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APOPTOSIS

On 30th January 2015

Summary
Apoptosis Market research report gives an insight into Apoptosis Mechanism, by Molecular Pathways,
Caspase Activators and Inhibitors, Protease/Proteasome Inhibitors, Bcl-2 Modulators, p53 Modulators
and Other. The study also focuses on major diseases for which the treatment is based on apoptosis
comprising Cancer, Neurodegenerative Diseases, Cardiovascular Diseases and other apoptosis based
diseases including HIV infection, Organ Transplant Rejection and MODS. The study provides apoptosis
market size related therapeutic products by the above apoptosis molecular pathways and also by the
disease areas. The study includes estimates and projections for the total global apoptosis related
therapeutic products market. Projections and estimates are also graphically illustrated by geographic
regions encompassing North America, Europe, Asia-Pacific and Rest of World. Business profiles of 50
major companies are discussed in the report. The report serves as a guide to global apoptosis market,
covering more than 300 companies that are engaged in apoptosis research, testing and supply of
products and services. Major Contract Research Organizations and Universities serving apoptosis market
are also covered in the Corporate Directory section of this report. Information related product
developments, partnerships, collaborations, and mergers and acquisitions are also covered in the
report. Compilation of Worldwide Patents and Research related to Apoptosis is provided.

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Other industries we cover:

Advertising and Media


Automotive and Parts
Consumer Goods
Healthcare and Medical
Finance and Banking
Food and Beverages
Travel and Tourism
Textiles and Clothing
SWOT Analysis

Table of Content
1. SCOPE AND METHODOLOGY
2. REPORT SYNOPSIS
2.I Foreword
Apoptosis
2.2 Segmentation of Apoptosis
Exhibit 1. Segmentation of Global Apoptosis Related Products Market by Apoptosis Molecular
Pathways and Therapeutic Areas
Molecular Pathways
Caspase Activators and Inhibitors
Protease Inhibitors
Bcl-2 Modulators
p53 Modulators
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Therapeutic Areas
Cancer
Neurodegenerative Diseases
Cardiovascular Diseases
Exhibit 2. Segmentation of Global Apoptosis Market by Imaging/Detection Technologies for
Cancer
Imaging Technologies (Cancer)
Molecular Imaging
Flow Cytometry
Optical Imaging
2.3 Apoptosis - Global Market Analysis
Exhibit 3. Apoptosis Related Products - Global Market Estimations & Predictions (2005-2020) in
US$ Million (Graphical Representation Included)
Exhibit 4. List of Major Global Companies
3. MARKET DYNAMICS
3.1 Market Overview
3.2 Global Apoptosis Related Products Market
Exhibit 5. Apoptosis Related Products - Global Market Estimations & Predictions (2005 - 2020)
in US$ Million by Geographic Region for North America, Europe, Asia-Pacific and Rest of World
(Graphical Representation Included)
Exhibit 6. Apoptosis Related Products - Global Market Shares (2010, 2015 & 2020) by
Geographic Region for North America, Europe, Asia-Pacific and Rest of World (Graphical
Representation Included)
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3.3 North American Apoptosis Related Products Market


