ISSN: 2395 - 0471

Original Article

1 Fatima Institute of Medical Sciences, Kadapah, Andhra Pradesh,

Shri BM Patil Medical College, Hospital & Research Center, Bijapur, Karnataka.
3 PDVVPFs Medical College, Ahmednagar, Maharashtra. 4Bhaskara Medical College, Hyderabad. 5 Santiram Medical College, Nadhyal, Andhra Pradesh.
2 BLDEUs

*Corresponding author email: ambu2mail@gmail.com

Received: 12th Jan 2015, Accepted: 14th Mar 2015.

ABSTRACT

KEYWORDS:

INTRODUCTION

MATERIALS AND METHODS

Int J Clin and Biomed Res. 2015;1(2): 99-101

Page 99

T Nageshwara Rao et al.

Effect of Nicorandil on Pentylenetetrazole (PTZ) Induced Convulsions in Mice

Duration of PTZ indused convulsions

14

Duration time (min)

12
10
8

6
4
2
0

STATISTICAL ANALYSIS

normal
saline

Sod ium Nico randil Nico randil Nico randil Nico randil
Valp roate (5 mg / (10 mg / (20 mg / (40 mg /
(200 mg /
Kg)
Kg)
Kg)
Kg)
Kg)

RESULTS

DISCUSSION

Onset of PTZ indused convulsions

Onset time (min)

5
4

3
2
1
0
normal Sod ium Nico randil Nico randil Nico randil Nico randil
saline Valp roate (5 mg / (10 mg / (20 mg / (40 mg /
(200 mg /
Kg)
Kg)
Kg)
Kg)
Kg)

Int J Clin and Biomed Res. 2015;1(2): 99-101

Page 100

Effect of Nicorandil on Pentylenetetrazole (PTZ) Induced Convulsions in Mice

T Nageshwara Rao et al.

CONCLUSION

REFERENCES

Int J Clin and Biomed Res. 2015;1(2): 99-101

Page 100