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ABSTRACTBOOK

Reims, France 13 - 14 April 2015

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150
150 years
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Excipients for orally disintegrating tablets.
Contact us via e-mail at pharma-ingredients@basf.com
or visit www.pharma-ingredients.basf.com/odt

| Excipients |

Chairs and Committees


Chair of the Conference
Prof. Jrgen Siepmann, Lille, France

Co-Chairs of the Conference


Prof. Franco Alhaique, Rome, Italy
Prof. Jrg Breitkreutz, Dsseldorf, Germany

Programme Committee Chair


Prof. Jrg Breitkreutz, Dsseldorf, Germany

Programme Committee
Prof. Franco Alhaique, Rome, Italy
Prof. Johannes Bartholomaeus, Aachen, Germany
Prof. Jrg Breitkreutz, Dsseldorf, Germany
Prof. Anna Maria Fadda, Cagliari, Italy
Dr. Alexandre Gil, Montpellier, France

International Support Pannel


Dr. Eva Roblegg, Graz, Austria
Prof. Chris Vervaet, Ghent, Belgium
Prof. Thomas Rades, Copenhagen, Denmark
Prof. Leena Peltonen, Helsinki, Finland
Prof. Marie-Christine Andry, Reims, France
Prof. Sandra Klein, Greifswald, Germany
Dr. Gza Regdon Jr, Szeged, Hungary
Prof. Elka Touitou, Jerusalem, Israel
Prof. Gaetano Giammona, Palermo, Italy
Prof. Vitalis Briedis, Kaunas, Lithuania
Prof. Malgorzata Sznitowska, Gdansk, Poland
Prof. Joao Pinto, Lisbon, Portugal
Prof. Julijana Kristl, Ljubljana, Slovenia
Prof. Maria Jos Alonso, Santiago de Compostela, Spain
Prof. Anette Larsson, Gothenburg, Sweden
Dr. Rainer Alex, Basel, Switzerland
Prof. Wim Hennik, Utrecht, The Netherlands
Prof. Sema alis, Ankara, Turkey
Prof. Yvonne Perrie, Birmingham, United Kingdom

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

Social programme
Monday, 13 April 2015
17:00

Welcome reception at the Centre des Congrs Reims


The Welcome Reception will be held in the exhibition halls of Centre des Congrs Reims (La Nef).
Enjoy a glass of champagne while networking with old and new friends.

Opening hours: business office and registration desk


Monday

13 April 2015

07:00 to 20:00

Tuesday

14 April 2015

08:00 to 17:00

Level 0 : R E C E P T I O N

BOULEVARD MAURICE NOIROT

Access by lift
for handicapped persons

Access to underground
car park

Access to underground
car park by stairs
LUGGAGE ROOM
STORAGE

Access to underground
car park by lift

RECEPTION DESK
Handicapped
persons
access
RECEPTION SPACE

RIA

Badge checkpoint
& access
to building
Lobby

MAIN ENTRANCE
Coffee
machine

PARC DE LA
PATTE D'OIE

0 1m

5m

10m

15m

20m
12.10 - Centre des congrs de Reims

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

Monday, 13 April 2015


Amphithtre Royal
09:00 Opening Ceremony and APGI Student Award
Jrg Breitkreutz, President of APV
Franco Alhaique, President of A.D.R.I.T.E.L.F.
Jrgen Siepmann, President of APGI
Arnaud Robinet, Mayor of Reims
09:15 Plenary lecture
Chair: F. Alhaique
Drug Targeting - Where are we?
Patrick Couvreur, Chtenay-Malabry (Paris), France
10:15 Coffee break (La Nef)
Poster session and industrial exhibition
10:45 Invited talks: Transdermal Drug Delivery
Chairs: A. M. Fadda/H. Franke
10:45 Transdermal drug delivery: A Mature and Evolving Technology
Richard Guy, University of Bath, Bath, United Kingdom
11:25 Transdermal Drug Delivery: An Industrial Viewpoint
Michel Sournac, Pierre Fabre, Toulouse, France
12:05 The new Guideline on Quality of Transdermal Patches:
New Requirements in Development
Sean Jones, Medicine and Healthcare Products Regulatory Agency, London, United Kingdom
12:45 Lunch break (La Nef)
Poster session and industrial exhibition
15:00 Invited talks: Oral Drug Delivery
Chairs: D. Craig/S. Page
15:00 Recent Challenges in Oral Controlled-Release Drug Delivery
Martin Lueck, Gruenenthal, Aachen, Germany
15:40 Therapeutic Index Issues around Oral Peptide Permeation Enhancers
David Brayden, University of Dublin, Dublin, Ireland
16:20 Orodispersible Dosage Forms
Dejan Djuric, Bayer, Berlin, Germany
17:00 End of session
17:00 Welcome Reception with Champagne Tasting in the exhibition area (La Nef)
1st European Conference on Pharmaceutics Drug Delivery
Reims, France 13 - 14 April 2015

Amphithtre Clovis
10:15 Coffee break (La Nef)
Poster session and industrial exhibition
10:45 Short talks: Oral Controlled Drug Delivery
Chairs: C. Caramella/P. Lefevre
10:45 How does the drinking volume affect gastric dissolution in infants?
New in vitro approaches for preclinical screening
E. Kersten and S. Klein
11:05 In-vitro dissolution testing of oral thin films (OTFs): theory and experiments
A. Adrover, M. Casadei, S. Pacelli, P. Paolicelli, S. Petralito and R. Spera
11:25 Proposal for a new dissolution method for soft chewable delivery systems
C. Stomberg, E. Melzer, J. Radtke and P. Kleinebudde
11:45 Assessing Softgel Disintegration in the Gastric Compartment:
Correlating the Dynamic Gastric Model with In Vivo Visualization by Camera-Capsules
H. Teles, K. van den Dries, S. Chessa, D. Bar-Shalom, H. Huatan, P. Sassene and A. Mllertz
12:05 Mucoadhesive polymeric nanocomposites for oral delivery of S-nitrosoglutathione
W. Wu, C. Gaucher, I. Fries, X. Hu, Y. Xiao, p. Maincent and A. Sapin-Minet
12:25 Amphiphilic Nucleic Acid Conjugates for Local Treatment of Intestinal Diseases
E. Moroz, S. Lee, H. Jahns, J. Hall, K. Yamada, M. Damha, B. Castagner and J. Leroux
12:45 Lunch break (La Nef)
Poster session and industrial exhibition
15:00 Short talks: Nanoparticles & Vesicles
Chairs: N. Dragicevic-Curic/C. Lemarchand
15:00 The effect of using different nebulisers on the delivery of Amphotericin B
and Cisplatin Non-Ionic Surfactant Vesicles
M. Puig, C. Carter and A. Mullen
15:20 Ex vivo and in vivo siRNA delivery to activated T cells as novel
anti-inflammatory asthma therapy
Y. Xie, N. Kim, A. Thakur, L. Lum, D. Bassett and O. Merkel
15:40 Chitosan-iron-based nanogels for the cellular delivery of polyphosphate drugs
G. Giacalone, H. Hillaireau, A. Bochot and E. Fattal
16:00 Anti-E6/E7/MCL1 pegylated lipoplexes for a vaginal treatment of cervical cancer
A. Lechanteur, T. Furst, B. Evrard, P. Delvenne, G. Piel and P. Hubert
16:20 Delivery of Andrographolide to the brain by human serum albumin nanoparticles
M. Bergonzi, C. Guccione, V. Piazzini, A. Torracchi, C. Grossi, F. Casamenti and A. Bilia
16:40 Percutaneous absorption of benzophenone-3 loaded lipid nanoparticles and
polymeric nanocapsules: a comparative study
E. Gilbert, L. Roussel and F. Pirot
17:00 End of session
17:00 Welcome Reception with Champagne Tasting in the exhibition area (La Nef)
6

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

Tuesday, 14 April 2015


Amphithtre Royal
09:00 Invited talks: Smart Drug Delivery Systems
Chairs: T. Rades/J. Voorspoels
09:00 Progresses in Anticancer Drug Delivery by Polymer Conjugation
Gianfranco Pasut, University of Padova, Padova, Italy
09:40 3D Printing
Clive Roberts, University of Nottingham, Nottingham, United Kingdom
10:20 Smart Drug Delivery from an industrial perspective
Paul Gellert, AstraZeneca, Macclesfield, United Kingdom
11:00 Coffee break (La Nef)
Poster session and industrial exhibition
11:30 Plenary lecture
Chair: J. Breitkreutz
Advances in Pulmonary Drug Delivery
Hartmut Derendorf, Gainesville, Florida, United States
12:30 Lunch break (La Nef)
Poster session and industrial exhibition
15:00 Invited talks: Peptide and Protein Delivery
Chairs: P. Matricardi/M. Lueck
15:00 Protein and Peptide Delivery: Current State of the Art
Wim Hennink, University of Utrecht, Utrecht, The Netherlands
15:40 Challenges and advances in vaccine delivery
Derek O Hagan, Novartis Vaccines and Diagnostics Inc., Cambridge, United States
16:20 Novel Application Systems for Transdermal Vaccine Delivery
Heiko Spilgies, LTS Lohmann Therapie-System AG, Andernach, Germany
17:00 End of session

Amphithtre Clovis
09:00 Short talks: Advanced Drug Delivery
Chairs: K. Andrieux/G. Verreck
09:00 Modifications of the stratum corneum barrier structure and function introduced
by freezing: consequences for drug permeation studies
L. Roussel, R. Abdayem, N. Zaman, E. Gilbert, F. Pirot and M. Haftek
1st European Conference on Pharmaceutics Drug Delivery
Reims, France 13 - 14 April 2015

09:20 IN VITRO PHAGE DISPLAY AS A STRATEGY TO ENHANCE


THE SKIN PENETRATION OF HEPARINS
S. Franz, C. Gennari, S. Pellegrino, F. Cilurzo and P. Minghetti
09:40 Hyaluronic acid gels containing liposomes for the sustained delivery
of a corticoid to the inner ear
N. El Kechai, F. Agnely, E. Mamelle, V. NIcolas, N. Huang, Y. Nguyen, E. Ferrary and A. Bochot
10:00 MESOPOROUS PHOSPHOLIPID PARTICLE AS A NOVEL DRUG DELIVERY PLATFORM
K. Kawakami, S. Zhang, G. Jayakumar, M. Fukushima, J. Hill and K. Ariga
10:20 THALIDOMIDE NASAL POWDERS FOR LOCAL TREATMENT OF NOSE BLEEDING IN
HEREDITARY HEMORRHAGIC TELANGECTASIA
V. Chiapponi, A. Rossi, G. Colombo and P. Colombo
10:40 In vitro estimation of drug delivery to stenosed coronary blood vessels via
drug-coated balloon catheters
A. Seidlitz, W. Kempin, T. Reske, S. Kaule, N. Grabow, S. Petersen, S. Nagel
and W. Weitschies
11:00 Coffee break (La Nef)
Poster session and industrial exhibition
11:30 Plenary lecture (Amphithtre Royal)
Chair: J. Breitkreutz
Advances in Pulmonary Drug Delivery
Hartmut Derendorf, Gainesville, Florida, United States
12:30 Lunch break (La Nef)
Poster session and industrial exhibition
15:00 Short talks: Development & Manufacturing of Solid Dosage Forms
Chairs: M. Repka/P. Gellert
15:00 Thermodynamics of API/Polymer Amorphous Formulations
G. Sadowski
15:20 Hot-melt extrusion of polyvinyl alcohol and plasticizer for oral immediate
release applications
W. De Jaeghere, T. Monteyne, T. De Beer, J. Remon and C. Vervaet
15:40 Melt blowing and electrospinning for dissolution enhancement
A. Balogh, B. Farkas, Z. Nagy, G. Marosi, I. Assche and G. Verreck
16:00 Exploring the Use of Pressurised Gyration for Large Scale Manufacture of
Pharmaceutical Nanofibres
B. Raimi-Abraham, S. Mahalingam, M. Edirisinghe and D. Craig
16:20 PAT tools for the control of the manufacturing processes of co-extruded implants,
tablets and capsules
F. Krier, A. Pestieau, G. Thoorens, T. Justine, D. Anas, T. Marion, M. Jrme, E. Ziemons,
P. Hubert and B. Evrard
16:40 The Application of Novel nano-Thermal and Imaging Techniques for Monitoring
the Drug Distribution within PLGA Microspheres
M. Zhao, F. Yang, D. Chen, Z. Guo, Y. Zhang and D. Craig
17:00 End of session
8

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

Posters
Monday, 13 April 2015
Posters
Exhibited continuously from 9:00 to 20:00, with special sessions from 12:45 to 15:00.
The number indicates the number displayed on the poster panel.

Advanced Drug Delivery Systems


1

Lipid-based formulations as a way to improve the solubilization of cinnarizine


S. Siqueira, G. Kasten, T. Rades, H. Mu and A. Mllertz

A new RNA delivery platform for tumor immunotherapy


H. Haas, K. Buch, I. Esparza, D. Fritz, M. Meng, L. Kranz, K. Reuter, M. Diken,
S. Kreiter and U. Sahin

Anti-inflammatory properties of synbiotic loaded chitosan-Ca-alginate


microparticles in animal model of colitis
T. Petreska Ivanovska, Z. Zhivikj, M. Jurhar Pavlova, M. Glavas Dodov, T. Ristoski, I. Gjurovski,
L. Petrushevska-Tozi and K. Mladenovska

Cationic lipid-free cationic nanoemulsions - a novel approach for the treatment of


ophthalmic infections
X. Li, N. A. Bou-Chacra, R. H. Mller and C. M. Keck

Charge reversal inulin-doxorubicin conjugate as tailor-made tool for cancer


targeted therapy
N. Mauro, C. Scialabba, M. Licciardi, G. Giammona, G. Adamo, S. Campora and G. Ghersi

Development and characterization of SEDDS containing babassu oil associated with


copaiba oil for treatment of benign prostatic hyperplasia
L. Abreu, F. Carmo and L. Cabral

DEVELOPMENT AND CHARACTERIZATION OF SELF NANOEMULSIFYING SYSTEM (SNEDDs)


FOR ROSUVASTATIN
H. Y. KARASULU, E. GUNDOGDU, T. TURGAY, S. APAYDIN, U. O. TURK, I. YILDIRIM SIMSIR,
C. YILMAZ and E. KARASULU

Development of internally self-assembled lipid-based systems for vaccine delivery


L. Pires Rodrigues, K. Kyriakos, C. Papadakis, G. Winter and M. Hubert

Development of microsponges as drug delivery carriers using multivariate analyses


M. Simonoska-Crcarevska, E. Mitanovksa-Janeva, N. Sibinovska, V. Komoni, N. Geskovski,
S. Dimcevska, K. Mladenovska, R. Slaveska-Raicki, S. Trajkovic-Jolevska and M. Glavas-Dodov

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

10

Development of mucoadhesive drug delivery systems by precipitation of chitosan


on drug-loaded microparticles
D. Preisig, M. Weingartner, F. J. Varum, R. Bravo, R. Alles, M. Puchkov and J. Huwyler

11

Does cinnarizine form amorphous complexes with lipids during digestion of


lipid-based drug delivery systems?
P. Sassene, M. Mosgaard, K. Lbmann, H. Mu, F. Larsen, T. Rades and A. Mllertz

12

Drug delivery in UTI treatment new perspectives by mimicking uropathogenic


Escherichia coli cytoinvasion
C. M. Pichl, C. Apfelthaler, B. Dunkl, B. Brauner, F. Gabor, M. Wirth and L. Neutsch

13

Drug-Loaded Silica for Oral Formulations


D. Lubda, R. Ognibene, G. Birk, M. Wagner, S. Kucera, F. Bauer and M. Zheng

14

Dry Coating for Taste-Masking of Bitter Drugs with Hydroxypropyl Cellulose Powders
H. Ichikawa, T. Andoh, Y. Fukumori, B. Ehlig, S. Kodama, S. Tsue and K. Sugisawa

15

Embedding of a poorly water-soluble drug in silica particle systems for the application
in orodispersible films
J. H. Finke, S. Melzig and A. Kwade

16

FUSED DEPOSITION MODELING (FDM) FOR 3D PRINTING OF DRUG DELIVERY CAPSULES


A. Melocchi, F. Parietti, G. Loreti, A. Maroni, L. Zema and A. Gazzaniga

17

Generation and characterization of small single domain antibodies inhibiting human


TNF receptor 1.
S. Steeland, L. Puimge, R. Vandenbroucke, F. Van Hauwermeiren, J. Haustraete, N. Devoogdt,
D. Laukens, P. Meuleman, M. Devos and C. Libert

18

How to Easily Provide Zero Order Release of Freely Soluble Drugs from Coated Pellets
B. Dekyndt, J. Verin, C. Neut, F. Siepmann and J. Siepmann

