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The online version of this article, along with updated information and services, is
located on the World Wide Web at:
http://www.pediatrics.org/cgi/content/full/120/2/281
The authors have indicated they have no financial relationships relevant to this article to disclose.
ABSTRACT
OBJECTIVES. In 2004, the American Academy of Pediatrics and the American Acad-
emy of Family Physicians released a clinical practice guideline on the management
www.pediatrics.org/cgi/doi/10.1542/
of acute otitis media that included endorsement of an observation option for peds.2006-3601
selected cases and recommendations of specific antibiotics. We sought to describe doi:10.1542/peds.2006-3601
primary care physicians’ current management of acute otitis media to compare it
Key Words
with the guideline’s recommendations and describe trends since 2004. otitis media, antibiotics, clinical practice
guidelines, primary care
DESIGN. We used a mail survey from March through June 2006 within the Slone Abbreviations
Center Office-Based Research Network, a national practice-based pediatric re- AOM—acute otitis media
search network. AAP—American Academy of Pediatrics
AAFP—American Academy of Family
Physicians
RESULTS. The response rate was 299 (62.7%) of 477. The observation option was
SCOR—Slone Center Office-Based
considered reasonable by 83.3%, compared with 88.0% in 2004, and was used in Research
a median of 15% of acute otitis media cases over the previous 3 months. The most Accepted for publication Mar 22, 2007
common physician-identified barriers to the use of the observation option were Address correspondence to Louis Vernacchio,
MD, MSc, Slone Epidemiology Center, 1010
parental reluctance (83.5%) and the cost and difficulty of follow-up of children Commonwealth Ave, Boston, MA 02215. E-
who do not improve (30.9%). In terms of antibiotic choices for acute otitis media, mail: lvernacchio@slone.bu.edu
agreement with the guideline’s antibiotic recommendation for 4 common clinical PEDIATRICS (ISSN Numbers: Print, 0031-4005;
Online, 1098-4275). Copyright © 2007 by the
scenarios was as follows: high-dose amoxicillin for acute otitis media with nonse- American Academy of Pediatrics
vere symptoms (57.2%), high-dose amoxicillin-clavulanate for acute otitis media
with severe symptoms (12.7%), high-dose amoxicillin-clavulanate for cases that
failed to respond to amoxicillin (42.8%), and intramuscular ceftriaxone for cases
that failed to respond to treatment with amoxicillin-clavulanate (16.7%). Each of
these proportions declined from 2004.
CONCLUSIONS. Most primary care physicians accept the concept of an observation
option for acute otitis media but use it only occasionally. Antibiotics prescribed for
acute otitis media differ markedly from the guideline’s recommendations, and the
difference has increased since 2004.
282 VERNACCHIO et al
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TABLE 1 Characteristics of 299 Physicians Who Responded to the TABLE 2 Acceptance of the Observation Option According to
Survey Physician Characteristics
Characteristics No. (%) Factor n/N (%) P
Gender Gender
Male 215 (71.9) Male 180/215 (83.2) .7
Female 84 (28.1) Female 69/84 (82.1)
Specialty Specialtya
Pediatrics 230 (76.9) Pediatrics 199/230 (86.5) .003
Family practice 66 (22.1) Family practice 47/66 (71.2)
Other 3 (1.0) AAP and/or AAFP membership
Academy membership Yes 224/265 (84.5) .1
AAP 209 (69.9) No 25/34 (73.5)
AAFP 55 (18.4) Year of medical school graduation
Neither 34 (11.4) Before 1970 38/49 (77.6) .03b
Both 1 (0.3) 1970s 91/113 (80.5)
Year of medical school graduation 1980s 102/119 (85.7)
Before 1970 49 (16.4) 1990s 18/18 (100.0)
1970s 113 (37.8) Practice setting
1980s 119 (39.8) Suburban 138/155 (89.0) .0003
1990s 18 (6.0) Rural 48/68 (70.6)
Practice setting Urban, non-inner city 51/57 (89.5)
Suburban 155 (51.8) Urban, inner city 12/19 (63.2)
Rural 68 (22.7) Region
Urban, non-inner city 57 (19.1) Midwest 57/69 (82.6) .6
Urban, inner city 19 (6.4) South 51/63 (81.0)
Region Midatlantic 45/56 (80.4)
Midwest 69 (23.1) West 34/42 (81.0)
South 63 (21.1) Southwest 31/36 (86.1)
Midatlantic 56 (18.7) New England 31/33 (93.9)
West 42 (14.1) an ⫽ 3 with other specialties not included in this analysis.
