Professional Documents
Culture Documents
DOI 10.1007/s10803-006-0238-3
ORIGINAL PAPER
K. H. Pitetti (&)
Department of Physical Therapy, College of Health
Professions, Wichita State University, Wichita, KS 672600043, USA
e-mail: ken.pitetti@wichita.edu
A. D. Rendoff
Department of Physician Assistant, College of Health
Professions, Wichita State University, Wichita, KS 672600043, USA
T. Grover
Heartspring, Wichita, KS, USA
M. W. Beets
Oregon State University, Corvallis, OR, USA
The health benefits (e.g., reducing the risk for heart disease and type 2 diabetes) of regular exercise/physical
activity are well established (Blair et al., 1989; Booth,
Gordon, Carlson, & Hamilton, 2000; Pate, Pratt, & Blair,
1995). It has been documented that children, adolescents,
and adults with developmental disabilities (e.g., mild to
moderate mental retardation) demonstrate physical fitness levels that are not only inferior to their non-disabled
peers but reflect a population exhibiting a sedentary
lifestyle (Fernhall & Pitetti, 2001; Pitetti & Campbell,
1991; Pitetti, Rimmer, & Fernhall, 1993; Pitetti, Jongmans, & Fernhall, 1999; Pitetti, Yarmer, Fernhall, 2001).
This is also true of youth with severe developmental
disabilities, including youth with autism, living in a residential/school treatment facility (Pitetti et al., 1999).
Thus, it is suggested that a sedentary lifestyle contributes
to an increased risk of early morbidity and mortality in
persons with developmental disabilities. This belief is
strengthened by data showing that adults with developmental disabilities may be at risk for preventable mobidity and motality because of insufficient healthpromoting behaviors, including physical inactivity
(Chanias, Reid, & Hoover, 1998; Hayden, 1998; Sutherland, Couch, & Iacono, 2002). Accordingly, it appears
that physical activity is an important contributor to
health in populations with developmental disabilities.
It has been shown that participation in exercise programs can improve the physical fitness and health profiles of persons with mild to moderate mental retardation
(Andrew, Reid, Beck, & McDonald, 1979; Beasley, 1982;
Bundschuh & Cureton, 1982; Fernhall, 1993; Frey,
McCubbin, Hannington-Downs, Kasser, & Skags, 1999;
Nordgren, 1971; Pitetti & Tan, 1991; Pitetti et al., 1993;
Rimmer, Heller, Wang, & Valerio, 2004; Schurrer,
Weltman, & Brannel, 1985) and persons with severe
123
998
mental retardation without autism (Tomporowski & Ellis, 1985; Tomporowski & Jameson, 1985). While exercise studies have been performed with youth diagnosed
with severe developmental disabilities including autism
(Bachman & Fugua, 1983; Bachman & Sluyter, 1988;
Baumeister & MacLean, 1984; Elliot, Dobbin, Rose, &
Soper, 1994; Kern, Koegel, Dyer, Blew, & Fenton, 1982;
Kern, Koegel, & Dunlap, 1984; McGimsey & Favell,
1988; Rosenthal-Malek & Mitchell, 1997), the main
interest was the reduction of maladaptive behaviors and
not specifically the ability to increase exercise capacity
or the reduction of body weight.
In a recent study, Lotan and colleagues (Lotan, Isakov, & Merrick, 2004) performed a 2-month treadmill
walking program with 4 children (8.511 years) with
Rett syndrome to determine the affect treadmill walking program on aerobic fitness. Although children with
Rett syndrome share behavior characteristics similar to
autism (Diagnostic and Statistical Manual of Mental
Disorders, 2000), they also demonstrate ataxic motor
anomalies (i.e., gait patterns are unsteady and initiating
motor movements can be difficult). Lotan et al. (2004)
reported improvements in physical fitness by changes in
resting and treadmill exercise heart rates. In addition,
the efficacy of the treadmill walking program to increase weekly activity levels was determine by the
amount of calories (kilo-calories) expended throughout
the study. However, the specific methodology used by
Lotan et al. (2004) to determine resting and treadmill
heart rates was not reported and the validity of the
method used to determine caloric expenditure for each
treadmill training session is problematic in that it did
not follow established guidelines (American College of
Sports Medicine, 2005).
