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Management of Acute Otitis Media by Primary Care Physicians: Trends Since

the Release of the 2004 American Academy of Pediatrics/American Academy of


Family Physicians Clinical Practice Guideline
Louis Vernacchio, Richard M. Vezina and Allen A. Mitchell
Pediatrics 2007;120;281-287
DOI: 10.1542/peds.2006-3601

The online version of this article, along with updated information and services, is
located on the World Wide Web at:
http://www.pediatrics.org/cgi/content/full/120/2/281

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ARTICLE

Management of Acute Otitis Media by Primary Care


Physicians: Trends Since the Release of the 2004
American Academy of Pediatrics/American Academy
of Family Physicians Clinical Practice Guideline
Louis Vernacchio, MD, MSc, Richard M. Vezina, MPH, Allen A. Mitchell, MD

Slone Epidemiology Center at Boston University, Boston, Massachusetts

The authors have indicated they have no financial relationships relevant to this article to disclose.

ABSTRACT
OBJECTIVES. In 2004, the American Academy of Pediatrics and the American Acad-
emy of Family Physicians released a clinical practice guideline on the management
www.pediatrics.org/cgi/doi/10.1542/
of acute otitis media that included endorsement of an observation option for peds.2006-3601
selected cases and recommendations of specific antibiotics. We sought to describe doi:10.1542/peds.2006-3601
primary care physicians’ current management of acute otitis media to compare it
Key Words
with the guideline’s recommendations and describe trends since 2004. otitis media, antibiotics, clinical practice
guidelines, primary care
DESIGN. We used a mail survey from March through June 2006 within the Slone Abbreviations
Center Office-Based Research Network, a national practice-based pediatric re- AOM—acute otitis media
search network. AAP—American Academy of Pediatrics
AAFP—American Academy of Family
Physicians
RESULTS. The response rate was 299 (62.7%) of 477. The observation option was
SCOR—Slone Center Office-Based
considered reasonable by 83.3%, compared with 88.0% in 2004, and was used in Research
a median of 15% of acute otitis media cases over the previous 3 months. The most Accepted for publication Mar 22, 2007
common physician-identified barriers to the use of the observation option were Address correspondence to Louis Vernacchio,
MD, MSc, Slone Epidemiology Center, 1010
parental reluctance (83.5%) and the cost and difficulty of follow-up of children Commonwealth Ave, Boston, MA 02215. E-
who do not improve (30.9%). In terms of antibiotic choices for acute otitis media, mail: lvernacchio@slone.bu.edu
agreement with the guideline’s antibiotic recommendation for 4 common clinical PEDIATRICS (ISSN Numbers: Print, 0031-4005;
Online, 1098-4275). Copyright © 2007 by the
scenarios was as follows: high-dose amoxicillin for acute otitis media with nonse- American Academy of Pediatrics
vere symptoms (57.2%), high-dose amoxicillin-clavulanate for acute otitis media
with severe symptoms (12.7%), high-dose amoxicillin-clavulanate for cases that
failed to respond to amoxicillin (42.8%), and intramuscular ceftriaxone for cases
that failed to respond to treatment with amoxicillin-clavulanate (16.7%). Each of
these proportions declined from 2004.
CONCLUSIONS. Most primary care physicians accept the concept of an observation
option for acute otitis media but use it only occasionally. Antibiotics prescribed for
acute otitis media differ markedly from the guideline’s recommendations, and the
difference has increased since 2004.

