FLNA

La lamina A (FLNA) es una protena codicada en

humanos por el gen FLNA.[1][2]

[2] Robertson SP, Twigg SR, Sutherland-Smith AJ, Biancalana V, Gorlin RJ, Horn D, Kenwrick SJ, Kim CA, Morava E, Newbury-Ecob R, Orstavik KH, Quarrell OW,
Schwartz CE, Shears DJ, Suri M, Kendrick-Jones J, Wilkie AO (Mar de 2003). Localized mutations in the gene
encoding the cytoskeletal protein lamin A cause diverse malformations in humans. Nat Genet 33 (4): 48791.
doi:10.1038/ng1119. PMID 12612583.

La lamina A, o protena de unin a actina, es una protena de 280 kDa que entrecruza los lamentos de actina
en redes ortogonales en citoplasma cortical y participa en el anclaje de protenas de membrana a travs del
citoesqueleto de actina. La remodelacin del citoesqueleto es crucial para la modulacin de la forma celular y
la migracin. La lamina A es una protena ampliamente
expresada que regula la organizacin del citoesqueleto de
actina mediante interaccin con integrinas, complejos de
receptores transmembrana y segundos mensajeros.[3]

[3] Entrez Gene: FLNA lamin A, alpha (actin binding protein 280).
[4] Nagano, Takashi; Yoneda Takunari, Hatanaka Yumiko,
Kubota Chikara, Murakami Fujio, Sato Makoto (Jul. de
2002). Filamin A-interacting protein (FILIP) regulates
cortical cell migration out of the ventricular zone. Nat.
Cell Biol. (England) 4 (7): 495501. doi:10.1038/ncb808.
ISSN 1465-7392. PMID 12055638. Parmetro desconocido |quotes= ignorado (ayuda);

Interacciones

La lamina A ha demostrado ser capaz de interaccionar

con:

[5] Ohta, Y; Suzuki N, Nakamura S, Hartwig J H, Stossel T

P (Mar. de 1999). The small GTPase RalA targets lamin to induce lopodia. Proc. Natl. Acad. Sci. U.S.A.
(UNITED STATES) 96 (5): 21228. ISSN 0027-8424.
PMID 10051605. Parmetro desconocido |quotes= ignorado (ayuda);

FILIP1[4]
RALA[5]

[6] Tu, Yizeng; Wu Shan, Shi Xiaohua, Chen Ka, Wu Chuanyue (Apr. de 2003). Miglin and Mig-2 link focal adhesions to lamin and the actin cytoskeleton and function in
cell shape modulation. Cell (United States) 113 (1): 37
47. ISSN 0092-8674. PMID 12679033. Parmetro desconocido |quotes= ignorado (ayuda);

FBLIM1[6]
FLNB[7]
Receptor sensor de calcio[8][9]
TRIO[10]

[7] Sheen, Volney L; Feng Yuanyi, Graham Donna, Takafuta Toshiro, Shapiro Sandor S, Walsh Christopher A (Nov.
de 2002). Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can
physically interact. Hum. Mol. Genet. (England) 11 (23):
284554. ISSN 0964-6906. PMID 12393796. Parmetro
desconocido |quotes= ignorado (ayuda);

SH2B3[11]
NPHP1[12]
BRCA2[13]

[8] Hjlm, G; MacLeod R J, Kifor O, Chattopadhyay N,

Brown E M (Sep. de 2001). Filamin-A binds to the
carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated
activation of mitogen-activated protein kinase. J.
Biol. Chem. (United States) 276 (37): 348807.
doi:10.1074/jbc.M100784200. ISSN 0021-9258. PMID
11390380. Parmetro desconocido |quotes= ignorado
(ayuda);

CD29[14][15]
Supresor tumoral Von Hippel-Lindau[16][17]

Referencias

[1] Gorlin JB, Henske E, Warren ST, Kunst CB, D'Urso M,

Palmieri G, Hartwig JH, Bruns G, Kwiatkowski DJ (Oct
de 1993). Actin-binding protein (ABP-280) lamin gene
(FLN) maps telomeric to the color vision locus (R/GCP)
and centromeric to G6PD in Xq28. Genomics 17 (2):
4968. doi:10.1006/geno.1993.1354. PMID 8406501.