Exhibit 7. Apoptosis Related Products - North American Market Estimations & Predictions (2005
- 2020) by Country for United States and Canada in US$ Million (Graphical Representation
Included)
Exhibit 8. Apoptosis Related Products - North American Market Shares (2010, 2015 & 2020) by
Country for United States and Canada (Graphical Representation Included)
3.3 (I) United States Apoptosis Related Products Market
3.3 (II) Canadian Apoptosis Related Products Market
Exhibit 9. List of Major North American Apoptosis Related Products Companies
3.4 European Apoptosis Related Products Market
Exhibit 10. Apoptosis Related Products - European Market Estimations & Predictions (2005 2020) in US$ Million by Country for Germany, United Kingdom, France, Russia and Rest of
Europe (Graphical Representation Included)
Exhibit 11. Apoptosis Related Products - European Market Shares (2010, 2015 & 2020) by
Country for Germany, United Kingdom, France, Russia and Rest of Europe
3.4 (I) German Apoptosis Related Products Market
3.4 (II) UK Apoptosis Related Products Market
3.4 (III) French Apoptosis Related Products Market
3.4 (IV) Russian Apoptosis Related Products Market
Exhibit 12. List of Major European Apoptosis Related Products Companies
3.5 Asia-Pacific Apoptosis Related Products Market
Exhibit 13. Apoptosis Related Products - Asia-Pacific Market Estimations & Predictions (2005 2020) by Country for Japan, China, India, South Korea and Rest of Asia-Pacific in US$ Million
(Graphical Representation Included)
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Exhibit 14. Apoptosis Related Products - Asia-Pacific Market Shares (2010, 2015 & 2020) by
Country for Japan, China, India, South Korea and Rest of Asia-Pacific (Graphical Representation
Included)
3.5 (I) Japanese Apoptosis Related Products Market
3.5 (II) Chinese Apoptosis Related Products Market
3.5 (III) Indian Apoptosis Related Products Market
3.5 (IV) South Korean Apoptosis Related Products Market
Exhibit 15. List of Major Asia-Pacific Apoptosis Related Products Companies
3.6 Rest of World Apoptosis Related Products Market
Exhibit 16. Apoptosis Related Products - Rest of World Market Estimations & Predictions (2005 2020) by Country for Australia, Brazil, Israel, South Africa and Other Countires in US$ Million
(Graphical Representation Included)
Exhibit 17. Apoptosis Related Products - Rest of World Market Shares (2010, 2015 & 2020) by
Country for Australia, Brazil, Israel, South Africa and Other Countires (Graphical Representation
Included)
3.6 (I) Australian Apoptosis Related Products Market
3.6 (II) Brazilian Apoptosis Related Products Market
3.6 (III) Israeli Apoptosis Related Products Market
3.5 (IV) South African Apoptosis Related Products Market
Exhibit 18. List of Major Rest of World Apoptosis Related Products Companies
3.7 Company Profiles - Major Players in Apoptosis Market
A.G. Scientific, Inc. (USA)
Abbott Laboratories (USA)
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AbGenomics International (USA)


Aegera Therapeutics, Inc. (Canada)
Aeterna Zentaris, Inc. (Canada)
More
3.8 Recent Activities in Apoptosis Market
Senesco Technologies Announces IND Filing for SNSO1-T
Cayman Launches Glutathione Cell-Based Detection Kit
Cleveland BioLabs Accepts USD 1.6 Million Development Agreement from Defense Threat
Reduction Agency of Department Of Defense For CBLB50
FDA Grants Orphan Drug Status to Senesco Technologies SNS01 T
Sunesis Pharmaceuticals Initiate Phase 3 Valor Trial of Vosaroxin
Eli Lilly Suspends Phase III Clinical Trials of Tasisulam
EpiCept Initiates Phase II Clinical Trials of CrolibulinTM for Anaplastic Thyroid Cancer
Human Genome Sciences and GSK Receives FDA Extension of Benlysta PDUFA
More
3.9 Analysis by Molecular Pathways
Exhibit 19. Apoptosis by Molecular Pathways - Global Market Estimations & Predictions (2005 2020) in US$ Million for Caspase Activators and Inhibitors, Protease Inhibitors, Bcl-2
Modulators, p53 Modulators and Other (Graphical Representation Included)
Exhibit 20. Apoptosis by Molecular Pathways - Global Market Shares (2010, 2015 & 2020) for
Caspase Activators and Inhibitors, Protease Inhibitors, Bcl-2 Modulators, p53 Modulators and
Other (Graphical Representation Included)
3.9.1 Global Apoptosis Caspase Activators and Inhibitors Market
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Exhibit 21. Caspase Activators and Inhibitors - Global Market Estimations & Predictions (2005 2020) in US$ Million by Country for North America, Europe, Asia-Pacific and Rest of World
(Graphical Representation Included)
Exhibit 22. Caspase Activators and Inhibitors - Global Market Shares (2010, 2015 & 2020) by
Country for North America, Europe, Asia-Pacific and Rest of World (Graphical Representation
Included)
Analysis by Application
3.9 (a) Drugs
Exhibit 23. Drugs (Caspase Activators & Inhibitors) - Global Value Market Estimations &
Predictions (2011 -2018) by Geographic Regions for North America, Europe, Asia-Pacific and
Rest of World in US$ Million
Exhibit 24. Drugs (Caspase Activators & Inhibitors) - Global Value Market Shares (2011 & 2018)
by Geographic Regions for North America, Europe, Asia-Pacific and Rest of World
3.9 (b) Diagnostics
Exhibit 25. Diagnostics (Caspase Activators & Inhibitors) - Global Value Market Estimations &
Predictions (2011 -2018) by Geographic Regions for North America, Europe, Asia-Pacific and
Rest of World in US$ Million
Exhibit 26. Diagnostics (Caspase Activators & Inhibitors) - Global Value Market Shares (2011 &
2018) by Geographic Regions for North America, Europe, Asia-Pacific and Rest of World
3.9 (c) Laboratory Reagents
Exhibit 27. Laboratory Reagents (Caspase Activators & Inhibitors) - Global Value Market
Estimations & Predictions (2011 -2018) by Geographic Regions for North America, Europe, AsiaPacific and Rest of World in US$ Million
Exhibit 28. Laboratory Reagents (Caspase Activators & Inhibitors) - Global Value Market Shares
(2011 & 2018) by Geographic Regions for North America, Europe, Asia-Pacific and Rest of World
3.9.2 Global Apoptosis Protease Inhibitors Market