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D ESPITE BEING ONE of the most common illnesses for
which children are brought to physicians, acute
otitis media (AOM) remains a management challenge
Approximately 6 weeks later, we sent a second survey to
nonresponders, half by mail and half by fax, determined
randomly. After another ⬃6 weeks, we called the office
for primary care providers. This is especially true given 2 of each nonresponder to verify the contact information
important trends in AOM management. First, the con- and faxed a third survey to the office.
cept of initial observation without antibiotic treatment To analyze open-ended responses about barriers to
has been adopted as standard practice in some parts of the use of the observation option, 1 investigator (Dr
the world1 and has begun to achieve acceptance in the Vernacchio) reviewed the responses and created catego-
United States as well.2–6 Second, the widespread emer- ries to which he assigned each response; a second inves-
gence of antimicrobial resistance has increased the ur- tigator (Dr Mitchell) independently assigned each re-
gency to reduce antibiotic use and, when antibiotic sponse to a category. When the investigators did not
treatment is chosen, has made the choice of antibiotic agree or when there were ⬍5 responses in a category,
more difficult. the response was coded as “other.” Proportions were
In May 2004, in response to these issues, the Amer- calculated as the number of each given response divided
ican Academy of Pediatrics (AAP) and the American by the total number of valid responses. Comparisons of
Academy of Family Physicians (AAFP) jointly issued a proportions between groups were performed by ␹2 anal-
clinical practice guideline entitled “Diagnosis and Man- ysis or, when the analysis was limited to responders to
agement of Acute Otitis Media.”7 The guideline endorsed both the 2004 and 2006 surveys, by McNemar’s test for
an observation option for selected children with AOM, paired observations. Comparison between 2004 and
specifically considering it an option for those ⱖ2 years 2006 of the median proportion of cases in which physi-
old with nonsevere symptoms or an uncertain diagnosis cians used the observation option was performed by
and for those 6 months to 2 years old with both nonse- using Wilcoxon signed ranks test. SAS 9 (SAS Institute,
vere symptoms and an uncertain diagnosis. The guide- Inc, Cary, NC) software was used for all analyses. The
line also made specific antibiotic recommendations for study was approved by the Boston University Medical
various common AOM scenarios, including high-dose Campus Institutional Review Board.
amoxicillin as first-line treatment for most children,
high-dose amoxicillin-clavulanate as first-line treatment RESULTS
for children with severe symptoms (moderate-to-severe Four hundred eighty-nine surveys were mailed; 7 were
otalgia or fever of ⱖ39°C), and various specific antibiot- undeliverable because the physician had relocated and a
ics for those whose conditions failed to respond to first- current address could not be determined, 3 physicians
line treatment. were no longer practicing primary care, and 2 others had
In October 2004, we surveyed the physician-mem- retired. Two hundred ninety-nine completed surveys
bers of the Slone Center Office-Based Research (SCOR) were received, for a response rate of 62.7%. Among the
Network to determine their familiarity with the guide- 299 respondents, 207 also responded to our 2004 sur-
line and to compare their practices with the guideline’s vey. Nonresponders did not differ significantly from re-
recommendations in several key areas.8 We now de- sponders by gender, practice setting, region, or specialty
scribe follow-up survey data from the same group of (data not shown). The demographics of the responders
physicians collected ⬃2 years after the publication of the are shown in Table 1.
guideline and 18 months after our initial survey. Overall, 249 (83.3%) believed the observation option
was reasonable for some children with AOM, whereas
METHODS 50 (16.7%) did not. The proportion who accepted the
The SCOR Network is a national practice-based, primary observation option did not differ significantly by the
care pediatric research network coordinated by investi- physician’s gender, region, or membership in AAP
gators at the Slone Epidemiology Center at Boston Uni- and/or AAFP, but it was higher among pediatricians
versity. In March 2006, we mailed surveys to all active (compared with family physicians), suburban and urban
physician-members of the network inquiring about their non–inner-city practices, and younger physicians (Table
opinions and practices regarding the observation option 2).
for AOM and about their preferred choices of antibiotics Compared with 2004, the overall proportion who
for 4 common AOM scenarios. The AOM scenarios in- accepted the observation option among this group of
cluded the following: AOM with nonsevere symptoms, providers declined somewhat, from 88.0% in 2004 to
AOM with severe symptoms, AOM that failed treatment 83.3% in 2006, although the difference was not statis-
with amoxicillin at 80 to 90 mg/kg per day, and AOM tically significant (P ⫽ .1). Among the 204 physicians
that failed treatment with amoxicillin-clavulanate at 80 who responded to this question on both the 2004 and
to 90 mg/kg per day. (The survey also contained a sec- 2006 surveys, the proportion declined from 90.2% to
tion on screening practices for type 2 diabetes mellitus in 84.3% (162 accepted the observation option at both
children, the results of which are not presented here.) time points, 10 did not accept the observation option at