Southwest 36 (12.0) b Test for trend.
New England 33 (11.0)
A
100% B
9.7% Other 9.7% 100% Other 6.0%
6.6%
90%
2.4% 4.7%
90% 6.1% Amoxicillin-
Amoxicillin
80% 22.0% 33.1% clavulanate 10.4%
40–45 mg/kg per day 80% 40–45 mg/kg per day
70%
70%
60% Amoxicillin
60%
40–45 mg/kg per day
50%
50%
40% Amoxicillina Amoxicillin
40% 67.0% 66.2%
68.3% 57.2% 80–90 mg/kg per day
80–90 mg/kg per day
30% 30%
20% 20%
Amoxicillin-
10% 10% clavulanate a 12.7%
17.9%
80–90 mg/kg per day
0% 0%
2004 2006 2004 2006
C D
100% Other 100%
12.2% 11.4% 13.4% 10.4%
Amoxicillin- Other
Re Re
90% 90%
clavulanate 4.7%
6.3% 7.4%
40–45 mg/kg per day 8.0% Cefuroxime
80% 80%
70%
8.3%
vie Azithromycin
8.0%
70% vie
15.2%
axetil
Azithromycin
16.4%
60% 21.5%
w Cefdinir 30.4% 60% w
50% Co 50% Co
40%
30% 51.7%
Amoxicillin-
clavulanate a
py 42.8%
40%
30%
35.7%
py
Cefdinir 51.8%
0% 0%
2004 2006 2004 2006
FIGURE 1
Antibiotic choices of physicians in 2004 and 2006 for 4 common AOM scenarios. A, AOM with nonsevere symptoms (a P ⫽ .01 for comparison of 2004 to 2006). B, AOM with severe
symptoms (a P ⫽ .1 for comparison of 2004 to 2006). C, AOM that failed treatment with amoxicillin at 80 to 90 mg/kg per day (a P ⫽ .05 for comparison of 2004 to 2006). D, AOM that
failed treatment with amoxicillin-clavulanate at 80 to 90 mg/kg per day (a P ⫽ .05 for comparison of 2004 to 2006). The antibiotics shown in bold type are recommended by the 2004
AAP/AAFP guideline on AOM.
284 VERNACCHIO et al
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group of providers fielded in late 2004, ⬃6 months after may be ameliorated somewhat by the use of a backup
the release of the AOM guideline. antibiotic prescription given to the parent at the time
The current survey, and the 2004 survey to which its of initial AOM diagnosis, a follow-up strategy demon-
results are compared, were performed within the SCOR strated to be practical in several clinical trials6,9,13,14 and
Network, a national, practice-based, pediatric research favored by a majority of the responding physicians. This
network consisting of nearly 500 pediatricians and fam- strategy does, however, place more decision-making re-
ily physicians. Members of the SCOR Network may not sponsibility in the parent’s hands and may not be wel-
be representative of all US pediatric primary care pro- comed by or appropriate for all families.
