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Epithelial Tissue
Consists of cells
Fitted tightly together to form a continuous
layer, or, sheet, of cells
Specialized for exchanging materials between
the cell and its environment
Epithelial tissue is organized into two general
types of structures: epithelial sheets and
secretory glands
Absorption
The epithelial tissue lining the digestive tract
absorbs nutrients and water into the body
Secretion
Some epithelial cells form glands that secrete
cell products such as hormones, enzymes or
sweat
Sensation
Other epithelial cells are sensory receptors
that receive information from the
environment
For example, epithelial cells in taste buds and
in the nose specialize as chemical receptors
Epithelial Membrane
Sheet of epithelial tissue and a layer of
underlying connective tissue
Types of epithelial membrane: mucous
membrane and serous membrane
Mucous membrane / mucosa
Lines a body cavity that opens to the outside of
the body, such as the digestive or respiratory
tract
The epithelial layer secretes mucus that
lubricates the tissue and protects it from drying
Serous membrane
Lines a body cavity that does not open to the
outside of the body
Consists of simple squamous epithelium over
a thin layer of connective tissue
This type of membrane secretes fluid into the
cavity it lines
Examples of serous membranes are the
pleural membranes lining the pleural cavities
around the lungs and the pericardial
membranes lining the pericardial cavity
around the heart
Classification of Epithelium
The traditional classification of epithelium is
based on two factors:
The number of cell layers and
The shape of the surface cells
The terminology, therefore, reflects only
structure, not function
Epithelium is described as
simple, when it is one cell layer thick
Stratified, when it has two or more cell layers
Pseudostratified Epithelium
Appears stratified, although some of the cells
do not reach the free surface; all rest on the
basement membrane
Thus, it is actually a simple epithelium
The distribution of pseudostratified
epithelium is limited in the body
Also it is often difficult to discern whether all
of the cells contact the basement membrane
Pseudostratified Epithelium
Pseudostratified Epithelium
Typical locations:
Trachea and bronchial tree
Ductus deferens
Efferent ductules of epididymis
Major functions:
Absorption
Secretion
Conduit (a channel through which water or
other fluid is carried)
Transitional Epithelium
Transitional (Urothelium)
Typical locations:
Renal calyces
Ureters
Bladder
Urethra
Major functions:
Barrier
Distensible property
Simple Squamous
Composed of a single layer of cells, which are flat
and plate like
In histologic sections, the nuclei appear flattened
and the cytoplasm is indistinct
Although squamous refers to any flat epithelium,
its use is restricted as many flat epithelia are
given more specific names, e.g. the flat
epithelium lining blood vessels being called
endothelium
Simple Squamous
Typical locations:
vascular system (endothelium)
Body cavities (mesothelium)
Bowmans capsule (kidney)
Respiratory spaces in lung
Major functions:
exchange, barrier in central nervous system
Exchange and lubrication
Simple Squamous
Simple Cuboidal
A simple cuboidal epithelium is composed of a
single layer of cells whose height, width and
depth are the same (they are not strictly
cuboidal)
In histologic section, such cells usually have a
centrally placed nucleus
Simple Cuboidal
Typical locations:
Small ducts of exocrine glands
Surface of ovary (germinal epithelium)
Kidney tubules
Thyroid follicles
Major functions:
Absorption
Barrier
Secretion
Simple Cuboidal
Simple Cuboidal
Simple Columnar
Composed of cells whose height is two or
three times greater than their width
The nuclei of columnar cells are basal and
arranged in an ordered layer
Simple Columnar
Typical locations:
Small intestine and colon
Stomach lining and gastric glands
Gallbladder
Major functions:
Absorption and secretion
Simple Columnar
Stratified Squamous
Composed of several layers such that cells high
up in the epithelium are not in contact with the
underlying extracellular matrix
Stratified squamous epithelium derives its name
from the flattened (squamous) appearance of
cells in the superficial part of the epithelium
Cells in the basal and middle layers of this type of
epithelium are in fact pyramidal or polygonal and
are not flattened
Stratified Squamous
Typical locations:
Epidermis
Oral cavity and esophagus
Vagina
Major functions:
Barrier
Protection
Stratified Squamous
Stratified Cuboidal
Typical locations:
Sweat gland ducts
Large ducts of exocrine glands
Anorectal junction
Major function:
Barrier
Conduit
Stratified Cuboidal
Glandular Epithelium
Glands are epithelial tissue derivative
specialized for secreting
Glands are formed during embryonic
development by pockets of epithelial tissue
that invaginate and develop secretory
capabilities
There are two categories of glands: exocrine
and endocrine
Classification of Glands
Glands can be classified according to:
Their histologic organization
Possession of ducts
Type of material secreted
Manner in which material is secreted
Glands that consist of only a single cell are
called unicellular; aggregates of secreting cells
form multicellular glands
Unicellular Glands
Unicellular, exocrine gland goblet cell
Found scattered among epithelial cell lining
the trachea, small intestine and colon
The cell has a narrow base and an expanded
apex filled with secretory granules
Goblet cells elaborate mucin, which, on
hydration, produces viscous lubricating fluid
called mucus
Multicellular Glands
The simplest form of multicellular exocrine
gland is the secretory sheet, exemplified by the
gastric lining epithelium, in which the secreting
cells form a continuous epithelial layer
Intraepithelial glands are small clusters of
secretory cells that lie wholly within an
epithelial sheet, clustered about a small lumen
Cells of both types of gland secrete their
product onto the epithelial surface