5 Reasons to recognize Compounds

Cannabidiol
Usually, when it comes to marijuana, people were thinking that marijuana
would make "giting" and dangerous for consumption. They think like this
because the public generally only knows one active compound in marijuana is
THC [Tetrahydrocannabinol]. THC is the compound that makes the wearer feel
the effects of euphoria or commonly spelled "giting". What has not been much
public
know
marijuana
is
one
of
the
compounds
named
Cannabidiol.IndonesianShare Cannabidiol [CBD], are compounds that are nonpsychoactive cannabis that has great therapeutic properties for health.
CBD high levels can enhance the positive effects of THC while pressing
the negative effects of THC as paranoid and feeling uncertain. CBD cooperation
with THC in the way it works. When used separately, CBD or THC would not
be as effective as treating chronic pain as if they are used simultaneously. The
problem is, the farmers realized that since the first THC was as an attraction that
sells marijuana, THC gives a sense of euphoria and giting and this is what has
always been associated with marijuana. To improve the content of THC, they
are trying to eliminate THC from certain types of cannabis, so the result of
marijuana that gives high experience psychoactive effects, which are considered
dangerous by those who support marijuana prohibition laws. The difference
between the use of THC and CBD simultaneously and the use of pure THC
Here are some reasons why we need to know CBD closer ..
# 5 CBD repair brain damage caused by alcohol.
According to research at the University of Kentucky, CBD brain change
physiologically and can repair damage due to acute alcoholic. The study found
that CBD could reduce nerve damage as much as 48.8% in the entorhinal
cortex. There have been many who know if some suction cannabis can relieve a
hangover, but this study focuses on the potential treatment of marijuana to a
new level.
# 4 CBD effectively cope with severe social anxiety.
Many have claimed that marijuana to relieve their anxiety while others say the
opposite. This is because the content of the CBD in every different marijuana
plants. A study is held to determine the impact of the CBD on social anxiety in
public speaking. Turns out they were previously given a dose of CBD, anxiety
and nervous they diminished during their public speaking. The researchers
stated that the CBD has many advantages compared with other anti-depressant
drugs because of the effect that fast with not cause a sense of dependency.

# 3 CBD kill cancer cells are found in metastasis [other organs involved terjalar
cancer cells]
Researchers at the California Pacific Medical Center found that CBD kill cancer
cells to spread. This study also makes UCLA study on marijuana does not cause
lung cancer becomes more attractive; Is own cannabinoids may be able to
eliminate carcinogens [cancer-causing] which are found in cigarettes?
Is it true that marijuana is a real anti-cancer drugs?
# 2 CBD is an anti-psychotic drugs are powerful.
A clinical trial in Germany found that the CBD effectively treat schizophrenia
as usual anti-psychotic drugs with little side effects. This shows yin-yang on
cannabis compounds which have the effect of high doses of THC psychotic.
CBD was the one that suppresses the negative properties of THC. And for this
reason the CBD well for those who have a family history of mental disorders.
# 1 And the last is, legally.
Yes, in some state laws for medical marijuana has been legalized. They can
plant, cultivate, even buy marijuana in accordance with the regulations set by
the government they are. This means they have easy access to cheap drugs.
CBD can be processed into food, beverage, oil, capsules, lotions, and even
chewing gum.
One of the reasons why marijuana is still illegal in Indonesia because
generally they generalize marijuana as a plant that can make the wearer feel
"giting" and therefore a hazard to health. The government also enter marijuana
in Group 1 Narcotics which they consider marijuana has no medical functions.

6 Effects Long-Term Use of Marijuana (Contrary

Evidence)
1. Abuse / Addiction
Chronic marijuana use can lead to physical and psychological
dependence, and experience withdrawal symptoms shortly after stopping use.
These symptoms may occur after chronic use for at least 3 weeks. These
symptoms peaked on day 4, and began to be resolved within 2 weeks calculated
from the last time use traditional cannabis. characteristic withdrawal symptoms
are restlessness, decreased appetite, nausea, irritability and sleep disruption
(Pope & Yurgelum-Todd, 1996). In general, these symptoms will only make the
user feel uncomfortable but no threat to life.
2. Cognitive Dysfunction
Chronic Cannabis Syndrome, better known by the term Amotivational
Syndrome is cognitive impairment in chronic users which resulted in a decrease

in the ability to plan or get the purpose of life; then causes the user is placed in a
job that requires only low-level cognition.
Research on humans and animals indicate that the use of cannabis at an
early age long impact on cognition and increase the likelihood neuropsikis
disorders (Schneider, 2008). Wilson et al. (2000) compared the long-term
marijuana users who start mengganja at the age of 17 years and below 17 years
and above. In pengganja which began at the age of 17 years and below shows
the low percentage of gray matter (neurons and dendrites, where the thought
process occurs) and the high percentage of white matter (myelinated axons)
compared with whole brain volume.
3. Mental illness
Many studies show that there is a correlation between the use of cannabis
with high risk of psychosis and some studies have found a link between the dose
response of psychosis (Fergusson, Poulton, Smith, & Boden, 2006; Zammit,
Allebeck, Andreasson, Lundberg, & Lewis, 2002). after browsing through the
available evidence, of the many results of published research can be concluded
that cannabis use may increase the risk of psychosis in young people, but it has
a significant effect on those who have a predisposition psychosis.
4. Cancer
Research in this area manunjukan many contradictions. Sidney,
Quesenberry, Friedman, & Tekawa (1997) found that smoking marijuana is not
at all associated with an increased risk of cancer. Meanwhile, in different places,
Fligiel (1997), found that histological and molecular changes in the bronchial
epithelium similar between smoking cannabis with tobacco smoking. The
conclusion that can be drawn while, there have not been enough studies to
provide an evaluation that is strong enough to suggest that smoking marijuana
associated with cancer risk.
5. Reproduction
One study found that marijuana use is associated with decreased
testosterone levels, sperm count and sperm motility in chronic users / intensive
cannabis (Kolodny, Masters, Kolodner, & Toro, 1974). One result, until recently
known as a substance that marijuana can cause male infertility. In fact, no study
has ever seen a link between the use of cannabis and male fertility.
6. Respiratory Effects
Gong, Fligiel, Tashkin, and Barber (1987) showed that smoking
marijuana rolled 3-4 in the same day with a 20-rolled tobacco smoked in a day
and cause cough, wheeze, and sputum production. Recent research has failed to
find a link between long-term marijuana pengggunaan with FEV1 / FVC
(forced expiratory volume in the first secondsetelah take a deep breath),