282 VERNACCHIO et al
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TABLE 1 Characteristics of 299 Physicians Who Responded to the TABLE 2 Acceptance of the Observation Option According to
Survey Physician Characteristics
Characteristics No. (%) Factor n/N (%) P
Gender Gender
Male 215 (71.9) Male 180/215 (83.2) .7
Female 84 (28.1) Female 69/84 (82.1)
Specialty Specialtya
Pediatrics 230 (76.9) Pediatrics 199/230 (86.5) .003
Family practice 66 (22.1) Family practice 47/66 (71.2)
Other 3 (1.0) AAP and/or AAFP membership
Academy membership Yes 224/265 (84.5) .1
AAP 209 (69.9) No 25/34 (73.5)
AAFP 55 (18.4) Year of medical school graduation
Neither 34 (11.4) Before 1970 38/49 (77.6) .03b
Both 1 (0.3) 1970s 91/113 (80.5)
Year of medical school graduation 1980s 102/119 (85.7)
Before 1970 49 (16.4) 1990s 18/18 (100.0)
1970s 113 (37.8) Practice setting
1980s 119 (39.8) Suburban 138/155 (89.0) .0003
1990s 18 (6.0) Rural 48/68 (70.6)
Practice setting Urban, non-inner city 51/57 (89.5)
Suburban 155 (51.8) Urban, inner city 12/19 (63.2)
Rural 68 (22.7) Region
Urban, non-inner city 57 (19.1) Midwest 57/69 (82.6) .6
Urban, inner city 19 (6.4) South 51/63 (81.0)
Region Midatlantic 45/56 (80.4)
Midwest 69 (23.1) West 34/42 (81.0)
South 63 (21.1) Southwest 31/36 (86.1)
Midatlantic 56 (18.7) New England 31/33 (93.9)
West 42 (14.1) an ⫽ 3 with other specialties not included in this analysis.
Southwest 36 (12.0) b Test for trend.
New England 33 (11.0)

TABLE 3 Physicians’ Preferred Follow-up Strategies for Children


With AOM Treated With the Observation Option
both time points, 10 did not accept the observation
option in 2004 but accepted it in 2006, and 22 accepted Follow-up Strategy No. (%)
the observation option in 2004 but did not accept it in Back-up antibiotic prescription given at time of initial 170 (56.9)
diagnosis; parent to fill prescription if child not
2006; P ⫽ .03).
improved in 48–72 h
During the 3 months before completing the survey, Scheduled follow-up visit in 48–72 h 126 (42.1)
the physicians reported by using the observation option Parent to call for phone-in antibiotic prescription if child 102 (34.1)
in a median of 15% of the AOM cases they diagnosed not improved in 48–72 h
(range: 0%–95%; 25th, 75th percentiles: 5%, 30%). For Parent to bring child back to office if child not improved 97 (32.4)
in 48–72 h
those physicians responding to both surveys, the propor-
Column total adds up to ⬎100%, because multiple responses were allowed.
tion of cases in which they used the observation option
did not significantly change from 2004 to 2006 (median:
15% in both surveys; P ⫽ .4). In 2006, 10.7% of the
responding physicians used the observation option in mendations, the surveyed physicians were asked which
half or more of their recent AOM cases. Their prefer- antibiotic they would prescribe; the results, compared
ences for follow-up strategies for children treated with with responses from 2004, are shown in the Figure 1.
observation are shown in Table 3. From 2004 to 2006, physicians’ adherence with the rec-
We asked 249 responding physicians who accepted ommended antibiotic choices declined for all 4 scenarios
the observation option to identify in an open-ended presented.
fashion up to 3 barriers to its use in their practices. A
total of 161 (64.7%) listed parents’ reluctance, demand DISCUSSION
for antibiotics, and/or anxiety about observation as the This survey of a group of US pediatric primary care
most important barrier, and 208 (83.5%) listed it as 1 of physicians offers a portrait of the office-based manage-
the 3 most important barriers. Other reported barriers to ment of AOM in 2006 and relates it to the recommen-
the use of the observation option are shown in Table 4. dations of the 2004 AAP/AAFP AOM clinical practice
For 4 common clinical AOM scenarios for which the guideline. In addition, we compared the current survey’s
AAP/AAFP guideline makes specific antibiotic recom- responses with those from a similar survey of the same