Therefore, the purpose of this study was to determine
the efficacy of incorporating a 9-month treadmill walking
program into the weekly academic curriculum of youth
with severe developmental disabilities including autism.
For this study, efficacy was defined as a significant progression in treadmill walking frequency, speed, elevation
(i.e., exercise capacity), and monthly calories expended
coupled with a reduction in body mass index.
Methods
Participants
Ten adolescents/young adults (6 male and 4 female)
participating in this study were clients of a Midwestern
residential/school treatment facility for people with
severe developmental disabilities. Written informed
consent was obtained from parents/guardians of the
123
18
18
18
15
14
Weight
(kg)
96.2
92.9
129.2
80.7
91.4
Height
(cm)
179.7
180.3
168.3
176.5
160.0
Body mass
(kg m2)
30.0
28.6
45.6
25.9
35.7
Participant
999
Diagnoses
Exercise group
1
Autism
Severe mental retardation
Obesity
Autism
Severe mental retardation
Visual impaired
Behavior disorder
Autism
Hypertension
Fibromyalgia
Chronic constipation
Hypercalcemia
Mild mental retardation
Autism
Chronic constipation
Severe mental retardation
Autism
Severe mental retardation
Reactive attachment Disorder
Oppositional defiant disorder
Post-traumatic stress disorder
Control group
6
Autism
Severe mental retardation
Mood disorder
IED
7
Autism
Visual impairment
Seizures
Mental retardation
Attention deficit hyperactivity
Disorder
10
Autism
Aspergers syndrome
Attention deficit hyperactivity
Disorder
PDD
Anxiety disorder
Autism
Seizure disorder
Disruptive behavior disorder
Severe mental retardation
Scoliosis
Autism
Mental retardation
Obesity
Medications
Risperdal 1 mg tab (1 tab BID)
Docusate Sodium (200 mg SID)
Certavite (1 tab SID)
Diphenhydramine (25 mg BID)
Benzac gel 10% (Apply to skin BID)
Clonidine 0.1 mg tab (1/2 tab am, 2 tabs pm)
Risperdal 1 mg tab (1 tab am, 2 tabs pm)
123
1000
Weight
98.0 18.3 93.0 32.3 92.9 15.5 91.2 30.9
(kg)
33 7.82 30.9 8.49 30.2 6.33 30.0 7.35*
BMI
(kg m2)
123
Initial
Treadmill
walking
group
Month 9
Control
group
Treadmill
walking
group
Control
group
1001
2
the: 2SE : The SE (standard
error of measurement)
p
was calculated by: SE s1 1 rxx ; where s1 is the
standard deviation of the control and experimental
group pre-test measure and rxx is the testretest
Fig. 1 Exercise group versus
control group BMI and body
weight
reliability coefficient of the measure. For our analysis, we used the Spearman Rank Order coefficient
(q) between baseline and month 1 measures. An RC
equal to or greater than 1.96 indicates significant
changes occurred in the measure, in this case BMI.
Given the limitations with the small sample size,
changes were graphically illustrated in outcome
variables for the TWG and CG over the 9-month
study.
Results
The primary outcomes of interest, body weight and
body mass index (BMI), for month 1 (i.e., baseline)
and month 8 for the TG and CG are presented in
Table 1. Monthly body weight and BMI for both
groups are shown in Fig. 1. At baseline, there were no
significant differences between groups for body weight
or BMI. Comparisons between baseline and month 8
for the TG and CG, separately, demonstrated the
following, (a) a significant decrease in BMI for the
TWG, t (4) = 3.23, P = .016, whereas no significant
changes in BMI for the CG, t (4) = 1.149, P = .315; and
(b) a non-significant reduction in weight for the TWG,
t (4) = 1.904, P = .065 and the CG, t (4) = 0.879,
P = .215 (see Table 2).
The effect size (ES) for change in BMI over the
duration of the study indicated a modest effect for the
TG (ES = .38) and a minimal effect for the CG
(ES = .03). The reliable change index (RC) indicated
that three of the five TG participants reliably reduced
their BMI (RC range 2.453.65) over the duration of
the study (see Table 1). Interestingly, one of the CG
participants also reduced their BMI during this same
34
220
33
32
210
31
205
30
200
215
29
195
28
1
Month
Exp Wht
Cont Wht
Exp BMI
Cont BMI
123
1002
1400
35
1200
1000
30
800
27.5
600
25
400
22.5
200
Exp BMI
20
123
5
Month
32.5
Exp CE
9
did not report (a) specific clinical diagnosis, or medication, and (b) individual or group mean weekly or
monthly initial and incremental increases in treadmill
speed, grade or walking duration. However, the major
methodological difference between studies concerned
determination of caloric expenditure. In the present
study, caloric expenditure was determined from equations established by the American College of Sports
Medicine (ACSM, 2005) and calculated accordingly.