diffusion capacity, or hyperactive breathing as occurs in tobacco smokers

(Tetrault, Crothers, & Moore, 2007).

Physical advantage Marijuana Users

Just as we SSO, the human brain is also divided into two main parts; right
and left hemispheres. Of course, the second part is related interacting with SSO.
Part of our right brain play a role in the process of receptive (understanding),
creative and nurturing experienced.Bagian used to interpret the aesthetic
experiences; such as music and art, moving experience and spatial reasoning.
Associated with cognition, makes the human brain is able to better understand
the meaning. The left brain play a role in the analytical process, linking,
mechanical situation; as a matter of mathematical, logical planning and
thinking. Both parts of the brain communicate with each other and are
associated in a complex system. However, differences of the situation, the
environment and other human beings have a tendency to make dominant in one
part of the brain alone; this is called hemisphericity.
Marijuana, through effects on SSO, can improve the ability of both parts
of the brain. In line with the increase in sympathetic nerve, the perception in the
left brain and the right brain receptive to increase at the same time. It is a
physiological fact! more and more blood flow to the brain, the better
performance of our brain. Then, the parasympathetic nervous making all dilated
capillaries so that blood flow to the brain becomes maximum. More blood
means more oxygen which makes the human mind is more clear and open.
The physiological variation unnerve many people from all kinds of
science. Marijuana natural ability to balance the body, are still not fully
understood. In fact, marijuana is a stimulant and a depressant (working
simultaneously) where the effect is difficult to predict and depends on its
condition.
When our body system terstimulus by the environment, marijuana can
calm her down. otherwise, marijuana can be used as a conduit of energy
workers in slavery (Chopra and Chopra). This evidence can not be ignored. It
can also explain the creative effects that occur when someone mengganja ie
increasing the ability of both parts of the brain, left brain where attention better
and right brain receives better anyway. This is a union between logic and
intuition. This situation is often referred to as the expansion of consciousness
(expansion of consciousness) which is physiologically can be explained as a
change of domination of one part of the brain becomes a balance (Sugerman &
Tarter), being particularly appropriate to explain the term giting.

PRINCIPLES RESPONSIBLE CANNABIES USE

Remember the days when the smoke has not enacted legislation? Many
smokers who smoke anywhere; eating at home, in the office, house of worship,
even in public transport. Finally, many are bothered by cigarette smoke,
especially those who do not smoke. Then diberlakukanlah government
regulations to maintain order in the smoke, so that all the people - smoke or not
- feel comfortable and not feel disadvantaged.
Likewise with marijuana, if marijuana is legalized then there will be legal
regulations governing the distribution and use of marijuana. So many questions
that came to us with regard to what would happen if marijuana was legalized.
Their concern minors will be using marijuana and disturbing achievement in
school, or the number of people who use marijuana everywhere, causing unrest
in the community, a lot of abuse and everywhere much under the influence of
marijuana.
We really understand their concerns about the impact of legalizing
marijuana in public, medical and leisure. This is because as long as the
government participated in the anti-marijuana propaganda by the UN global
cannabis prohibition law, it is understandable that there are many people who
oppose the legalization of marijuana because of bad information about
marijuana they received and their ignorance of marijuana itself.
So, what would happen if marijuana is legalized? How to order which
would regulate the distribution and use of marijuana for the convenience
together? Looks like we can learn from policies that have been implemented by
the developed countries that have legalized marijuana, one of which was made
by the organization's Board of NORML (The National Organization for the
Reform of Marijuana Laws), they are the oldest and largest group in the United
States that was formed to change laws on marijuana, and has established a set of
principles for the use of marijuana in charge. When marijuana enjoyed
responsibly, arrest and criminalize responsible marijuana users actually do not
provide benefits in general and cause a terrible injustice. For your safety and the
common good, the economy, and also justice together, the marijuana prohibition
laws should be changed until they do not criminalize those responsible
marijuana users.
A series of cannabis use are the responsibility principles are as follows:
1. Only for Those Who Already Adult. Is not responsible for providing
marijuana to those who are still minors *.
There are things that can be done by those who are still minors and some are not
allowed. Those who are still minors should not drive a motor vehicle, signed a
contract or marriage, smoking, or drinking alcohol. What we want and we hope