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Exhibit 29. Protease Inhibitors - Global Market Estimations & Predictions (2005 -2020) in US$
Million by Country for North America, Europe, Asia-Pacific and Rest of World (Graphical
Representation Included)
Exhibit 30. Protease Inhibitors - Global Market Shares (2010, 2015 & 2020) by Geographic
Region for North America, Europe, Asia-Pacific and Rest of World (Graphical Representation
Included)
3.9.3 Global Apoptosis Bcl-2 Modulators Market
Exhibit 31. Bcl-2 Modulators - Global Market Estimations & Predictions (2005 -2020) in US$
Million by Geographic Region for North America, Europe, Asia-Pacific and Rest of World
(Graphical Representation Included)
Exhibit 32. Bcl-2 Modulators - Global Market Shares (2010, 2015 & 2020) by Geographic Region
for North America, Europe, Asia-Pacific and Rest of World (Graphical Representation Included)
3.9.4 Global Apoptosis p53 Modulators Market
Exhibit 33. p53 Modulators - Global Market Estimations & Predictions (2005 -2020) in US$
Million by Geographic Region for North America, Europe, Asia-Pacific and Rest of World
(Graphical Representation Included)
Exhibit 34. p53Modulators - Global Market Shares (2010, 2015 & 2020) by Geographic Region
for North America, Europe, Asia-Pacific and Rest of World (Graphical Representation Included)
3.9.5 Global Other Apoptosis Molecular Pathways
Exhibit 35. Other Molecular Pathways of Apoptosis - Global Market Estimations & Predictions
(2005 -2020) in US$ Million by Geographic Region for North America, Europe, Asia-Pacific and
Rest of World (Graphical Representation Included)
Exhibit 36. Other Molecular Pathways of Apoptosis - Global Market Shares (2010, 2015 & 2020)
by Geographic Region for North America, Europe, Asia-Pacific and Rest of World (Graphical
Representation Included)
3.10 Analysis by Therapeutic Areas