PEDIATRICS Volume 120, Number 2, August 2007 283


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TABLE 4 Physician-Identified Barriers to the Use of the Observation Option for AOM
%
Most Important Second Most Third Most Total (Mentioned as
Barrier Important Barrier Important Barrier 1 of Top 3 Barriers)a
Parental expectations/demand for antibiotics 64.7 20.1 12.0 83.5
Cost/time/difficulty of follow-up visits 8.4 16.5 11.2 30.9
Physician’s concern about patient’s AOM-related symptoms 5.2 11.6 5.2 18.5
(eg, pain, fever)
Physician’s concern about parents’ reliability/adherence to 3.6 4.8 3.6 11.2
treatment plan
Legal liability 0.8 5.2 2.0 8.0
Young age of patient 2.8 2.8 1.2 6.8
Physician’s own habits/previous practices 1.6 3.6 2.0 6.8
Physician’s concern about AOM complications (eg, 0.8 2.4 3.6 6.4
tympanic membrane rupture, mastoiditis, meningitis)
Parent will find another doctor who will prescribe antibiotics 1.6 1.6 1.6 4.4
Patient with severe illness/ill appearance 1.2 1.6 0.8 3.6
Daycare/school regulations 0.4 0.8 2.0 3.2
Patient’s history of AOM/recurrent AOM 0.8 0.8 0.4 2.0
Other 7.2 11.2 9.2 25.7
a The total column does not always equal the sum of the first 3 columns, because some respondents listed multiple barriers that were placed in the same category.

A
100% B
9.7% Other 9.7% 100% Other 6.0%
6.6%
90%
2.4% 4.7%
90% 6.1% Amoxicillin-
Amoxicillin
80% 22.0% 33.1% clavulanate 10.4%
40–45 mg/kg per day 80% 40–45 mg/kg per day
70%
70%
60% Amoxicillin
60%
40–45 mg/kg per day
50%
50%
40% Amoxicillina Amoxicillin
40% 67.0% 66.2%
68.3% 57.2% 80–90 mg/kg per day
80–90 mg/kg per day
30% 30%

20% 20%
Amoxicillin-
10% 10% clavulanate a 12.7%
17.9%
80–90 mg/kg per day
0% 0%
2004 2006 2004 2006

C D
100% Other 100%
12.2% 11.4% 13.4% 10.4%
Amoxicillin- Other

Re Re
90% 90%
clavulanate 4.7%
6.3% 7.4%
40–45 mg/kg per day 8.0% Cefuroxime
80% 80%

70%
8.3%

vie Azithromycin
8.0%

70% vie
15.2%
axetil

Azithromycin
16.4%

60% 21.5%
w Cefdinir 30.4% 60% w
50% Co 50% Co
40%

30% 51.7%
Amoxicillin-
clavulanate a
py 42.8%
40%

30%
35.7%

py
Cefdinir 51.8%

80–90 mg /kg per day


20% 20%

10% 10% 27.7% Ceftriaxone IM a 16.7%

0% 0%
2004 2006 2004 2006

FIGURE 1
Antibiotic choices of physicians in 2004 and 2006 for 4 common AOM scenarios. A, AOM with nonsevere symptoms (a P ⫽ .01 for comparison of 2004 to 2006). B, AOM with severe
symptoms (a P ⫽ .1 for comparison of 2004 to 2006). C, AOM that failed treatment with amoxicillin at 80 to 90 mg/kg per day (a P ⫽ .05 for comparison of 2004 to 2006). D, AOM that
failed treatment with amoxicillin-clavulanate at 80 to 90 mg/kg per day (a P ⫽ .05 for comparison of 2004 to 2006). The antibiotics shown in bold type are recommended by the 2004
AAP/AAFP guideline on AOM.