to those who are still minors are they growing as a responsible adult. Adult
means thinking about any decision to be taken carefully and be accountable for
the decisions and outcomes of those decisions. And those who've grown
obligations was to demonstrate to those who are still under the age of what it
means to a responsible adult
Those who want to use marijuana've done it earlier though the legal status
of marijuana is still illegal. And indeed there will be some other adults who will
use marijuana if marijuana is regulated by the government. The legal regulation
of marijuana would regulate the circulation of marijuana that the law would be
different with cigarettes, alcohol, soda, and even heroin. And for teenagers and
those who are still minors, the legal regulation of marijuana would likely
narrow the scope of the black market that sells marijuana to them. And the legal
regulations ensure marijuana is sold only in the place specified by the
government with a reasonable law, one of which is to prove that the person is
old enough to get marijuana and memilliki permission from doctors to use
marijuana as their treatment [if legalized for medical special]. And where the
sale of marijuana were given permission by the government will lose its right to
sell marijuana if proven to have been sold to those who are still minors.
*) Except for patients who are still minors who supervised his marijuana use
and on the recommendation of a doctor
2. Driving.
Responsible cannabis users do not drive a motor vehicle or other
dangerous machinery during the influence of marijuana, as well as the influence
of other drugs. Although experts say that the use of marijuana is safer than
alcohol and other drugs, but the safety of the public wants those who are under
the influence of marijuana should not get in the way and a way to know how
many levels of marijuana on the driver under the influence of marijuana should
be developed and used rather than test it chemically. This does not mean the
evidence that cannabis adversely affect the nerves of motion. Many studies
prove that the driving influence of marijuana is harmless compared to the
influence of alcohol. Under the influence of alcohol, drivers tend not careful,
feeling brave and challenged, and improper coordination. While the driver
under the influence of marijuana tend to drive with caution, not ambition to
drive quickly, and was not challenged to penetrate the personal speed record.
Although many feel able to get behind the wheel, traffic-related legal marijuana
regulations require them to not driving for the sake of common security.
Because the law banning marijuana has been proven unsuccessful and
had a lot of people who use cannabis despite the illegal status, then it is time to
accept the fact that the legal regulation of marijuana would likely prohibit those
under the influence of cannabis on driving. With the enforcement of marijuana
laws regulations; time, energy, and funds the government to arrest those who
use cannabis are the responsibility of the home / not in a public place, could be

diverted to allow the police to arrest the real offenders, including the driver who
is under the influence of marijuana.
3. Situation & Conditions.
Responsible cannabis users will be cautious in behavior, procedures, and
regulate its use with either. "The situation" here refers to setting the values,
attitudes, experience and personality, and "condition" here relates to the
physical and social situation of the users of the marijuana. Responsible
marijuana users will always be aware of the situation and condition, place, time,
mood, etc. and did not hesitate to say "NO" if you feel in an unsafe condition,
uncomfortable, and or not being productive and or neglect of duty and
responsibility.
4. Not Abusing.
The use of cannabis that can affect health, personal development and
achievement, is tantamount to abuse that should be shunned by the user who is
responsible. Abuse means dangerous. There is a dangerous cannabis use,
although usually harmless. The use of a dangerous one who should be avoided,
that it should not be done. Then what kind of dangerous marijuana abuse? If the
use of marijuana is shown to interfere with the health and quality of life itself,
then you should use the dihentikkan marijuana.
5. Respect the Rights of Others.
Responsible cannabis users do not step over the rights of others, can bring
themselves appropriately according to standards of decency in the eyes of the
public, and they are fully appreciate not interested in marijuana. Public concern
over the impact of legal marijuana one of them is going to use cannabis
marijuana users everywhere and cause public unrest. Although marijuana is
proven not to cause aggression on the users, for the sake of convenience along
with the use of marijuana should not be done in public. Responsible cannabis
users also do not force anyone to use marijuana, not deride those who choose
not to use marijuana, and reward those who do not want to expose them to the
public use of marijuana.

Countries in the world that's been legalize cannabis

Here is a list of the countries in the world that have legalized marijuana
possession.
1. Netherlands - Cannabis can be bought and consumed directly in
"Coffeshop," but sell and consume marijuana outside Coffeshop, illegal.
Since 1976, the Netherlands has been a leader in reforming the Narcotics
Act to draw a clear distinction between soft drugs (soft drugs) and heavy
drugs (hard drugs). Marijuana into the mild narcotic and legal groups in
limited quantities.
2. Germany - Ownership to 6 grams of marijuana is legal. In some cities a
case of Berlin, the ownership limit can be up to 10 grams.
3. Argentina - Consuming marijuana for personal use in small amounts,
legally. In 2009, the Supreme Court in Argentina legalize the use of
marijuana for personal use in small amounts.
4. Cyprus - Ownership to 15 grams of marijuana legal for personal use and
allowed to grow to 5 trunk.
5. Ecuador - According to Law 108, possession of marijuana is not declared
illegal.
6. Mexico - marijuana legal for personal use up to 5 grams. Narcotics Law
in Mexico in 2009 has been decriminalizing possession of small amounts
of marijuana and all other narcotics such as cocaine, heroin, ecstasy and
methamphetamine.
7. Peru - Ownership of marijuana is legal until 8 grams limit as long as the
user is not in possession of other narcotics.
8. Switzerland - On January 1, 2012, in the state of cantons Vaud,
Neuchtel, Geneva and Fribourg cultivation of cannabis plants were
allowed to a maximum of 4 trunks per person. The goal is to eradicate the
illegal marijuana trade in the streets. Switzerland since 2000 has reduced
the penalty for possession of marijuana.
9. Spain - the decriminalization of marijuana policy in Spain tolerate private
ownership as much as 2 plants.