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Exhibit 37. Apoptosis by Therapeutic Area - Global Market Estimations & Predictions (2005 2020) in US$ Million for Cancer, Neurodegenerative, Cardiovascular and Other (Graphical
Representation Included)
Exhibit 38. Apoptosis by Therapeutic Area - Global Market Shares (2010, 2015 & 2020) for
Cancer, Neurodegenerative, Cardiovascular and Other (Graphical Representation Included)
3.10.1 Global Market for Apoptosis based Cancer Therapeutics
Exhibit 39. Apoptosis based Cancer Therapeutics - Global Market Estimations & Predictions
(2005 -2020) in US$ Million by Geographic Region for North America, Europe, Asia-Pacific and
Rest of World (Graphical Representation Included)
Exhibit 40. Apoptosis based Cancer Therapeutics - Global Market Shares (2010, 2015 & 2020) by
Geographic Region for North America, Europe, Asia-Pacific and Rest of World (Graphical
Representation Included)
3.10.1 (I) North American Market for Apoptosis based Cancer Therapeutics
3.10.1 (II) European Market for Apoptosis based Cancer Therapeutics
3.10.1 (III) Asia-Pacific Market for Apoptosis based Cancer Therapeutics 3.10.1 (IV) Rest of
World Market for Apoptosis based Cancer Therapeutics
3.10.2 Global Market for Apoptosis based Neurodegenerative Diseases Therapeutics
Exhibit 41. Apoptosis based Neurodegenerative Diseases Therapeutics - Global Market
Estimations & Predictions (2005 -2020) in US$ Million by Geographic Region for North America,
Europe, Asia-Pacific and Rest of World (Graphical Representation Included)
Exhibit 42. Apoptosis based Neurodegenerative Diseases Therapeutics - Global Market Shares
(2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of
World
3.10.2 (I) North American Market for Apoptosis based Neurodegenerative Diseases
Therapeutics
3.10.2 (II) European Market for Apoptosis based Neurodegenerative Diseases Therapeutics
3.10.2 (III) Asia-Pacific Market for Apoptosis based Neurodegenerative Diseases Therapeutics
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3.10.2 (IV) Rest of World Market for Apoptosis based Neurodegenerative Diseases
Therapeutics
3.10.3 Global Apoptosis Market for based Cardiovascular Diseases Therapeutics
Exhibit 43. Apoptosis based Cardiovascular Diseases Therapeutics - Global Market Estimations
& Predictions (2005 -2020) in US$ Million by Geographic Region for North America, Europe,
Asia-Pacific and Rest of World (Graphical Representation Included)
Exhibit 44. Apoptosis based Cardiovascular Diseases Therapeutics - Global Market Shares (2010,
2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World
3.10.3 (I) North American Apoptosis Market for based Cardiovascular Diseases Therapeutics
3.10.3 (II) European Apoptosis Market for based Cardiovascular Diseases Therapeutics
3.10.3 (III) Asia-Pacific Apoptosis Market for based Cardiovascular Diseases Therapeutics
3.10.3 (IV) Rest of World Apoptosis Market for based Cardiovascular Diseases Therapeutics
3.10.4 Global Market for Apoptosis based Other Therapeutic Products
Exhibit 45. Therapeutic Products for Other Apoptosis based Diseases - Global Market
Estimations & Predictions (2005 -2020) in US$ Million by Geographic Region for North America,
Europe, Asia-Pacific and Rest of World (Graphical Representation Included)
Exhibit 46. Therapeutic Products for Other Apoptosis Based Diseases - Global Market Shares
(2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of
World
3.11 Analysis by Imaging Technologies for Cancer
Exhibit 47. Imaging Technologies for Apoptosis in Cancer - Global Value Market Estimations &
Predictions (2005 - 2020) in US$ Million for Molecular Imaging, Optical Imaging, Flow Cytometry
and Other^ Imaging Technologies
Exhibit 48. Imaging Technologies for Apoptosis in Cancer - Global Value Market Shares (2010,
2015 & 2020) for Molecular Imaging, Optical Imaging, Flow Cytometry and Other^ Imaging
Technologies
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3.11.1 Global Market for Molecular Imaging Technologies for Apoptosis in Cancer
Exhibit 49. Molecular Imaging Technologies for Apoptosis in Cancer - Global Market Estimations
& Predictions (2005 - 2020) in US$ Million for North America, Europe, Asia-Pacific and Rest of
World+
Exhibit 50. Molecular Imaging Technologies for Apoptosis in Cancer - Global Market Shares
(2010, 2015 & 2020) for North America, Europe, Asia-Pacific and Rest of World+
3.11.2 Global Market for Flow Cytometry for Apoptosis in Cancer
Exhibit 51. Flow Cytometry for Apoptosis in Cancer - Global Market Estimations & Predictions
(2005 - 2020) in US$ Million for North America, Europe, Asia-Pacific and Rest of World+
Exhibit 52. Flow Cytometry for Apoptosis in Cancer - Global Market Shares (2010, 2015 & 2020)
for North America, Europe, Asia-Pacific and Rest of World+
3.11.3 Global Market for Optical Imaging Technologies for Apoptosis in Cancer
Exhibit 53. Optical Imaging Technologies for Apoptosis in Cancer - Global Market Estimations &
Predictions (2005 - 2020) in US$ Million for North America, Europe, Asia-Pacific and Rest of
World
Exhibit 54. Optical Imaging Technologies for Apoptosis in Cancer - Global Market Shares (2010,
2015 & 2020) for North America, Europe, Asia-Pacific and Rest of World+
3.11.4 Global Market for Other Imaging Technologies for Apoptosis in Cancer
Exhibit 55. Other Imaging Technologies for Apoptosis in Cancer - Global Market Estimations &
Predictions (2005 - 2020) in US$ Million for North America, Europe, Asia-Pacific and Rest of
World
Exhibit 56. Other Imaging Technologies for Apoptosis in Cancer - Global Market Shares (2010,
2015 & 2020) for North America, Europe, Asia-Pacific and Rest of World+
3.12 Apoptosis - Market Outlook
4. PRODUCT RESEARCH
4.1 Introduction
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Apoptosis - The Major Form of Programmed Cell Death


