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Synapse a specialized site of contact between two neurons or a neuron and an effector (gland or muscle) that
allows one-way flow of neural impulses (Fig 12.20); synapses are the basis for change in the nervous system
both in development and in learning and memory; synapses can excite or inhibit a postsynaptic cell
Neuromuscular junction synapse between a neuron and a muscle
Neuroglandular junction synapse between an neuron and a gland
Synaptic bulb (Fig 12.20) tips of the presynaptic neuron that contain synaptic vesicles
containing a neurotransmitter that will aid in signal transmission across the synaptic cleft (2030nm in length)
In a neuron-to-neuron synapse, the postsynaptic neuron receives the impulse (Fig 12.18, 12.19)
o ex. spinal motor neuron 10,000 synapses: 8,000 on the dendrites and 2,000 on the soma
Neurotransmitters
more than 100 different neurotransmitters have been identified since the first, acetylcholine, was
discovered in 1921
can have an excitatory or inhibitory effect on the postsynaptic cell this depends on the properties
of the receptors on the postsynaptic membrane and not the neurotransmitter itself
each neuron exposed to a variety of neurotransmitters (so we will talk about only a couple in isolation
but remember that the cells are constantly receiving signals from many presynaptic neurons with many
different neurotransmitters)
Examples include:
o acetylcholine (ACh) widespread throughout CNS and PNS; released in cholinergic synapses
and all neuromuscular junctions; excitatory or inhibitory
o norepinephrine (NE) released in adrenergic synapses; excitatory or inhibitory
o dopamine released in the brain; can be inhibitory (movement control; loss = Parkinsons
disease) or excitatory (cocaine prevents removal from synapses = high)
o serotonin CNS; low levels effects attention span and emotions, severe chronic depression
Synapse transmission excitatory cholinergic synapse
Action potential arrives at the synaptic knob; voltage-regulated Ca2+ channels in the
synaptic membrane open
Ca2+ enters synaptic knob and triggers exocytosis of ACh
ACh diffuses across the cleft and binds chemically (ligand)-regulated Na+ channels;
channels open allowing Na+ in = depolarize postsynaptic membrane 20ms
Only about half the ACh released actually binds to the postsynaptic membrane
influx of Na+ produces a local potential that carries to the axon hillock and if strong
enough will generate an action potential
Synapse transmission inhibitory GABA-ergic synapse
Steps 1 and 2 are the same except that GABA (-aminobutyric acid) is released by exocytosis
Step 3 GABA binds to chemically-regulated Cl- channels; chloride enters the postsynaptic cell
If we add negative ions to the inside of the cell what will that do to the membrane potential?
Hyperpolarize the membrane so it is harder to generate an action potential
Neural integration is based on the postsynaptic potentials produced by the neurotransmitters released.
Remember that a neuron has an RMP of -70 mV and a threshold of -55 mV. The threshold must be reached to
produce an action potential.
Postsynaptic potentials (Fig 12.24)
graded potentials that develop in the postsynaptic membrane (local potentials)
o excitatory postsynaptic potential (EPSP) graded depolarization of postsynaptic membrane:
open Na+ channels, moves membrane closer to threshold
o inhibitory postsynaptic potential (IPSP) graded hyperpolarization of postsynaptic
membrane: open Cl- channels or sometimes K+ channels; moves membrane further from
threshold
o Which will result in an action potential?
Summation (Fig 12.25, 12.26)
One neuron may receive input from thousands of other neurons. Some incoming signals may produce EPSPs
and some may produce IPSPs. The neurons response depends on the additive effects of the EPSPs and IPSPs.
So we will start with EPSPs to make it simplecombine or add EPSPs until threshold is reached and an
action potential is generated
o Temporal summation addition of stimuli in a short period of time at a single synapse
EPSP lasts 20msec; new AP can arrive every 1ms
fill a bathtub with 1 bucket by adding water quickly
o Spatial summation addition of EPSPs from multiple synapses
many friends with many buckets
We can also have temporal and spatial summation of IPSPs which would hyperpolarize the membrane
and not generate an action potential
Summation of EPSPs and IPSPs
when we combine the opposing effects of the two we have our system of information processing
o equal number and speed no change in water level (no change in membrane potential)
o more IPSPs hyperpolarization; farther from threshold
o more EPSPs closer to threshold and generation of action potential
o the results are further effected by neuromodulators and hormones, caffeine, nicotine, etc.
Facilitation
Neurons work in groups to modify each others actions. Facilitation is the process in which one neuron
enhances the effect of another.
o this can be accomplished by the arrival of EPSPs (not enough to reach but closer with each
arrival); in spatial summation (Fig 12.25) one neuron will not produce a strong enough graded
potential to produce an action potential but with all three working together an action potential is
generated
o this can also be accomplished by certain drugs and chemicals
nicotine, caffeine, theobromine (cocoa) or theophylline (tea)
lower the threshold of the initial segment and increase levels of ACh released
Presynaptic Inhibition (Fig 12.27)
the opposite of facilitation, in this case a presynaptic neuron suppresses another presynaptic neuron
alters the release of the neurotransmitter from the synaptic bulb (presynaptic neuron)
o axoaxonal synapse
inhibition lowers levels of neurotransmitter released