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The GIT can be divided into three regions --the upper (mouth, stomach and upper portion
of duodenum), the middle (lower half of the duodenum to the ileocolic sphincter) and the
lower (caecum, colon and rectum).
Carminatives: These are aromatic substances which assist the eructation reflex, their
mode of action is obscure. Dill oil is used for relief of flatulence. Eg. Fennel, cinnamon,
chamomile etc.
(Gelidiaceae)
psyllium and
Isapghol
Senna
Hydrophillic colloids
producing laxative
Plantago ovata
( Plantaginaceae)
Cassia angustifolia
Contain anthraquinone
(Leguminosae)
Rhamnus purshiana
mucosa
Same as senna
(Rhamnaceae)
Rhubarb
Rheum emodi
(Polygonaceae)
Aloes
Castor oil
Aloe barbadensis
(Liliaceae)
Ricinus communis
(Euphorbiaceae)
on hydrolysis yield
riconoleic acid, irritant to
Podophyllum resin,
Podophyllum hexandrum
(Berberidaceae)
Jalap resin
Ipomoea purga
(Convolvulaceae)
Morphology
Condition
Type
Size
Colour
Apex
Alexandrian
Dry
Paripinnately compound leaflets
2 4cm (L) , 7 12mm (W)
Pale grayish green
Acute apex with sharp spine
Indian
Dry
Paripinnately compound leaflets
2.5 6 cm(L), 7 8mm (W)
Grayish green
less acute with sharp spine
Shape
Base
Margin
Surface
Texture
Venation
(mucronate)
Ovate to lanceolate
Uniformly lanceolate
Unequal (more asymmetrical)
Less asymmetrical
Entire , curled
Entire
More pubescent
Less pubescent with press markings
Thin and brittle
Firm and flexible
Pinnate veins anatomizing towards Pinnate veins anatomizing towards
Gen.
margin
Less entire(more broken)
margin
Entire(less broken)
Appearance
Odour
Faint
Taste
Mucilaginous and slightly bitter
Faint
Mucilaginous and slightly bitter
.
Chemical constituents: Anthracene glycosides
Sennoside A,Sennoside B, Sennoside C and D.
Free aglycones: Rhein, Aloe-emodin
Uses: Used as laxative. In general all anthraquinones containing drugs cause irritation of
the muscular coat of large intestine and have some griping effect, thus they are prescribed
along with other carminatives.
Borntragers test: The drug is boiled with dilute sulphuric acid, filtered and to the
filtrate organic solvent like benzene, chloroform or ether is added and shaken well.
The organic layer is separated to which ammonia is added slowly. The ammoniacal
layer shows pink to red colour due to the presence of anthraquinone glycoside.
FENNEL FRUIT
Botanical Source: the dried ripe fruits of Foeniculum vulgare Family: Umbelliferae
Geographical source: Cultivated in Europe ,India, China and Egypt
MORPHOLOGY OF FENNEL FRUIT
Macroscopy:
Active constituents:
A mixture of Isoquinoline alkaloids (2-5%) consisting of Cephaeline (about 30%),
Emetine (70%), it also contains psychotrine, methyl psychotrine and emetamine.
Uses: It is used as expectorant, emetic and anti-amoebic.
ISAPGOL
Source: Isapgol consists of the dried seeds of Plantago ovata. Family: Plantaginaceae
Geographical source: Pakistan, India
Chemical constituents:
Carbohydrates-Mucilage (Pentosan + Aldobionic acid)
Fixed oil and proteins
Therapeutically and pharmaceutical uses
1. Demulcent
2. Bulk laxative in chronic constipation
3. In chronic dysentery of amoebic and bacillary origin