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SEC 1G
ANATOMY
growth
hormone (50%)
Lactotrophs prolactin (1030%)
b. Basophils
Gonadotrophs FSH and LH
(20%)
Corticotrophs ACTH and
MSH (10%)
Thyrotrophs TSH (5%)
2. Chromophobes
o Degranulated secretory cells
SEC 1G
Target gland
Anterior
Pituitary
Gonadotrophin
releasing
hormone
(GnRH)
Corticotropin
relaeasing
hormone (CRH)
Anterior
Pituitary
Growth
hormone releasing
hormone
(GHRH)
Growth
hormone
inhibitory
hormone
(somatostatin)
Prolactin
Inbibiting
hormone
(PIH)
Anterior
Pituitary
Anterior
Pituiatry
Action
Stimulates
secretion of
trophic
hormones (TSH)
Stimulates
secretion of
gonadotropes
(FSH, LH)
Stimulates
secretion of
coticotropes
(ACTH)
Stimulates
secretion of
somatotropes
(GH)
Anterior
Pituiatry
Inhibits
secretion of
somatotropes
(GH)
Anterior
Pituiatry
Inhibits synthesis
and secretion of
lactotropes
(prolactin)
ENDOCRINE AXIS
Three levels of Endocrine Axis:
1. Hypothalamus
2. Pituitary Gland
3. Peripheral Endocrine Gland
Hypothalamic-Pituitary-Thyroid Axis
Hypothalamus -> release TRH -> stimulates the anterior
pituitary -> release TSH -> stimulate the thyroid gland ->
release thyroid hormones T3, T4
Effect
Thyrotropin control the rate of section of T3
and T4 which control the rate of most
intracellular reactions in the body
If there is a release of T4, peripherally it will be
converted into T3. Target tissues: Heart, liver, gonads,
CNS.
If there is an increase T3 and T4 there will be a negative
feedback to the pituitary gland and the hypothalamus
TSH also has a strong tropic effect and
stimulates hyperthrophy, hyperplasia, and
survival of thyroid epithelial cells
GONADOTROPIN RELEASING HORMONE (GnRH)
Gonadotrope secretes FSH and LH
Secreted in a pulsatile manner
SEC 1G
Secretions:
1 pulse per hour increase in LH secretion (luteal
phase)
1 pulse in 3 hours increase in FSH secretion (follicular
phase)
Continuous infusion down regulation/decrease of
receptors
Hypothalamic-Pituitary-Gonadal Axis
Hypothalamus -> release GnRH (LHRH) -> stimulates
anterior pituitary -> release of LH and FSH -> stimulates
gonads (ovaries and testis) -> release of estrogen,
progesterone, testosterone, inhibin
The FSH will stimulates the ovaries/testis to
produce Inhibin
Increase levels of Inhibin will cause a negative
feedback to the hypothalamus and pituitary
gland
In women, progesterone and testosterone has a
negative feedback on the gonadotropic function
at the level of hypothalamus and pituitary
Estrogen levels
A low dose of estrogen negative feedback on
FSH and LH secretion
High estrogen levels maintained for 3 days
cause a surge in LH (ovulation will occur) and to
a lesser extent, FSH secretion (positive
feedback)
PROLACTIN
Produced by Lactotrope
Structurally related to GH and HPL (Human
Placental Lactogen)
Acts on non-endocrine cells: mammary gland
It is normally under tonic inhibition by the
hypothalamus: Dopamine
It is one of the many hormones released in
response to stress
Stimulated by TRH and PRH
Actions:
Physiological development of the breast and
SEC 1G
SEC 1G
2. Frolichs Syndrome
- Adipogenitalis syndrome (involves
hypothalamus and pituitary gland)
Adiposogenital Dystrophy
- Usually associated with tumours of the
hypothalamus
causing
increased
appetite and depressed secretion of
gonadotropin
- Rare childhood metabolic disorder
characterized by: obesity, growth
retardation and retarded development
of the genital organs.
3. Simmonds Disease
- Destruction of hypothalamus and
pituitary gland
4. Sheehans Syndrome
- Destruction of adenohypophysis during
pregnancy due to massive bleeding thus
causing necrosis of the pituitary gland
ABNORMALITIES ASSOCIATED WITH GROWTH
HORMONE
Dwarfism
Pre-pubertal GH deficiency
Generalized deficiency of anterior pituitary
secretion
Well-proportional
Does not pass through puberty
No hypothyroidism
No mental retardation
Could have sexual infantilism
Cute dwarf
Other Dwarfism
1. Laron Dwarfism
- GH insensitivity due to a defect in GH
receptors and a marked decrease in
IGF-1
2. African Pygmies
- Rate of GH secretion is normal or high
but IGF-1fails to increase at the time of
puberty
3. Glucocorticoid excess
4. Cretinism
- Thyroid hormone deficiency
- Ugly dwarf
Excess in Growth Hormone
1. Gigantism
- Excessive
GH
secretion
before
adolescence -> giant
- Full blown diabetes mellitus -> increase
blood glucose level (hyperglycemia)
2. Acromegaly
- Acidophilic
tumors
occur
after
adolescence
- Bone can become thicker, soft tissues
can continue to grow
- Enlargement of hands and feet
- Course facial features
- Visceralomegaly (tongue, liver, kidney)
- Skin thickening
SEC 1G
Polyuria
Polydipsia
Hypotension
Dilute Urine
SEC 1G
Clinical Features
Water retention and weight gain
Edema
Hypertension
Serum dilution
OXYTOCIN
Increased oxytocin will stimulate estrogen that
will dominates uterus to contract and initiate
labor
Orgasm will stimulate oxytocin release thus
contracting uterus to facilitate transport of
sperm
Suckling the nipple
Actions of Oxytocin
1. Contraction of the myoepithelial cells in the
mammy glands
- Milk is forced from the alveoli into the
ducts and delivered to the infant
- Mechanism: Milk letdown or Milk
Ejection
2. Contraction of the uterus
- During pregnancy the number of
oxytocin receptors increases as
parturition approaches