viders in that they have chosen to be involved in re- This survey also demonstrates significant discrepan-
search. However, they do represent a diverse group of cies between the recommendations of the AAP/AAFP
office-based physicians from 42 US states and a variety guideline and physicians’ choices of antibiotics to treat
of practice and community settings, and thus can pro- AOM. For AOM with nonsevere symptoms, slightly
vide valuable insights into how the AOM guideline’s more than half chose the recommended high-dose
recommendations are being implemented and which of amoxicillin. Nearly one third opt for standard-dose
them are most problematic for primary care providers. amoxicillin, a significant increase from 2004. This trend
As for the possibility of response bias in the survey, the back to standard-dose amoxicillin for nonsevere disease
fact that the demographics of responders did not differ may represent an awareness of recent data that wide-
significantly from those of nonresponders is reassuring. spread use of the heptavalent pneumococcal conjugate
Yet, other unmeasured biases could have been associ- vaccine has reduced the circulation of penicillin-resistant
ated with response. For example, we consider it likely Streptococcus pneumoniae in some communities.15,16
that physicians who are more familiar with the guideline For AOM with severe symptoms, only 1 of 8 physi-
and/or more inclined to follow its recommendations cians agreed with the recommendation for high-dose
would also have been more likely to complete the sur- amoxicillin-clavulanate, whereas a much larger number
vey. This possibility, combined with the fact that SCOR chose high-dose amoxicillin. The widespread nonadher-
Network physicians have all agreed to be involved in ence with this recommendation may reflect a feeling
practice-based research, suggests that our results likely that the guideline strayed from the evidence that AOM
represent a “best case” scenario in terms of familiarity with severe symptoms is more likely because of S pneu-
with and adherence to the guideline’s recommenda- moniae (for which the addition of clavulanate is not
tions. helpful) than nontypeable Haemophilus influenzae and
In this survey, we found that most of these physicians Moraxella catarrhalis.17,18 Alternatively, initially prescrib-
accept the concept of an observation option for selected ing amoxicillin-clavulanate for children with AOM and
children with AOM, but the proportion who accept it severe symptoms may leave physicians feeling that they
has not increased since 2004 and may have decreased do not have a comfortable second-line option (ie,
slightly. Those who are most accepting of the observa- switching to a different oral antibiotic with no better
tion option include pediatricians (as opposed to family microbiologic coverage for the likely organisms or giving
physicians), younger physicians, and those practicing in a painful and expensive daily intramuscular injection of
suburban and urban non–inner-city locations. Overall, ceftriaxone for 3 consecutive days, as the guideline rec-
the responding physicians currently use the observation ommends).
option in ⬃15% of the AOM cases they diagnose, ap- For children whose treatment with amoxicillin failed,
proximately the same proportion as in 2004, but just just under half of the responding physicians chose the
over 1 in 10 of them are enthusiastic early adopters of recommended amoxicillin-clavulanate, with a substan-
observation, using it with at least half of their diagnosed tial and increasing number choosing cefdinir instead.
AOM cases. Cefdinir’s rise as a second-line agent at the expense of
When questioned in an open-ended fashion about amoxicillin-clavulanate may reflect heavy marketing of
barriers to the use of the observation option in their the drug, more convenient dosing options, and/or a
practices, these physicians overwhelmingly pointed to lower risk of diarrhea.19
parental reluctance to accept this approach. There is, Finally, for children whose treatment with amoxicil-
however, growing evidence that many US parents will lin-clavulanate failed, the majority chose an oral antibi-
accept observation when this option is presented in an otic alternative (primarily cefdinir or azithromycin,
appropriate context,5,6,9–12 thus there is a disconnect be- which have inferior or at best equivalent microbiologic
tween what studies show parents will accept and what coverage to amoxicillin-clavulanate for the likely organ-
physicians think parents will accept. About one third of isms), whereas only 1 in 6 chose the recommended
physicians also cited the time, cost, and general difficulty intramuscular ceftriaxone, suggesting a strong prefer-
associated with follow-up for children managed initially ence for oral over intramuscular administration.
with observation who do not improve within an accept- We did not ask the surveyed physicians to provide a
able time frame as an important barrier. This concern rationale for their antibiotic choices, thus we can only
286 VERNACCHIO et al
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