Dareal Philip W.

Manatad

DRUG

INDICATION

ADVERSE
EFFECT

NURSING
RESPONSIBIL
ITIES

Amitriptyline
Hydrochloride

Indicated in
patients with
depression(outpa
tient and
hospitalized
patients)

Stroke,
seizures, coma,
heart block,
arrhythmias, MI,
agranulocytosis
,
thrombocytope
nia, leukopenia,
hypoglycemia

Desipramine
Hydrochloride

Indicated for
patients with
depression and
Bulimia Nervosa

Doxepin
Hydrochloride

For patients with

depression;
anxiety and
insomnia

Seizures,
hypoglycemia,
tremors,
weakness,
confusion,
headache,
nervousness,
restlessness,
agitation
Drowsiness,
dizziness,
seizures,
hypoglycemia,
headache,
anorexia,
constipation

- Advise families
and caregivers
to closely
observe patient
for suicidal
thinking and
behavior.
- Advise patient
to avoid alcohol
during drug
therapy
- Monitor mental
status
- assess for
suicidal
tendencies
- obtain BMI
- Monitor Blood
Pressure
- Monitor mental
status
- administer with
or immediately
after meal

ANTIDEPRESSA
NT

- Monitor patient
for nausea,
headache, and
malaise after
abrupt
withdrawal of
long term
therapy; these
symptoms dont

indicate
addiction
- assess for
sexual
dysfunction
Imipramine
Hydrochloride

For patients with

depression and
attention deficit
hyperactivity
disorder

Seizures,
stroke, MI,
arrhythmias,
heart block,
precipitation of
heart failure,
bone marrow
depression,
hypoglycemia

- If signs or
symptoms of
psychosis occur
or increase,
expect
prescriber to
reduce dosage.
-Record mood
changes.
-Monitor patient
for suicidal
tendencies.

Imipramine
Pamoate

For patients with

depression and
attention deficit
hyperactivity
disorder

Seizures,
stroke, MI,
arrhythmias,
heart block,
precipitation of
heart failure,
bone marrow
depression,
hypoglycemia

-If signs or
symptoms of
psychosis occur
or increase,
expect
prescriber to
reduce dosage.
-Record mood
changes.
-Monitor patient
for suicidal
tendencies.

Nortriptyline
Hydrochloride

For patients with

depression and
irritable bowel
syndrome

Stroke,
seizures, MI,
heart block,
thrombocytope
nia, weakness,
fatigue,
headache

- Monitor patient
for nausea,
headache, and
malaise after
abrupt
withdrawal of
long term
therapy; these

Citalopram
hydrobromide

Depression,
premenstrual
disorders,
obsessivecompulsive
disorders

Suicide
attempt,
tachycardia,
decreased
libido

Escitalopram
Oxalate

Treatment and
maintenance
therapy for
patients with
major depressive
disorder,
generalized
anxiety disorder,
posttraumatic
stress disorder
Depression,
obsessivecompulsive
disorder,
maintenance
therapy for
depression in
stabilized
patients , panic
disorder,
agoraphobia,
resistant
depression,
borderline
personality
disorder,
posttraumatic

Suicidal
behavior,
fatigue, fever,
insomnia,
vertigo

Fluoxetine
Hydrochloride

Suicidal
behavior, flulike
syndrome,
weight loss,
nausea,
constipation,
headache

symptoms dont
indicate
addiction
- monitor mental
status
- assist suicidal
tendencies
- monitor blood
pressure
- Monitor mental
status
- Get BMI
- Caution patient
and patients
family to report
signs of
worsening
depression to
prescriber
immediately
- Note signs of
suicidal behavior
- Teach patient to
recognize and
immediately
report symptoms
of serotonin
toxicity
- monitor mood
changes
- assess suicidal
tendencies
- monitor
appetite and
nutritional intake

stress disorder
Sertraline
Hydrochloride

Depression,
obsessivecompulsive
disorder, panic
disorder,
posttraumatic
stress disorders,
social anxiety
disorders,
premenstrual
dysphoric
disorder

