during the cascade generation process.
Its important to note that individuals enter and/or leave the continuum of HIV services at any point
in the cascade and, as a consequence, it becomes difficult to infer causal relationships between
cascade bars. The utilization of coordinated UIC systems are particularly helpful for monitoring the
linkages between services, reducing episodes of double counting, and tracking individuals as they
transition from services and locations.
2. Consistency is critical. When implementers do not use core indicators in the construction
of cascades and when they do not clearly identify geographic location, time, data source, or
population it limits the usefulness of the cascade and makes it difficult for others to reliably
assess service performance.
3. The cascade is an important but not sole tool in HIV service planning and quality
improvement efforts. It should be used together with other programmatic and strategic
information/M&E tools such as service mapping, quality improvement monitoring, epidemic
modeling, and gender/policy/service access assessments to better understand and program
for the response.
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2. Where? Distinguish the geographic area of focus or scope. Is it the national HIV system? The provincial or
district response? A particular program? One facility? Knowing the focus of a cascade will help implementers
identify key data needs and steer them towards appropriate data sources.
3. Which service area will be emphasized? Will focus be on the full CoPC? Outreach? Care and treatment? Knowing the CoPC technical focus will assist
implementers to distinguish which cascade bars will be examined.
4. Who? Identify the population. Will data disaggregation be by key population or gender? Or will total population figures be used? Because women/men and
key population sub-groups may have unique CoPC service access, acceptability or utilization issues, it is recommended that implementers use disaggregated
data whenever possible.
5. When? Plot the time period, clearly specifying the start and end dates (e.g. month/year). Ensure that the time period reflects an official reporting cycle, such
as the end of a month, quarter, semi-annual or annual episode.
6. How? Distinguish presentation format. Will a cascade graph be used, or another representational style, such as a dashboard or trend graph.
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Adjusting data
In Vietnam, HIV testing and counseling data records the number of tests conducted,
rather than the number of individuals who test for HIV. This means that the data
must be adjusted in order to estimate a true number of KPs who test, with repeat
testers which can constitute, on average, 25% of total tests subtracted from
the totals. Implementers can use the following formula to adjust the data for the
number of key populations tested, and for the number of key populations who test
HIV positive (which may be included within this column bar):
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HIV CASCADE TOOLKIT: A USERS GUIDE for constructing, presenting , interpreting and using HIV cascades in Vietnam
V.
1. Title. All CoPC cascades should have a title that illustrates (a) geographic
location or scope; (c) population focus (as applicable); and (d) targeted
time period, with month/year if possible.
2000
1500
1500
1100
1000
500
0
75%
Identified
Individuals
73%
8%
88
91%
80
75
85%
Initinated
ART
Sustained
on ART
94%
Reached
Tested
Diagnosed Enrolled in
Individuals individuals
PLHIV
Care
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Gender, by showing the differences between men and women as they move
Figure 10 | HIV CoPC Cascade of People Who Inject Drugs in Province E, 2013
Persons
300000
Female
258524
250000
65558
111% 219163
Persons
200000
Male
2000
3000
4000
5000
6000
7000
8000
9000
8000
Tested Individuals
9%
72543
76%
150000
1000
750
Diagnosed PLHIV
71%
100000
85532
192966
146620
42%
50000
38%
Identified PLHIV
Diagnosed PLHIV
84457
30255
99%
55277
99%
Enrolled in Care
Enrolled in Care
29898
54559
530
85%
Ininiated ART
450
Initiated ART
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KPs who test positive for HIV, as compared to the total who tested
Figure 12 | HIV Care and Treatment Cascade of Site A compared to other Sites
in Province C, 2013
1400
5000
KPs
Others
4500
1200
434
3000
600
200
708
3500
5%
800
400
Other sites
4000
Persons
Persons
1000
Site A
2500
2000
4015
97%
97%
690
664
1500
750
4%
KPs: 48%
Others: 67%
21
30
0
Tested individuals Diagnosed PLHIV
10
KPs: 70%
Others: 75%
20
Enrolled in Care
1000
7
15
Initiated ART
40%
500
0
Diagnosed PLHIV
1615
97%
Enrolled in Care
1566
Initiated ART
Adding complexity to simple cascades is possible, if the data is available. Implementers should be sure to label stacked bars with relevant information and to
designate data sources whenever possible.