10.Belgium - According to the law, adults can carry up to 3 gramganja.

Belgium is one of the first countries to make perbedaanhukum between
"Possession of cannabis for personal use and other types of drug type of
offense."
11.Czech Republic - Since 2010, possession of drugs and psychotropic
already didekriminalisasi. Because according to the study, the Narcotics
Act tidakhanya increase pravelensi drug use in the country, but also failed
to stop the illicit trafficking of illicit drugs.
12.Brazil - Decriminalization of marijuana and drug decriminalization of
personal untukkeperluan in place since 2006. It is the result of Narcotics
revisiUU massively in 2006.
13.Chile - Consuming marijuana in small amounts is allowed as long as it is
done in the home and alone.
14.Uruguay - Ownership of marijuana for personal use is not penalized and
the amount allowed for personal use is not explicitly written in the law.
15.Paraguay - Have no more than 10 grams of marijuana will not
dihukumpidana, unless the court decides that the person is an addict.
16.Colombia - Colombia's Constitutional Court decided to decriminalize
possession of small amounts of marijuana and cocaine for personal use.
Possession of marijuana under 20 grams and possession of one gram of
cocaine would not be prosecuted or detained.
17.Australia - The decriminalization of marijuana users to use a small
number of countries in the region-state; Capital Territory, the Northern
Territory, South Australia and Western Australia. In other states, illegal.
18.United States - Marijuana legal in the state of Colorado and Washington.
19.Colorado: Starting on December 6, 2012 has been officially legalized
marijuana for personal use with the regulation of marijuana for adults
aged 21 and above. Cannabis plant also allows up to 6 trunks of trees
planted in the room as long as a closed (indoor).
20.Washington: Users marijuana legally allowed to have at most 28 grams of
marijuana. Growing marijuana is still not permitted unless the person is a
medical authorization. (cpt)

In Cannabis Compounds Inhibit Cancer

Compounds found in marijuana is believed by scientists United States
can stop the spread of breast cancer throughout the body.
The team of "California Pacific Medical Center Research Institute" hope that
cannabidiol or CBD could be a non-toxic alternative to chemotherapy.
Unlike cannabis, CBD does not have the characteristics of psychoactive so that
its use does not violate the law, the report of the "Molecular Cancer
Therapeutics".
The author emphasizes that they do not advise patients to smoke
marijuana.
They add that it is very unlikely that effective concentrations of CBD could be
reached by smoking cannabis.
CBD works by blocking the activity of a gene called Id-1 are believed to be
responsible for the aggressive spread of cancer cells from the tumor site of
origin - a process called metastasis. Previous research has shown that CBD can
block aggressive human brain cancers. Recent research found that CBD
appeared to have a similar effect on breast cancer in laboratory

5 Marijuana Compounds That Could Help Combat

Cancer, Alzheimers, Parkinsons (If Only They Were
Legal)
Imagine there existed a natural, non-toxic substance that halted diabetes,
fought cancer, and reduced psychotic tendencies in patients with schizophrenia
and other psychiatric disorders. You dont have to imagine; such a substance is
already here. Its called cannabidiol (CBD). The only problem with it is that its
illegal.
Cannabidiol is one of dozens of unique, organic compounds in the cannabis
plant known as cannabinoids, many of which possess documented, and in some
cases, prolific therapeutic properties. Other cannabinoids include cannabinol
(CBN), cannabichromene (CBC), cannabigerol (CBG), and
tetrahydrocannabivarin (THCV). Unlike delta-9-tetrahydrocannabinol (THC),
the primary psychoactive cannabinoid in marijuana, consuming these plant
compounds will not get you high. Nonetheless, under federal law, each and
every one of these cannabinoids is defined as schedule I illicit substances

because they naturally occur in the marijuana plant.

Thats right. In the eyes of the US government, these non-psychotropic
cannabinoids are as dangerous to consume as heroin and they possess absolutely
no therapeutic utility. In the eyes of many scientists, however, these
cannabinoids may offer a safe and effective way to combat some of the worlds
most severe and hard-to-treat medical conditions. Heres a closer look at some
of these promising, yet illegal, plant compounds.
Cannabidiol
After THC, CBD is by far the most studied plant cannabinoid. First identified in
1940 (though its specific chemical structure was not identified until 1963),
many researchers now describe CBD as quite possibly the most single important
cannabinoid in the marijuana plant. That is because CBD is the cannabinoid that
arguably possesses the greatest therapeutic potential.
A key word search on the search engine PubMed Central, the U.S. government
repository for peer-reviewed scientific research, reveals over 1,000 papers
pertaining to CBD with scientists interest in the plant compound increasing
exponentially in recent years. Its easy to understand why. A cursory review of
the literature indicates that CBD holds the potential to treat dozens of serious
and life-threatening conditions.
Studies have suggested a wide range of possible therapeutic effects of
cannabidiol on several conditions, including Parkinsons disease, Alzheimers
disease, cerebral ischemia, diabetes, rheumatoid arthritis, other inflammatory
diseases, nausea and cancer. That was theconclusion of researcher Antonio
Zuardi, writing about CBD in the Brazilian Journal of Psychiatry in 2008. A
2009 literature review published by a team of Italian and Israeli investigators
indicates that the substance likely holds even broader clinical potential. They
acknowledged that CBD possesses anxiolytic, antipsychotic, antiepileptic,
neuroprotective, vasorelaxant, antispasmodic, anti-ischemic, anticancer,

