Professional Documents
Culture Documents
Downs Syndrome
American Journal on Mental Retardation: March 2004, Vol. 109, No. 2, pp. 126-141
Triplica(on
of
chromosome
21
defect
Stubby brain
Down SyndromeDementi
Alzheimers disease
NeurotransmiIer
defects
Cholinergic
Norepinephrine
Control
Gluatmatergic
DS
AD
Neurotrophin
defects
proNGF/tubulin
Neurotrophin
defects
NCI
MCI
Inamma(on
Inamma(on
Demen%a
Demen%a
AD
Mechanism:
Mouse model:
Results:
Clincal
trials
(yes/no)
Estrogen
An%-oxidant/protec%ve
Ts65Dn
Protec%on
Rescue
No
Meman%ne
Ts65Dn
Symptoma%c
On going
Vitamin E
An%-oxidant
Ts65Dn
Preven%ve
Yes
Fluoxe%ne
Serotonin
reuptake
inhibitor
Ts65Dn
No formal trial
GABA5-selec%ve
inverse
agonists
Roche
L-DOPS
GABA inhibi%on
Ts65Dn
NE precursor
Ts65Dn
Choline
Acetylcholine
precursor
Ts65Dn
ELND005
Transi%on
Therapeu%cs
Reduce
beta-amyloid
aggrega%on
PS1xAPP AD
Increased
neurogenesis
Normalize
GABA
release
Rescue
learning
and
memory
Rescue
AD
pathology
and
memory
Rescue
AD
pathology
and
memory
No
adverse
side
aects
Rescue
AD
pathology
Ongoing
No
NO
On
going
Alzheimers disease
Collaborators
Rush University Med. Ctr
Jack Fox
Scott Counts
Sue Leurgans
Cassia Overk
Sylvia Perez
Joanne Wuu (Univ. Miami Med. School)
Rush ADC
Nathan Kline Institute
Steven Ginsberg
Shaoli Che
Northwestern University
Lester (Skip) Binder
Laurel Vana
Eli Lilly
Kelly Bales (Pfizer)
Christian Felder
University of Pittsburgh
Stephen DeKosky (UVA)
Milos Ikonomovic
University of Kentucky
Stephen Scheff
Emory University
Alan Levey
James Lah
Michelle Gillmor
McMaster University
Margaret Fahnestock
Shiyong Peng
McGill University
Claudio Cuello
Martin Bruno
We are indebted to members of the clergy participating in the Rush Religious Orders Study.
Support by NIA Grants PO1 AG14449, RO1AG043375 and P50AG10610.