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Figure 14 | HIV Care and Treatment Cascade of Site A compared to other Sites
in Province C, 2013
10000
5000
9360
4500
8000
4000
6000
4000
708
3000
2500
2000
4015
97%
97%
690
1500
2000
1000
3%
Reached KPs
Tested KPs
Other sites
3500
80%
Persons
Persons
7448
Site A
232
100%
Newly diagnosed
PLHIV
232
Enrolled in
Care
40%
500
0
Diagnosed PLHIV
97%
1615
Enrolled in Care
664
1566
Initiated ART
1. Cascade graphs. Our preferred style of presentation, cascade graphs visually display leaks in the HIV service system, where individuals may not be accessing
CoPC services and receiving the services they need.
2. Indicator dashboards. This data visualization tool can provide implementers with an at a glance listing of key cascade indicators. Dashboards show
recent program performance and actionable information. While dashboards do not track individuals as they progress through the CoPC, they do provide
a cross-representational representation of different groups of individuals at different stages of the cascade.
3. Trend graphs. Trend graphs are particularly useful when implementers assess progress or improvements over time of particular indicators.
A cascade graph is illustrated in Figures 13 and 14; indicator dashboards and trend graphs are shown in Figure 15.
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Figure 15 | HIV CoPC Cascade of Enhanced Outreach Approach, May October, 2014
14000
13159
Sex partners, 15%
12000
10729
3799
3500
FSW, 39%
3000
10000
8000
Clients
Clients
2500
6000
2000
PWID, 29%
82%
1000
MSM/TG, 17%
3%
Reach KPs
Test KPs
321
101%
Diagnose PLHIV
325
Enroll in Care
Percentages
70%
67%
72%
5%
77%
50%
40%
30%
0%
4%
3.42%
3%
2.63%
2.39%
2.71%
Months
%KPsTested
Aug-14
Sep-14
Oct-14
May-14
180
95%
Jun-14
Jul-14
Aug-14
Sep-14
Months
%HIV+
HIV Threshold 6%
104%
160
93
140
100
56
65
80
60
36
16
27
37
May-14
Jun-14
89
62
Jul-14
# Enroll in Care
#Diagnose PLHIV
0%
200
106%
59
40%
1%
Jul-14
59%
60%
0%
Jun-14
Oct14
120
80%
20%
2%
May-14
Sep14
4.13%
20%
10%
97%
100%
4.30%
60%
Aug14
Months
123%
120%
86%
Percentages
80%
85%
Jul14
140%
Percentages
85%
Jun14
7%
6%
90%
May14
933
500
2000
0
1939
1511
1500
4000
2608
2369
Clients
53
Aug-14
Months
40
53
20
Sep-14
% PLHIV in Care
Oct-14
Oct-14
23
23
Sep-14
Oct-14
Number
20
15
12
10
5
0
10
9
4
May-14
Jun-14
Jul-14
Aug-14
Months
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VII. Supporting others to generate, present and use simple HIV CoPC cascades
Key resources
USAID/SMART TA has prepared training materials for individuals who would like to support others to prepare and present CoPC cascades. Click here to access all
resource materials.
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VIII. Summary
This introductory guide has been designed to help government and civil society implementers construct, present, interpret and use HIV CoPC cascades in Vietnam
with available data and minimal technical assistance.
The cascade approach identifies leaks in the system, targeting resources on interventions that diagnose people with HIV, quickly initiate ARV treatment, and
sustain PLHIV in care. Using the cascade - in every facility, commune, district and province will help Vietnam monitor HIV service system performance and focus
its remaining human, financial and programmatic resources on the ultimate aim of the HIV response: viral suppression. Knowing where the drop-offs are most
pronounced can assist decision makers and service providers to implement system improvements and service enhancements that make the greatest impact for
individuals, communities and Vietnamese society.
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