antiemetic, antibacterial, antidiabetic, anti-inflammatory, and bone stimulating

properties. Martin Lee, cofounder and director of the non-profit group Project
CBD which identifies and promotes CBD-rich strains of cannabis agrees.
Cannabidiol is the Cinderella molecule, writes Lee in his new book, Smoke
Signals: A Social History of Marijuana Medical, Recreational, and Scientific
(Scribner, 2012). [Its] the little substance that could. [Its] nontoxic,
nonpsychoactive, and multicapable.
Its also exceptionally safe for human consumption. According to a just
published clinical trial in the journal Current Pharmaceutical Design, the oral
administration of 600 mg of CBD in 16 subjects was associated with no acute
behavioral and physiological effects, such as increased heart rate or sedation.
In healthy volunteers, CBD has proven to be safe and well tolerated,
authors affirmed. A 2011 literature review published in Current Drug Safety
similarly concluded that CBD administration, even in doses of up to 1,450
milligrams per day, is non-toxic, well tolerated, and safe for human
consumption.
Yet despite calls from various researchers to allow for clinical trials to assess the
use of CBD in the treatment of various ailments, including breast cancer, colon
cancer, prostate cancer, and schizophrenia, a review of the website the online
registry for federally supported federal trials worldwide identifies only four
US-based clinical assessments of CBD. Two of these are safety studies; the
other two are evaluations of CBDs potential to mitigate cravings for heroin and
opiates. Sativex, a pharmaceutically produced, patented oromucosal spray
containing extracts of THC and CBD, is also undergoing testing in North
America for use as a cancer pain reliever under the name Nabiximols. The drug
is already available by prescription in Canada, the United Kingdom, and
throughout much of Europe for the treatment of various indications, including
multiple sclerosis.
Presently, however, options for US patients wishing to utilize CBD are
extremely limited. Most domestically grown strains of cannabis contain

relatively little CBD and many smaller-sized cannabis dispensaries do not

consistently carry such boutique varieties. A handful of prominent cannabis
dispensaries, mostly in California and Colorado, do carry CBD-rich strains of
cannabis or CBD-infused products. However, in recent months, several of these
providers, such as Harborside Health Center in Oakland and El Camino
Wellness in Sacramento, have been targeted for closure by the federal Justice
Department, which continues to deny evidence of CBDs extensive safety and
efficacy.
Cannabinol
Cannabinol (CBN) is largely a product of THC degradation. It is typically
available in cannabis in minute quantities and it binds relatively weakly with the
bodys endogenous cannabinoid receptors. Scientists have an exceptionally long
history with CBN, having first isolated the compound in 1896. Yet, a keyword
search on PubMed reveals fewer than 500 published papers in the scientific
literature specific to cannabinol. Of these, several document the compounds
therapeutic potential including its ability to induce sleep, ease pain and
spasticity, delay ALS (Lou Gehrigs Disease) symptoms, increase appetite, and
halt the spread of certain drug resistant pathogens, like MRSA (aka the
Superbug). In a 2008 study, CBN was one of a handful of cannabinoids found
to be exceptional in its ability to reduce the spread MRSA, a skin bacteria
that is resistant to standard antibiotic treatment and is responsible for nearly
20,000 hospital-stay related deaths annually in the United States.
Cannabichromene
Cannabichromene (CBC) was first discovered in 1966. It is typically found in
significant quantities in freshly harvested, dry cannabis. To date, the compound
has not been subject to rigorous study; fewer than 75 published papers available
on PubMed make specific reference to CBC. According to a 2009 review of
cannabichromine and other non-psychotropic cannabinoids, CBC exerts antiinflammatory, antimicrobial, and modest analgesic activity. CBC has also been

shown to promote anti-cancer activity in malignant cell lines and to possess

bone-stimulating properties. More recently, a 2011 preclinical trial reported that
CBC influences nerve endings above the spine to modify sensations of pain.
[This] compound might represent [a] useful therapeutic agent with multiple
mechanisms of action, the study concluded.
Cannabigerol
Similar to CBC, cannabigerol (CBG) also has been subject to relatively few
scientific trials since its discovery in 1964. To date, there exist only limited
number of papers available referencing the substance a keyword search on
PubMed yields fewer than 55 citations which has been documented to possess
anti-cancer, anti-inflammatory, analgesic, and anti-bacterial properties.
According to a 2011 review published in the British Journal of Pharmacology,
[A] whole plant extract of a CBG-chemotype would seem to offer an
excellent, safe new antiseptic agent for the treatment of multi-drug resistant
bacteria. A more recent review published this year in the journal Pharmacology
& Therapeutics further acknowledges that CBG and similar non-psychotropic
cannabinoids act at a wide range of pharmacological targets and could
potentially be utilized in the treatment of a wide range of central nervous system
disorders, including epilepsy.
Tetrahydrocannabivarin
Discovered in 1970, tetrahydrocannabivarin (THCV) is most typically identified
in Pakistani hashish and cannabis strains of southern African origin. Depending
on the dose, THCV may either antagonize some of the therapeutic effects of
THC (e.g., at low doses THCV may repress appetite) or promote them. (Higher
doses of THCV exerting beneficial effects on bone formation and fracture
healing in preclinical models, for example.) Unlike, CBD, CBN, CBC, CBG,
high doses of THCV may also be mildly psychoactive (but far less so than
THC).
To date, fewer than 30 papers available on PubMed specifically reference
THCV. Over half of these were published within the past three years. Some of
these more recent studies highlight tetrahydrocannabivarins anti-epileptic and

anticonvulsant properties, as well as its ability to mitigate inflammation and

pain in particular, difficult-to-treat neuropathy.
Like CBD, THCV is on the radar of British biotech GW Pharmaceuticals
(makers of Sativex). According to its website, the company has expressed
interest in the potential use of tetrahydrocannabivarin in the treatment of
obesity, diabetes and other related metabolic disorders. Though the compound
has been subject to Phase I clinical testing, a keyword search
on clinicaltrials.gov yields no specific references to any ongoing studies at this
time.