284 VERNACCHIO et al
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group of providers fielded in late 2004, ⬃6 months after may be ameliorated somewhat by the use of a backup
the release of the AOM guideline. antibiotic prescription given to the parent at the time
The current survey, and the 2004 survey to which its of initial AOM diagnosis, a follow-up strategy demon-
results are compared, were performed within the SCOR strated to be practical in several clinical trials6,9,13,14 and
Network, a national, practice-based, pediatric research favored by a majority of the responding physicians. This
network consisting of nearly 500 pediatricians and fam- strategy does, however, place more decision-making re-
ily physicians. Members of the SCOR Network may not sponsibility in the parent’s hands and may not be wel-
be representative of all US pediatric primary care pro- comed by or appropriate for all families.
viders in that they have chosen to be involved in re- This survey also demonstrates significant discrepan-
search. However, they do represent a diverse group of cies between the recommendations of the AAP/AAFP
office-based physicians from 42 US states and a variety guideline and physicians’ choices of antibiotics to treat
of practice and community settings, and thus can pro- AOM. For AOM with nonsevere symptoms, slightly
vide valuable insights into how the AOM guideline’s more than half chose the recommended high-dose
recommendations are being implemented and which of amoxicillin. Nearly one third opt for standard-dose
them are most problematic for primary care providers. amoxicillin, a significant increase from 2004. This trend
As for the possibility of response bias in the survey, the back to standard-dose amoxicillin for nonsevere disease
fact that the demographics of responders did not differ may represent an awareness of recent data that wide-
significantly from those of nonresponders is reassuring. spread use of the heptavalent pneumococcal conjugate
Yet, other unmeasured biases could have been associ- vaccine has reduced the circulation of penicillin-resistant
ated with response. For example, we consider it likely Streptococcus pneumoniae in some communities.15,16
that physicians who are more familiar with the guideline For AOM with severe symptoms, only 1 of 8 physi-
and/or more inclined to follow its recommendations cians agreed with the recommendation for high-dose
would also have been more likely to complete the sur- amoxicillin-clavulanate, whereas a much larger number
vey. This possibility, combined with the fact that SCOR chose high-dose amoxicillin. The widespread nonadher-
Network physicians have all agreed to be involved in ence with this recommendation may reflect a feeling
practice-based research, suggests that our results likely that the guideline strayed from the evidence that AOM
represent a “best case” scenario in terms of familiarity with severe symptoms is more likely because of S pneu-
with and adherence to the guideline’s recommenda- moniae (for which the addition of clavulanate is not
tions. helpful) than nontypeable Haemophilus influenzae and
In this survey, we found that most of these physicians Moraxella catarrhalis.17,18 Alternatively, initially prescrib-
accept the concept of an observation option for selected ing amoxicillin-clavulanate for children with AOM and
children with AOM, but the proportion who accept it severe symptoms may leave physicians feeling that they
has not increased since 2004 and may have decreased do not have a comfortable second-line option (ie,
slightly. Those who are most accepting of the observa- switching to a different oral antibiotic with no better
tion option include pediatricians (as opposed to family microbiologic coverage for the likely organisms or giving
physicians), younger physicians, and those practicing in a painful and expensive daily intramuscular injection of
suburban and urban non–inner-city locations. Overall, ceftriaxone for 3 consecutive days, as the guideline rec-
the responding physicians currently use the observation ommends).
option in ⬃15% of the AOM cases they diagnose, ap- For children whose treatment with amoxicillin failed,
proximately the same proportion as in 2004, but just just under half of the responding physicians chose the
over 1 in 10 of them are enthusiastic early adopters of recommended amoxicillin-clavulanate, with a substan-
observation, using it with at least half of their diagnosed tial and increasing number choosing cefdinir instead.
AOM cases. Cefdinir’s rise as a second-line agent at the expense of
When questioned in an open-ended fashion about amoxicillin-clavulanate may reflect heavy marketing of
barriers to the use of the observation option in their the drug, more convenient dosing options, and/or a
practices, these physicians overwhelmingly pointed to lower risk of diarrhea.19
parental reluctance to accept this approach. There is, Finally, for children whose treatment with amoxicil-
however, growing evidence that many US parents will lin-clavulanate failed, the majority chose an oral antibi-
accept observation when this option is presented in an otic alternative (primarily cefdinir or azithromycin,
appropriate context,5,6,9–12 thus there is a disconnect be- which have inferior or at best equivalent microbiologic
tween what studies show parents will accept and what coverage to amoxicillin-clavulanate for the likely organ-
physicians think parents will accept. About one third of isms), whereas only 1 in 6 chose the recommended
physicians also cited the time, cost, and general difficulty intramuscular ceftriaxone, suggesting a strong prefer-
associated with follow-up for children managed initially ence for oral over intramuscular administration.
with observation who do not improve within an accept- We did not ask the surveyed physicians to provide a
able time frame as an important barrier. This concern rationale for their antibiotic choices, thus we can only

