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Redox Rep, January 1, 2005; 10(3): 145-9.

Effect of Ganoderma lucidum on human DNA is dose dependent and
mediated by hydrogen peroxide.
S Wachtel-Galor, SW Choi, and IF Benzie
Department of Health Technology & Informatics, The Hong Kong Polytechnic University, Hong
Hum, Hong Kong, SAR China.

MEDLINE ABSTRACT
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Ganoderma lucidum, an oriental fungus, is widely used for the Download to Citation Manager
promotion of health and longevity and is reported to have
antioxidant and genoprotective properties. The aim of this study
Related Articles in Medline
was to investigate the effect of G. lucidum on human
lymphocytic DNA ex vivo using the comet assay, and to explore Articles in Medline by Author:
Wachtel-Galor, S
the mechanism of action and the effect of dose. Results showed
that G. lucidum has a genoprotective effect at low concentration
Choi, SW
(0.0001% w/v), but damaged DNA at higher concentrations. The
Benzie, IF
mechanism of damage appeared to be mediated by hydrogen
peroxide, which was generated in vitro by G. lucidum, as the effect was ameliorated by the
presence of catalase. At concentrations at which no damage was induced, G. lucidum appeared to
confer protection against subsequent oxidant challenge to cells. The production of hydrogen
peroxide by G. lucidum and its cytotoxic effects should be considered as a factor in future studies.
However, the protective effect of G. lucidum at low concentration may explain, in part, some of
the reported health benefits of this herb.
Publication Types:

Journal article
Research support, non-u.s. gov't

MeSH Terms:

Antioxidants
Comet Assay
DNA
Dose-Response Relationship, Drug
Drugs, Chinese Herbal
Free Radical Scavengers
Humans
Hydrogen Peroxide
Lymphocytes
Oxidants
Plant Extracts
Reishi

PMID: 16156953
MEDLINE data is licensed from the National Library of Medicine. Some material in the NLM databases is from copyrighted publications of the
respective copyright claimants. Users of the NLM databases are solely responsible for compliance with any copyright restrictions and are
referred to the publication data appearing in the bibliographic citations, as well as to the copyright notices appearing in the original publications,
all of which are hereby incorporated by reference.

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