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Analytic studies:
Case Control Study
Cohort Study
II- Experimental Studies (Interventional studies):
Clinical Trials
Community Trials
I- Observational Studies:
A. Descriptive Studies: Hypothesis generating
These studies usually explore frequency (prevalence) and describe pattern (i.e.
distribution according to person, time and place) of the disease in the community. This will
help us to develop hypothesis about risk factors of the disease.
Cross Sectional Survey:
In this type the health status of individual is assessed with respect to presence or
absence of exposure to disease at the same point of time (a cross-section of the
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population). For this reason you cannot determine if really exposure preceded disease
or not, e.g. assess the presence of obesity in relation to diabetes mellitus.
Screening Tests
Definition:
Application of tests, examinations, or other procedures which can be applied rapidly to sort
out apparently well persons; who probably have a disease from those who probably do not.
Why using screening tests:
The disease is an important public health problem.
Early detection of disease.
Early treatment that help rapid cure.
Criteria of screening test:
Simple, easy to conduct.
Not invasive.
Not painful.
Not time consuming.
Cheap.
Valid (sensitive and specific) and accurate.
Reliable (give similar results whenever repeated).
Validity: is the rate at which a test is capable of differentiating the presence or absence of a
disease concerned.
Example:
Screening test done to neonate to detect low level of TSH (done in Egypt, in PHC
facilities).
Studies could be conducted with the least resources (personnel and equipment).
2.
3.
2. Cohort Study:
It is a prospective study i.e. follows up the incidence of a disease in the future.
It involves:
i. Study cohort:
Individuals exposed to a certain factor that may be associated with a disease e.g. smoking
and lung cancer.
ii. Control cohort:
A group of individuals not exposed to the studied factor.
II-
Large number
Temporal sequence
Loss to follow up
Multiple outcome
Expensive
Benefits of Sampling:
- Saves effort, money and time.
- Testing every unit can be destructive.
3 Steps to Sampling:
- Identify the population.
- Determine the required sample size.
- Select the sample.
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Sampling Techniques:
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data
information
Sources of Data:
1. Census Data: It is usually taken every ten years to;
Enumerate the population.
Know socio-demographic characteristics of people.
Calculate vital statistics (morbidity, mortality, and fertility indices).
2. Records:
a. Records of health offices :
These are records for registration of births, deaths, occurrence of infectious diseases
and immunization of newborns and children.
b. Annual statistical reports:
These reports are published by the Ministry of Health (MOH) and the
World Health Organization (WHO).
c. Case records : It is usually reported by hospitals and outpatient clinics.
3. Survey: data collection for a specific health problem by conducting special studies.
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Variable:
Definition:
Variable is a character with different measurement (values) that may vary from object
to object, each measure give different disease picture. Variable are better expressed as data.
e.g. Age is a variable has different measurements.
Sex is variable has 2 measurement Male, Female.
Types of variables (data):
Quantitative
Qualitative
I- Quantitative (Numerical):
Measurements are expressed in numbers.
A- Discrete variables: variable expressed as a whole number with no fraction.
e.g. - Number of children in family.
- Number of pregnancies.
- Pulse rate.
e.g. : Sex (Male and Female), Presence of Hypertension (Yes or No) (Dichotomous).
- Blood group (ABO) and race (White, Black, and Hispanic)
(Multichotomous).
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Frequency
Interval
Relative
Frequency
1019
2029
3039
4049
5059
6069
7079
Total
5
19
10
13
4
4
2
57
Histogram
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(%)
8.8
33.3
17.5
22.8
7.0
7.0
3.5
100.0
Frequency polygon
If the smooth line passes between the points instead polygon, it is known as frequency
curve.
Frequency curve
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Parameters:
In quantitative variables we use two concomitant measures to summarize the data,
measures of central tendency (the middle) and measures of dispersion (variability).
I- Measures of Central Tendency: mean and median only
a. Mid Range:
The value that lies mid way between the highest (maximum) and lowest
(Minimum) values.
Where (Greek letter sigma) means to add, X represents the individual observations,
and n is the number of observations.
c. The Median:
The median is the middle value in a set of data arranged in order of magnitude. It
divides the data into 2 equal groups above and below the median value.
d. The Mode:
The mode is the value that occurs most frequently.
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In percentile, we divide the data into 100 equal parts, each part represent 1 % of all
values, 90 percentile is the value which 90 % of all values below it & 10 % above it,
50 % percentile equal the median value of the data set. Deciles divide the data into 10
equal parts. While quartile divides the data into four equal parts. The interquartile
range IQR contains the middle 50% of the scores. It is obtained by Q3 Q1 (i.e. the
75th percentile the 25th percentile).
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Sex
Male
Female
Total
Number
42
18
60
Percent %
70
30
100
Diseased
12
8
20
Not diseased
30
10
40
Total
42
18
60
Graph:
Two types of graphs can be used
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a. Bar chart:
Bar Chart
b. Pie Chart:
Pie chart
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Parameters:
-Proportion= part/total100
-Ratio= part/part
-Rate is a proportion has a relation to time.
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Presentation of Data
Quantitative data
Tables
Graphs
Qualitative data
Parameters
Of central tendency;
Midrange
Mean
Frequency polygon Median
Relative frequency table
Mode
Frequency distribution
Histogram
Tables
Simple frequency
Bar chart
Parameters
Ratio
Frequency curve
Of dispersion;
Range
SD
Percentile, deciles & interquartile
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Graphs
Proportion
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Inferential statistics mean the use of statistics to make conclusions about a population
the basis of the results obtained from a sample drawn from that population. The common
2 methods which used are estimation of the parameters and hypothesis testing.
Hypothesis Testing:
To answer a statistical question, we should translate it into hypothesis to be subjected to
a test. Depending on the result of the test we accept or reject the hypothesis. The hypothesis
testing is known as null hypothesis (H0), for every null hypothesis there is alternative
hypothesis (HA)
Statistical tests used in testing a hypothesis:
The type of statistical test to be used depends on type of data, how the data distributed,
and the objectives of the study.
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Quantitative data
Qualitative data
Parametric
Non-parametric
Parametric
(Data obtained from normal distribution)
(Data not obtained from normal distribution)
Z- test
2 groups;
Student t-test
> 2 groups;
ANOVA test
2 groups;
Mann-Whitney test
> 2 groups;
Kruskal - wallis test
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Non- parametric
Chi- square