B.

Tech (Hons) in Biotechnology and Biochemical Engineering

Semester 3
Sl. Course
Name
Number
No. code
1. IC-9
MA20103 Mathematics (Partial
different equation)
2. D1
BT20005 Biochemical Reaction
Engineering &
Bioenergetics
3. D2
BT20001 Biochemistry

P Credit Semester

0 3

0 4

0 4

4.

D3

BT20003 Microbiology

0 3

L1

0
0
0

0 2
0 2
3 2

6.

Bio-Sc
2
Env Sc
2
BT29001 Biochemistry Laboratory 0

7.

IP-3

EA19003 EAA-3

3 0

8.

L2

BT29003 Microbiology Laboratory 0

3 2

15

9 22

5.

Total

Semester 4
Sl. Course Number
No. code
1

IC-10

2.

IC-11

3.

D4

4.

D5

5.

B1

6.

IL-7

7.

L3

IP-4

Name

Credit Semester

MA20102 Mathematics
(Probability &
Statistics)
Basic Electronics

BT20002 Cell & Molecular

Biology
Economics (HSS as
Dept core)
(HSS) B1

Basic Electronics Lab 0

15

22

BT29002 Cell & Molecular

Biology Laboratory
EA19004 EAA-4
Total

Semester 5
Sl. Course Number
No. code

Name

P Credit Semester

0 4

0 4

1.

D6

2.

D7

CH20003 Chemical Process

Calculations
BT30005 Genetics

3.

D8

CH30005 Mass Transfer 1

0 4

4.

D9

0 4

5.

B2

BT31007 Environmental
Biotechnology
Breadth (MNGT)

0 3

6.

L4

3 2

7.

L5

BT39003 Biochemical Engineering 0 0

Laboratory
BT39001 Analytical Biochemistry 0 0
Laboratory
15 2
Total

3 2

6 23

Semester 6
Sl. Course Number Name
No. code
1. D10
BT30006 Plant Cell Tissue culture

Credit Semester

2.

D11

BT30008 Bioinformatics

3.

D12

BT61030 Protein Engineering

4.

D13

BT31014 Immunology

5.

L6

6.

L7

BT39006 Plant Cell and Tissue

0
culture laboratory
BT39008 Bioinformatics Laboratory 0

7.

L8

CH39018 Mass Transfer Lab

12 2

20

Total

Semester 7
Sl. Course Number Name
No. code
01 D14
BT40009 Bioprocess Technology

P Credit Semester

0 4

02. B3

Breadth ( IT)

0 3

03. E1

Elective -1

0 3

04. E2

Elective -2 (Flexible)

0 3

05. L9

BT49001 Enzyme Technology

Laboratory
BT48017 Summer/ Industrial
Training
BT47015 Project Part I

3 2

0 2

6 4

12

9 21

06. ST
07. P1

Total
Semester 8
Sl. Course Number Name
No. code
01. E3
Elective 3

L T P Credit Semester
3

0 3

02. E4

Elective 4

0 3

03. E5

Elective 5 :

0 3

04. E6

Elective 6 (Flexible)

0 3

05. D15

BT41022 Neurophysiology

0 4

06. CV

BT48026 Comprehensive Viva

0 2

07. P2

BT47024 Project Part 2

9 6

Total

15 0

9 24

Total credits :
1st Semester : 23
2nd Semester : 24
3rd Semester : 22
Total credits : 179

4th Semester : 22
5th Semester : 23
6th Semester : 20

7th Semester :
8th Semester :

21
24

Elective I
Sl. Course Number Name
No. code
01.
CY50005 Drug Design and developments

Credit

02

CY50007 Chemistry of Natural products

03.

CY50009 Spectroscopic methods for

structure determination
BT41021 IPR in Biotechnology

CS41009 Principles of programming

languages

04.
05.

Elective 2 (Flexible)
Sl.
Course Number Name
No. code
01.
BT41013 Bioreactor Analysis and design
02
03.

BT41011 Transport phenomena in

Bioprocesses
CH42005 Project Engineering

Elective 3
Sl. Course
No. code

Number

01.

Credit

P Credit

MM6008 Cancer Biology

0 3

02.

BT41024 Bioresource Technology

0 3

03.