[9] Awata, H; Huang C, Handlogten M E, Miller R T

(Sep. de 2001). Interaction of the calcium-sensing receptor and lamin, a potential scaolding protein.
J. Biol. Chem. (United States) 276 (37): 348719.
doi:10.1074/jbc.M100775200. ISSN 0021-9258. PMID

11390379. Parmetro desconocido |quotes= ignorado

(ayuda);
[10] Bellanger, J M; Astier C, Sardet C, Ohta Y, Stossel T
P, Debant A (Dec. de 2000). The Rac1- and RhoGspecic GEF domain of Trio targets lamin to remodel cytoskeletal actin. Nat. Cell Biol. (ENGLAND) 2
(12): 88892. doi:10.1038/35046533. ISSN 1465-7392.
PMID 11146652. Parmetro desconocido |quotes= ignorado (ayuda);
[11] He, X; Li Y, Schembri-King J, Jakes S, Hayashi J (Aug.
de 2000). Identication of actin binding protein, ABP280, as a binding partner of human Lnk adaptor protein.
Mol. Immunol. (England) 37 (10): 60312. ISSN 01615890. PMID 11163396. Parmetro desconocido |quotes=
ignorado (ayuda);
[12] Donaldson, John C; Dise Rebecca S, Ritchie Marylyn
D, Hanks Steven K (Aug. de 2002). Nephrocystinconserved domains involved in targeting to epithelial cellcell junctions, interaction with lamins, and establishing
cell polarity. J. Biol. Chem. (United States) 277 (32):
2902835. doi:10.1074/jbc.M111697200. ISSN 00219258. PMID 12006559. Parmetro desconocido |quotes=
ignorado (ayuda);
[13] Yuan, Y; Shen Z (Dec. de 2001). Interaction with
BRCA2 suggests a role for lamin-1 (hsFLNa) in DNA
damage response. J. Biol. Chem. (United States) 276
(51): 4831824. doi:10.1074/jbc.M102557200. ISSN
0021-9258. PMID 11602572. Parmetro desconocido
|quotes= ignorado (ayuda);
[14] van der Flier, Arjan; Kuikman Ingrid, Kramer Duco,
Geerts Dirk, Kreft Maaike, Takafuta Toshiro, Shapiro
Sandor S, Sonnenberg Arnoud (Jan. de 2002). Dierent splice variants of lamin-B aect myogenesis, subcellular distribution, and determine binding to integrin
[beta] subunits. J. Cell Biol. (United States) 156 (2):
36176. doi:10.1083/jcb.200103037. ISSN 0021-9525.
PMID 11807098. Parmetro desconocido |quotes= ignorado (ayuda);
[15] Loo, D T; Kanner S B, Aruo A (Sep. de 1998). Filamin
binds to the cytoplasmic domain of the beta1-integrin.
Identication of amino acids responsible for this interaction. J. Biol. Chem. (UNITED STATES) 273 (36):
2330412. ISSN 0021-9258. PMID 9722563. Parmetro
desconocido |quotes= ignorado (ayuda);
[16] Tsuchiya, H; Iseda T, Hino O (Jul. de 1996). Identication of a novel protein (VBP-1) binding to the von HippelLindau (VHL) tumor suppressor gene product. Cancer
Res. (UNITED STATES) 56 (13): 28815. ISSN 00085472. PMID 8674032. Parmetro desconocido |quotes=
ignorado (ayuda);
[17] Zhou, Mina I; Wang Hongmei, Ross Jonathan J,
Kuzmin Igor, Xu Chengen, Cohen Herbert T (Oct.
de 2002). The von Hippel-Lindau tumor suppressor
stabilizes novel plant homeodomain protein Jade-1.
J. Biol. Chem. (United States) 277 (42): 3988798.
doi:10.1074/jbc.M205040200. ISSN 0021-9258. PMID
12169691. Parmetro desconocido |quotes= ignorado
(ayuda);

ENLACES EXTERNOS

3 Enlaces externos
GeneReview/NCBI/NIH/UW entry on Otopalatodigital Spectrum Disorders

Texto e imgenes de origen, colaboradores y licencias

4.1

Texto

FLNA Fuente: https://es.wikipedia.org/wiki/FLNA?oldid=64860742 Colaboradores: Gonn, BOTarate, TiriBOT, ZroBot y KLBot2

4.2

Imgenes

Archivo:Protein_FLNA_PDB_2aav.png Fuente: https://upload.wikimedia.org/wikipedia/commons/8/82/Protein_FLNA_PDB_2aav.

png Licencia: CC BY-SA 3.0 Colaboradores: Trabajo propio Artista original: Emw

4.3

Licencia de contenido

Creative Commons Attribution-Share Alike 3.0