19

Improving the delivery of vaginal dosage forms


H. STRAUB and D. CADE

20

In situ Gel Formulation for Intravesical Gemcitabine Hydrochloride Installation


S. Y. Karavana, Z. Ay S enyigit, . aliskan and E. Baloglu

21

In situ liposomes from novel pre-liposome tablets for vaginal drug delivery
Z. Vanic, N. Skalko-Basnet and I. Tho

22

Influence of size and protein concentration on the cross-linking degree of serum


albumin microcapsules
F. Deshayes, E. Charpentier, E. Bourguet and F. Edwards-Lvy

23

Influence of the Ester Group Structure of Modified Alginates on the Preparation of


Microparticles by Transacylation with Serum Albumin
I. HADEF, M. OMRI, C. BLIARD, B. ROGE and F. EDWARDS-LEVY

24

Interaction studies of Memantine loaded biodegradable polymeric nanoparticles


M. A. Egea, E. Snchez, M. Espina, N. Carmona, G. Ramos, A. C. Calpena and M. L. Garca

25

Lipid self-assembled structures as carriers for antimicrobial peptides


L. Boge, H. Bysell, L. Ringstad and M. Andersson

10

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

26

Lyophilized microemulsions: the influence of heating on the droplet size and


phase transition
A. Rochelle do Vale Morais

27

Microcontainers improve oral bioavailability of furosemide


L. Hagner Nielsen, A. Melero, S. Sylvest Keller, A. Mllertz and A. Boisen

28

Mucoadhesion of thiolated poly(aspartic acid) polymers for ophthalmic use


G. Horvt, B. Gyarmati, B. Szilgyi, T. Csihi, G. Sandri, M. C. Bonferoni, C. Caramella, A. Szilgyi,
E. Csnyi and M. Budai-Szucs

29

Nanotubes-in-Microgel Oral System (NiMOS) by prilling for Protein Delivery


J. K. de Kruif, G. Ledergerber, C. Garofalo and M. Kuentz

30

New Two Piece Enteric Drug Delivery Capsules: Human gamma-scintigraphy and
pharmacokinetic evaluation
A. Sivert, P. Dfossez, M. Clauzel, D. Nombret, D. Cad and H. Benameur

31

Phosphorous dendrimers siRNA complexes for treatment of chronic inflammation


A. Bohr, N. Tsapis, A. Chamarat, J.-P. Majoral, C. Foged and E. Fattal

32

PLATELET LYSATE EMBEDDED SCAFFOLD FOR WOUND HEALING: IN VITRO AND


PRELIMINARY IN VIVO CHARACTERIZATION
G. Sandri, F. Saporito, M. C. Bonferoni, S. Rossi, F. Ferrari, M. Mori, I. Liakos, C. Boselli,
A. Invernizzi and C. Caramella

33

PREPARATION OF MODIFIED RELEASE DRUG LOADED HPMC-AS MATRIX


MICROPARTICLES SUITABLE FOR PRECLINICAL DELIVERY
S. Sood, C. Freire and M. Saunders

34

Redox-responsive mesoporous silica as carriers for controlled drug delivery


Y. Wang, Q. Zhao, Y. Gao, B. Hou, J. Zhang and S. Wang

35

Serum Albumin-Alginate Microparticles Prepared by Transacylation:


Effect of Polymer Interfacial Interactions
I. HADEF, B. ROGE and F. EDWARDS-LEVY

36

Serum Albumin-Alginate Microparticles Prepared by Transacylation: Physicochemical


and Structural Properties
I. HADEF, B. ROGE and F. EDWARDS-LEVY

37

Smart ruthenium nanodrugs for tumor targeted delivery: a new approach to fight cancer
A. Valente, M. H. Garcia, F. Marques, A. Matos and P. Zinck

38

SmartCrystals - stability in dermal hydrogels and creams


X. Li, X. Zhai, R. H. Mller and C. M. Keck

39

SOLVENT FREE APPROACH FOR ENHANCEMENT OF DRUG SOLUBILITY USING


MESOPOROUS SILICA
F. Monsuur, Y. Choudhari and W. McCarthy

40

Synthesis and Characterization of Poly(-Caprolactone)- vitamin E TPGS Copolymers


for Potential Applications in Drug Delivery
Z. Binkhathlan

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

11

41

Targeted Poly-(L)-glutamic acid drug delivery systems for intravesical therapy of


non-muscle invasive bladder cancer
C. Apfelthaler, C. M. Pichl, P. Gassenbauer, F. Gabor and M. Wirth

42

The drug-initiated method: a convenient approach for the synthesis of efficient


polymer prodrug nanoparticles
D. T. Bui, S. Harrisson, A. Maksimenko, P. Couvreur and J. Nicolas

Controlled Drug Delivery


43

A Mechanistic Model for Drug Release Using Spherical Particles Made of PLGA
K. SEVIM and J. PAN

44

CHARACTERIZATION OF SUPRAMOLECULAR SYSTEMS CONTAINING FENBUFEN,


PLURONIC AND CYCLODEXTRINS
A. Figueiras, S. Nunes, S. Simes, A. Pais and F. Veiga

45

Controlled release from drug/Eudragits delivery systems


Y. Ji, M. Lemberg, A. Prudic and R. Paus

46

Controlled Release Implants prepared by compression of spray-dried PLGA/water-soluble


polymer microparticles
M. Hamoudi, R. Pattacholi, C. Debraize and J. Siepmann

47

Controlled release of quercetin encapsulated in biopolymer films modulated by


electron beam irradiation
N. Benbettaieb, T. Karbowiak, A. Assifaoui, F. Debeaufort and O. Chambin

48

Core shell coated chitosan microspheres at low pH durability for controlled drug release
M. nal

49

Development of novel formulations for organoboron drugs by association


to anionic clays
S. Sn, S. Bgu, C. Gervais and D. Laurencin

50

Drug release from PEO-hot melt extrudates: impact of the drug loading
O. Cantin, F. Siepmann, F. Dande, Y. Karrout and J. Siepmann

51

Factors Shaping the Release Profile from Film Coated Pellets Controlling Drug Release
Through Cracks
S. Muschert, F. Siepmann, Y. Rosiaux, A. Axelsson and J. Siepmann

52

Hot Melt Extrusion can Provide More Robust Drug Release from PEO Matrices than
Direct Compression
O. Cantin, F. Siepmann, Y. Karrout and J. Siepmann

53

Importance of Diffusion and Limited Drug Solubility in Silicone Matrices for


Cochlear Implants
M. Gehrke, J. Sircoglou, C. Vincent, J. Siepmann and F. Siepmann

54

In vitro accelerated drug release from parenteral levonorgestrel butanoate suspensions


K. Tietz, D. Friend and S. Klein

12

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

55

Influence of controlling agent and fillers on acetylsalicylic acid release kinetics


from matrix tablets
J. Conceio, S. Fernandes, P. Costa and J. M. Sousa Lobo

56

INFLUENCE OF POLYMERIC COMPOSITION IN BENZNIDAZOLE RELEASE FROM MODULAR


ASSEMBLED FLOATING DELIVERY SYSTEM
A. C. Melo-Miranda, M. A. Segatto-Silva, P. Colombo and A. Rossi

57

Novel polymeric carriers for the sustained release of an antipsychotic drug


D. Bikiaris, P. Siafaka, M. Lazaridou, C. Koulouktsi, G. Papageorgiou, E. Koutris and E. Karavas

58

Release Study and Anti-inflammatory Activity of Pentacyclic Triterpenes


H. L. Alvarado Bonilla, G. Abrego Escobar, A. Parra Coca, L. E. Sosa Diaz, M. L. Garduo Ramirez,
B. Clares Naveros, A. C. Calpena Campmany and M. L. Garcia Lopez

59

Slow-release drug-loaded mini-tablets for ocular use: effect of polymer particle size
on formulation behaviour
A. S. Mohmad Sabere, S. Barker and D. Craig

60

Sustained Release Formulations for a New Broad-Spectrum Antibacterial Agent


against Colitis
M. S. Nieto Bobadilla, F. Siepmann, M. Djouina, L. Dubuquoy, J. Siepmann, L. Dubreuil
and C. Neut

61

Synthesis and characterization of S-nitrosoglutathione-alginate as an NO donor


S. U. SHAH, M. SOCHA and S. GIBAUD

62

Why increasing drug loadings might lead to faster drug release from Kollicoat SR
coated pellets
J. Fahier, C. Velghe, S. Muschert, G. Byrne, F. Siepmann and J. Siepmann

63

Why sugar cores might lead to slower drug release from coated pellets compared
to MCC cores
J. Fahier, C. Velghe, S. Muschert, G. Byrne, F. Siepmann and J. Siepmann

Oral Delivery
64

An investigation of interaction between ibuprofen and modified diatomite:


potential drug carrier
J. Janicijevi

c,
D. Krajinik, B. ?alija, V. Dobrici c and J. Mili c

65

Development of a Bioequivalent Montelukast 5mg Zydis Dosage Form


A. Cusack and L. Grother

66

Development of a coated ODT nutraceutical formulation


J. CAMARGO, G. WEISS, G. LE BIHAN and P. LEFEVRE

67

Effect of curcumin encapsulation in whey protein-pectin beads upon their properties


with intestinal medium
B. Fernandez, T. A. Nguyen, Y. Wach, M. Subirade, I. Fliss and O. Chambin

68

Effect of digestion on absorption of halofantrine from SNEDDS and super-SNEDDS


in a rat model
M. H. Michaelsen, K. Wasan, T. Rades and A. Mllertz

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

13

69

Encapsulation of anthocyanins from purple corn cob by spray drying and release studies
of encapsulated powder
N. Kapcum, J. Uriyapongson, M. Meenune, G. Roudaut and O. Chambin

70

Evaluating different manufacturing options to formulate loperamide HCl as orally


disintegrating tablet
T. Agnese and T. Cech

71

Evaluating poly(vinyl acetate) as taste masking agent for paracetamol formulated in


chewable tablets
F. Bang, T. Cech and M. Mistry

72

Evaluating various disintegrants regarding their performance in orally disintegrating


tablet formulations
T. Agnese, F. Bang, T. Cech and M. Mistry

73

Evaluating various wet binders to gain lactose based agglomerates applicable for orally
disintegrating tablet formulations
T. Agnese, T. Cech and M. Mistry

74

Examination of the behaviour of hydroxypropyl cellulose free films with lidocaine base
for oral use with thermal analysis method
G. Regdon, jr., M. Gottnek and K. Pintye-Hdi

75

Experimental design of self-nanoemulsifying drug delivery systems containing


monoacyl phosphatidylcholine
T. T. Tran, T. Rades and A. Mllertz

76

HOT MELT EXTRUSION TECHNOLOGY (HME): DISSOLUTION RATE ENHANCEMENT OF


RITONAVIR IN GASTRIC pH WITH EUDRAGIT EPO
D. Jaiswar, P. Amin, M. Seervi, D. Sarvaiya, H. Kundaikar and A. Gangurde

77

Hydroxypropyl methyl cellulose based Efavirenz Solid Dispersions by Hot Melt Extrusion
and Spray drying Technique: Physical Characterization and Insilico study
S. Javeer, H. Kundaikar, A. Gangurde, J. Pawar, M. Degani and P. Amin

78

Ibuprofen self-emulsifying pellets prepared with colloidal silicon dioxide/microcrystalline


cellulose and triglycerides
A. PANAGOPOULOU, K. MAVRIDOU, T. AVGERINOS and I. NIKOLAKAKIS

79

Influence of Artificial Saliva on Taste Masking Studies


M. Khaydukova, L. I. Immohr, D. Kirsanov, A. Legin and M. Pein

80

Influence of pore former and sintering temperature on the mechanical properties of


hydroxyapatite tablets
K. Kachrimanis, N. Kantiranis, C. Grammenos and I. Nikolakakis

81

Low density floating matrix tablets prepared by hot melt extrusion


W. Kriangkrai, S. Puttipipatkhachorn, P. Sriamornsak, F. Siepmann, J. Siepmann and
S. Sungthongjeen

82

MESOPOROUS SILICA GEL AS FORMULATION AID FOR MOISTURE SENSITIVE


DRUG/EXCIPIENT
F. Monsuur, Y. Choudhari and W. McCarthy

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83

Milk protein-pectin beads a novel means for curcumin encapsulation


T. A. Nguyen, T. U. Huynh, P. Winckler, Y. Wach, M. Subirade and O. Chambin

84

Mucoadhesive films for treatment of oral infections containing vermiculite/chlorhexidine


nanocomposites
J. Gajdziok, H. Landov, P. Doleel and D. Vetch

85

New Enteric Coating Method with AQOAT (HPMCAS)


V. Henner, A. Sauer and S. Kikuchi

86

Novel fenofibrate-gelatin microcapsules with improved solubility and excellent flow


property: preparation, physicochemical characterization and pharmacokinetic evaluation
A. Yousaf, D. W. Kim, T. Ramasamy, O. Mustapha, F. Din, J. O. Kim, C. S. Yong and H.-G. Choi

87

Overcome the Color Stability Issue Exhibited by Indigo Carmine: AquariusTM Preferred
HSP Film Coating System
T. Tuglu, N. Ekmekciyan, E. Stoyanov and S. Porter

88

Overcoming Disintegration Challenges in an Oral Biologic Tablet Formulation


A. Balasundaram, J. Sutch and K. Van den Dries

89

Preparation of Fast Dissolving Drug-Loaded Sucrose Fibers using a Cotton-Candy


Floss Machine
S. Marano, D. Craig, S. Barker, B. T. Raimi-Abraham, S. Missaghi and A. Rajabi-Siahboomi

90

Preparation of lysozyme enzyme containing orally disintegrating tablets


I. Olh, J. Lasher, G. Baki, A. Kenneth, T. Sovny, K. Pintye-Hdi and G. Regdon Jr

91

Process integration for the improved production of nanoparticle-loaded


orodispersible films
D. Steiner, J. H. Finke and A. Kwade

92

Protein distribution in solid lipid microparticles visualized using coherent


anti-Stokes Raman scattering
P. C. Christophersen, D. Birch, J. Saarinen, A. Isomki, H. M. Nielsen, M. Yang, C. J. Strachan
and H. Mu

93

Quality by Design (QbD) approach to optimize the disintegration time of enteric


coated capsules
T. Dassinger, N. Hauschildt and T. Kuntz

94

QUATERNARY POLYMETHACRYLATE - ALGINATE COATED TABLETS: EFFECT OF ALGINATE


BLOCK STRUCTURE ANG CURING ON DRUG RELEASE
T. Pongjanyakul, R. Khlibsuwan and N. Khuathan

95

Simple Process Changes to Overcome Reduced Dissolution of Agglomerating


Micronized API
J. Sutch, A. Balasundaram and K. van den Dries

96

SPRAY-DRIED CHITOSAN-MAGNESIUM ALUMINUM SILICATE COMPOSITE TABLETS:


EFFECT OF CHITOSAN MOLECULAR WEIGHT
R. Khlibsuwan and T. Pongjanyakul

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97

STUDIES ON DISSOLUTION RATE ENHANCEMENT, PHYSICOCHEMICAL


CHARACTERIZATION, AND IN-SILICO MOLECULAR MODELLING OF ARTEMETHER
USING HYDROPHILIC CARRIERS.
J. PAWAR, R. SHETE, H. KUNDAIKAR, S. JAVEER, A. GANGURDE, M. DEGANI and P. AMIN

98

Study of the relationships among mechanical and texture properties of mucoadhesive


oral films using multivariate data analysis
D. Vetch, J. Gajdziok, P. Doleel and H. Landov

99

The influence of polysaccharide carrier on solid SMEDDS characteristics and on


dissolution profile of naproxen

M. Gaperlin, K. Cerpnjak,
F. Vrecer
and A. Zvonar

100 The role of different salts in drug release from -carrageenan matrices
S. De Robertis, L. Elviri and R. Bettini
101 Type III lipid-based formulations design for oral delivery of acyclovir
J. Jankovic, L. Djekic and M. Primorac
102 Type III lipid-based formulations for oral delivery of high-dosage drugs: design and
in vitro evaluation
L. Djekic, J. Jankovic and M. Primorac
103 Understanding the formation of co-amorphous drug-amino acid formulations
K. Tarp Jensen, K. Lbmann, H. Grohganz and T. Rades
104 D/A Model to Evaluate Absorption Effects from a Transient Supersaturated State
R. Berthelsen, A. L. Slot and A. Mllertz

Pulmonary Delivery
105 A framework for a Biopharmaceutical Classification of Antibiotics for Pulmonary Delivery
S. M. Marchand, J. Brillault, N. Grgoire, I. Lamarche, P. Gobin and W. Couet
106 Aerodynamic and structural evaluation of microcomposites containing
meloxicam potassium
R. Ambrus, A. Chvatal, A. Pomzi and P. Szab-Rvsz
107 Ciprofloxacin-loaded mineral calcium-hyaluronan composite microparticles to treat
chronic bacterial lung infection
F. Tewes, J. Brillault, B. Lamy, P. OConnell, J.-C. Olivier, W. Couet and A. M. Healy
108 Compared toxicity of lung delivered nanoparticles, biodegradable or not: in vitro
and in vivo studies
H. Hillaireau, N. Grabowski, L. A. Santiago and E. Fattal
109 Construction of amikacin dry powders for inhalation by a Central Composite Design
S. Belotti, A. Rossi, P. Colombo, R. Bettini, D. Rekkas, S. Politis, G. Colombo, A. G. Balducci
and F. Buttini
110 CYCLODEXTRINS INHALATION PREVENTS ALLERGEN-INDUCED INFLAMMATION AND
AIRWAY HYPERRESPONSIVENESS ASSOCIATED WITH ASTHMA
G. Dufour, N. Rocks, S. Ormenese, C. Leonard, M.-P. Mingeot-Leclercq, D. Cataldo and B. Evrard

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111 Development of dry powder carrier systems for pulmonary application


R. Ambrus, B. Szab and P. Szab-Rvsz
112 Development of Theophylline Effervescent Powder for Pulmonary Drug Delivery
J. Napaporn, T. Seetawun, P. Tarnsuwan and W. Junkheiw
113 Effect of polymeric nanoparticles on the stability of biomimetic models of the
lungs surfactant
W. Daear, P. Lai, M. Anikovskiy and E. J. Prenner
114 FORMULATION AND CHARACTERIZATION OF ANTIBIOTIC AND MUCOLYTIC CONTAINING
DRY POWDER INHALER FORMULATIONS
Y. Akdag Cayli, S. Sahin, I. Vural and L. Oner
115 Formulation of levofloxacin-loaded chitosan microspheres for pulmonary delivery
M. Da Costa Gaspar, A. Pais, J. Sousa, F. Tewes and J.-C. Olivier
116 Inhaled SLM for anti-TB therapy by DPI device: process parameters affecting
freeze-drying and breathability
E. Maretti, E. Porcheddu, E. Imbuluzqueta, A. G. Balducci, F. Buttini, F. Sacchetti, M. Romagnoli,
E. Leo and V. Iannuccelli
117 Lecithin/TPGS-based spray-dried SMEDDS for lung cancer: in vitro pulmonary deposition
and cytotoxicity
R. Ishak and R. Osman
118 Microencapsulated rifabutin-loaded lipid nanoparticles for inhaled therapy
D. Gaspar, P. Taboada, A. Almeida and C. Remun-Lpez
119 Nanomicelle-based dry powders for inhalation for targeted delivery to lung cancer cells:
in vitro evaluation and in vivo local pulmonary tolerance on healthy mice
R. Rosire, M. Van Woensel, I. Langer, V. Mathieu, K. Amighi and N. Wauthoz
120 Nebulization characteristics of surface modified liposomes optimized for pulmonary
drug delivery
B. Lehofer, P. P. Jain, F. Bloder, R. Leber, L. M. Marsh, H. Olschewski, A. Olschewski and R. Prassl
121 Polyaspartamide based microparticles for Tobramycin delivery to the lung in FC therapy
C. Sardo, M. Licciardi, E. G. Di Domenico, D. De Rocco, P. Del Porto, F. Ascenzioni, G. Giammona
and G. Cavallaro
122 Polymeric micelles based on a polyaspartamide copolymer for pulmonary delivery of
beclomethasone dipropionate
D. Triolo, C. Sardo, E. F. Craparo, G. Giammona and G. Cavallaro
123 Rifabutin-loaded solid lipid nanoparticles for pulmonary delivery
D. Gaspar, V. Faria, L. Gonalves, C. Remun-Lpez and A. Almeida

Dermal preparations
124 Application of factorial design methodology in transdermal absorption: optimization of
skin absorption from cosmetic/pharmaceutical formulations
F. Laredj and M. Salmon

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125 Azithromycin smartCrystals for prevention of infections by tick bites


N. Jin, S. Staufenbiel, C. M. Keck and R. H. Mller
126 Characterization and Ex-Vivo Permeation Studies of Melatonin-Incorporated
Elastic Niosomes
G. Arslan Azizoglu,
S. Tuncay Tanriverdi and . zer
127 Confocal Raman Microscopic (CRM) methodology for the analysis of the penetration of
pharmaceutical actives into the skin
D. Lunter
128 Development of sulphur-salicylic gel systems as new bioactive formulations for the
topical treatment of acne vulgaris
R. Langasco, G. Spada, S. T. Tanriverdi, O. Ozer, P. Giunchedi and E. Gavini
129 Development, Characterization and Skin Delivery Studies of Related Ultradeformable
Vesicles: Transfersomes, Ethosomes and Transethosomes
A. Ascenco, S. Raposo, C. Baptista, P. Cardoso, T. Mendes, F. Praa, M. Bentley and S. Simes
130 Employing Pickering emulsions as carrier system for retinol palmitate and
-tocopherol acetate
J. Schfer, T. Agnese, T. Cech and T. Schmeller
131 Enhanced Delivery of Actives to Skin with Silicone Technologies
M. EEMAN, H. ALIYAR, M. LE MEUR and X. THOMAS
132 Glycolic acid in alkyl polyglucosed based vehicle
M. Lukic, T. Isailovic, I. Pantelic, R. Daniels and S. Savic
133 Improved Treatment of Atopic Dermatitis with Corticosteroid Loaded Liposomes
I. Eroglu,
E. Azizoglu, M. zyazici, M. Nenni, H. Grer Orhan, S. zbal, I. Tekmen, I. Ertam,
I. nal and . zer
134 In-vitro study of imiquimod skin retention
S. Nicoli, I. Tel, C. Padula and P. Santi
135 Investigating the impact of phosphate buffer on the gel
F. Bang, T. Cech and F. Soergel
136 Investigation of physico-chemical characteristics of W/O liquid emulsion with high
hydrating effect
B. Vucelic, J. Bjeletic, N. Dragicevic-Curic and M. Bajcic
137 Microencapsulated haiir dyes: safety and efficacy
M. Centini, E. Hanno, F. Francescon and C. Anselmi
138 Nanoemulsion with clotrimazole - design and optimalization the mean droplet size
using high pressure homogenizer
K. Sosnowska, E. Szymanska

and K. Winnicka
139 Nanosuspensions improve diclofenac dermal delivery
R. Pireddu, F. Lai, C. Sinico, F. Marongiu, G. Ennas and A. M. Fadda

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140 PLATELET LYSATE AND MANUKA HONEY COMPONENTS LOADED IN PECTIN PARTICLES
FOR THE TREATMENT OF CHRONIC SKIN ULCERS
M. Tenci, S. Rossi, F. Ferrari, M. Daglia, A. Di Lorenzo, M. C. Bonferoni, G. Sandri, M. Mori,
C. Boselli and C. Caramella
141 Pluronic F127 micellar carriers for topical acne treatment
S. Gngr
142 Preparation and characterization of topical hydrogel containing nanonized
papaverine hydrochloride
S. Berk, R. Ambrus, G. Dek, P. Szab-Rvsz, L. Pajor and E. Csnyi
143 PREPARATION AND EVALUATION OF COLLAGEN-LAMININ DERMAL MATRIX
IMPREGNATED WTH RESVERATROL MICROPARTICLES
E. H. GOKCE, I. EROGLU, N. TSAPIS, S. TUNCAY-TANRIVERDI, G. GOKCE, E. FATTAL and O. OZER
144 Preparation, characterization and long-term stability evaluation of O/W cream
containing coenzyme Q10-loaded nanoemulsion in galenical laboratory conditions
N. Dragicevic-Curic, J. Bjeletic, B. Vucelic and M. Bajcic
145 Quercetin smartCrystals: production, antioxidant activity, and physical stability
in nonionic gels
T. Hatahet, M. Morille, A. Hommoss, R. Muller and S. Bgu
146 Release profile and antioxidant activity evaluation of a topical gel enriched with
bioactive extract from grape pomace
M. Allegro, J. Marto, C. Montoya, N. Oliveira, S. Gonalves, A. Paiva, S. Barreiros, P. Simes,
L. Gonalves and H. Ribeiro
147 Silicone Pressure Sensitive Adhesive as a topical cream
M. Le Meur, L. Marteaux, F. Galeone, X. Thomas, H. Aliyar, L. Maes and M. Eeman
148 SKIN ADAPTED AGAR DIFFUSION ANTIBIOGRAM AS IN-VITRO PHARMACODYNAMIC
EQUIVALENCE MODEL
M. Sacha, A. Fargier and E. Haltner
149 smartPearls/SYLOID 3D - superior generation of dermal delivery systems based on
amorphous actives/drugs
R. H. Mller, F. Monsuur, H. H. Hfer and C. M. Keck
150 Starch nanocapsules as potential carriers for topical delivery of hydrophobic drugs
J. Marto, L. Gouveia, L. Gonalves, E. Oliveira, H. Ribeiro and A. Almeida
151 Starch-based Pickering emulsions containing a hydrophilic drug for topical application:
a quality by design approach
J. Marto, L. Gouveia, I. Jorge, L. Gonalves, E. Oliveira, A. Almeida and H. Ribeiro
152 STUDY OF HUMAN SKIN BIOMECHANICAL PROPERTIES AFTER TOPICAL APPLICATION
OF AN ANTIFUNGAL NANOSTRUCTURED EMULSION
C. Caadas, J. Suer, M. Mallandrich, L. Halbaut, A. M. del Pozo and A. C. Calpena
153 Sucrose esters and polysorbate 80 as co-emulsifiers in development of nanoemulsions
for improved aceclofenac skin delivery
T. Isailovic,
S. Dordevic,
M. Lukic,
I. Pantelic,
D. Randelovic,
B. Markovic and S. Savic

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154 The effect of PAMAM-NH2 G2 and G3 on physicochemical properties of hydrogels


with erythromycin
K. Winnicka, M. Wroblewska and K. Sosnowska

Physical Pharmacy
155 Amorphous Recrystallisation to the Hydrated State: Correlation between Predictive
Thermodynamic Approaches and Real-Time Stability Studies
M. d. F. Pina, J. Pinto, J. Sousa, D. Craig and M. Zhao
156 Cerebroprotection of S-nitrosoglutathione-loaded in situ forming microparticles against
thromboembolic stroke
M. Parent, F. Dupuis, J. Perrin, C. Vigneron, N. Violle, J.-F. Bisson, I. Lartaud and A. Boudier
157 Processing induced lactose polymorphism
A. Della Bella, M. Muller, L. Soldati and R. Bettini
158 Sustained-release formulations of monoclonal antibody for subcutaneous delivery:
pK study in rats
S. Marquette, A. Yates, L. Denis, I. Langer, K. Amighi and J. Goole
159 The use of a low glass transition temperature polymer allows in situ formation of
solid dispersions
M. Doreth, K. Lbmann, H. Grohganz, R. Holm, H. Lopez de Diego, A. Mllertz, T. Rades
and P. Priemel
160 Tobramycin solid-state investigation
D. Frascio, E. Salomi, F. Martinelli, M. Di Cuia, A. G. Balducci, P. Colombo, F. Buttini and R. Bettini
161 Towards the fabrication of electrospun fibers for controlled drug release: controlling
the release kinetics by overcoming drug crystal formation
S. Seif and M. Windbergs

Preformulation
162 Influence of excipients on solvent-mediated hydrate formation of piroxicam studied
by dynamic imaging
W. Kirchmeyer, N. Wyttenbach, J. Alsenz and M. Kuentz
163 Adjusting the particle sizes of solid lipid microparticle dispersions for various drug
delivery applications
A. Lauterbach and C. C. Mller-Goymann
164 Assessment of drug-stabilizer interactions by contact angle and surface plasmon
resonance measurements
T. Viitala, S. Langeraert, A. Kartal.Hodzic, C. Vervaet, J. Hirvonen and L. Peltonen
165 Benefits of hypromellose capsules Vs. hard gelatin capsules to improve stability
hydroxy-acids based formulation: ascorbic acid case study
F. Maron
166 DEVELOPMENT AND CHARACTERIZATION OF A NEW RECTAL FORM
J. BOUYSSOU, L. GRISLAIN, P. GUEROULT, D. LARROUTURE, G. LEMAGNEN and E. VIOLET

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167 Dissolution behavior of crystalline and quench cooled carbamazepine in biorelevant


gastric and intestinal media
L. Jensen, P. Priemel, F. Skautrup, A. Mllertz and T. Rades
168 DSC studies on water effusion as a complementary tool for drug release investigations
B. Bellich, M. Borgogna and A. Cesro
169 Effect of polymers on the stability of anhydrous olanzapine during processing
M. Paisana, M. A. Wahl and J. F. Pinto
170 Alkylamine Template Based Hexagonal Mesoporous Silica (HMS) For Dissolution
Enhancement Of fenofibrate
N. Jadhav and P. Vavia
171 Is thermodynamic solubility of tadalafil in Kollidon VA 64 the key parameter affecting
physical stability of the amorphous solid dispersion?
K. Wlodarski, W. Sawicki, L. Tajber and M. Paluch
172 Moisture sorption of granulated pyridostigmine bromide
T. Avgerinos, K. Kachrimanis, A. Avgerinos and I. Nikolakakis
173 Molecular water interaction in lipid-based formulations regarding capsule compatibility
A. Machado, T. Kokubo, R. Bravo, B. Jones, C. Scialdone, G. Dujovny and M. Kuentz
174 Pharmacokinetics evaluation of tramadol in thermoreversibles gels
G. Tofoli, J. Pedrazzoli Junior, S. A. Calafatti, D. R. de Araujo and J. Z. B. Papini
175 Production and Stabilization of Olanzapine Nanoparticles with Rapid Expansion
of Supercritical Solutions (RESS)
M. Paisana, K. Mllers, J. F. Pinto and M. A. Wahl
176 Supersaturation of zafirlukast in fasted and fed intestinal media with and without
precipitation inhibitors
C. M. Madsen, A. Mllertz and T. Rades
177 SURFACE ACTIVITY OF NOVEL SURFACE ACTIVE COMPOUNDS, PRODUCTS OF CATALYTIC
OXYETHYLATION OF CHOLIC ACID AND THEIR MICELLAR ADDUCTS WITH SELECTED
LIPOPHILIC THERAPEUTIC AGENTS
M. Kolodziejczyk, M. Nachajski, M. Lukosek and M. Zgoda
178 TABLETS WITH THE CONTENT OF CORNELIAN CHERRY (CORNUS MAS L.) PREPARED
BY DIRECT COMPRESSION
A. Franc, S. Krahujec, P. Doleel, D. Sabadkov and J. Muselk

Protein Formulation & Aggregation


179 In vivo evaluation of rh-insulin loaded microemulsion as oral delivery system
G. Erel, M. Kotmaki, S. Szer Karadagli
and A. G. Kantarci
180 Novel in vitro instrument for estimating formulation performance of subcutaneously
administered therapeutics
H. Kinnunen, K. Box and R. Mrsny
181 The Use of SAXS for Screening the Dissolution Behavior of Lyophilized Protein
V. Wahl, E.-M. Saurugger, J. Khinast and P. Laggner
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Gene Delivery
182 Cationic Polyaspartamide as siRNA delivery systems for down regulation of a
proinflammatory cytokine
S. Di Gioia, C. Sardo, D. Triolo, G. Belgiovine, S. Castellani, M. Conese, G. Giammona and
G. Cavallaro
183 Development of non-toxic, cationic lipid coated, magnetic nanoparticles (MNPs) for gene
delivery with a novel method
H. Akbaba, U. Karagz, Y. Selamet and A. G. Kantarci
184 IN VIVO ELECTROPORATION: A VERSATILE AND MULTITASK TECHNOLOGY TO
FIGHT CANCER
E. Marra
185 Lipid Nanoparticles Formulated with HM-Chitosan for siRNA Delivery
O. Tezgel, A. Szarpak-Jankowska, R. Auzly-Velty, F. Navarro and I. Texier-Nogues
186 Mucoadhesive hydroxyethyl-cellulose sponges as lipoplexes delivery system for
vaginal application
T. Furst, A. Lechanteur, B. Evrard and G. Piel
187 Polyplex based on polycarbonate polymers for an efficient delivery of HDAC5
and HDAC7 siRNA
A. Frre, S. Tempelaar, B. Evrard, O. Peulen, L. Mespouille, D. Mottet and G. Piel

Miscellaneous
188 Development of hydrogel-formulations containing local anesthetics in poly
(-caprolactone) nanocapsules for topical oral application.
M. Franz-Montan, C. B. da Silva, S. d. C. Santos, B. V. Muniz, C. M. G. da Silva, E. de Paul,
M. C. Volpato, F. C. Groppo and L. F. Fraceto
189 Influence of Papp values on prediction of plasma levels by in silico modeling of
inhalation products
S. Salar-Behzadi, C. Meindl, S. Stranzinger, N. Dzidic, S. Mohr, S. Wu, A. Mercuri and E. Frhlich
190 Jet coating for the development of drug eluting stents
N. Scoutaris, F. Chai, B. Maurel, J. Sobocinski, M. Zhao, J. Moffat, D. Craig, N. Blanchemain
and D. Douroumis
191 Clinical analysis of Paclitaxel Eluting Stent compared with Simvastatin Eluting Stent,
coated by means of inkjet printing technology
N. Scoutaris, F. Chai, B. Maurel, J. Sobocinski, M. Zhao, J. Moffat, D. Craig, N. Blanchemain
and D. Douroumis
192 ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF CURCUMIN BY EUDRAGIT
EPO-BASED SOLID DISPERSIONS PREPARED BY HOT MELT EXTRUSION AND SPRAY
DRYING TECHNOLOGY
A. Gangurde, S. Javeer, J. Pawae, D. Jaiswar and P. Amin
193 Formulation of magnetic siRNA nanovectors (MSN) as a promising theranostic tool
for (breast) cancer
S. David, H. Marchais, D. Bedin and I. Chourpa

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1st European Conference on Pharmaceutics Drug Delivery


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Tuesday, 14 April 2015


Posters
Exhibited continuously from 9:00 to 17:00, with special sessions from 12:30 to 15:00.
The number indicates the number displayed on the poster panel.

Bioavailability & Absorption Enhancement


1

Biphasic dissolution studies: Impact of concentration and particle size on partition rate
J. Comer, K. Box and R. Taylor

Co-Crystals and Their Advantages for Life Cycle Management of APIs with
Difficult Properties
M. Viertelhaus, A. Hafner, T. Chiodo, T. Hintermann and M. Vossen

Effect of organic solvents on the recrystallization behavior of amorphous solid


dispersions prepared by spray drying
C. Marschall, R. Maurer and S. Page

Lipid Based Capsule Products to Increase Bioavailability and Reduce Food Effect for
a Poorly Soluble Compound
A. IGONIN, J. MENSCH, S. INGHELBRECHT, J. CEULEMANS, H. VERMEERSCH, H. BENAMEUR
and J. VERTOMMEN

Optimization of a PGSS manufacturing process of lipid-based solid dispersion containing


fenofibrate
A. Pestieau, F. Krier, P. Lebrun and B. Evrard

Pharmacokinetics of pro-pheroid formulated amodiaquine


A. Grobler, L. Gibhard, C. Masimirembwa and R. Thelingwani

Preparation and Characterization of Nano Suspension of Poorly Soluble Drugs using


Hydroxypropyl Cellulose (HPC)
S. Kodama, K. Sugisawa, B. Ehlig, R. Fukuda, T. Andoh and H. Ichikawa

Production of amorphous nano-solid dispersions using a solvent controlled


precipitation process
. Duarte, R. Pereira, J. Vicente, J. F. Pinto and M. Temtem

Scale-up Transition from Spray Drying to HME with AFFINISOL HPMC HME
W. Porter III, O. Kevin, S. Wes and S. Uma

10

Study of the synergic effect of naringenin and quercetin in their permeability and
metabolic fate
N. Orrego-Lagarn, M. Martnez-Huelamo, M. R. Lamuela-Ravents and E. Escribano

11

Supersaturation, phase separation and the measurement of drug precipitation rates


J. Comer, K. Box and R. Taylor

12

Transbuccal delivery of semi-solid formulations containing doxepin: ex vivo and in


vivo evaluation
R. Sanz, B. Clares, M. Mallandrich and A. C. Calpena

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23

Buccal & Nasal Delivery


13

Chitosan particulate delivery system for intranasal influenza DNA vaccine


C. Sawaengsak, Y. Mori, K. Yamanishi, W. Chaicumpa and N. Sinchaipanid

14

Composite hydroxylpropylmethylcellulose based films and wafers for buccal


drug delivery
O. Okeke and J. Boateng

15

CORRELATION BETWEEN DISSOLUTION AND BUCCAL PERMEATION OF KETOPROFEN


ORODISPERSIBLE FILMS
M. Sacha, A. Fargier, R. Krampe, D. Sieber, P. Kleinbudde, J. Breitkreutz and E. Haltner

16

Fillet: A New Dosage Form Combining Orodispersible Films and Orodispersible Tablets
- Influence of Different Films and Tablets R. Krampe, D. Sieber, C. Stolze, V. Lenhart, M. Preis and J. Breitkreutz

17

Fillet: A New Dosage Form Combining Orodispersible Films and Orodispersible Tablets
- Preparation concepts D. Sieber, R. Krampe, C. Stolze, V. Lenhart, M. Preis and J. Breitkreutz

18

In vitro permeability study of betahistine dihydrochloride delivered by bioadhesive


microspheres intended for nasal drug delivery
B. Pilicheva, M. Draganova-Filipova, P. Zagorchev and M. Kassarova

19

In-Vitro Models Simulating Buccal Tissue in the Oral Cavity


C. Schimpel, B. Teubl, E. Frhlich and E. Roblegg

20

Intranasal delivery of anti-Galectin-1 formulation to increase the efficiency of


chemo- and immunotherapy for glioblastoma
M. Van Woensel, N. Wauthoz, R. Rosiere, K. Amighi, V. Mathieu, F. Lefranc, S. Van Gool,
T. Mathivet and S. De Vleeschouwer

21

Oromucosal film preparations for peptides - Points to consider


S. Lindert, M. Pein, F. K. Hansen and J. Breitkreutz

22

Whey proteins: a promising excipient to promote oral drug delivery and permeability
H. Hsein, V. Hoffart, G. Garrait, E. Dat-Lain and E. Beyssac

Nanoparticles & Vesicles


23

A Novel Oxalipatin Derivative Showed Enhanced Efficacy in an Orthotopic Model of


Ovarian Cancer
A. Abu Ammar, T. Nassar, D. Gibson and S. Benita

24

A PROCESS FOR PREPARATION OF ULTRASMALL CURCUMIN NANOPARTICLES


R. Kalhapure, S. Sonawane and T. Govender

25

Aminodextran-coated magnetic nanoparticles as a new hyperthermia approach


M. K. Lima Tenrio, E. Alfonso Gmez Pineda, H. Fessi and A. Elaissari

24

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Ammonium glycyrrhizinate-loaded niosomes as potential nanotherapeutics for


inflammation: a comparative study
C. Marianecci, F. Rinaldi, C. Ingallina, P. N. Hanieh, D. Paolino, C. Celia, F. Cilurzo, S. Pieretti
and M. Carafa

27

Amorphous Flubendazole Dispersed in Electrospun Nanofibers: Bioavailability in the


Rat and Tablet Formation
G. Verreck, I. Van Assche, C. Mackie, P. Boeykens, M. E. Brewster, Z. K. Nagy, T. Vigh, A. Balogh
and G. Marosi

28

Antibiofilm activity of Melaleuca alternifolia nanoparticles


M. Ebling de Souza, R. de Almeida Vaucher, L. Quintana Lopes, R. Raffin, D. Martinez Stefani,
R. Christ Vianna Santos and P. Gomes

29

Antidepressant-like activity of liposomal formulation containing nimodipine treatment


in the tail suspension and forced swim test in mice
L. C. G. e A. I. Moreno, J. M. Irache, R. M. Freitas and N. S. Santos Magalhes

30

Arsenic loaded anti-GD2 immunoliposomes: Design and in vitro targeting to


neuroblastoma cells
H. Deibel and R. Schubert

31

Aspherical Nanoparticles for Drug Delivery Application


A. Castoldi, P. Dersch, S. Gordon and C.-M. Lehr

32

Biocompatibilization of micelles by hyaluronan


T. Pilgrov and M. Peka r

33

Biocompatible nanoparticles and gadolinium chelates: towards new hypersensitive


MRI contrast agents
M. Callewaert, V. G. Roullin, Y. Belabassi, C. Cadiou, C. Portefaix, S. Laurent, L. Vander Elst,
M. Molinari, F. Chuburu and M.-C. Andry

34

Biological evaluation of liposomes containing 6BrCaQ, a C-terminal Hsp90 inhibitor,


for prostate cancer treatment
F. Sauvage, S. Franze, S. Messaoudi, M. Alami, S. Lesieur, F.-X. Legrand, E. Fattal, G. Barratt
and J. Vergnaud-Gauduchon

35

Carbohydrate Ligand Anchored Nanoparticles with Improved Efficacy in the


Fibrosarcoma Tumor Model
S. Pranatharthiharan and P. Devarajan

36

Cardiovascular risk potential of PLGA-PEG nanoparticles used in drug delivery and


targeting
R. Bakhaidar, S. O'Neill and Z. Ramtoola

37

Cationic nanoparticles. An analytical approach to biological relevance


R. Gossmann, M. Hummel, D. Mulac, J. Brockmeyer and K. Langer

38

Cholesterol Free Pegylated Liposomes: A Potential for Brain Targeting


P. Wavikar and P. Vavia

39

Co-encapsulating lipid nanoparticles for transdermal and oral delivery


M. Mendes, C. Vitorino, J. Sousa and A. Pais

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40

Comparison of different nanonization approaches for -carotene


P. Scholz, S. Lohan, M. C. Meinke, R. H. Mller and C. M. Keck

41

Comparison of m-PEG-PCL polymersomes size measurements by 3 optical techniques:


DLS, NTA and two-photon microscopy
M. Inkichari, C.-H. Brachais, C. Bouvier, A. Assifaoui, P. Winckler, R. Seigneuric, S. Auguste
and O. Chambin

42

Cyclosporin smartPearls for improved topical delivery


S. Staufenbiel, G. B. Romero, N. Jin, C. M. Keck and R. H. Mller

43

Design of new nanoparticles as tools for CNS disease diagnosis


E. Teston, Y. Hamdous, C. Chuon, J. Seguin, C. Marie, T. Maldiney, B. T. Doan, N. Mignet,
C. Richard and K. Andrieux

44

DESIGN OF POLYMERIC NANOFIBER DIAMETER, DRUG LOADING AND RELEASE


J. Kristl, . Zupansi s,
P. Kocbek and S. Baumgartner

45

Development and characterization of piroxicam loaded nanospheres to enhance the


solubility and bioavailability adopting electrospraying technique
O. Mustapha, F.-U.-. Din, A. Yousaf, D. W. Kim, R. Rashid, J. H. Park, T. Ramasay, J. O. Kim,
C. S. Yong and H.-G. Choi

46

Electrospun cyclodextrin-based formulation of aripiprazole and its in vitro


dissolution-absorption testing using micro-FluxTM
G. Marosi, E. Borbas, Z. Nagy, A. Balogh and B. Sinko

47

Development of novel solid lipid nanoparticles-loaded dual-reverse thermosensitive


nanomicelle with improved bioavailability and reduced toxicity
F. Din, O. Mustapha, A. Yousaf, D. W. Kim, R. Rashid, J. H. Park, T. Ramasamy, J. O. Kim,
C. S. Yong and H.-G. Choi

48

Development, evaluation and mathematical modeling of insulin release from chitosan


and chitosan derivatives nanoparticles
J. Hecq, F. Siepmann, J. Siepmann, K. Amighi and J. Goole

49

Dexamethasone nanocrystals for improved ocular delivery


G. Bahu Romero, C. M. Keck, N. Bou-Chacra and R. H. Mller

50

Effect of ionic strength on the formation of fluoride loaded pectin nanoparticles


for dental delivery
S. Nguyen, S. Pistone, C. Claudio, G. Smistad and M. Hiorth

51

Effects of suberin fatty acids on the formation and physical stability of medicated
nanofibers intended for wound healing
I. Tamm, L. Rammo, I. Laidme, U. Paaver, K. Kirsime, N. Skalko-Basnet, A. Halenius, J. Yliruusi,
J. Heinmki and K. Kogermann

52

Encapsulation efficiency of a drug into a nanosize carrier & amp; assessment of


nanoparticle stability in a complex liquid matrix: Two working examples of NTA
characterization
P. PEOTTA, P. HOLE, B. CARR and P. VINCENT

53

Encapsulation of dexamethasone palmitate into PLGA-PEG nanoparticles


R. Simn-Vzquez, N. Tsapis and E. Fattal

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54

Enhancing Vancomycin Delivery via Lipid-Polymer Hybrid Nanoparticles


N. Seedat, R. Kalhapure, C. Mocktar and T. Govender

55

Evaluation of biodegradability of novel polymeric nanoparticles based on amphiphilic


polylactide-polyaspartamide derivatives
B. Porsio, E. F. Craparo, D. Triolo, G. Giammona and G. Cavallaro

56

Evaluation of Chitosan Nanoparticles for Intravesical Administration of Gemcitabine HCl


for the Treatment of Superficial Bladder Cancer
Z. Ay S enyigit,
D. Ilem zdemir, S. Y. Karavana, . aliskan, S. S en and E. Baloglu

57

Evaluation of cytotoxicity of Geranium oil-loaded nanoemulsions


J. Giongo, R. Vaucher, A. Ourique, M. Steffler, M. Sagrillo, P. Gomes and M. Steppe

58

Exploring drug release from magnetic nanocarriers by low-level magnetic stimulation


R. Spera, F. Apollonio, M. Liberti, M. A. Casadei, C. Merla, R. Pinto and S. Petralito

59

Factorial design-aided development of salicylic acid loaded-nanostructured lipid carriers


B. Sto, N. Ungvri, E. Csnyi, P. Szab Rvsz and S. Berk

60

Feasibility of encapsulation dihydromyricetin in cationic nanocapsules


A. J. Figueir Dalcin, A. Ferreira Ourique, R. Platcheck Raffin, R. Christ Vianna Santos
and P. Gomes

61

Flavanones: Cytotoxic activity and release study of nanoestructured emulsion


B. Andrade, C. Caadas, M. Mallandrich, V. No, B. Clares, A. Calpena, M. L. Garca
and M. L. Garduo

62

Formation and stability of curcumin nanoemulsions prepared by phase inversion


temperature method
A. Jintapattanakit, R. Leam-or, S. Maneejansook and V. Junyaprasert

63

FORMULATING LINOLEIC ACID AS A NANOEMULSION ENHANCES ITS


ANTIMICROBIAL ACTIVITY
S. Sonawane, C. Mocktar, R. Kalhapure and T. Govender

64

Formulation and In Vitro Evaluation of Furosemide Nanosuspensions


T. Glsn Inal, S. Ebadi Borna, I. Vural and S. Sahin

65

Formulation and stability evaluation of novel antimicrobial nanofibrous wound dressings


U. Paaver, I. Tamm, A. Toom, I. Laidme, A. Meos, K. Kirsime, N. Skalko-Basnet, J. Heinmki
and K. Kogermann

66

Gemcitabine-squalene nanoparticles: involvement of plasma lipoproteins in the


therapeutic response
D. Sobot, S. Mura, L. Dalbin, S. Lepetre and P. Couvreur

67

Human Serum Albumin (HSA) nanoparticles stabilized by polymer coating for the
delivery of suramin
I. Luis de Redin, M. Ageros, J. M. Llabot, C. Boiero and J. M. Irache

68

PHB based microparticles for ivermectin sustained release


E. Engasheva, S. Yakovlev, A. Zernov, A. Bonartsev, G. Bonartseva, E. Daugalieva, K. Shaitan
and S. Engashev

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69

In vitro behaviour of hybrid lipid/chitosan nanoparticles for the oral delivery of heparin
F. Sacchetti, R. Aracri, E. Maretti, V. Iannuccelli, M. Montanari, B. Pavan, A. Dalpiaz and E. Leo

70

In Vitro Release and In Vivo Tolerance of Pranoprofen-Loaded Nanoparticles Hydrogel


B. Guevara Granados, G. Abrego Escobar, M. L. Garca Lopez and A. C. Calpena Campmany

71

Influence of colloidal lipid carrier matrix on fenofibrate loading capacity a passive


loading approach
K. Gke and H. Bunjes

72

Influence of polymer end-chemistry on the morphology of perfluorohexane polymeric


microcapsules intended as ultrasound contrast agents
L. Mousnier, N. Huang, E. Morvan, E. Fattal and N. Tsapis

73

Investigating the influence of glass transition temperature on the release behaviour of


flurbiprofen- and mTHPP-loaded poly(D,L-lactic-co-glycolic acid) nanoparticles
S. Lappe and K. Langer

74

Investigation of titanate nanotube-API composites as promising drug delivery systems


B. Sipos, T. Sovny, A. Spi, Z. Knya, K. Pintye-Hdi and G. Regdon jr.

75

LABELING EFFICIENCY AND CELL BINDING of 99mTc LABELED CHITOSAN NANOPARTICLES


E. Gundogdu, D. Ilem Ozdemir, M. Ekinci, E. Ozgenc and M. Asikoglu

76

Layer-by-layer nanoencapsulation of paclitaxel


A. Polomska, H. Merten, A. Plckthun, M.-A. Gauthier and J.-C. Leroux

77

LIPOSOME CONTAINING ESTETROL FOR THE TREATMENT OF ISCHEMIA DISEASES


IN PREMATURE BABIES
C. Palazzo, R. Karim, M. Mawet, C. Maillard, J.-M. Foidart, B. Evrard and G. Piel

78

LIPOSOMES AS CARRIERS OF LIPID SOLUBLE ANTIOXIDANTS- RESVERATROL IN


PRESENCE OF VITAMIN E
V. KENCHAPPA, M. WAHL, L. BUKARICA, J. CEVIC and H. HEINLE

79

Loading of Aloe-Emodin in gemini based cationic liposomes by the acetate


gradient method
C. Bombelli, C. Giuliani, B. Altieri, G. Mancini, L. Galantini, A. Stringaro and M. Colone

80

Manufacture of Perfluorocarbon-Nanoemulsions for site specific targeting of activated


platelets via a single-chain variable fragment binding to glycoprotein IIb/IIIa
C. Grapentin and R. Schubert

81

MIL100 nanoparticles as a Busulfan delivery system


T. Simon-Yarza, L. L. Lesuer, A. Seck, T. Baati, M. Chiper, A. Paci, P. Couvreur, C. Serre, R. Gref
and P. Horcajada

82

NLC and nanocrystal combination for effective treatment of couperosis


S. M. Pyo, G. B. Romero, M. Meinke, A. Klein, T. C. Fischer, C. M. Keck and R. H. Mller

83

Novel Approaches for Gelatin Nanoparticle Preparation


K. Geh, M. Hubert and G. Winter

28

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84

Novel formulations for mitochondrial delivery based on alkylphosphonium


bolaamphiphiles
F. Ceccacci, C. Bombelli, S. Sennato, E. Rossi, S. Gallina, B. Altieri, V. Moresi, E. Pigna
and M. Diociaiuti

85

OLEIC ACID DERIVED HETEROLIPID BASED SMEDDS ENHANCE THE AQUEOUS SOLUBILITY
OF CURCUMIN
R. Kalhapure, D. Sikwal and T. Govender

86

Optimization of the production of curcumin liposomes by ultrasonication based on


Pharmaceutical Quality by Design approach
A. R. Bilia, F. Mazzacuva, C. Guccione and M. C. Bergonzi

87

PEGylated liposomes containing apigenin for the treatment of glioblastoma


R. Karim, C. Palazzo, N. Dubois, V. Bours, C. Passirani and G. Piel

88

Peptide-functionalized Nanoparticles for Selective Targeting of Pancreatic Tumor


S. MURA, S. VALETTI, F. MAIONE, D. DESMAELE, M. NOIRAY, J. VERGNAUD, C. VAUTHIER,
L. CATTEL, E. GIRAUDO and P. COUVREUR

89

pH sensitive PEGylated Liposomes delivering active hydrophilic peptide with anticancer


activity: in vitro study on cDDP-resistant ovarian cell line
F. Sacchetti, C. Marraccini, D. D'Arca, D. Pinetti, F. Genovese, E. Maretti, V. Iannuccelli,
M. P. Costi and E. Leo

90

Physicochemical Stability and Corneal Permeation of Pranoprofen-Loaded Nanoparticles


Based Hydrogel
G. Abrego Escobar, H. Alvarado Bonilla, B. Guevara Granados, A. C. Calpena Campmany
and M. L. Garcia Lopez

91

Pigs scleral permeation by freeze drying carprofen nanoparticles


A. Parra, M. Mallandrich, H. L. Alvarado, B. Clares, M. L. Garca and A. C. Calpena

92

Poly(ethylene glycol)-cholesterol molecules for liposomal surface modification via the


sterol-based post-insertion technique (SPIT) and their behavior towards acceptor media
D. Molnar

93

Poly-L-Lysine-coated liposomes as potential delivery systems for treatment of diabetic


vascular diseases.
M. L. Manca, D. Valenti, F. Marongiu, M. Manconi, G. Brotzu and A. M. Fadda

94

Polysaccharide-based nanohydrogel systems for drug delivery applications


P. Matricardi, C. Di Meo, E. Montanari, C. Cencetti, S. Laserra, G. Manzi, T. Coviello
and F. Alhaique

95

Preformulation study of liposomes as nanosized drug delivery systems


In vitro drug transport.
K. Dr, J. Malth, P. Hegyi, P. Szab-Rvsz and P. Sipos

96

Preparation and Pharmaceutical Evaluation of Nano-fiber Matrix Supported Drug


Delivery System using the Solvent-Based Electrospinning Method
M. Hamori, K. Yoshida, K. Nagano, S. Kakimoto, A. Nishimura, K. Naruhashi and N. Shibata

97

Preparation of liposomes with asymmetric bilayers produced from nanoemulsions in


a centrifugal field
J.-H. Sommerling, M. de Matos, E. Hildebrandt, G. Leneweit and H. Nirschl

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98

Preparation of New Nanovectors from Biomass: Chemo-Enzymatic Synthesis of


Glycerolipidyl-Cyclodextrins and study of drug encapsulation
V. Bonnet, Y. Miao, A. Furlan and C. Sarazin

99

Preparation of submicron magnetic latex particles for biomedical applications:


Morphology control
E. Taveira Tenrio-Neto, T. Jamshaid, N. Zine, A. Errachid El-Salhi, M. Hiroiuqui Kunita,
H. Fessi and A. Elaissari

100 Production of chitosan nanoparticles as matrix to sustain drug release across orally
disintegrating tablets with the aid of design of experiment to optimize conditions
A. Matoug-Elwerfalli and A. El-shaer
101 Protective effect of curcumin-loaded new polymer-glycerosome systems on
pulmonary diseases.
M. L. Manca, I. Castangia, C. Caddeo, M. C. Cardia, M. Manconi, C. Sinico and A. M. Fadda
102 Remote loading of Voacamine in cationic liposomes for the treatment of
osteosarcoma resistant cell lines
L. Giansanti, B. Altieri, M. Condello, E. Pellegrini, G. Mancini and S. Meschini
103 smartCrystals for functional foods: BIOSMARTS
G. Bahu Romero, C. M. Keck, E. Brysch, W. Brysch and R. H. Mller
104 smartLipids the smarter Nanostructured Lipid Carriers (NLC)
R. H. Mller, R. Ruick and C. M. Keck
105 The Use of Excited-State Proton Transfer in Observation of The Interaction of Potential
Hyaluronan-Surfactant Drug Nanocarriers
J. Mondek and M. Pekar
106 Thermoresponsive mesoporous silica nanoparticles as a topical delivery system for
antioxidants
S. Sapino, E. Ugazio, L. Gastaldi, S. A. Jadhav, V. Brunella, D. Scalarone, I. Miletto and G. Berlier
107 Transcorneal delivery of PLGA-based nanoparticles of Ketorolac
M. Mallandrich, A. Calpena, A. Parra, M. L. Garcia and F. Fernndez-Campos
108 Use of Lipid Nanocapsules for air bubbles stabilization
C. R. A. MOUZOUVI, P. SAULNIER and A. BIGOT
109 Verbascoside loaded in liposomes: increased stability and prolonged antineuropathic and
antiinflammatory activities
A. R. Bilia, B. Isacchi, M. C. Bergonzi, C. Ghelardini and N. Galeotti
110 ZnO-based Quantum Dots for biological applications
E. Berbel Manaia, B. Caetano, V. Briois, R. Kiatkoski Kaminski, L. Chiavacci and C. Bourgaux

Transdermal Delivery
111 Aceclofenac loaded bicontinuous microemulsions: in vitro release, tape stripping
and pharmacokinetic study
M. Todosijevic, V. Savic, M. Savic, D. Randelovic, M. Gaperlin, B. Batinic, T. Isailovic,
B. Markovic and S. Savic

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112 Captisol as Dermal Penetration Enhancer for Lipophilic Drugs


A. Juluri and N. Murthy
113 Early preclinical evaluation of transdermal druglikeness - a case study with selective
androgen receptor modulators
T. Ullrich, H. Keller, S. Weiler and P. G. Santos
114 Hydrogels of carboxymethyl scleroglucan: a smart biocompatible system for
topical formulations
P. Paolicelli, S. Pacelli, S. Petralito, A. Adrover and M. A. Casadei
115 In vitro and ex vivo evaluation of a ready to use transdermal vehicle for the permeation
of ondansetron
F. BOURDON, M. LECOEUR, P. ODOU, C. VACCHER and C. FOULON
116 Influence of formulation polarity on transdermal delivery by implementation of the
delivery gap principle
M. Gerber, C. Burger, J. Du Preez and J. Du Plessis
117 Investigation of microemulsion microstructure and its impact on skin delivery of
flufenamic acid
D. Mahrhauser, H. Khlig, E. Partyka Jankowska, K. Kwizda and C. Valenta
118 Macromolecules penetration in irritant contact dermatitis
M. Abdel-Mottaleb, A. Bduneau, Y. Pellequer and A. Lamprecht
119 Microrheological study of hyaluronan based system for dermal delivery applications
Z. Hnyluchov and M. Pekar
120 Modified Chitosan sponges as antibacterial agents
P. Siafaka and D. BIkiaris
121 Non-invasive in vivo comparison of penetration enhancers containing hydrogel
formulations
B. Balzs, M. Bakonyi, S. Berk, M. Budai-Szucs and E. Csnyi
122 Optimization of microemulsion composition applying experimental planning
V. Jukait, M. ilius, K. Ramanauskien and V. Briedis
123 PDT(Photo Dynamic Therapy) using LPC (Lysophosphatidylcholines) and the photosensitizer chlorine- derivatives useful for Trichophyton rubrum
Y. Woo, Y. Park, H. Ji, J. Kim, S. Jo and H. Yu
124 Physical characterization and release of a silver sulfadizine-chitosan hydrogel for
wound treatment
R. d. O. Batista, G. d. S. Nascimento, L. M. Verssimo, P. S. H. Picciani, K. G. d. H. Silva
and F. Reynaud
125 Preparation and characterization of alcohol-free, grapefruit oil base microemulsions
N. Jaipakdee and E. Limpongsa
126 smartPearls - stability and performance in topical gels
N. Jin, S. Staufenbiel, C. Keck and R. Mller
127 The impact of low molecular weight polysiloxanes on the skin barrier
K. Mojsiewicz-Pienkowska, K. Szymkowska, D. Glamowska, K. Cal and Z. Jankowski

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128 Thermal Analysis of Stratum Corneum using Modulated Temperature Differential


Scanning Calorimetry (MTDSC)
C. F. Goh, D. Craig, J. Hadgraft and M. Lane
129 Topical delivery of lidocaine and prilocaine with the use of Pheroid technology
J. Du Plessis, D. Nell, J. Du Preez and M. Gerber
130 Transdermal iontophoretic delivery of propofol (CAPTISOL-enabled Complex);
plasma and brain pharmacokinetic study
A. Juluri, N. Murthy and P. Manda

Parenteral Delivery
131 Development of an Ex-Vivo Pig Skin Model to Determine Mechanistic Effects of Antibody
Formulations Following Subcutaneous Injection
S. Eichling, C. Jahn, A. Popp, W. Frie and G. Fricker
132 Indocyanine green-loaded chitosan/alginate microparticles for transcatheter arterial
embolization (TAE) in hepatocellular carcinoma (HCC)
E. P. Porcu, A. Salis, G. Rassu, E. Gavini, P. Dionigi, M. Maestri and P. Giunchedi
133 Investigation of a flow through cell adapter for dissolution testing of an intramuscular
applied aqueous solution and an oily suspension
M. Probst, M. Schmidt, E. Noll, A. Seidlitz and W. Weitschies
134 Is poloxamer 188 desorbed from the trimyristin nanoparticle interface upon dilution?
A DSC study
E. Roese and H. Bunjes
135 Monitoring of size changes of single PLGA-microparticles and comparison with
drug release
H. Gasmi, J. Siepmann and F. Siepmann
136 Nanostructured Lipid Carriers (NLC) of Artemether-Lumefantrine combination for
intravenous malaria therapy
P. Prabhu, M. Joshi, S. Pathak, S. Sharma and V. Patravale
137 Parenteral nanoemulsions for risperidone brain delivery: design, characterization and
in vivo evaluation
S. Dordevic, T. Isailovic, N. Cekic, M. Savic, S. Savic, D. Randelovic and S. Savic
138 Progress in Complex Parenteral Formulations for the Delivery of Biopharmaceuticals and
Small Molecules Microencapsulation Scale Up and Product Enhancements
T. Tice, K. Burton, J. Atkinson, P. Markland and G. Winchester

Pediatric & Geriatric Drug Delivery


139 A novel versatile gastro-resistant paediatric formulation based on Omeprazole/SBA-15
loaded in alginate beads by prilling
P. Del Gaudio, F. De Cicco, S. Giovagnoli, M. Ricci and R. P. Aquino

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140 An in vivo taste assessment method for the optimisation of taste-masking formulations:
the rat brief-access taste aversion (BATA) model
J. Soto, R. Turner, S. Desset-Brthes, G. Winzenburg, M. Orlu Gul and C. Tuleu
141 Anti-CD19-Targeting of Doxorubicin Liposomes for an Improved Treatment of Pediatric
Acute Lymphoblastic Leukemia
K. Zfle and R. Schubert
142 Development and Characterization of Orodispersible Mini-tablets Manufactured
by Direct Compression
M. Mnster, C. Pfeifer and J. Breitkreutz
143 Development of aged cell culture model to assess the in vitro fate of drug delivery
systems for older patients
I. Espadas Garcia, S. Hanning, M. Bunc, J. M. Prieto-Garcia and M. Orlu-Gul
144 Development of casein micellar pediatric formulations
M. Brachkova, J. T. Pinto, A. I. Fernandes and J. F. Pinto
145 Development of extended release Compritol 888 mini matrix tablets for geriatric
administration
R. Grybos, L. Freerks, Y. Rosiaux, D. Marchaud and S. Klein
146 Evaluation of the ability of powdered milk to produce mini-tablets containing
paracetamol
J. T. Pinto, M. Brachkova, A. I. Fernandes and J. F. Pinto
147 Formulation of orodispersible films for children
Z. Senta-Loys, S. Bourgeois, S. Brianon and H. Fessi
148 Hot melt coating - taste-masked multiparticulate drug delivery systems with immediate
drug release
A. Zimmer, K. Becker and S. Salar-Behzadi
149 In situ preparation of microcapsules with ethylcellulose and polyacrylate shells
incorporated in a lyophilized matrix
K. Hoppe and M. Sznitowska
150 Multiparticulate extended release dosage form for pediatric use development and
characterization
M. E. Martinez Teran, S. Mangalaboyi and M.-P. Flament
151 Orally Disintegrating Tablet Preparation by Dry Granulation Method Using Super Fine
Powder, Special Low Viscosity Hydroxypropyl Cellulose
K. Sugisawa, S. Kodama, S. Tsue, B. Ehlig, Y. Takeuchi and H. Takeuchi
152 Patient centric and age appropriate drug product design: Theory biased and
evidence based
S. Stegemann, R. Becker, R. Messina and D. van Riet-Nales

Pharmaceutical Manufacturing & Engineering


153 Comparison of a novel aerodynamic dry granulation method and conventional slugging
method in preparation of granules and tablets
A. Penkina, T. Saarinen, O. Antikainen, A. Lust, K. Kogermann, J. Yliruusi and J. Heinmki
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154 Continuous manufacturing of delta mannitol via spray drying


V. Vanhoorne, P.-J. Van Bockstal, B. Van Snick, P. Gomes, T. De Beer, J.-P. Remon and C. Vervaet
155 Evaluating the validity of the Unified Theory of Compaction using sodium chloride
and ammonium sulphate tablets
M. Gamlen, T. Uddin and L. Martini
156 Evaluating Youngs Modulus from diametral compression data
M. Gamlen, H. Dhaliwal and L. Martini
157 Evaluation of binders for dry granulation
M. Kirsolak, H. Mangal and P. Kleinebudde
158 Co-Extrusion as innovative method for Pharmaceutics
K. Paulsen, I. Ruff and D. Leister
159 Improved Spray Drying Capability with AFFINISOL HPMCAS and HPMC High
Productivity Polymers
W. Porter III, K. ODonnell, B. Schmitt, M. Brackhagen, M. Sprehe, M. Knarr and W. Spaulding
160 Influence of different drying conditions on mono- and double-layer orodispersible films
during continuous manufacturing
Y. Thabet and J. Breitkreutz
161 Interaction of emulsifier and membrane material during the preparation of
nanoemulsions by premix membrane emulsification
S. Gehrmann and H. Bunjes
162 NANEX: Process design with potential matrix materials
R. Baumgartner, J. G. Khinast and E. Roblegg
163 Production of Dexpanthenol Loaded Polyethylene Oxide Nanofiber Mats for
Wound Healing
E. Azizoglu, C. elik, S. Tuncay Tanriverdi and . zer
164 Production, stability and downstream processing of high speed electrospun amorphous
solid dispersion of itraconazole
Z. K. Nagy, B. Dmuth, A. Balogh, H. Pataki, E. Borbs, G. Marosi, I. V. Assche and G. Verreck
165 Small Scale Twin-Screw Extrusion - Evaluation of Continuous Split Feeding in Wet
Extrusion/Spheronization
C. Mhlenfeld, D. Ghanam, J. Schwarz and M. Thommes
166 Tablet strength related to adhesion forces of tablet components measured at
the nanoscale
M. Badal Tejedor, N. Nordgren, M. Schuleit, M. W. Rutland and A. Millqvist-Fureby
167 Taguchi method used for optimization of coating process for minitablets
M. Czajkowska and M. Sznitowska
168 The Impact of Crospovidone as a Superdisintegrant for Hard Gelatin Capsule
Formulations
C. Muehlenfeld, G. Warnke, M. Opitz and S. Stegemann

34

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

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1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

35

Monday, 13 April 2015


La Nef

Poster Sessions and Exhibition

Amphithtre Royal
Invited talks: Transdermal Drug Delivery

09:00

Amphithtre Royal

Opening Ceremony and APGI Student Award

09:15

Amphithtre Royal

Plenary lecture: Drug Targeting - Where are we?, Patrick Couvreur

10:45

Advanced Drug Delivery Systems


Controlled Drug Delivery

Transdermal drug delivery: A Mature and Evolving


Technology
R. Guy

Amphithtre Clovis
Short talks: Oral Controlled Drug Delivery

How does the drinking volume affect gastric dissolution in


infants? New in vitro approaches for preclinical screening
E.Kersten

Oral Delivery
Pulmonary Delivery

11:05

Dermal preparations

In-vitro dissolution testing of oral thin films (OTFs):


theory and experiments
A. Adrover

Physical Pharmacy
Preformulation
Protein Formulation & Aggregation

11:25

Gene Delivery

Transdermal Drug Delivery: An Industrial Viewpoint


M. Sournac

Proposal for a new dissolution method for soft


chewable delivery systems
C. Stomberg

09:00 20:00; all day

11:45

Assessing Softgel Disintegration in the Gastric Compartment:


Correlating the Dynamic Gastric Model with In Vivo
Visualization by Camera-Capsules
H. Teles

12:05

The new Guideline on Quality of Transdermal Patches: New


Requirements in Development
S. Jones

Mucoadhesive polymeric nanocomposites for oral delivery of


S-nitrosogluta-thione
W. Wu

12:25

Amphiphilic Nucleic Acid Conjugates for Local Treatment of


Intestinal Diseases
E. Moroz

15:00

Poster Sessions and Exhibition

Invited talks: Oral Drug Delivery

Short talks: Nanoparticles & Vesicles

Advanced Drug Delivery Systems

Recent Challenges in Oral Controlled-Release Drug Delivery


M. Lueck

The effect of using different nebulisers on the delivery of


Amphotericin B and Cisplatin Non-Ionic Surfactant Vesicles
M. Puig

Controlled Drug Delivery


Oral Delivery
Pulmonary Delivery

15:20

Ex vivo and in vivo siRNA delivery to activated T cells as novel


anti-inflammatory asthma therapy
Y. Xie

Dermal preparations
Physical Pharmacy
Preformulation
Protein Formulation & Aggregation

15:40

Gene Delivery

Therapeutic Index Issues around Oral Peptide Permeation


Enhancers
D. Brayden

Chitosan-iron-based nanogels for the cellular delivery of polyphosphate drugs


G. Giacalone

09:00 20:00; all day

16:00

Anti-E6/E7/MCL1 pegylated lipoplexes for a vaginal treatment


of cervical cancer
A. Lechanteur

16:20

Orodispersible Dosage Forms


D. Djuric

Delivery of Andrographolide to the brain by human serum


albumin nanoparticles
M. Bergonzi

16:40

Percutaneous absorption of benzophenone-3 loaded lipid


nanoparticles and polymeric nanocapsules: a comparative
study
E. Gilbert

Tuesday, 14 April 2015


Amphithtre Royal

La Nef

Amphithtre Clovis

09:00

Poster Sessions and Exhibition

Invited talks: Smart Drug Delivery Systems

Short talks: Advanced Drug Delivery

Bioavailability & Absorption Enhancement

Progresses in Anticancer Drug Delivery by Polymer Conjugation


G. Pasut

Modifications of the stratum corneum barrier structure and


function intro- duced by freezing: consequences for drug
permeation studies
L. Roussel

Buccal & Nasal Delivery


Nanoparticles & Vesicles
Transdermal Delivery

09:20

In vitro phage display as a strategy to enhance the skin


penetration of heparins
S. Franz

Parenteral Delivery
Pediatric & Geriatric Drug Delivery
Pharmaceutical Manufacturing & Engineering
Quality Assurance

09:40

3D Printing
C. Roberts

Quality Control & PAT


Stability Testing

Hyaluronic acid gels containing liposomes for the sustained


delivery of a corticoid to the inner ear
N. El Kechai

Technical Innovations
Green & Sustainable Pharma

10:00

Mesoporous phospholipid particle as a novel drug delivery


platform
K. Kawakami

In-vitro/In-vivo Correlations

09:00 17:00; all day

10:20

Smart Drug Delivery from an industrial perspective


P. Gellert

Thalidomide nasal powders for local treatment of nose


bleeding in hereditary hemorrhagic telangectasia
V. Chiapponi

10:40

In vitro estimation of drug delivery to stenosed coronary


blood vessels via drug-coated balloon catheters
A. Seidlitz

11:30

Amphithtre Royal

Plenary lecture: Advances in Pulmonary Drug Delivery, Hartmut Derendorf

15:00

Poster Sessions and Exhibition

Invited talks: Peptide and Protein Delivery

Short talks: Development & Manufacturing of


Solid Dosage Forms

Bioavailability & Absorption Enhancement

Protein and Peptide Delivery: Current State of the Art


W. Hennink

Thermodynamics of API/Polymer Amorphous Formulations


G. Sadowski

Buccal & Nasal Delivery


Nanoparticles & Vesicles
Transdermal Delivery

15:20

Hot-melt extrusion of polyvinyl alcohol and plasticizer for


oral immediate release applications
W. De Jaeghere

Parenteral Delivery
Pediatric & Geriatric Drug Delivery
Pharmaceutical Manufacturing & Engineering
Quality Assurance

15:40

Quality Control & PAT

Challenges and advances in vaccine delivery


D. O Hagan

Stability Testing

Melt blowing and electrospinning for dissolution enhancement


A. Balogh

Technical Innovations
Green & Sustainable Pharma

16:00

Exploring the Use of Pressurised Gyration for Large Scale


Manufacture of Pharmaceutical Nanofibres
B. Raimi-Abraham

In-vitro/In-vivo Correlations

09:00 17:00; all day

16:20

Novel Application Systems for Transdermal Vaccine Delivery


H. Spilgies

PAT tools for the control of the manufacturing processes of


co-extruded implants, tablets and capsules
F. Krier

16:40

The Application of Novel nano-Thermal and Imaging


Techniques for Monitoring the Drug Distribution within
PLGA Microspheres
M. Zhao

Te
T
e chnolo
c h n o l o gic
gica
all L ac ttose
o se E xcipient
x c i p i en t s

Quality Assurance/Quality Control & PAT


169 In vitro dissolution behavior of extended release theophylline tablets in ethanolic media
K. Knop and P. Kleinebudde
170 BIORELEVANT DISSOLUTION METHOD IN QUALITY CONTROL OF DRUGS CONTAINING
API IN THE FORM OF SALTS OF WEAK ACIDS
J. Muselk, A. Franc, R. Gonc, D. Vetch, D. Majerckov and V. Durovcov
171 Improvement of pharmacists service in Pharmacy Belgrade
J. Bjeletic

Stability Testing
172 Evaluation of stability of bupivacaine hydrochloride 0.5% solution for injection under
non-temperature controlled conditions
A. Zygler, B. Kubiak, R. Lunio, A. Kot-Wasik, W. Sawicki and K. Wlodarski
173 Interaction and stability of biomolecules
A. Audfray and M. Terray
174 Investigation into a Potential Stabilizer for Moisture Induced Amorphous-Amorphous
Phase Separation of Solid Dispersions
C. Orive and M. Zhao

Technical Innovations
175 Analysis of Nano-sized Particles for the Precise Engineering of Drug Delivery Systems
for Nanomedicine Applications
C. Roesch, M. Broom and R. Vogel
176 Explicit Identification of Sub-Visible Particulates in Solution-Phase BioFormulations:
A Hybrid Approach
M. Terray and K. Dahl
177 Is Ion Mobility Mass Spectrometry the Missing Tool in Polymer Drug Delivery
Development?
J. R. N. Haler, D. Morsa, J. Far, P. Lecomte, C. Jrme and E. De Pauw
178 New perspectives for fabrication and analysis of biomimetic electrospun scaffolds for
skin tissue engineering applications
V. Planz, S. Seif and M. Windbergs
179 Stability and Structure of Therapeutic Proteins
S. Kenyon and M. Terray

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

39

Green & Sustainable Pharma


180 Particle engineering of cocrystals using a solvent-free approach by spray congealing
. Duarte, M. Pereira, L. Padrela, J. F. Pinto and M. Temtem
181 Release profile and antioxidant activity evaluation of two topical gels enriched with
bioactive extracts from agro-industrial coffee wastes
M. Allegro, J. Marto, C. Montoya, N. Oliveira, S. Gonalves, A. Paiva, S. Barreiros, P. Simes,
L. Gonalves and H. Ribeiro

In-vitro/In-vivo Correlations
182 Selection of a Discriminant Dissolution Test for Extrudates Containing Itraconazole
J. Thiry, F. Krier, A. Pestieau and B. Evrard

40

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

Acknowledgements
We thank our sponsors:

Main sponsor

Platinum Sponsor

Silver sponsor

Bronze sponsor

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

41

10th World Meeting on Pharmaceutics, Biopharmaceutics

and Pharmaceutical Technology


4th 7th April 2016
SECC, Glasgow, Scotland

SEE YOU IN GLASGOW IN 2016


Find out more

42

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

SPONSORS
Reims, France 13 - 14 April 2015

We thank our sponsors


1st European Conference on Pharmaceutics Drug Delivery
Reims, France 13 - 14 April 2015

43

Sirius Analytical Main sponsor


BOOTH 18
Sirius Analytical is the market leader in instrumentation and CRO services for measurement of pKa, logP/logD, Solubility and Dissolution
in aqueous, solvent, biorelevant media and in the presence of formulation additives.
Our unique solutions for automated supersaturation measurement
reveal new insights about the pH-dependent supersaturation a compound can exhibit and how supersaturation may be enhanced or
suppressed via the use of formulation additives and excipients.
With facilities in the US and UK Sirius offers global coverage with detailed and reliable analysis, expert
staff and rapid turnaround.

Contact
Paul Whittles
Forest Row Business Park
Station Road, Forest Row
East Sussex, RH18 5DW
United Kingdom

Phone: +44 1 34 28 20 72 0
Fax:
+44 1 34 28 20 72 5
E-mail: sales@sirius-analytical.com

www.sirius-analytical.com

Advantest Platinum sponsor


BOOTH 17
A world-class technology company, Advantest is the leading producer of
automatic test equipment (ATE) for the semiconductor industry and a
premier manufacturer of measuring instruments. The companys leadingedge systems and products are integrated into the most advanced semiconductor production lines in the world.
The company also focuses on R&D for emerging markets that benefit
from advancements in nanotech and terahertz technologies, and has recently introduced critical multi-vision metrology scanning electron microscopes and 3D imaging analysis tools for pharmaceutical and industrial applications. Founded in Tokyo
in 1954 has subsidiaries worldwide.

Contact
Anthony Petrolonis
Director TAS Sales +
Business Development
508 Carnegie Ctr. # 102
NJ 08540 Princeton
USA

44

Phone: +1 6 09-89 77 32 6
E-mail: anthony.petrolonis@advantest.com

www.advantest.com
1st European Conference on Pharmaceutics Drug Delivery
Reims, France 13 - 14 April 2015

armor pharma Platinum sponsor


BOOTH 13
ARMOR PHARMA manufactures and markets 3 ranges of pharmaceutical
grade lactose for all your applications:
- ARMOR PHARMA lactose monohydrate: sieved & milled lactose
- EXCIPRESS: lactose for Direct Compression
- EXCIPURE: lactose for Dry powder Inhalation
Its state of the art industrial facility, located in Brittany, FRANCE, is in full
compliance with pharmaceutical standards (cGMP, GDP, PAT) and enables
the production of lactose in line with pharmaceutical regulations: Ph-EU,
USP-NF and JP.
ARMOR PHARMAs ambition is to design solutions that best support customers development. Its positionning reflects this philosophy, centred on a question that makes sense: How would you like your lactose?

Contact
Phone: +33 2 99 18 39 29
E-mail: contact@armor-pharma.com
www.armor-pharma.com

Ashland Platinum sponsor


BOOTH 12
Since the 1950s, Ashland has provided solutions for tablet binding, film
coating and disintegration, controlled-release formulation and drug solubilization including Aqualon and Blanose sodium carboxymethylcellulose, Aqualon ethylcellulose, Aquarius coating systems,
AquaSolve and AquaSolve AS hypromellose acetate succinate (hydroxypropylmethylcellulose acetate succinate or HPMCAS), Benecel
methylcellulose and hypromellose, Cavamax*, Cavitron and Cavasol*
cyclodextrins, Klucel hydroxypropylcellulose, Natrosol hydroxyethylcellulose, Plasdone povidone and copovidone and Polyplasdone crospovidone.
*Registered trademark owned by Wacker Chemie AG. Ashland Inc. acts as a worldwide distributor for
Wacker.

Contact
Dr. Christian Mhlenfeld
Pharmaceutical Scientist

Phone: +49 2 11 74 9 11 38
E-mail: cmuehlenfeld@ashland.com

www.ashland.com
1st European Conference on Pharmaceutics Drug Delivery
Reims, France 13 - 14 April 2015

45

BASF SE Platinum sponsor


BOOTH 16
BASFs Pharma Ingredients & Services produces and markets a broad
range of active ingredients and excipients, as well as exclusive synthesis
services for the pharmaceutical industry. Our products are made using
the latest technologies, to the highest quality standards and in compliance with cGMP guidelines. The division has been a trusted partner to
the pharmaceutical industry for decades and customers benefit from our
unique expertise and extensive experience. Innovation is at the heart of
BASFs business and our excipients portfolio reflects our commitment to
research and development as highlighted by products such as Kollicoat
Smartseal 30D, Soluplus and Ludiflash or our end-to-end dermatology
portfolio.

Contact
Florian Wildschek
Chemiestr. 22
68623 Lampertheim
Germany

Phone: +49 6 21 60 76 93 4
Fax:
+49 6 21 60 76 93 2
E-mail: florian.wildschek@basf.com
www.pharma-ingredients.basf.com

DOW Pharma & Food Solutions Platinum sponsor


BOOTH 01
Dow Pharma & Food Solutions is a leader in global research, manufacturing and innovation of pharmaceutical excipients. It is dedicated to developing new technologies that will enhance the formulation, solubilisation
and delivery of active ingredients and boasts an outstanding portfolio of
cost-effective, high quality cellulose ethers and polyethylene oxide chemistries such as ETHOCEL, POLYOX, METHOCEL, WALOCEL and
AFFINISOL.
Dow has developed the AFFINISOL line of excipients to facilitate solubility enhancement:
Our AFFINISOL polymers are uniquely tailored to address the solubilization performance requirements
of your APIs, whether you have chosen to formulate via Spray-Dried Dispersion or Hot Melt Extrusion.

Contact
Marielle Fiore
Bachtobelstrasse 3
8810 Horgen
Switzerland

46

Phone: +41 4 47 28 25 73
Fax:
+41 4 47 28 31 50
E-mail: Fiore@dow.com
www.dowpharmaandfood.com
1st European Conference on Pharmaceutics Drug Delivery
Reims, France 13 - 14 April 2015

MEDELPHARM Platinum sponsor


BOOTH 17
MEDELPHARM, headquartered in Lyon, are specialist developers & manufacturers of innovative solutions for R&D Tablet Presses and powder characterization services.
In addition to manufacturing tablet presses MEDELPHARM also offers a
comprehensive range of Powder Compaction and Characterisation Services
- Powder analysis and characterization
- Theoretical and hand-on training on tablet presses and tools
- Troubleshooting in production
- Process optimization
MEDELPHARM R&D Tablet Presses portfolio includes:
- STYLOne CLASSIC Multilayer development press,
- STYLOne Evolution, the latest servo-mechanical Compaction simulator,
MEDELPHARM are exclusive distributors in France of ADVANTEST, FITZPATRICK, OHARA, QUADRO,
RIVA, Romaco Kilian and XPLore

Contact
Ingrid Coyle
E-mail: icoyle@medelpharm.com
Director Sales International &
Business Development
12, rue des Petites Combes
01700 Beynost (Lyon)
France

www.medelpharm.com

Croda Europe Ltd Silver sponsor


We contribute to a healthier world by offering ingredients of superior
quality and providing unique formulation expertise, which help our pharmaceutical customers get the best possible performance from their active
ingredients.
Crodas portfolio is unsurpassed in excellence and designed to meet the
most stringent customer demands. Our proprietary manufacturing and
purification technology yields high quality products that meet the exacting
requirements of international Pharmacopoeia.
Crodas ongoing investment in GMP API technologies and R&D ensures the continual delivery of exceptional ingredients and the development of new speciality products to answer current and future health
and wellness needs.

Contact
Steve Mellor

E-mail: steve.mellor@croda.com
www.croda.com

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

47

LTS Lohmann Silver sponsor


LTS is the market leader in the development and manufacture of transdermal therapeutic systems (TTS) and oral thin films (OTF). As a B2B partner
to the pharmaceutical industry, LTS offers solutions at all stages of product
development, including feasibility assessments, research and development
of new formulations, production of clinical, as well as commercial scale
supplies, primary and secondary packaging. Products developed by LTS
comprise a multitude of innovations, like the first TTS for treatment of
Alzheimer and against Parkinson's Disease. Furthermore the innovation
potential of LTS resulted in OTF products for smoking cessation and for
the treatment of breakthrough pain.
Contact
Klaudia Haczkiewicz
Lohmannstr. 2
56626 Andernach
Germany

Phone: + 49 2 63 29 92 21 6
Fax:
+ 49 2 63 29 92 51 5
E-mail: klaudia.haczkiewicz@ltslohmann.de
www.ltslohmann.de

Sanofi Silver sponsor


Contact
www.sanofi.com

Seppic Bronze Sponsor


Excipients are our business, Health is our commitment: Our top priority is patient health and wellbeing. To that end, SEPPICs pharmaceutical division develops and supplies cutting-edge, effective excipients, including coating
solutions, injectables, adjuvants, functional excipients and dermopharmacy
polymers. Our specialty products are backed by exhaustive research, dedicated application laboratories and outstanding regulatory support. Combining
the strength and resources of a large group with the energy and responsiveness of a small company, SEPPIC is equally dedicated to both customer care
and product quality.

Contact
Kathleen Allain
22 Terrasse Bellini
92800 Puteaux
France

48

Phone: + 33 1 42 91 40 00
E-mail: kathleen.allain@airliquide.com

www.seppic.com
1st European Conference on Pharmaceutics Drug Delivery
Reims, France 13 - 14 April 2015

EXHIBITION
Reims, France 13 - 14 April 2015

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

49

Index
ADRITELF

51

ADVANTEST

BOOTH 17

51

AGILENT TECHNOLOGIES

BOOTH 37

52

APGI

52

APV

53

AR2I - ANALYTICAL LABORATORY FOR DEVELOPMENT BOOTH 25

53

ARMOR PHARMA

BOOTH 13

54

ASHLAND

BOOTH 12

54

BASF SE

BOOTH 16

55

BAYER

BOOTH 44

55

CAPSUGEL

BOOTH 14

56

DOW PHARMA & FOOD SOLUTIONS

BOOTH 01

56

ELSEVIER

BOOTH 39

57

EQUIPEMENTS SCIENTIFIQUES (ES) / MICROFLUIDICS

BOOTH 10

57

EVONIK INDUSTRIES AG

BOOTH 02

58

GAMLEN TABLETING LTD.

BOOTH 20

58

GLATT

BOOTH 15

59

MALVERN INSTRUMENTS

BOOTH 08

59

MEDELPHARM

BOOTH 17

60

NISSO CHEMICAL EUROPE GMBH

BOOTH 26

60

SHIN-ETSU

BOOTH 19

61

SIGMA-ALDRICH

BOOTH 38

61

SIRIUS ANALYTICAL

BOOTH 18

62

SOTAX AG

BOOTH 09

62

STRATGIE SANT

BOOTH 21

63

SYMPATEC GMBH SYSTEM | PARTIKEL | TECHNIK

BOOTH 04

63

SYNERSY

BOOTH 11

64

THERMO FISHER SCIENTIFIC

BOOTH 07

64

FLOORPLAN

50

66

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

ADRITELF
Founded in 1972, A.D.R.I.T.E.L.F. (Italian Association for Pharmaceutical
Technology and Regulatory Affairs) is a non-profit making scientific society
with about 300 active members from all over Italy. This Italian Association
of Professors and Academic Researchers of Pharmaceutics, Pharmaceutical
Technology, Biopharmaceutics and Regulatory Affairs is devoted to the
promotion of interactions and collaborations, throughout the world,
among researchers from academy and industry within these scientific
fields. The society is also actively involved in the education and training of
young researchers in the field of pharmaceutics. Together with APGI (France) and APSTJ (Japan), the association is publishing the "Journal of Drug Delivery Sciences and Technologies". Main activities are the
biannual scientific congress and the cooperation with other scientific societies for the organization of international meetings.

Contact
Prof Anna Maria Fadda
Via Ospedale, 72
09100 Cagliari
Italy

Phone: +39 0 70 68 58 56 5
Fax:
+39 0 70 67 58 55 3
E-mail: mfadda@unica.it
www-3.unipv.it/adritelf/

Advantest Platinum sponsor


BOOTH 17
A world-class technology company, Advantest is the leading producer of
automatic test equipment (ATE) for the semiconductor industry and a
premier manufacturer of measuring instruments. The companys leadingedge systems and products are integrated into the most advanced semiconductor production lines in the world.
The company also focuses on R&D for emerging markets that benefit
from advancements in nanotech and terahertz technologies, and has recently introduced critical multi-vision metrology scanning electron microscopes and 3D imaging analysis tools for pharmaceutical and industrial applications. Founded in Tokyo
in 1954 has subsidiaries worldwide.

Contact
Anthony Petrolonis
Director TAS Sales +
Business Development
508 Carnegie Ctr. # 102
NJ 08540 Princeton
USA

Phone: +1 6 09 89 77 32 6
E-mail: anthony.petrolonis@advantest.com

www.advantest.com

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

51

Agilent Technologies
BOOTH 37
Agilent is a leader in life sciences, diagnostics and applied chemical markets. The company provides laboratories worldwide with instruments,
services, consumables, applications and expertise, enabling customers to
gain the insights they seek.
Agilent has one of the broadest solutions portfolios of any company serving the pharmaceutical industry. Our solutions provide precise answers
for every segment of the pharmaceutical industry, from disease research
and drug discovery to drug development, manufacturing and quality
control. The start-to-finish solution set means customers can get products to market faster. Customers
trust us to help them test the purity of their therapeutics. Agilent also ensures that their instruments and
processes conform to the highest compliance regulations.

Contact
Luc Arnaud
3 Avenue du Canada
91978 Les Ulis
France

Phone: +33 6 72 99 03 25
E-mail: luc_arnaud@agilent.com
www.agilent.com/home

APGI
The APGI (Association de Pharmacie Galnique Industrielle/International
Society of Drug Delivery Sciences and Technology) was created in 1964 in
Paris, and is an association accessible to all, academics and individuals in
industry, who are concerned with pharmaceutical technology and the design, formulation and pharmacotechnical, biopharmaceutical and pharmacokinetic assessment of dosage forms and delivery systems, whether
pharmaceutical or dermopharmaceutical. The APGI has members covering
more than thirty different nationalities and counts contacts and friends in
over fifty countries. The APGI is a member of the FIP (Fdration Internationale Pharmaceutique).
The APGI is publishing the newsletter La Gazette and the scientific publication the Journal of Drug Delivery Sciences and Technology, which is the official journal of the APGI, the A.D.R.I.T.E.L.F. (Italy) and the
APSTJ (Japan).

Contact
Catharina Kroling
5 Rue Jean-Baptiste Clement
92296 Chateney-Malabry
France

52

Phone: +33 6 29 36 67 39
E-mail: apgi.asso@u-psud.fr

www.apgi.org

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

APV
The APV (International Association for Pharmaceutical Technology) is a
non-profit scientific association located in Mainz, Germany, which publishes its own scientific journal (EJPB European Journal of Pharmaceutics
and Biopharmaceutics). At present, the association is governed by an executive board consisting of 8 members.
Membership is granted upon application.
The APV organises approximately 100 events of various types ranging from expert meetings, seminars
and conferences to international scientific
congresses and exhibitions.

Contact
Dr Martin Bornhft
Kurfrstenstr. 59
55118 Mainz
Germany

Phone: +49 6 13 19 76 90
Fax:
+49 6 13 19 76 96 9
E-mail: apv@apv-mainz.de
www.apv-mainz.de

AR2i - Analytical Laboratory for Development


BOOTH 25
AR2i is a Contract Research Organisation (CRO) with expertise in chemical analysis methods and which carries out research and development
work in the fields of pharmaceuticals, parapharmaceuticals and cosmetics.
The AR2i laboratory was established in 1994 by scientists working in the
industrial, hospital and university sectors.
The main activity of AR2i lies in assisting its clients in the development of
new drugs with the view to obtaining a CTD agreement. The R&D support is a main dimension to AR2is
activity, its consists in development and validation of analysis methods, stability studies for pharmaceutical products, expert assessments for clients, in particular pharmaceutical laboratories and consultancy
firms. We develop analytical methods for raw materials, finished products or bulk substances.

Contact
Christian Sarbach
18-20 avenue Edouard Herriot
92350 Plessis-Robinson
France

Phone: +33 1 45 37 10 93
Fax:
+33 1 45 37 04 21
E-mail: contact@ar2i.fr
www.ar2i.fr

1st European Conference on Pharmaceutics Drug Delivery


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53

armor pharma Platinum sponsor


BOOTH 13
ARMOR PHARMA manufactures and markets 3 ranges of pharmaceutical
grade lactose for all your applications:
- ARMOR PHARMA lactose monohydrate: sieved & milled lactose
- EXCIPRESS: lactose for Direct Compression
- EXCIPURE: lactose for Dry powder Inhalation
Its state of the art industrial facility, located in Brittany, FRANCE, is in full
compliance with pharmaceutical standards (cGMP, GDP, PAT) and enables
the production of lactose in line with pharmaceutical regulations: Ph-EU, USP-NF and JP.
ARMOR PHARMA's ambition is to design solutions that best support customers development. Its positionning reflects this philosophy, centred on a question that makes sense: How would you like your lactose?

Contact
Phone: +33 2 99 18 39 29
E-mail: contact@armor-pharma.com
www.armor-pharma.com

Ashland Platinum sponsor


BOOTH 12
Since the 1950s, Ashland has provided solutions for tablet binding, film
coating and disintegration, controlled-release formulation and drug solubilization including Aqualon and Blanose sodium carboxymethylcellulose, Aqualon ethylcellulose, Aquarius coating systems,
AquaSolve and AquaSolve AS hypromellose acetate succinate (hydroxypropylmethylcellulose acetate succinate or HPMCAS), Benecel
methylcellulose and hypromellose, Cavamax*, Cavitron and Cavasol*
cyclodextrins, Klucel hydroxypropylcellulose, Natrosol hydroxyethylcellulose, Plasdone povidone and copovidone and Polyplasdone crospovidone.
*Registered trademark owned by Wacker Chemie AG. Ashland Inc. acts as a worldwide distributor for
Wacker.

Contact
Dr. Christian Mhlenfeld
Pharmaceutical Scientist

Phone: +49 2 11 74 9 11 38
E-mail: cmuehlenfeld@ashland.com
www.ashland.com

54

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

BASF SE Platinum sponsor


BOOTH 16
BASFs Pharma Ingredients & Services produces and markets a broad
range of active ingredients and excipients, as well as exclusive synthesis
services for the pharmaceutical industry. Our products are made using
the latest technologies, to the highest quality standards and in compliance with cGMP guidelines. The division has been a trusted partner to
the pharmaceutical industry for decades and customers benefit from our
unique expertise and extensive experience. Innovation is at the heart of
BASFs business and our excipients portfolio reflects our commitment to
research and development as highlighted by products such as Kollicoat
Smartseal 30D, Soluplus and Ludiflash or our end-to-end dermatology
portfolio.

Contact
Florian Wildschek
Chemiestr. 22
68623 Lampertheim
Germany

Phone: +49 6 21 60 76 93 4
Fax:
+49 6 21 60 76 93 2
E-mail: florian.wildschek@basf.com
www.pharma-ingredients.basf.com

Bayer
BOOTH 44
Bayer is a global enterprise with core competencies in the fields of health
care, agriculture and high-tech polymer materials. As an innovation company, it sets trends in research-intensive areas. Bayers products and services are designed to benefit people and improve the quality of life.
At Bayer you have the opportunity to be part of a culture where we
value the passion of our employees to innovate and give them the
power to change.
We are looking forward to informing you about entry and career opportunities at Bayer.

Contact
Bayer University & Talent Relations
Hauptstrae 105
51368 Leverkusen
Germany

Phone: +49 2 14 30 64 00 0
E-mail: universitymarketing@bayer.com

www.career.bayer.de

1st European Conference on Pharmaceutics Drug Delivery


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55

Capsugel
BOOTH 14
Capsugel is a global leader in delivering high-quality, innovative dosage
forms and solutions to its customers in the health care industry. The
company's Hard Capsule business unit offers customers the broadest
portfolio of gelatin, vegetarian and other specialized capsule technologies. Capsugels Dosage Form Solutions (DFS) business unit solves customers most pressing product development challenges, including
bioavailability enhancement, modified release, abuse deterrence, biotherapeutic processing, and inhalation formulation. Capsugel DFS accelerates and improves product development through an array of proprietary
technologies including lipids and liquids, spray-dried dispersions, hot-melt extrusions, an through specialized manufacturing including FDA/MHRA-accredited finished dosage sites that can handle highly potent,
controlled substance, hormonal and oncology compounds. Headquartered in Morristown, N.J., Capsugel
serves more than 4,000 customers in more than 100 countries.

Contact
Phoenix Barringer
64550 Research Rd.
Morristown, N.J.,
USA

Phone: +1 5 41 38 24 10 0
E-mail: phoenix.barringer@capsugel.com

www.capsugel.com

DOW Pharma & Food Solutions Platinum sponsor


BOOTH 01
Dow Pharma & Food Solutions is a leader in global research, manufacturing and innovation of pharmaceutical excipients. It is dedicated to developing new technologies that will enhance the formulation, solubilisation
and delivery of active ingredients and boasts an outstanding portfolio of
cost-effective, high quality cellulose ethers and polyethylene oxide chemistries such as ETHOCEL, POLYOX, METHOCEL, WALOCEL and
AFFINISOL.
Dow has developed the AFFINISOL line of excipients to facilitate
solubility enhancement:
Our AFFINISOL polymers are uniquely tailored to address the solubilization performance requirements
of your APIs, whether you have chosen to formulate via Spray-Dried Dispersion or Hot Melt Extrusion.

Contact
Marielle Fiore
Bachtobelstrasse 3
8810 Horgen
Switzerland

56

Phone: +41 4 47 28 25 73
Fax:
+41 4 47 28 31 50
E-mail: Fiore@dow.com
www.dowpharmaandfood.com
1st European Conference on Pharmaceutics Drug Delivery
Reims, France 13 - 14 April 2015

Elsevier
BOOTH 33
Elsevier is a world-leading provider of information solutions that enhance
the performance of science, health and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of
knowledge and human progress. In pharmaceutical sciences, Elsevier publishes leading journals like Advanced Drug Delivery Reviews, the Journal
of Controlled Release, the European Journal of Pharmaceutical Sciences,
the European Journal of Pharmaceutics & Biopharmaceutics (with APV),
the International Journal of Pharmaceutics, and the Journal of Drug Delivery Science and Technology (with APGI, Adritelf and APSTJ).

Contact
Anne Marie Pordon
Radarweg 29
1043 NX Amsterdam
The Netherlands

Phone: +31 6 12 98 41 28
Fax:
+31 2 04 85 32 28
E-mail: a.pordon@elsevier.com
www.elsevier.com

Equipements Scientifiques (ES) / Microfluidics


BOOTH 10
We are an Exclusive producer of Microfluidizer high shear fluid processors. Microfluidizer Processor Technology is used for Emulsification (dispersion of one liquid phase into another liquid phase) and for dispersion
of a solid into a liquid.
The Microfluidizer processor excels at: Particle size reduction, Cell disruption, nano Emulsions, encapsulation and Liposomes.
The innovative technology solutions offered by Microfluidics are used
globally by laboratories for synthesis and formulation, as well as for production. The combined performance and scalability of Microfluidics
equipment is well known and acknowledged in the world of Nanotechnologies. 40 years serving customers worldwide with over 3000 machines for 2000 customers. Equipements Scientifiques (ES) is our local Partner in France for all inquiries relating to Microfluidcs products.