CH42002 Non conventional Energy

Engineering

0 3

P Credit

Elective 4
Sl.
Course Number
No. code

Name

Name

01

BT41018 Metabolic Engineering

0 3

02.

MS41006 Biomaterials

0 3

03.

CH20004 Phase equilibrium

thermodynamics

0 4

Elective 5
Sl. Course Number Name
No code
01
CE31218 Biomechanics

P Credit

0 3

02.

CS41022 Artificial intelligence

0 3

03.

CS23005 Design and analysis of algorithm 3

0 3

Elective 6 (Flexible)
Sl. No. Course Number Name
code
01.
BT40016 Downstream processing

P Credit

0 3

02.

BT41020 Food Biotechnology

0 3

03.

CE31302 Environmental Engineering 3

0 3

Minor requirement in Biotechnology and Biochemical engineering

(six theory subjects and one lab).
Total Credit 23
Number
Subject

L-T-P Credit

BT 20001

Biochemistry

3-1-0

BT20003

Microbiology

3-0-0

BT29003

Microbiology Lab

0-0-3

BT20005

Biochemical Reaction
3-1-0
Engineering and
Bioenergetics
Bioreactor analysis and
3-0-0
design (Elective)
Cell and Molecular Biology 3-1-0

Downstream Processing
(elective)

BT41013
BT20002
BT40016

3-0-0

3
4

23

DETAILED SYLLABUS OF B.TECH (HONS)

IN
BIOTECHNOLOGY & BIOCHEMICAL ENGINEERING ( SOM committee)
29_01_09)
SEMESTER - 3
1.

BT20001 Biochemistry (3-1-0=4) :

Chemistry and metabolism of biopolymers (Carbohydrates; lipids; proteins; nucleic
acids and nucleoproteins), vitamins and hormones. Amino acid, Primary, Secondary,
tartiary and quaternary structure of proteins. Nutritional aspects of lipids;
carbohydrates and proteins. Physiological functions of vitamins; minerals and
hormones. Enzymes and co-enzymes. Glycolytic pathway and TCA cycle. Electron
transport and oxidative phosphorylation. Plant and microbial biochemistry photosynthesis, Difference in respiratory mechanisms of aerobes and anaerobes.
2. BT29001 Biochemistry Laboratory (0-0-3=2) :
Estimation of amino acid, protein, total protein, phospho-protein, from different
biological samples; electrophoresis; effect of pH temperature; substrate concentration;
concentration of enzyme; Km; Vmax and Ki determination of half-life period of the
enzyme and effect of protein denaturant.
3. BT20003 Microbiology (3-0-0=3) :
Microbial taxonomy including modern approaches of taxonomy such as DNA
homology and numerical taxonomy. Different groups in bacteria. Morphology and
cell structure of prokaryotes and eukaryotes (bacteria; fungi, algae and viruses);
different culture techniques; isolation and preservation methods. Microbial
metabolism: nutrition; Media and methods; effect of environment; metabolic products
of industrial importance. metabolic pathways. amphicatabolic and biosynthetic.
Growth; Synchronous and asynchronous, pure culture; growth inhibitory substances.
Effect of environment; Sporulation and cell differentiation; Water; food and milk
microbiology; Transformation, conjugation and transduction. Plasmids as vectors,
Deletions, base pair subsitutions and frame shift mutations.
4. BT29003 Microbiology Laboratory ( 0-0-3=2) :
Experiments on isolation-streak plate, spread plate, enrichment culture; staining and
measurement of microbes; Effect of environment of microbial growth. lyophilisation.
Testing of microbiological qualities of milk and water. Growth and product
formation- batch culture, enzyme production; assay of enzymes. Microbial assay of
antibiotics. Studies on auxotrophs.