The validity of the formula used by Lotan et al. (2004)
to determine caloric expenditure was not established
(i.e., no reference(s) were given). That is, according to
ACSM (2005) equations, and using Lotan et al. (2004)
highest reported treadmill speed (1.5 k h1) and grade
(1%), average weekly duration (19.9 min), and an
estimated weight of 45 kg (although body weight was
not reported), the total caloric expenditure would be
24.1 calories for that session. Lotan et al. (2004)
reported an average of 213.5 calories per session, an
885% difference. Even if one increased or decreased
the estimated body weight of 45 kg by 50%, this would
not account for the significant differences in estimating
caloric expenditure.
The U.S. Surgeon General (U.S. Department of
Health and Human Services, 1996) along with the
Centers for Disease Control and Prevention and the
American College of Sports Medicine recommend a
minimum duration of 30 min of moderate intensity,
physical activity for 57 days of the week (Pate et al.,
1995). Brisk walking (i.e., 34 mph) has been recognized as a type of moderate activity and has been
shown to substantially reduce the risks for heart disease, stroke, and type 2 diabetes (Gregg, Gerzoff,
Caspersen, Williamson, & Narayan, 2003; Hakim et al.,
1999; Hu et al., 1999; Lee, Rexrode, Cook, Manson,
1003
Table 4 Average treadmill walking speed, time, elevation and METS per exercise group participant per month
Participant
1
2
3
4
5
Mean
SD
Month 1
Month 2
Freq
Speed
Time
ElVN
METS
Freq
Speed
Time
ElVN
METS
Freq
Speed
Time
ElVN
METS
1.8
3.0
1.8
2.3
3.5
2.5
.8
2.35
3.02
3.00
3.50
2.78
2.93
.42
8.50
16.55
17.63
20.21
20.00
16.57
4.78
.00
.00
.00
.17
.06
.05
.07
28.25
114.61
68.19
146.04
151.31
101.68
52.71
4.8
3.8
3.0
2.3
4.5
3.7
1.0
2.91
3.10
3.07
3.44
2.94
3.09
.21
16.29
17.50
19.50
20.96
18.85
18.62
1.80
.07
.00
.08
.00
.10
.05
.05
184.46
154.49
147.54
163.81
210.73
172.21
25.63
2.8
6.0
2.3
3.0
4.0
3.6
1.5
3.23
3.17
3.22
3.54
3.14
3.26
.16
14.03
15.10
20.08
22.38
18.83
18.08
3.48
.34
.10
.88
.31
.46
.42
.29
139.39
236.95
198.25
213.85
237.53
205.19
40.33
17.13
18.60
21.27
15.50
20.12
18.52
2.30
.19
1.08
3.47
2.44
1.48
1.73
1.26
111.75
394.04
928.83
299.19
386.36
424.03
304.24
18.61
19.94
15.36
17.38
18.43
17.94
1.71
1.68
2.00
1.75
1.83
1.26
1.70
.28
584.70
747.06
511.11
444.20
436.66
544.75
127.92
Month 4
1
2
3
4
5
Mean
SD
4.8
3.3
2.0
1.5
5.3
3.4
1.7
3.46
3.24
3.36
3.55
3.20
3.36
.15
Month 5
18.59
19.44
21.61
19.46
20.30
19.88
1.14
.96
.76
1.25
1.46
.44
.97
.40
484.04
272.67
231.19
278.08
375.93
328.38
101.94
Month 7
1
2
3
4
5
Mean
SD
Month 3
4.0
6.0
4.0
2.8
5.3
4.4
1.2
3.40
3.19
3.38
3.54
3.25
3.35
.14
4.3
4.0
3.3
2.3
4.3
3.6
.9
3.47
3.13
3.33
2.66
3.27
3.17
.31
Month 6
20.19
19.21
21.51
17.33
20.49
19.75
1.58
1.34
1.57
2.60
2.29
1.58
1.87
.54
528.86
464.68
628.14
411.20
564.33
519.44
84.61
Month 8
19.84
18.75
20.25
18.48
19.25
19.31
.74
2.03
1.14
2.21
2.10
1.28
1.75
.50
600.08
603.73
660.37
464.09
517.29
569.11
77.78
6.5
5.5
4.0
3.3
4.5
4.8
1.3
3.58
3.50
3.54
3.68
3.53
3.57
.07
1.8
4.3
3.8
1.0
2.8
2.7
1.4
3.29
3.08
3.46
2.80
3.28
3.18
.25
Month 9
18.89
19.21
20.17
19.53
20.60
19.68
.70
1.75
1.85
2.00
1.75
1.80
1.83
.10
861.99
784.39
639.32
559.10
680.92
705.14
119.51
4.0
4.3
4.3
3.5
4.5
4.1
.4
3.90
3.93
3.79
4.00
3.70
3.86
.12
123
1004
bio-markers (e.g., fasting blood glucose) indicating reduced risk for these diseases were not collected in the
current study. Nevertheless, the overall percent reduction in BMI and weight suggests the health profiles of
the participants were positively impacted.