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speculate as to their reasons for not following the guide- charged with their implementation find them both sci-
line’s recommendations. In addition to the possible rea- entifically convincing and clinically practical. In the case
sons cited above, one general possibility for nonadher- of the 2004 AAP/AAFP AOM guideline, the experts still
ence is that the physicians are not familiar with the face the substantial challenge of convincing pediatric
guideline’s antibiotic recommendations. However, the practitioners that the recommendations represent the
widespread dissemination of the AAP/AAFP guideline to best interpretation of the data and of assisting those
the pediatric primary care community after its publica- practitioners in overcoming barriers to their implemen-
tion, as well as data from our 2004 survey indicating that tation.
⬎90% read the guideline or summaries of it, argue
against this conclusion.8 Nonetheless, previous research ACKNOWLEDGMENTS
demonstrated that casual familiarity with a clinical prac- We thank the physician-members of the SCOR Network
tice guideline does not necessarily result in putting its for participation in the survey.
specific recommendations into practice, and that may be
the case here.20 Also, other pressures, such as pharma- REFERENCES
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ity, and parent reported outcomes for cefdinir vs. high-dose prescribing rates for children and adolescents. JAMA. 2002;
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dia in young children. Curr Med Res Opin. 2006;22: 24. Finkelstein JA, Stille C, Nordin J, et al. Reduction in antibiotic
1839 –1847 use among US children, 1996 –2000. Pediatrics. 2003;112:
20. Cabana MD, Rand CS, Powe NR, et al. Why don’t physicians 620 – 627

BEING A JUNIOR DOCTOR IN NATIONAL HEALTH SERVICE

“Lindsay Palling graduated with a medical degree from the University of


Cambridge in February 2005. Currently working in Nottingham City Hospi-
tal, she is waiting for the results of the MTAS job recruitment process— due
to be made public in June—to hear whether she still has a job. The form she
had to complete left no room for her qualifications or professional experience;
the only thing selectors judged her on were a series of 150-word answers to
nebulous questions. ‘The people who short-listed us didn’t see what we had
done or where we went to university, so none of our experience helped. No
one ever felt that they would do something like this,’ she says sadly. ‘They say
there are jobs for most of us, but they are talking about 6000 losing out. In the
old days it would have been people who failed their exams, but now that
doesn’t seem to count for anything anymore.’ Palling describes how the
MTSA debacle has drained her enthusiasm for the job. ‘I don’t feel the same
sort of dedication to it now,’ she says. ‘[This mess] has taken idealism about
the job away from all of us. It is now just a job. And not particularly well paid
for the hours. People die all the time. It is hard.’ Dealing with the uncertainty
of the recruitment process makes adjusting to other workplace problems ever
harder, says Palling. ‘We have had a really bad winter here. Quite a lot of
wards closed and we were parking patients in the corridor. There is nowhere
to do your job properly. You can’t do a proper examination.’ The insecurity
is affecting everyone in the hospital. ‘No one feels their job is safe,’ she says,
but it has also made her aware of how important it is to watch what is
happening on a political level. ‘We’ve always thought that we should have
been focusing on our patients and letting others look after the NHS. We are
all so caught up in our daily jobs but we should have been paying more
attention to the health reforms all the way through,’ she says. ‘I just feel so
helpless about it all. If I get a job in August I will try and become more
involved in politics. I think we all will. It has made us all feel that way.’”
Brown H. Lancet. May 18, 2007
Editor’s Note: A real disaster in England!
Noted by JFL, MD

PEDIATRICS Volume 120, Number 2, August 2007 287


Downloaded from www.pediatrics.org by John C Kim on September 27, 2007
Management of Acute Otitis Media by Primary Care Physicians: Trends Since
the Release of the 2004 American Academy of Pediatrics/American Academy of
Family Physicians Clinical Practice Guideline
Louis Vernacchio, Richard M. Vezina and Allen A. Mitchell
Pediatrics 2007;120;281-287
DOI: 10.1542/peds.2006-3601
Updated Information including high-resolution figures, can be found at:
& Services http://www.pediatrics.org/cgi/content/full/120/2/281
References This article cites 22 articles, 13 of which you can access for free
at:
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Citations This article has been cited by 1 HighWire-hosted articles:
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Subspecialty Collections This article, along with others on similar topics, appears in the
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http://www.pediatrics.org/cgi/collection/infectious_disease
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