The Process of Apoptosis
Cell Death Due to Injury
Cell Death Due to Suicide
Reasons for Cell Suicide
Procedures for Apoptosis Identification
The ISEL technique
TUNEL technique
Methods for Understanding Apoptosis
DNA Fragmentation to Aid Apoptosis Measurement
Measurement of Variations in Apoptosis by Cdk
Apoptotic Cell Clearance Measurement In Vitro
Exploring Apoptosis in Drosophilas
4.2 Apoptosis Molecular Pathways
Key Molecular Pathways of Apoptosis
Caspases
Types of Caspase Proteins
Initiator Caspases
Effector Caspases
The Caspase Flow
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Function of Caspases in Apoptosis, Development and Cytokine Maturation


Card Domains
Protease Inhibitors
Bcl-2 Modulators
Structure of Bcl-2 Family
The Role of Bcl-2 in Diseases
Biochemical Properties of Bcl-2 Proteins
Cytoplasmic Proteins
p53 Modulators
Other Apoptosis Molecular Pathways
Inhibitors of Apoptosis Proteins
Identification of IAP Gene Family Proteins
TRAIL
MLK Inhibitor
Factor 5A
Protein Kinase Pathway Modulators
Chemotherapeutic Role of Telcyta in Various Cancers
Nicotinic Acetylcholine Receptor Agonist
HSP2
4.3 Disease Areas Connected with Apoptosis
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Cancer
Major Companies in Global Cancer Market
Exhibit 57. Global Market for Cancer Therapeutic Products (2008): Percentage Breakdown of
Market Share for Top 10 Companies (Graphical Representation Included)
Neurodegenerative Disease
Alzheimers
Importance of Apoptosis in Alzheimers Disease
Familial Alzheimers Disease and Role Of Mutant APP
Parkinsons
Function of Apoptosis in PD and Symptoms of Neuronal Degradation
Apoptosis in Parkinsons Disease and Nigral Neuronal Death
Potential Markers of Apoptosis in Parkinsons Disease
Rheumatoid Arthritis
Role of Apoptosis in Rheumatoid Arthritis Synovium
Multiple Sclerosis
The Diagnosis of MS
Functioning of Oligodendrocytes Apoptosis in MS and EAE
Cardiovascular Diseases - Role of Cell Apoptosis
Other Apoptosis Based Diseases
Organ Transplant Rejection
Types of Organ Rejection
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Hyperacute Rejection
Acute Rejection
Chronic Rejection
Treating Rejection
HIV Infection
Sepsis and Multiple Organ Dysfunction Syndrome
Requirement of Logical Strategies
Sepsis Controlled by Apoptosis
4.4 Apoptosis Therapeutics
Technologies Involved in Drug Making Process for Apoptosis Based Treatment
Target Discovery and Validation
Structural Biology
Drug Candidate Identification
Antisense
Types of Antisense
The nbl Antisense
Antisense CK
Np73 Antisense
Np73 Function in SH-SY5Y Neuroblastoma Cells
Small Molecule Mimetics
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Drug Discovery
Combinatorial Chemistry
High Throughput Screening
Analysis of Apoptosis Based Drugs - Listed by Molecular Pathways
Caspases
Executioner Caspases
CASPASECaspaseIDN-655
Application of IDN-6556 for Human Liver Preservation Injury
MX112
MX101
Protease Inhibitors
VELCADE (BORTEZOMIB)
Bcl-2 Modulators
Genase
Genasense in combination with chemotherapy
Genasense: Positive effects On Bladder Tumor
HA14p53 Modulators
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SCH5850
INGN 24
INGN 241 in combination with Introgen
Administration of INGN 241 with Herceptin
INGN 25
ONYX-01
Apoptosis Related Products in Developments
The Combination of Apoptosis with Anti-Apoptosis Yields Better Results
Personalized Cancer Therapy with CaspaseExhibit 58. Sales of Approved Drugs -Apoptosis Inhibitors & Inducers
Methods and Technologies for Imaging/Detecting Apoptosis
Assays for Apoptosis
Membrane Alterations
Detection of Apoptosis in Whole Mounts
Mitochondrial Assays
Application of Luminescent Assays for effective Measurement of Caspase Activity
Fluorescent Assays for Measuring Caspase Activity
Colorimetic Assay for Detecting Caspase Activity
FITC-VAD-FMK the newly developed In Situ Marker for CaspaseActive Caspase-3 Detection by the application of an Antibody
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Use of Mitochondrial Markers for Cell Death Detection


