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ABSTRACT
Traditionally, psychiatry has been defined and practiced as a
branch of medicine focused on the diagnosis and treatment
of mental illnesses. Based on growing empirical evidence, we
believe that this definition warrants expansion to include the
concept of positive psychiatry. In the present article, we provide
a critical overview of this emerging field and a select review of
relevant scientific literature. Positive psychiatry may be defined as
the science and practice of psychiatry that seeks to understand
and promote well-being through assessment and interventions
involving positive psychosocial characteristics (PPCs) in people
who suffer from or are at high risk of developing mental or
physical illnesses. It can also benefit nonclinical populations.
Positive psychiatry has 4 main components: (1) positive mental
health outcomes (eg, well-being), (2) PPCs that comprise
psychological traits (resilience, optimism, personal mastery and
coping self-efficacy, social engagement, spirituality and religiosity,
and wisdomincluding compassion) and environmental factors
(family dynamics, social support, and other environmental
determinants of overall health), (3) biology of positive psychiatry
constructs, and (4) positive psychiatry interventions including
preventive ones. There are promising empirical data to suggest
that positive traits may be improved through psychosocial
and biological interventions. As a branch of medicine
rooted in biology, psychiatry, especially with the proposed
conceptualization of positive psychiatry, is well poised to provide
major contributions to the positive mental health movement,
thereby impacting the overall health care of the population.
J Clin Psychiatry
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Clinical Points
Jeste et al
Traditional Psychiatry
Those with mental
illnesses
Positive Psychiatry
Those suffering from or at
high risk of developing
mental or physical illnesses
Assessment focus Psychopathology
Positive attributes and
strengths
Research focus
Risk factors
Protective factors
Psycho/neuropathology Psycho/neuroplasticity
Treatment goal
Symptom relief and
Recovery, increased wellrelapse prevention
being, successful aging,
posttraumatic growth
Main treatments Medications and,
Psychosocial/behavioral (and
generally, short-term
increasingly, biological)
psychotherapies for
interventions to enhance
symptom relief and
positive attributes
relapse prevention
Prevention
Largely ignored
Important focus across the
lifespan
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outcomes across a range of medical populations.29 Metaanalysis of 148 studies (N>300,000) found a 50% increased
likelihood of survival among participants with strong
social relationships compared to others with weak social
relationships, across different groups based on age, gender,
initial health status, cause of death, and follow-up period.30
Spirituality and religiosity. Spirituality refers to
the degree to which ones personal beliefs, thoughts,
and behaviors focus on transcendent topics such as the
meaning of life, belief in a higher being, and power or
level of consciousness. Religiosity is usually reserved for
reference to organized religion and has an inherent social
connotation, whereas spirituality can be personalized.
Religious and spiritual practices are associated with greater
well-being as well as better health outcomes throughout
ones lifespan.31 Proposed mechanisms include emotional
support and optimism derived from religious communities,
but spirituality may remain a significant determinant even
when controlling for these factors.32
Wisdom. Despite variability among definitions of
wisdom, common elements include prosocial behaviors
(compassion, empathy, altruism), social decision-making,
insight, decisiveness, acknowledgment of uncertainty,
emotional regulation, tolerance of divergent value systems,
openness to new experience, spirituality, and a sense of
humor.33 What unites these components is their usefulness
for the self and for others. Greater wisdom may be important
for an older adults ability to survive, and even thrive, in spite
of worsening physical health; similarly, wisdom transmitted
to younger generations may provide a fitness advantage
and help to neutralize the loss of fertility in old agethe
so-called Grandma hypothesis.34
Positive Environmental Factors
Environment also plays a critical role in ensuring positive
health outcomes.
Family dynamics. There is considerable literature on
the impact of family dynamics and support on symptom
severity, treatment response, and possibility of recovery for
a number of neuropsychiatric and physical disorders.35
Social support. Social support refers to the degree to
which other people are available for emotional and physical
support. Strong social support is associated with reduced
depression, anxiety, substance use disorders, hypertension,
cardiovascular disease, and dementia, as well as longer
survival.36
Other environmental determinants of psychosocial
functioning. There is no health without mental health; at
the same time, mental health depends, to some extent, on
general health. Therefore, availability of regular medical care;
opportunities for physical, cognitive, and social activities;
and provision of adequate nutrition are necessary for
positive mental health. Such factors illustrate the importance
of positive psychiatrists reclaiming and embracing their
roles as physicians in addition to their roles as mental health
professionals. There is also evidence that social planning and
community environment affect mental health.37
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BIOLOGY OF POSITIVE
PSYCHIATRY CONSTRUCTS
Potential Biomarkers of Positive Mental Health
Allostatic load. Allostatic load is a measure of the bodys
cumulative physiological response to frequent and sustained
exposure to environmental stressors, with the downstream
result being an increased risk for disease. Allostatic load
also is related to cognitive functioning and psychological
factors.38 A composite variable of the following parameters
of biological functioning has been used in several
investigations: systolic and diastolic blood pressure, body
mass index, high-density lipoprotein (HDL) cholesterol,
total cholesterol/HDL cholesterol, plasma norepinephrine,
and plasma epinephrine.39
Telomere length. Telomere length is an indicator of
biological age and represents a cumulative index of the
number of cell divisions and exposures to genotoxic and
cytotoxic processes such as oxidation. Perceived stress is
more critical than objective measures of stress in its impact
on telomere length.12 Telomere length is maintained by
the enzyme telomerase, and there is preliminary evidence
that healthy lifestyle changes as well as psychosocial stress
reduction interventions can increase telomerase activity.4042
Other mechanisms. Oxidative stress, caused by an
overproduction of free radicals or underproduction of
antioxidant molecules, damages DNA, protein, lipids, and
other macromolecules in many tissues, especially in the
brain.43-47 F2-isoprostanes are stable molecules that provide
an accurate index of whole body oxidative stress.48 Prolonged
or repeated exposure to oxidative stress may accelerate
aspects of biological aging, leading to greater comorbidity
and mortality. Similarly, neuroinflammation and immune
function are also related to several PPCs as noted below.
General Biology of
Positive Psychological Traits
Resilience and optimism. Resilience and optimism are
both partially heritable.49,50 Candidate genes for resilience
include those related to limbic and prefrontal cortex
reactivity, such as HPA axis-related genes (CRHR1, FKBP5),
serotonin transporter (5-HTTLPR), and others (COMT,
NPY, BDNF, MAO-A, and NGFI-A).51 Genetic association
studies have linked optimism to the oxytocin receptor gene
and the 5HTTLPR variation in SLC6A4, a gene responsible
for serotonin transport, as well as CACNA1C52 and the
OXTR gene.53 Beginning in development, an individuals
genes and their interactions with environmental factors
(plus stochastic events) may shape the neural circuitry
and neurochemical function expressed in psychological
traits.50 Genetic polymorphisms affect a persons limbic
reactivity and prefrontal-limbic connectivity. Adaptive
functioning of social-behavior (eg, fear, reward, impulsivity)
circuits underlies a resilient persons capacity to face stress.
Stochastic, epigenetic changes occurring during brain
development that drive resilience promote survival during
periods of high stress.
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