NATHAN BASISTY

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Nathan Basisty
Curriculum Vitae
August 16, 2015
2211 NE 50th St. Apt 5
Seattle, WA 98105
206-214-8296
nbasisty@uw.edu
EDUCATION
2015 (expected)
2009
2006

RESEARCH
2010-2015
2008-2010

University of Washington
1959 NE Pacific Ave
HSB K-081, Box 357705
Seattle, WA 98195-7705

Ph.D. Molecular Basis of Disease

Department of Pathology, University of Washington, Seattle, WA
B.S. Biochemistry
University of Washington, Seattle, WA
A.S. Biology
Highline Community College, Des Moines, Washington

Graduate Research Associate, Rabinovitch Laboratory

Department of Pathology, University of Washington, Seattle, WA
Lab Technician/Undergraduate Research, Beavo Laboratory
Department of Pharmacology, University of Washington, Seattle, WA

HONORS/AWARDS
2015
Aging Cell Best Paper Prize 2014 - Altered proteome turnover and
remodeling by short-term caloric restriction or rapamycin rejuvenate the
aging heart
2015
Glen-AFAR Scholarship for Research in the Biology of Aging
2013-2015
Honor Society
2008-2009
Deans List
2005-2006
Whos Who Among Students in American Junior Colleges
2005-2006
Phi Theta Kappa
2004-2006
Honors Scholar Program
2004-2006
Vice Presidential Honor Roll
2004-2006
Running Start
2004-2005
Deans List
PUBLICATIONS (**co-first author)
Published
Tocchi A, Quarles E, Basisty N, Lemuel G, Rabinovitch PS (2015). Mitochondrial
Dysfunction in Cardiac Aging. Biochemica et Biophysica Acta.
doi:10.1016/j.bbabio.2015.07.009
Karunadharma PP**, Basisty N**, Chiao YA**, Dai D-F, Drake R., Levy N,
Rabinovitch PS (2015). Respiratory Chain Protein Turnover Rates in Mice are Highly
Heterogeneous but Strikingly Conserved Across Tissues, Ages, and Treatments. The
FASEB Journal.

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Quarles EK, Dai D-F, Tocchi A, Basisty N, Gitari L, Rabinovitch PS (2015). Quality control
Systems in Cardiac Aging. Ageing Research Reviews.
Karunadharma PP**, Basisty N**, Dai DF, Chiao YA, Quarles E, Crispin D, Bielas J,
Ericson N, Beyer RP, MacKay V, MacCoss MJ, Rabinovitch PS (2015). Subacute
Calorie Restriction and Rapamycin Discordantly Alter Mouse Liver Proteome
Homeostasis and Reverse Aging Effects. Aging Cell.
Dai DF**, Karunadharma PP**, Chiao YA**, Basisty N**, Crispin D, Hsieh EJ, Chen T, Gu
H, Djukovic D, Raftery D, Beyer RP, MacCoss MJ , Rabinovitch PS (2014). Altered
Proteome Turnover and Remodeling by Short-term Caloric Restriction or Rapamycin
Rejuvenate the Aging Heart. Aging Cell. 13, 529-539. (winner of Aging Cell Best
Paper Prize 2014)
Dai DF, Hsieh EJ, Chen T, Menendez LG, Basisty N, Tsai L, Beyer RP, Crispin DA,
Shulman NJ, Szeto HH, Tian R, MacCoss MJ, Rabinovitch PS (2013). Global
Proteomics and Pathway Analysis of Pressure-overload-induced Heart Failure and its
Attenuation by Mitochondrial-targeted Peptides. Circ Heart Fail. 6, 1067-1076.
Murakami CJ**, Wall V**, Basisty N, Kaeberlein M (2011). Composition and Acidification
of the Culture Medium Influences Chronological Aging Similarly in Vineyard and
Laboratory Yeast. PLoS One. 6, e24530.
Submitted
Kruse, SE, Karunadharma PP, Basisty N, Johnson R, Beyer RP, MacCoss MJ,
Rabinovitch PS, Marcinek DJ. (2014). Age Modifies Mitochondrial Function and
Protein Homeostasis in a Muscle Type-specific Manner. Aging Cell.
In preparation
Basisty N, Karunadharma PP, Dai DF, Gagnidze A, Levy N, Lemuel G, Fredrickson J,
Beyer RP, Hsieh EJ, MacCoss MJ, Rabinovitch PS. Working Title: Overexpression of
Mitochondrial-Targeted Catalase Exhibits Reverse Antagonistic Pleiotropy in the Aging
Proteome. Antioxidant and Redox Signaling.
Basisty N, Liu Y, Karunadharma PP, MacCoss MJ, Rabinovitch PS. Working Title: Calorie
Restriction and Rapamycin Restore the Balance between the Insoluble and Soluble
Proteome in Aging Liver.
Basisty N, Karunadharma PP, Reynolds J, Liu Y, Fredrickson J, MacCoss MJ,
Rabinovitch PS. The Changing Landscape of Poly-Ubiquitin Mediated Homeostasis in
Aging, Calorie Restriction, and Rapamycin Treatment.
PRESENTATIONS
Oral Presentations
Mitochondria and Metabolism Interest Group Seminar. UW South Lake Union, Seattle,
WA. June 4h, 2015. Overexpression of Mitochondrial-Targeted Catalase is Good for
the Old Mouse Proteome but not for the Young: Reverse Antagonistic Pleiotropy
Genetic Approaches to Aging Trainee Research Presentations. University of Washington,
Seattle, WA. Nov 20, 2014. The Changing Landscape of Poly-Ubiquitin Mediated
Homeostasis in Aging, Calorie Restriction, and Rapamycin Treatment.
Mitochondria and Metabolism Interest Group Seminar. UW South Lake Union, Seattle,