Suicidal
behavior
nervousness,
somnolence,
insomnia,
fatigue,
headache,
tremor,
paresthesia

- Advise families
and caregivers
to closely
observe patient
for increased
suicidal thinking
and behavior

Clomipramine
Hydrochloride

For patients with

ObsessiveCompulsive
Disorder and
Panic Disorder

Somnolence,
tremor, seizure,
orthostatic
hypotension,
weight gain,
purpura,
bronchospasm,
altered libido

Drug may
increase risk of
suicidal thinking
and behavior in
children,
adolescents, and
young adults
ages 18-24 years
old during the
first 2 months of
treatment,
especially in
those with major
depressive
disorder or other
psychiatric
disorder

Fluvoxamine
Maleate

Obsessivecompulsive
disorder, social
anxiety disorder,
bulimia nervosa,

Agitation,
headache,
asthenia,
depression, CNS
stimulation,

Dont use for the

treatment of
major depressive
disorders in
children younger

Anti obsessive
agent

panic disorder,
posttraumatic
stress disorder

nervousness,
anxiety,
insomnia

than age 18
because of an
increased risk of
suicidal behavior.

Chlordiazepoxide
hydrochloride

Mild to moderate
anxiety, severe
anxiety,
withdrawal
symptoms of
acute alcoholism,
preoperative
apprehension and
anxiety

Drowsiness,
lethargy,
edema,
jaundice,
altered libido,
agranulocytosis

Paroxetine
Hydrochloride

Depression,
Obsessivecompulsive
disorder,
generalized
anxiety disorder,
social anxiety
disorder, panic
disorder,
posttraumatic

Suicidal
behavior,
tremors,
anxiety,
decreased
libido, yawning,
nervousness,
somnolence

- Use of this drug

may lead to
abuse and
addiction. Dont
withdraw drug
abruptly after
long term use
because
withdrawal
symptoms may
occur
- assess anxiety
level
- monitor Blood
Pressure
- Record mood
changes,
- monitor patient
for suicidal
tendencies,
- allow only
minimum supply
of drug

Psychosis, mania
and behavioral
disorders:
hyperactivity

Neuroleptic
malignant
syndrome,
seizures,
dizziness,

- Warn patients
to avoid
activities that
require alertness
or good

Anti anxiety

ANTI
PSYCHOTIC
Chlorpromazine
Hydrochloride

drowsiness
Leukopenia,
agranulocytosis
, aplastic
anemia,
thrombocytope
nia

coordination
until effects of
drug are known.

Neuroleptic
malignant
syndrome,
seizures,
constipation,
dark urine,
headache

- Monitor patient
for tardive
dyskinesia which
may occur after
prolonged use. It
may not appear
until months or
years later and
may disappear
spontaneously
or persist for life,
despite ending
drug

Fluphenazine
Decanoate

Psychotic
disorder

ProchlorperazineMal
eate

For patients with

schizophrenia

Thioridazine
Hydrochloride

Schizophrenia in
patients who
dont respond to
treatment with at
least two other
antipsychotic
drugs

neuroleptic
malignant
syndrome,
transient

- Advise patient
to inform health
care providers
that he is taking
thioridazine
before starting
new medication

Thiothixene

Mild to moderate
psychosis, severe

neuroleptic
malignant

- Watch for signs

of neuroleptic

- Advise patient
to wear
protective
clothing when
exposed to
sunlight

psychosis

syndrome,
transient

agranulocytosis
, weight gain

Trifluoperazine
Hydrochloride

Anxiety rates,
schizophrenia,
other psychotic
disorders

neuroleptic
malignant
syndrome,
transient

agranulocytosis
, weight gain

malignant
syndrome,
hyperthermia,
autonomic
disturbance
which is rare but
deadly

- Watch for signs

of neuroleptic
malignant
syndrome,
hyperthermia,
autonomic
disturbance
which is rare but
deadly