Low-dose vaporized cannabis significantly improves

neuropathic pain.
We conducted a double-blind, placebo-controlled, crossover study
evaluating the analgesic efficacy of vaporized cannabis in subjects, the majority
of whom were experiencing neuropathic pain despite traditional treatment.
Thirty-nine patients with central and peripheral neuropathic pain underwent a
standardized procedure for inhaling medium-dose (3.53%), low-dose (1.29%),
or placebo cannabis with the primary outcome being visual analog scale pain
intensity.
Psychoactive side effects and neuropsychological performance were also
evaluated. Mixed-effects regression models demonstrated an analgesic response
to vaporized cannabis. There was no significant difference between the 2 active
dose groups' results (P > .7). The number needed to treat (NNT) to achieve 30%
pain reduction was 3.2 for placebo versus low-dose, 2.9 for placebo versus
medium-dose, and 25 for medium- versus low-dose. As these NNTs are
comparable to those of traditional neuropathic pain medications, cannabis has
analgesic efficacy with the low dose being as effective a pain reliever as the
medium dose.
Psychoactive effects were minimal and well tolerated, and
neuropsychological effects were of limited duration and readily reversible
within 1 to 2 hours. Vaporized cannabis, even at low doses, may present an
effective option for patients with treatment-resistant neuropathic pain.
PERSPECTIVE:
The analgesia obtained from a low dose of delta-9-tetrahydrocannabinol
(1.29%) in patients, most of whom were experiencing neuropathic pain despite
conventional treatments, is a clinically significant outcome. In general, the

effect sizes on cognitive testing were consistent with this minimal dose. As a
result, one might not anticipate a significant impact on daily functioning.

Marijuana Linked To Better Brain Function In

Bipolar Patients
Results from a new study show indicate that bipolar patients with a
history of marijuana use have better neurocognitive function than those who
have never used cannabis.
The team, from The Zucker Hillside Hospital in Glen Oaks, New York,
found that patients with bipolar I (BD I) disorder who used marijuana
performed better on tests of attention, processing speed, and working memory
than other BD 1 patients, reports Mark Cowen atNews Medical.
"These data could be interpreted to suggest that cannabis use may have a
beneficial effect on cognitive functioning in patients with severe psychiatric
disorders," said lead researcher Raphael Braga.
"However, it is also possible that these findings may be due to the requirement
for a certain level of cognitive function and related social skills in the
acquisition of illicit drugs," Braga said.
In other words, it's possible, at least according to Braga, that the higherfunctioning patients self-selected due to the challenge of finding weed.
The results came from a study of 200 BD I patients, 50 of whom used cannabis,
or, in the medical parlance, under which almost everything seems to be
pathologized as a "disorder," "Cannabis Use Disorder," or, as they cutely call it,
"CUD." (Sigh...)All of the patients participating in the study underwent clinical

evaluations and completed a battery of tests measuring neurocognitive

functioning.
There were no significant differences between patients who used
cannabis ("suffered from CUD") and those who didn't, regarding age, race, or
education, the researchers wrote in Psychiatry Research.But, according to the
researchers, patients with "Cannabis Use Disorder" were more likely to have a
history of psychosis than those who didn't toke up, at 82 percent versus 67.3
percent.
But patients "with CUD" (dammit, I mean pot smokers) had significantly
better attention, processing speed/set-shifting, and working memory than those
without, putting the lie to the tired old stereotypes of "burnouts" and "stoners."
"These analyses indicate an interesting pattern suggesting superior
neurocognitive performance among bipolar patients with comorbid CUD when
compared to bipolar patients without a history of cannabis use," Braga and team
concluded. "Moreover, this cognitive advantage is noted in spite of evidence of
a more severe clinical course."
"We hope that the results from this study will help guide and encourage future
large studies and help further elucidate the multifaceted associations and
possible impact of cannabis use in bipolar disorder," the researchers wrote

Cannabis Can Help in Alzheimer's Battle

Add another link to the growing chain of studies showing that certain
chemicals found in the cannabis plant can help Alzheimer's patients. A study
published earlier this year in the Journal of Alzheimer's Disease shows that THC
can slow or end the progress of the disease.
But it's more complicated than giving patients a joint to toke -- though puffing
apparently has it's benefits as well. Researchers at the University of South
Florida treated isolated Alzheimer's cells in a lab with varying amounts of THC.
The results show that THC reduces or eliminates the protein buildup associated
with the disease.
Alzheimer's attacks the brain by building up plaques that cause
inflammation. Marijuana, coincidentally, has amazing anti-inflammatory
properties.

"THC is known to be a potent antioxidant with neuroprotective properties, but

this is the first report that the compound directly affects Alzheimer's pathology
by decreasing amyloid beta levels, inhibiting its aggregation, and enhancing
mitochondrial function," the study's lead author wrote in the journal. "Decreased
levels of amyloid beta means less aggregation, which may protect against the
progression of Alzheimer's disease. Since THC is a natural and relatively safe
amyloid inhibitor, THC or its analogs may help us develop an effective
treatment in the future."
But even toking up regularly can help prevent the disease from taking
hold, according to some studies. An Ohio State University researcher earlier this
year told the Seattle Post Intelligencer that a puff of pot a day can help reverse
memory impairment.

How to Make Drugs of Marijuana?

Half a kilogram of dried cannabis flowers can produce 55 grams of
quality extracts. The amount is usually used to cure cancer is the most serious,
except for patients whose cancer has damaged his body as a result of
chemotherapy and radiation. In such cases, the patient will require 120-180
grams to repair all the damage caused by chemotherapy and radiation. After the
patient recovered should still use extracts for health care with a dose of 1 gram
per month.
Cannabis extract is not the same as cannabis seed oil. In Europe or
America, herbal food stores often sell the oil made from the seeds of cannabis
and cannabis extracts misinterpreted as. Although cannabis seed oil is very
beneficial for health but does not contain enough THC (cannabinoids) that
serves to kill the disease.
Cannabis extracts should be made of the results of his own planting.
Make extracts from the black market does not guarantee the quality and
cleanliness so dangerous to the health of patients. Especially in Indonesia, many
marijuana being sold in the black market are not suitable for consumption
(trans. Moldy or too dry).
In general, Cannabis Sativa is used to treat patients with depression while
Cannabis indica is used to provide relaxation and rest periods. In Indonesia,
most of the cannabis available is kind of Cannabis Sativa. Cannabis is a better

kind used in the morning as an energy booster and treatment of other chronic
diseases.
Rick Simpson always make extracts of the type of strong Indica, but
cannabis Indica dominant result of cross breeding it is Sativa can produce good
extract. There are thousands of types of cannabis that has been repeatedly cross
are married and each has a different effect on health. Some types of marijuana
good for pain relief, while others return to control blood sugar levels for
diabetics or ocular pressure glaucoma patients.
Dosage and Treatment:
Take extract 1/3 the size of grain of rice and put it on the tip of the index
finger. Put the extract at some point of the gums (see illustration below).
Movement of the tip of the index finger slowly and circle until the extract was
stuck in the gums. Lift the finger and repeat the same process on the other
gums. Do this until the extracts were stuck in the fingers disappeared.
Remember that patients can use all parts of their gums to put extracts. When
patients use false teeth, false teeth off the first and did as instructed above.
Cannabis extract is a powerful drug! Patients should really understand
this. Always start treatment with the lowest dose (1/3 grain of rice) and
gradually increase the dose until 1gram per day. 1 gram dose is the dose
required to kill various diseases, especially cancer. It takes approximately 5
weeks until the patient is able to consume 1 gram of extract per day. With
increasing dosage, the patient should be carefully dividing the amount of extract
consumed each day. Patients should really take the time to find the dosage and
how to use the right in this treatment.
Patients can use the size of one big seed extract every day as a precaution
and maintaining a healthy body.
Tips:
Patients will require adaptation time until the body is completely ready to
receive this drug. Everyone has a system adaptation is different, so patients
really need to be sure and patient. Most patients require 3-5 days of adaptation.
If carried out in accordance with the procedures, this treatment will not
cause a sense of high (euphoria). Many patients do not feel the effects of the
extract when you first use and then add the dose itself, consequently there is a

sense of euphoria at times unexpected. If patients follow the instructions given

in the near future patients will feel small changes in everyday until finally
reaching a healthy condition completely.
Be sure to use cannabis extract in the morning. Jump-start with breakfast,
brush teeth, mouth wash, and use the extract according the manufacturer's
instructions. Always use the extract after eating and repeat these steps each time
the patient wants to consume the extract. This prevents sticking cannabis extract
in the leftovers and then attached to the teeth or swallowed into the stomach
(may cause high / euphoria).
Increasing doses of the extract means increasing the frequency of use,
instead of adding a dose every time wear. For example, you are able to consume
1 rice seed extract every day and wants to increase the dose to 1 grains of
rice. Your use of rice seed extract 2 times a day or equal to taking one grain
of rice every day. To reach 1 grain rice, you only need to use the extract three
times a day with the same dose. If you want to increase the dose to 2 grains of
rice a day, you eat four times a day; and so on.
1 gram of extract daily dose is usually divided into 8-10 times
consumption. This method is very helpful because it can create a system in the
body of the patient remains stable.
Patients should feel the changes that occur in the body. If patients
experience nausea, eating snacks and drinking water is sufficient to suppress it.
If allowed to occur, the patient may feel anxiety. Immediately eat and drink
water to overcome.
When using cannabis extract, make sure the body of water consumed.
Although patients do nothing, your metabolism will increase patient during
extract react. Make sure there is water around the patient and drink immediately
after the patient urinated.
Patients should consult with a health care professional if you want to use
the extract and still under treatment; especially with regard to blood pressure
medication, pain and sleep. Remember to always drink water and live a healthy
lifestyle.

CBD protection against Ebola virus

There is good scientific evidence that cannabis compounds in particular
Cannabidiol the possibility to control the immune system and protection from
viral infection. Cannabis has been known as inhibitors of fungi and bacteria and
is considered as a new class of antimicrobials for work differently from other
antimicrobials.
Ebola is a virus RNA complex organism that causes cells to "eat"
pinocytosis [events liquid intake into the cell] and then the virus hijacks the cell
to replicate itself. Replication involves can involve many mutations in the RNA
code that would make it difficult if not impossible to make an effective vaccine.
There is a US patent that shows evidence that the anti-viral activity of
compounds.
Usually the virus-infected cells will produce a surface protein that is
identified as a foreign body and the immune system will attack the cells were
infected with this. Ebola virus infection causes the cells to produce proteins that
hide the virus from the immune system. This mechanism allows the viral RNA
to hide the infected cells by the immune system to protect dr.
The cause of death by this virus is the immune system responds to the
virus inveksi. This is the cause of mortality and morbidity from this inveksi.
Furthermore, the virus triggers the immune cells to release enzymes [cytokines:
a protein made by cells that affect the behavior of other cells] that they hold.
The release of this enzyme causes lymphocytes [a type of white blood cells in
the immune system of vertebrates being] the other to release more cytokines.
This process is also called a cytokine storm.
Small blood clots in the blood vessels of the so-called DIC [Disseminated
Intravascular Coagulation] cause coagulopathy [blood clotting disorders or
excessive bleeding] where blood would not clot simultaneously with DIC
[bleeding and clotting occurs at the same time]. Symptoms of shock against

toxins [Toxic Shock Syndrome] occurs when cytokines are released causing
blood vessels to dilate in such a way.Marijuana compounds proven to reduce
and prevent against toxic shock and DIC (2)
Ebola virus also attacks the attachment of the cells caused by killer cells
immune to release VEGF [vascular endothelial growth factor: signaling proteins
produced by cells that menstimulasivasculogenesis and angiogenesis. It is part
of a system that restores oxygen supply to tissues when blood circulation is
inadequate] which resulted in the destruction of the tight relationship between
the cells and lead to leaking of fluid between cells until bleeding.
Cannabis compounds can inhibit VEGF processes that occur in the
relationship between cells. Obstructing VEGF by cannabis compounds may
prevent bleeding such cells.Cannabis compounds can inhibit VEGF and inhibit
glioma brain tumors [type of tumor that begins in the brain or spinal cord] (6).
Very reasonable to estimate that cannabis compounds that inhibit VEGF and
other cytokines when Ebola virus attack will help the survival of this deadly
virus (6 & 7). Stopping the release of cytokines aka a major feature of the
treatment of this deadly disease.
The discovery and application of the endocannabinoid Signalling System
is proven to control almost all of the disease to humans. Compounds of
medicinal marijuana emerge as a new classification that is capable of treating
infections from bacteria, fungi, and viruses are different which is actually the
way it works is not found in the classification of other drugs (1).
Cannabis compounds are clearly shown to have activity of killer viruses
including Hepatitis C and HIV. Regulate marijuana compounds inhibiting the
immune response to inveksi (2) (3). Excerpts from US patent (3 & 4) is
evidence that cannabis compounds can inhibit many different types of viruses of
viral replication process itself. The patent also proves that cannabis compounds
can decrease the immune response stimulated by virus infection. The claims
made in US Patent is as follows:
(refer to the patent for the proper citation and clear)
- A method for treating HIV disease by directly inhibiting viral replication
process using derivative cannabidiol [CBD]
- Compounds CBD cannabis which is used to treat HIV disease by directly
inhibiting the virus replica

- A method for treating diseases of the immune function that produces an

infection such as Simian Immunodeficiency Virus, Feline Immunodeficiency
Virus, Herpes Simplex virus, Epstein-Barr virus, cytomegalovirus, hepatitis B
and C, influenza virus, rhinovirus and inveksimikrobakteri use Cannabidiol
derivative claim 2
- US Patent this, proving that cannabis compounds to treat disorders of the
immune system called a cytokine storm caused by different viruses (4)
- In the description, the patent US proved that the regulation of the immune
system may be the key to the survival of people with HIV and can be applied to
the survival of patients with Ebola. The process of direct lethal marijuana
compounds [virus infection] proved in HIV infection (4) but not on Ebola.
However, inhibition of VEGF is essential to prevent leakage of endothelial
[lining cells that line blood vessels and lymph, liver, and other body cavities]
and bleeding.
Because marijuana is very safe to eat, especially under the supervision of a
doctor, the authors believe that snagat important for the medical community to
begin human trials for the sake of the survival of the Ebola virus survival
regardless of political obstacles.

References:
1) Antibacterial Cannabinoids from Cannabis sativa: A Structure - Activity
Study Antibacterial Cannabinoids from Cannabis sativa: A Structure - Activity
Study; Giovanni Appendino et al. The School of Pharmacy, University of
London
2) Protection Against Septic Shock and Suppression of Tumor Necrosis Factor
and Nitric Oxide Production by Dexanabinol (HU-211), a cannabinoid
Nonpsychotropic Ruth Gallily1, Aviva Yamin1, Departments of Immunology,
The Hebrew University, Faculty of Medicine, Jerusalem, Rehovot, Israel .
3) cannabinoid derivatives US patent 20,070,179,135 A1
4) Treatment of HIV and diseases of immune dysregulation US 20,080,108,647
A1

5) Curr Pharm December 2006; 12 (24): 3135-46. Cannabinoids, immune

system and cytokine network. Massi PVaccani AParolaro D, University of
Insubria, Via A. da Giussano 10, 21052 Busto Arsizio (VA), Italy
6) Cancer Res August 15, 2004 64; 5617 Cannabinoids inhibit the Vascular
Endothelial Growth Factor Pathway in Gliomas Cristina Blzquez
HYPERLINK "http://cancerres.aacrjournals.org/content/64/16/5617.full"1,
7) How Cannabis Might Keep Coronary Stents Open Longer,
www.cbds.com/.../how-cannabis-might-keep-coronary-stents-open-longer, June
10, 2014 David Allen MD