Professional Documents
Culture Documents
Side Effects
Renal failure
Gastro toxicity: ie. Diarrhea
Hypersensitivity
Neurotoxicity: can damage or interfere with function of nerve tissue
o Ex. aminoglycoside can collect in 8th cranial nerve and cause dizziness,
vertigo, and hearing loss.
Superinfections: infection by one type of bacteria that may be resistant and
is allowed to proliferate. Can also be secondary infection such as a yeast
infection.
Aminoglycosides
Carbapenems
Cephalosporins
Similar to penicillins in structure. 2nd and 3rd generations mostly used now.
Bactericidal action by inhibiting cell membrane synthesis. The affected
bacteria cells weakened cell walls swell and burst by osmotic pressure.
Cross sensitivity with penicillins is common (if allergic to one good chance
allergic to other).
Apparently well absorbed by GI, but drug book says IM and IV is best.
Toxic to kidney and liver, monitor liver enzymes and kidney function.
Common Side Effects:
CNS: SEIZURES (HIGH DOSES) .
GI: PSEUDOMEMBRANOUS COLITIS, diarrhea, nausea, vomiting.
Derm: rashes, pruritis, urticaria.
Hemat: agranulocytosis, bleeding, eosinophilia, hemolytic anemia,
neutropenia, thrombocytopenia.
Local: pain at IM site, phlebitis at IV site.
Misc: ALLERGIC REACTIONS INCLUDING ANAPHYLAXIS , superinfection.
Drug to Drug: cephalosporin and aminoglycoside concurrent use can increase
nephrotoxicity. Also, anticoagulant (Coumadin) use with cephalosporin can
increase bleeding risk.
Teach symptoms of blood loss, no alcohol up to 72 hours after discontinuation
of drugs.
Name:
G: cefotaxime
B: Claforan
Classification:
Ther. Class: anti-infective
Pharm. Class: third generation cephalosporin
Fluoroquinolones
Sulfonamides
Macrolides (Erythromycins)
Newer types have longer half lifes. Ex Z pack 3-5 days but will stay in system
for 10 or more days.
Broad spectrum, mostly gram +.
SE: GI, take with food
Azithromycin (Zithromax)- PO or IV, long half life; less GI effects,
bacteriostatic, used commonly for resp infection (bronchitis)
Clindamycin (Cleocin)- PO, IM, IV, topical- inhibits bacterial protein synthesis;
often given with other drugs for broader spectrum.
Vancomycin (Vancocin)- IV- bactericidal for gram +; used for MRSA, C. diff,
cardiac surgery prophylaxis for clients with penicillin allergy
o SE: ototoxicity and nephrotoxicity
o Frequent peak trough numbers to avoid toxicity
Linezolid(Zyvox)- new antibiotic for MRSA and VRE
TB
Antivirals
Anti Fungals
Other Agents
Respiratory Drugs
Antitussives
Decongestants
Antihistamines
Expectorant
Mucolytics
Bronchodilators/Antiasthmatics
Used to manage and treat bronchial spasm, asthma, and other obstructive
pulmonary conditions. Ex. albuterol
Sympathomimetics: drugs that mimic sympathetic NS, ie. Dilation of bronchi
and increased rate/depth of breathing.
Mech of action: most are beta 2 found in bronchi. They also increase BP, HR,
vasoconstriction, decrease renal and GI BF. This can limit usefulness in some
pts(ex. HTN)
Pharmacokinetics: inhaled or oral. Rapid if inhaled.
Monitor: dont give if it would aggravate with sympathetic stimulation
SE: Things attributed to sympathetic stimulation; sweating, pallor, HTN, etc
Education: Use 30 to 60 min before exercise to unsure peak effect when
needed.
Anticholinergics
Inhaled Steroids