Contact
Daniel Guez
Equipements Scientifiques
127 rue de Buzenval
92380 Garches
France

Phone: +33 1 47 95 99 90
Fax:
+33 1 47 0 16 22
E-mail: bio@es-france.com
www.es-france.com
www.microfluidicscorp.com

1st European Conference on Pharmaceutics Drug Delivery


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57

Evonik Industries AG
BOOTH 02
Evonik, a global leader in specialty chemicals, with its Health Care Business Line provides pharmaceutical excipients, drug delivery technologies,
development services, and GMP manufacturing for oral and parenteral
formulations as well as active pharmaceutical ingredients.

Contact
Dr. Christian Thlig
Business Director Northern
and Western Europe

Phone: +49 6 15 11 8 35 12
Fax:
+49 6 15 11 8 84 35 12
E-mail: christian.thuelig@evonik.com

Kirschenallee
64293 Darmstadt
Germany

www.eudragit.com
www.resomer.com

Gamlen Tableting Ltd.


BOOTH 20
Gamlen Tableting Ltd developed and market the Gamlen Tablet Press
(GTP), a unique benchtop, computer controlled tablet press used for formulation development, product evaluation and small scale manufacturing. The GTP is ideal for use in both the laboratory and university
setting. It has been shown to accurately predict the compression behaviour of materials on high speed production machines operating at full
speed, and is an important tool for measuring the compactibility of drug
substances, excipients, and drug products. Its super-accurate force and
displacement measurement are also used to measure in-die compression
parameters such as Heckel and Kawakita plots.

Contact
Michael Gamlen

Phone: +44 1 15 91 24 27 1
Fax:
+44 1 15 91 24 27 8
Biocity Nottingham Pennyfoot Street E-mail: michael.gamlen@gamlentableting.com
Nottingham NG1 1GF
United Kingdom
www.gamlentableting.com

58

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

Glatt
BOOTH 15
Glatt Pharmaceutical Services develops and produces solid pharmaceutical dosage forms. Our focus is on multiparticulate systems such as pellets, micropellets and granules. Whether you are looking for optimal
bioavailablity or taste masking, improved solubility or stabilization of the
dosage form, we have the right solution for every challenge. Glatt Pharmaceutical Services brings together fundamentals, experience and innovative technology expertise. With our comprehensive services, we
support you from product idea to market launch.
For clinical studies and market supply, we manufacture medicines in bulk and efficiently bring your products to market. Our technical capabilities facilitate a seamless scale-up from the lab to commercial production scale, for which we conduct all requisite analytical studies and stability tests. These services are
provided in sites Binzen/Germany and in Ramsey, New Jersey in the United States.

Contact
Philippe Tschopp
Werner-Glatt-Str. 1
79589 Binzen
Germany

Phone: +49 7 62 16 64 50 6
E-mail: philippe.tschopp@glatt.com

www.glatt.com

Malvern Instruments
BOOTH 08
Malvern Instruments characterizes particles ranging from powders to
proteins. The new laser particle size analyzers measure size, charge,
shape and molecular weight. In 2014 Malvern acquired MicroCal and
sells and installs ITC (Isothermal Titration Calorimetry) and DSC (Differential Scanning Calorimetry). Malvern launched in January 2015 a new system called PEAQ for GPC/SEC which follows a new SEC MALS detector
in 2014. The company is also heavily involved in the Biosciences with 5
new instruments: Viscosizer using the Taylor dispersion, Morphologi G3
ID combining image analysis and Raman spectroscopy, Archimedes characterizing protein aggregates, Helix identifying chemical bonds with DLS
combined with Raman and Nanosight to count nanoparticles in complex
environments.
Contact
Michel Terray
30 rue Jean Rostand
91893 Orsay-Cedex
France

Phone: +33 1 69 35 11 65
Fax:
+33 1 60 19 13 26
E-mail: Michel.Terray@malvern.com
www.malvern.com

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

59

MEDELPHARM Platinum sponsor


BOOTH 17
MEDELPHARM, headquartered in Lyon, are specialist developers & manufacturers of innovative solutions for R&D Tablet Presses and powder characterization services. In addition to manufacturing tablet presses
MEDELPHARM also offer a comprehensive range of Powder Compaction
and Characterisation Services
- Powder analysis and characterization
- Theoretical and hand-on training on tablet presses and tools
- Troubleshooting in production
- Process optimization
MEDELPHARM R&D Tablet Presses portfolio includes:
- STYL'One CLASSIC Multilayer development press,
- STYL'One Evolution, the latest servo-mechanical Compaction simulator,
MEDELPHARM are exclusive distributors in France of ADVANTEST, FITZPATRICK, OHARA, QUADRO,
RIVA, Romaco Kilian and XPLore

Contact
Ingrid Coyle
Director Sales International &
Business Development
12, rue des Petites Combes
01700 Beynost (Lyon)
France

E-mail: icoyle@medelpharm.com

www.medelpharm.com

NISSO CHEMICAL EUROPE GmbH


BOOTH 26
NISSO CHEMICAL EUROPE GmbH (NCE) was founded in 1989 as a subsidiary of Nippon Soda Co., Ltd. Tokyo, Japan. Based in Dsseldorf, NCE is
able to respond swiftly and effectively to customer needs both in Europe
and Africa. NISSO HPC (Hydroxypropyl Cellulose) is one of the key products for NISSO group. NCE distributes NISSO HPC to European, and
African market, offering a wide range of viscosities and particle size formats for wet granulation, direct compression, ODT, modified release,
and film coating applications. NISSO HPC is EP, USP/NF, and JP compliant.
Latest unique offering are special low viscosity grades of NISSO HPC.
Contact
Dr. Berna Ehlig
Berliner Allee 42
40212 Dsseldorf
Germany

60

Phone: +49 2 11 13 06 68 60
Fax:
+49 2 11 32 82 31
E-mail: ehlig@nisso-chem.de
www.nissoexcipients.com
1st European Conference on Pharmaceutics Drug Delivery
Reims, France 13 - 14 April 2015

Shin-Etsu
BOOTH 19
Shin-Etsu began producing pharmaceutical excipients in 1962. Since
then, thanks to feedback from our customers and inspection by the FDA,
we have further developed and improved our quality and control systems
to high standards. Shin-Etsu's cellulose excipients can make a valuable
contribution in various areas of pharmaceutical technology, for example
as film coatings (Pharmacoat), solid dispersion (Shin-Etsu Aqoat
HPMCAS), matrix tablets (Metolose SR), enteric coating (HPMCP and
HPMCAS)and ODT (L-HPC & SmartEx).
Our technical services we have now opened a new application laboratory for customer trials, and are
now offering QbD samples kits for your development. Please visit the booth for more information.

Contact
Veronique Henner

E-mail: Veronique.Henner@SE-PFMD.com
www.se-pfmd.com

SIGMA-ALDRICH
BOOTH 38
Sigma-Aldrich is a leading Life Science and High Technology company.
Our biochemical and organic chemical products and kits are used in
scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical
and other high technology manufacturing.

Contact
Dr Bruno Lelong
LIsle DAbeau Chesnes
BP 701
38297
Saint Quentin Fallavier
France

Phone: +33 6 03 36 33 27
E-mail: bruno.lelong@sial.com

www.sigmaaldrich.com/materials-science.html

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

61

Sirius Analytical Main sponsor


BOOTH 18
Sirius Analytical is the market leader in instrumentation and CRO services for measurement of pKa, logP/logD, Solubility and Dissolution
in aqueous, solvent, biorelevant media and in the presence of formulation additives.
Our unique solutions for automated supersaturation measurement
reveal new insights about the pH-dependent supersaturation a compound can exhibit and how supersaturation may be enhanced or
suppressed via the use of formulation additives and excipients.
With facilities in the US and UK Sirius offers global coverage with detailed and reliable analysis, expert
staff and rapid turnaround.

Contact
Paul Whittles
Forest Row Business Park
Station Road, Forest Row
East Sussex, RH18 5DW
United Kingdom

Phone: +44 1 34 28 20 72 0
Fax:
+44 1 34 28 20 72 5
E-mail: sales@sirius-analytical.com

www.sirius-analytical.com

Sotax AG
BOOTH 09
SOTAX, founded in 1973 in Switzerland, is a fast-growing group leader
in providing high-quality dissolution testing systems, composite assay
and content uniformity workstations, and physical tablet testing instruments for the pharmaceutical industry throughout the world. SOTAX
also offers SPS Pharma Services (CRO), a contract research lab dedicated
to dissolution testing research, and integrated the Zymark automation
product line, resources and services in 2008. Since 2013, the Dr. Schleuniger Pharmatron brand completes the SOTAX product portfolio and
expertise in the physical testing segment.
Contact
Samir Haddouchi
SPS Pharma Services
3 rue Chateaubriand
45071 Orleans Cedex 2
France

62

Phone: +33 6 18 74 34 53
Fax:
+33 2 34 59 72 60
E-mail: samir.haddouchi@sps-pharma.com

www.sps-pharma.com

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

Stratgie Sant
BOOTH 21
Stratgie Sant is an independent French company providing assistance and advisory services to Pharmaceutical Companies.
Thanks to our proven expertise in Pharmaceutical Development, Project Management and Regulatory Affairs, we support our clients
throughout all phases of the product development. We helps clients
to achieve the best development strategy, take in charge each stage
of the project, select and coordinate all sub-contractors from the raw
material sourcing to the registration batches manufacturing, including completion of the technical parts of the dossier. Our regulatory
expertise enables us to advise clients in elaborating the most efficient
registration strategy. We assure the writing (CTD and eCTD) and the registration of the dossier, including
its follow-up all over the product life cycle.

Contact
Didier Terracol
19, rue Georges Clemenceau
78000 Versailles
France

Phone: +33 1 42 86 86 00
Mobile:+33 6 06 71 39 44
E-mail: didier.terracol@strategiesante.com
www.strategiesante.com

Sympatec GmbH System | Partikel | Technik


BOOTH 04
Sympatec develops, manufactures, sells, services and supports an innovative range of best instruments for particle size and shape analysis in laboratory and process for customers worldwide. With
continuous innovations in the technological fields of laser diffraction,
dynamic image analysis, ultrasonic extinction and photon cross-correlation spectroscopy (PCCS), Sympatec makes a prominent contribution to the development, production and quality control of most
challenging particulate systems. Typical applications cover dry
powders and granules, fibres, suspensions, emulsions, gels, sprays
and inhalants within a size range from 1 nm to 34,000 m. Modular
instruments show great versatility and can be adapted to the specific task within your laboratory. The
proven measurement technologies are also available for integration into your process. Moreover, all instruments reliably deliver most accurate, reproducible and comparable results at shortest measuring
times. Sympatec The Particle People.

Contact
Philippe Violle
18 rue Charles de Gaulle
91400 Orsay
France

Phone: +33 1 69 18 19 55
Fax:
+33 1 69 28 16 73
E-mail: pviolle@sympatec.com
www.sympatec.com

1st European Conference on Pharmaceutics Drug Delivery


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63

Synersy
BOOTH 11
Synersy is an independent French company specialized in sales & services for dissolution, transdermal diffusion and physical testing.
Synersy is working with several reliable suppliers all over the world,
manufacturing high quality systems & accessories:
- Hanson: world leader in dissolution test technology for the
pharmaceutical industry
- Cambtek RES: new technology system for improvement of content
uniformity analysis
- Argus Dissolution from Solvias: most powerful, flexible & multipurpose dissolution software
- Electrolab physical testing systems & USP4: high quality & cost effective systems
- Uniflex: innovative system for dissolution vessels cleaning.

Contact
Celine Terrats
13 Rue Lavoisier
66600 Rivesaltes
France

Phone: +33 9 63 69 53 97
Fax:
+33 4 68 51 45 31
E-mail: c.terrats@synersy.fr
www.synersy.fr

Thermo Fisher Scientific


BOOTH 07
Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with revenues of $17 billion and approximately 50,000
employees in 50 countries. Our mission is to enable our customers to
make the world healthier, cleaner and safer. We help our customers
accelerate life sciences research, solve complex analytical challenges,
improve patient diagnostics and increase laboratory productivity.
Through our premier brands Thermo Scientific, Applied Biosystems,
Invitrogen, Fisher Scientific and Unity Lab Services we offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support.
Contact
Cristina Zara

Phone: +39 02 95 05 92 26
Fax:
+39 02 95 05 92 56
E-mail: cristina.zara@thermofisher.com
www.thermoscientific.com

64

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

INSPIRING
TECHNOLOGIES

Your partner
for transdermal patches
and oral thin films

LTS LOHMANN THERAPIE-SYSTEME AG


LOHMANNSTRASSE 2, 56626 ANDERNACH, GERMANY, WWW.LTSLOHMANN.DE

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

65

Floor Plan Reims, France 13 - 14 April 2015

BUREAUX
REIMS
EVENEMENTS
REIMS
EVENEMENTS
BUREAUX
MENTS

TERRASSE

WARDROBE

SECURITY

Poster pannels

Poster pannels

27

28

29

30

EVONIK

03

BUFFET
1,662
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26

Platinum
Sponsor

01

DOW

02

BUF

SOTAX

Poster pannels

31

35

Poster pannels

32

34
Poster pannels

33

36

ES/MICROFLUDICS

SYNERSY
11

10

09
GAMLEN
TABLETING

Main Sponsor
18

SHINETSU

20

S,5,86$1$/<7,&$/

Platinum
Sponsor

ASHLAND
12

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Platinum
Sponsor

$
3+

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AGILENT

$5L

STRATEGIE
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37

BUFFET

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IRU 'HYHORSPHQW

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RECEPTION DESK
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Booths 9m2
Booths recommended to
PLATINIUM Sponsors >

High Tabl
Available

BOOKED

Poster pa

Electricity
Available

66

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

BUREAUX OFFICE DE TOURISME DE REIMS


TERRASSE

TERRASSE

WARDROBE

LEVEL 1

(/6(9,(5

39


FET

40

APGI Desk

SYMPATEC

Equipped 8 m2 booths with a meeting room


Meeting Meeting
Room
Room

45

BAYER Meeting Meeting


Room
Room
4

46
45

43

latinum
Sponsor

5025
+$50$
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CAREER CENTRE

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BUFFET

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Paravents

LEVEL 1

Paravents

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hibition

es
Exihibition-Lunch/Coffee Break - Champagne reception Area

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Manifestation : ADRITELF - APGI -APV

y in the floor if needed

1st European Conference on Pharmaceutics Drug Delivery


Reims, France 13 - 14 April 2015

Dates : 13 & 14 April 2015

= 2 mtres

67

Power of Purity
Looking to enhance the bioavailability,
delivery and efficacy of your dosage form?
With Crodas high purity functional excipients and formulation expertise you
can discover how to get the best performance from your active ingredients.
Croda offers a complete range of products including high purity
multicompendial solvents, solubilisers and surfactants to meet your
needs across all delivery forms. Our Super RefinedTM excipients will
optimise the delivery and stability of your APIs and drug formulations
while maintaining API integrity.
To discover how to maximise oxidative stability, optimise API stability
and increase API delivery contact us:
www.crodahealthcare.com
Europe, Middle East & Africa hc-europe@croda.com

Innovation you can build on

TM

A new range of ingredients for nutri-cosmetics


to improve Skin
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Beauty
ENCAPSULATION
SOLUTIONS

At SEPPIC, we know that every application has unique challenges and


requirements.
We can offer excipients and solutions for various encapsulation
technologies, including:

Prilling

Hot Melt Coating

Coacervation
For more information, contact:
Mr Yves DUCCINI
Business Development Manager
Email: yves.duccini@airliquide.com
Phone: + 33 6 82 81 87 84

80%

9 high-potential projects

4.8 bn

of our development
projects are biologics

are in late-stage*

of investment in R&D
in 2013

EXPLORING THE BOUNDARIES OF MEDICAL INNOVATION


Sanofi has created an open innovation model, based on solid collaborations with its partners
and the scientific community. With this new R&D approach, Sanofi can meet its main challenges:
accelerating the transformation of scientific innovation into targeted therapeutic solutions for
patients and developing new biologic entities.
www.sanofi.com

DRUG
DELIVERY

EVERYTHING UNDER CONTROL FROM R&D TO


SCALE-UP AND PRODUCTION

MEDELPHARM S.A.S
12, rue des petites
Combes, Z.I. Nord
F-01700 Beynost,
France
+33 478 976 210
www.medelpharm.com

Medelpharm headquartered in Lyon, is a specialist developer and manufacturer


of unique solutions for R&D tablet presses & powder characterization services
Medelpharm is an exclusive distributor in France, Switzerland and Belgium of
ADVANTEST Fitzpatrick OHara Quadro Romaco Kilian and Xplore

Protect. Deliver.
Stabilize. Enhance.

From matrix to film coating, your full-service


pharmaceutical technology resource
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With good chemistry great things happen.

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Sirius Analytical
Forest Row Business Park, Forest Row, East Sussex, RH18 5DW, UK
Telephone:+44 (0) 1342 820720 Fax:+44 (0) 1342 820725
Email: sirius@sirius-analytical.com www.sirius-analytical.com