The significant decrease in BMI by the TWG becomes
even more noteworthy when considering that two participants in the TWG (#1 and #2) were taking daily doses
of 1 mg of risperdal (risperidone, Table 2). Resperidone
has been shown to have efficacy for treating aggression,
self-injury, and property destruction for persons with
developmental disabilities, including adolescents and
young adults with autism (APA, 2000). However, it was
found that significant weight gain was a limiting side
effect when using daily dosages of reperidone, similar to
the daily dosages used by participants #1 and #2 (i.e.,
1 mg/day) (Hellings, Zarcone, Crandall, Wallace, &
Schroeder, 2001). As stated by Hellings et al. (2001),
...the drug treatment (resperidone) may be stopped
prematurely because of weight gain in spite of good
efficacy (on behavior), without any trials of nutritional
consultation and exercise intervention. Participant #1
demonstrated a reduction in body weight (212188 lbs)
and BMI (3025.6), while the body weight and BMI for
Table 5 Average caloric expenditure per exercise group participant per week by month and location
Participant Month 1
Class
1
2
3
4
5
28.5
.0
169.0 19.0
155.3
.0
207.3
.0
209.8 33.0
Mean SD
20.0
0.0
.0
.0
.0
48.5
188.0
155.3
207.3
242.8
168.38 74.1
Month 4
1
2
3
4
5
741.8 55.0
417.8
.0
522.3
.0
209.3
.0
562.3
.0
Mean S.D.
Month 3
Class
Class
233.8 20.0
242.0
0.0
334.8
.0
175.5
.0
282.0 42.5
Mean SD
9.5
21.0
.0
.0
26.8
806.3
438.8
522.3
209.3
589.0
513.14 217.7
1089.5
.0
40.3
1015.5 45.0
84.8
1446.0
.0 111.3
820.8
.0
.0
796.3 92.5
43.5
Mean S.D.
783.5
657.8
1411.8
689.3
831.5
Mean
57.3
10.0
.0
.0
12.3
311.5
252.0
334.8
175.5
336.8
282.12 68.7
1129.3
1145.3
1557.3
820.8
932.0
1116.94 281.4
57.8
97.0
.0
.0
53.8
S.D.
28.5
6.8
.0
.0
.0
222.8 0.0
267.0 82.3
449.3
.0
339.3
.0
335.3 16.5
Mean SD
13.0
37.3
.0
.0
24.3
235.8
386.5
449.3
339.3
376.0
357.38 78.7
Month 6
Month 8
123
Month 5
Month 7
1
2
3
4
5
Month 2
869.8
761.5
1411.8
689.3
885.3
923.54 284.5
177.8
.0
.0
546.8 36.5 54.0
2082.0
.0
.0
403.5
.0
.0
574.8 38.0
.0
Mean S.D.
177.8
637.3
2082.0
403.5
612.8
782.68 749.5
Month 9
1292.3
858.5
.0 16.3
1346.8
1213.8
.0
.0
1492.5
1084.5
.0
.0
667.0
754.0
.0
.0
1072.3
585.3 31.3 22.8
1174.18 321.2 Mean S.D.
874.8
1213.8
1084.5
754.0
646.0
914.62 233.4
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