5. BT20005 Biochemical Reaction Engineering and Bioenergetics ( 3-1-0=4)

Biochemical Reaction Engineering; Kinetics of homogeneous reactions; reaction
mechanism; Temperature dependency from Arrhenius law; Theoretical prediction of
rate constant: Interpretation of batch kinetic data; Kinetics of enzyme catalyzed
reactions in free and immobilized states: Michaelis-Menten equation and its various
modifications. Effects of External mass transfer in immobilized enzyme systems;
analysis of intra-particle diffusion and reaction; Kinetics of substrate utilization,
product formation and biomass production: Monod growth model and its various
modifications; structured and unstructured kinetic rate models; Thermal death
kinetics of cells and spores;
Chemical mechanisms of biological energy conversion in mitochondria and
chloroplasts, Experimental studies and theories photosynthesis energy transfer
kinetics; Cytochrome c oxidase (Cytochrome Oxidase Oxygen Heme) or photosystem
II (Photosystem II Manganese Oxygen); bacteriorhodopsin proton pumping); DNA
base recognition and replication fidelity; Gibbs Free Energy; Protein folding and
stability; Ligand binding; Protein-Protein and Protein-DNA interactions; Osmosis,
Dialysis; Donnan Effect; Practical techniques e.g.: Isothermal Calorimetry (ITC);
Spectroscopy; Fluorescence and Scanning Microscopy; X-ray diffraction
SEMESTER 4

1. BT 20002 Cell & Molecular Biology ( 3-1-0=4) :

Structure and function of nucleus; organization of the chromosome; eu-and
heterochromatins; nucleosome; cell cycle regulation - CDC mutants, protein kinase;
cyclin; synthetic pattern and control of cell divisions; biochemistry of meiosis. The
biochemical basis of inheritance; DNA as the genetic material; DNA structure,
nucleotide sequence composition: unique, middle and highly repetitive DNA;
Redundant DNA; DNA replication in Prokaryotes and eukaryotes; Genetic Code;
transcription and translation machinery in Prokaryotic and eukaryotic system.
Regulation of gene expression in E. coli-operon concept; Lac and Trp operon,
hormonal control of gene expression in eukaryotes. RNA processing, Posttranslational modification of proteins.
2. BT29002 Cell & Molecular Biology Laboratory (0-0-3=2) :
Microscopy; chromosome staining schedules; study of mitosis and meiosis;
differential staining of euchromatin and heterochromatin; chromosome staining by
fluorescence dye; photomicrography and dark room techniques. Isolation of genomic
DNA; quantification of DNA; restriction digestion; agarose gel electrophoresis;
Isolation and analysis of RNA. Southern blotting.

SEMESTER 5

1. BT39003 Biochemical Engineering Laboratory (0-0-3=2)

Demonstration of various bioreactor configurations, parts and integrated process
control systems; In-situ sterilization of medium; Sterilization cycle; Arrhenius plot;
Air sterilization; Efficiency of air filters; Microbial death kinetics; Determination of
Nabla Factor and L90 Value; Demonstration of inoculation and sampling in a CSTR;
Determination of mixing time and Power number; Demonstration of batch, fed-batch
and continuous processes in CSTR, Microbial cell growth kinetics; Determination of
volumetric mass-transfer coefficient (KLa). Preparation and characterization of
immobilized enzymes, Determination of kinetic constants in free and immobilized
enzyme systems, Evaluation of Effectiveness factor and Thiele modulus; Studies on
biotransformations in continuous flow reactors (Packed-bed and Plug-flow).
2.CH20003 Chemical Process Calculations (3-1-0) Prerequisite None
Numerical techniques for solving material & energy balance equations.
Material balance with and without chemical reactions: recycle, bypass, purge
calculations, computer based calculations. Vapor-liquid equilibrium: Bubble point,
dew point calculations, phase envelop calculations. Introduction to Fuels (solid, liquid
and gas): Important properties and specifications. Energy balances with and without
chemical reactions; psychrometric calculations; fuel calculations, adiabatic flame
temperature; computer-based calculations for energy balance.
3. BT 30005 Genetics (3-0-0=3)
Mendelian inheritance, physical basis of inheritance, gene interaction, multiple
alleles, complementation, linkage, recombination and chromosome mapping,
extrachromosal inheritance, sex determination, special types of chromosomes.
Chromosomal variations: numerical - euploidy and aneuploidy; structural - deletion,
duplication, inversion and translocation. Genes at the population level. Bacterial and
viral genetic systems: genomes of E.coli, lambda, and other DNA and RNA viruses.
Molecular mechanisms of recombination; mutagenesis; and transposable elements.
Molecular basis of genetic diseases and genetic counseling. Application of molecular
genetic techniques.
4. CH30005 Mass Transfer- I (3 1 0) