Professional Documents
Culture Documents
11 July 2011
Many people with type 2 diabetes can manage blood sugar levels effectively on oral
diabetes medications and lifestyle changes alone. Others will need to combine oral
diabetes medications with injectable diabetes drugs in order to bring their blood glucose
levels into a healthy range. Finding the right combination is the key to managing diabetes
successfully.
For years, insulin was the only injectable diabetes medication available to help control
blood sugar. Today, several newly approved injectable diabetes drugs are available. A
growing number of medication options are also available, so doctors can individualize
diabetes treatment with greater precision than ever before.
Combining Diabetes Medications for Optimal Effect
How will your doctor decide the best diabetes drug regimen for you? The first principle
is to make life as easy and therapy as effective as possible, says Daniel Einhorn, MD,
president of the American Association of Clinical Endocrinologists and medical director
of the Scripps Whittier Diabetes Institute in La Jolla, Calif. Type 2 diabetes is a lifelong
problem. We want to choose therapies that people can easily live with.
One factor is how comfortable people feel giving themselves injections. Some patients
are fine with injectable medications. Others will do anything not to have to give
themselves injections, says Eleftheria Maratos-Flier, MD, professor of medicine at Beth
Israel Deaconess Medical Center in Boston.
The second principle of combination diabetes drug therapy, according to Einhorn, is
choosing medication therapies that work in complementary ways. Today we have a
variety of drugs that work in very different ways, so combinations can be especially
effective, says Einhorn.
One of the most commonly used oral drugs, metformin (sold under the brand names
Blumetza, Fortamet, Glucophage, and Riomet), is considered the cornerstone of most
combination therapy. It works by decreasing the amount of glucose produced by the liver.
Metformin can be paired with insulin or with a GLP-1 agonist, which stimulates insulin
production.
Doctors may also combine insulin with a GLP-1 agonist and a thiazolidinedione oral
medication (Actos and Avandia), which sensitizes the body to insulin. For people
comfortable with using injectable drugs, doctors may recommend one of the two new
GLP-1 agonists, Byetta and Victoza. For people who dont want an injectable drug, the
alternative is a DPP-4 inhibitor (Januvia, Tradjenta, and Onglyza), which is taken orally.
Both of these classes of drugs work in a similar way and are considered equivalent.
the regimen if patients stop responding to a certain drug or develop side effects.
To make sure your diabetes medication regimen is working adequately, its important to
monitor blood sugar levels. How often you test blood sugar levels will depend on the
medications youre taking and how well your blood sugar levels are controlled.
The sooner you bring blood sugar levels down to normal, and the better control you
have over time, the less likely your diabetes is to progress, says Einhorn.