Professional Documents
Culture Documents
Chemistry
Project
A
Compa
rative
Study
of
Effecti
veness
of
Antaci
ds
CERTIFICATE
This is to certify that the work entered in this
project file is of Master Kaushal Nerkar of
class XII Science Roll no.09 has satisfactorily
completed the Required Project in Chemistry
Copyright Kaushal and Omkar (2014)
Principals
Internal
External
Signature
Examiner
Examiner
Date:
ACKNOWLEDGEMENT
I would like
gratitude to
to
express
my
sincere
INDEX
Copyright Kaushal and Omkar (2014)
Introduction
Antacids
Classifications of antacids
Experiments
Aim
Apparatus
Procedure
Observations
Result& Inference
Precautions
Difficulties
Bibliography
Photos
INTRODUCTION
Copyright Kaushal and Omkar (2014)
Antacids
Antacids are commercially available products
which neutralize the excess HCl secreted in
the stomach.
The action of antacids is based on the fact
that base can neutralize an acid forming salt
and water.
The antacid should not contain excess alkali
that may lead to an alkaline medium in the
stomach and make the enzyme inactive.
Thus some additional compounds are added
to the antacids to keep the pH optimum. The
action of an acid is for a short time,
irrespective of dose; hence it is required to
take an antacid at frequent intervals.
Commercially Available
Antacids
Classification of Antacids
Absorbable Antacids:NaHCO3 mixture is commonly used for giving
relief from indigestion.
It has moderate neutralizing power.
However, it releases CO2 gas in the stomach
and causes swelling of deep Ulcers and hence
it is not generally used.
Non Absorbable Antacids:These are available in three broad groups
1.
Aluminium salts: All these drugs have
common buffering action and reduce
acidity in the stomach .Eg-Al(OH)3,AlPO4.
2.
Magnesium salts: Their action is slow
and these cause a purgative action.EgMgCo3, MgO, Mg(OH)2.
3.
Calcium salts: These are powerful
antacids. They have no buffering action
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EXPERIMENT
Aim:- A comparative study of effectiveness of
different commercially available antacids .
Apparatus:- burrete, pipette, conical flask
,glass rod, mortar and pastel, weighing
machine, measuring flask, beaker.
Chemical required :- HCl 0.1N solution, NaOH
0.1N solution ,phenolphthalein , methyl
orange, antacids.
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PROCEDURE
1.
Prepare 0.1N NaOH solution by
dissolving 0.2 Gram of NaOH in 50 ml of
water.
2.
Take 50ml of 0.1N HCl in conical flask.
3.
Add 2-3 ml of phenolphthalein or
methyl orange to the conical flask which
serves as an indicator.
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4.
Add 1 gram of finely powered antacid
to the conical flask. Use mortar and pastel
to powder it.
5.
Shake well and now titrate the solution
by taking NaOH in the burette, and HCl in
conical flask.
6.
Observe the end point a pink or
yellow colored solution.
7.
Repeat this with other antacids and
note the readings.
Take 50
ml of
0.1N HCl
Add 1gm
of
antacid
13
Titrate
against
0.1N
NaOH
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OBSERVATIONS
Tablet/sam
ple
antacid
(1gm)
Volume
of NaOH
used
(ml)
Digine
Eno
Omez
Gelusil
Ulgel
30.6
22.3
21.2
32.6
26.8
Volume of
HCl
neutralize
d
(ml)
19.4
27.7
28.8
17.4
23.2
Volume of
HCl
neutralize
d /gm of
antacid
19.4
27.7
28.8
17.4
23.2
35
30
Volume of NaOH used
25
20
15
10
5
Volume of HCl neutralized /gm of antacid
0
Digine
Eno
Omez
Gelusil
Ulgel
15
RESULT
Among the five different antacids tested,
OMEZ has highest acid neutralizing capacity
per gram of the antacid.
INFERENCE
OMEZ is better antacid amongst the five we
tested because it could neutralize more
amount of HCl (0.1 N) than any other antacid.
16
PRECAUTIONS
1.
The weighing should be accurate.
2.
Powder should be fine to promote
maximum dissolution.
3.
Should not add much of indicator.
4.
The amount of HCl should be
sufficiently in excess so as to neutralize
every bit of antacid.
5.
Should keep the eye in level with the
Meniscus of the solution.
6.
Should read the lower meniscus in
case of colorless solutions.
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DIFFICULTIES
While carrying out above experiment some
antacid salts like solution of rabicip,
Eno(orange) and Zantac, the color of salt
solution was red, orange and red respectively,
so while titration of these antacids the
indicator did not show any significant change
in color, so finding end point of titration was
very difficult .
Due to pink colour of antacid gelusil,
phenolphthalein was not used as indicator
and methyl orange was used.
18
BIBLIOGRAPHY
Following sources of information have been
referred for this project: Together with Chemistry lab manual.
Wikipedia
Chem4kids.com
PHOTOS
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