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WA. June 6th, 2014. High Heterogeneity in Turnover Rates of Respiratory Chain
Proteins is Conserved across Tissues and Treatments in Mice.
American Aging Association 43rd Annual Meeting. San Antonio, Texas. May 31, 2014. The
Changing Landscape of Poly-Ubiquitin Mediated Homeostasis in Aging, Calorie
Restriction, and Rapamycin Treatment.
Poster Presentations
Gordon Research Seminar and Conference. Newry, ME. July 18th 25th, 2015.
Overexpression of Mitochondrial-Targeted Catalase is Good for the Old Mouse
Proteome but not for the Young: Reverse Antagonistic Pleiotropy
US HUPO 10th Annual Conference. Seattle, WA. April 7th, 2014. High Heterogeneity in
Turnover Rates of Respiratory Chain Proteins is Conserved across Tissues and
Treatments in Mice
Gerontology Society of America 66th Annual Scientific Meeting. New Orleans, LA.
Nov 21, 2013. Multi-Tissue Assessment of Mitochondrial Respiratory Chain Turnover
with Age, CR, and Rapamycin Treatment.
GRANTS/FELLOWSHIPS
2012 2015
2015 Present

Genetic Approaches to Aging Training Grant - NIA T32AG00057

Advisor: Peter Rabinovitch
Glen-AFAR Scholarship for Research in the Biology of Aging

MENTORING
2014

Yuxin Liu, SUNY Upstate Medical University

Medical Student Training in Aging Research (MSTAR)
Proteostasis in the Aging Liver: Investigations in Protein Aggregates

Selected for Poster Presentation at the American Medical

Association Research Symposium

Selected for oral presentation at 2015 American Geriatric Society

Meeting

2011

Jason Reynolds, Idaho State University

Amgen Scholars Program
Proteostasis in Aging and Longevity-Associated Treatments in Mice

MEMBERSHIPS
2014-2015
2014-2015
2013-2014

UW Geroscience Peer Mentorship Group

American Aging Association
Gerontological Society of America

ADMINISTRATION
2015
2015

Path Presents Graduate Student Speaker Selection Committee

Abstract/symposium submission reviewer, Gerontology Society of America

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AVOCATIONAL
2014-2015
2014-2015
2008-2009
2004-2006
2005-2006
2005-2006

Moderator for AskScience (http://www.reddit.com/r/AskScience)

Moderator for Gerontology (http://www.reddit.com/r/Gerontology)
Sports Medicine Club Secretary
Students for Progressive Change member
International Service Learning Project
Cultural Caf Host

SKILLS/SPECIALIZATION

R Programming
R Shiny (example https://nbasisty.shinyapps.io/qvalues/)
LC-MS/MS
Skyline Software Certified
Ingenuity Pathway Analysis
Topograph Software (precursor pool corrected turnover estimation)
MSDaPl (spectral counting)
Protein Preparation: Pulldowns, fractionation, precipitation
Sequest
Percolator (FDR)
X-caliber (Thermo)
Mouse work
Bench work: westerns, qPCR, enzyme activity, IHC, confocal

REFERENCES
Peter S. Rabinovitch, MD., PhD.
University of Washington
Department of Pathology
Box 357705
1959 NE Pacific Street, HSB K-081
Seattle, WA 98195-7705
206-685-3761
petersr@uw.edu

Matt Kaeberlein, PhD

University of Washington
Department of Pathology
Box 357470
1959 NE Pacific Street, HSB D-514
Seattle, WA 98195-7470
206-221-4849
kaeber@uw.edu

George M. Martin, M.D.

University of Washington
Department of Pathology
Box 357470
1959 NE Pacific Street, HSB K-543A
Seattle, WA 98195
206-543-5088
gmmartin@uw.edu

Michael MacCoss, PhD

University of Washington
Department of Genome Sciences
Foege Building S113
3720 15th Ave NE
Seattle, WA 98195-5065
206-395-4123
maccoss@uw.edu