THVLPFEKINEGFDLLRSGESI

Primary

Quaternary

Secondary

Tertiary

Tertiary Structure
Arrangement of
secondary structure within
a single polypeptide

Quaternary Structure
Arrangement of several
polypeptides within a protein
complex

SCOP Protein Folds

1500

1000

500

New Folds

Total Folds

Protein Structures
100000
75000
50000
25000
0

Total Folds

Total Structures

Image credits:

All molecular structures were created from copyright-free PDB files available at www.pdb.org. The PDB
identifier of each file, and the original reference, are provided here for scholarly purposes.

Alcohol dehydrogenase: PDB ID 1ADC
Li H, Hallows WH, Punzi JS, Pankiewicz KW, Watanabe KA, et al. (1994) Crystallographic studies of
isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two
ternary complexes. Biochemistry 33: 1173411744.

Carbonic anhydrase: PDB ID 1CA2
Eriksson AE, Jones TA, Liljas A (1988) Refined structure of human carbonic anhydrase II at 2.0 A
resolution. Proteins 4: 274282. doi:10.1002/prot.340040406.

Myoglobin: PDB ID 1MBO
Phillips SE (1980) Structure and refinement of oxymyoglobin at 1.6 A resolution. J Mol Biol 142: 531554.

Hemoglobin: PDB ID 2DN1
Park S-Y, Yokoyama T, Shibayama N, Shiro Y, Tame JRH (2006) 1.25 A resolution crystal structures of
human haemoglobin in the oxy, deoxy and carbonmonoxy forms. J Mol Biol 360: 690701. doi:10.1016/
j.jmb.2006.05.036.

Image credits (key appears at end of video)

1PLQ:
Krishna TS, Kong XP, Gary S, Burgers PM, Kuriyan J. Crystal structure of the eukaryotic DNA
polymerase processivity factor PCNA. Cell(Cambridge,Mass). 1995;79: 12331243. doi:
10.1016/0092-8674(94)90014-0
1STD:
Lundqvist T, Rice J, Hodge CN, Basarab GS, Pierce J, Lindqvist Y. Crystal structure of
scytalone dehydratase--a disease determinant of the rice pathogen, Magnaporthe grisea. Structure.
1994;2: 937944. doi:10.1016/S0969-2126(94)00095-6
4TIM:
Noble ME, Verlinde CL, Groendijk H, Kalk KH, Wierenga RK, Hol WG. Crystallographic and
molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the
predicted and observed structures of the complex with 2-phosphoglycerate. J Med Chem. 1991;34:
27092718.
1TSP:
Steinbacher S, Seckler R, Miller S, Steipe B, Huber R, Reinemer P. Crystal structure of P22
tailspike protein: interdigitated subunits in a thermostable trimer. Science. 1994;265: 383386.
4BCL:
Tronrud DE, Matthews BW. Refinement of the Structure of a Water-Soluble Antenna Complex
from Green Photosynthetic Bacteria by Incorporation of the Chemically Determined Amino Acid
Sequence. Photosynthetic Reaction Center. 1998;1: 13null.
2POR:
Weiss MS, Schulz GE. Structure of porin refined at 1.8 A resolution. JMolBiol. 1992;227: 493
509. doi:10.1016/0022-2836(92)90903-W
1AFC:
Zhu X, Hsu BT, Rees DC. Structural studies of the binding of the anti-ulcer drug sucrose
octasulfate to acidic fibroblast growth factor. Structure. 1993;1: 2734. doi:
10.1016/0969-2126(93)90006-3

Image credits (key appears at end of video)

1BRS:
Buckle AM, Schreiber G, Fersht AR. Protein-protein recognition: crystal structural analysis of
a barnase-barstar complex at 2.0-A resolution. Biochemistry. 1994;33: 88788889.
2BBK:
Chen L, Doi M, Durley RC, Chistoserdov AY, Lidstrom ME, Davidson VL, et al. Refined crystal
structure of methylamine dehydrogenase from Paracoccus denitrificans at 1.75 A resolution. J Mol Biol.
1998;276: 131149. doi:10.1006/jmbi.1997.1511
1BL8:
Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, et al. The structure of
the potassium channel: molecular basis of K+ conduction and selectivity. Science. 1998;280: 6977. doi:
10.1126/science.280.5360.69
2CCY:
Finzel BC, Weber PC, Hardman KD, Salemme FR. Structure of ferricytochrome c from
Rhodospirillum molischianum at 1.67 A resolution. J Mol Biol. 1985;186: 627643.
2HLA:
Garrett TP, Saper MA, Bjorkman PJ, Strominger JL, Wiley DC. Specificity pockets for the side
chains of peptide antigens in HLA-Aw68. Nature. 1989;342: 692696. doi:10.1038/342692a0
1CCA:
Goodin DB, McRee DE. The Asp-His-Fe triad of cytochrome c peroxidase controls the
reduction potential, electronic structure, and coupling of the tryptophan free radical to the heme.
Biochemistry. 1993;32: 33133324.
1MSA:
Hester G, Kaku H, Goldstein IJ, Wright CS. Structure of mannose-specific snowdrop
(Galanthus nivalis) lectin is representative of a new plant lectin family. NatStructBiol. 1995;2: 472479.
doi:10.1038/nsb0695-472
1DFJ:
Kobe B, Deisenhofer J. A structural basis of the interactions between leucine-rich repeats and
protein ligands. Nature. 1996;374: 183186. doi:10.1038/374183a0

2CCY

1BL8

4TIM
1CCA

1STD

1BRS

2BBK

4BCL

1PLQ
1DFJ

2POR

1TSP
2HLA

1AFC
1MSA