Mitochondrial Dyes and its application to analyze dell death
Apoptosis detection by measuring variations in Cell Membrane
Apoptosis detection using DNA Fragmentation
Multiplexing Assays
Imaging Technologies
Molecular Imaging
Molecular Imaging of Apoptosis in Cancer
PET
Mechanism of PET
Production of [F-18] Fluoroannexin for Imaging Apoptosis with PET
Magnetic Resonance Imaging (NMRI)
MRI Imaging of Apoptosis
Flow Cytometry Technique for Apoptosis
Protein Expression
Caspases Activation
Alterations in Mitochondrial Membrane Capacity
Plasma Membrane Variations
Rise in Membrane Permeability
DNA Degradation
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Optical Imaging
Optical Imaging of Apoptosis
NIR Tracers
Other Imaging Technologies
Fluorescence Microscopy
Apoptosis Imaging Using Fluorescence Microscopy
Ultrasound
DNA Electrophoresis
Microscopy
Future Outlook of Imaging Technologies
Apoptosis Detection Kit
Cell Apoptosis DAPI Detection Kit
Main Features
Cell Apoptosis PI Detection Kit
Caspase 3 Colorimetric Assay Kit
Main Features
Double Stain Apoptosis Detection Kit
Main Features
Mitochondrial Apoptosis Detection Kit
Main Features
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TUNEL (TdT-Mediated dUTP Nick-End Labeling) Detection Kits


Annexin V-FITC Apoptosis Detection Kit
FLICA Apoptosis Detection Kits
Apoptosis Reagents
The TUNEL Assay
Annexin V
4.5 Research Briefs
Obatoclax Initiates ATG7-Dependent Autophagy Independent of BACLIN-1 and also BAX/BAK
Preoteolytic Degradation of BRCA1 in Ionization-Induced Apoptosis
Cancer Cell Senescence Induced by the BH3 Mimetic ABT-73
Analysis of Apoptosis Signaling in Pancreatic Cancer by Computational Signal
Transduction Analysis
The Determination of Various Forms of Transient RNAi during Apoptosis in Mammalian Cells
Cord Blood Stem Cell-Mediated Induction of Apoptosis in Glioma down regulates X-Linked
Inhibitor of Apoptosis Protein or XIAP
Dynamic Computational Model Indicates That Cellular Citizenship Is Very Important for
SelectiveTumor Apoptosis
Thiazole Antibiotics Aim at FoxM1 and Induce Apoptosis in Human Cancer Cells
MYC Prevents Apoptosis and Subsequently Enhances Endoreduplication when Induced by
Paclitaxel
5. CORPORATE DIRECTORY

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6. PATENTS INFORMATION

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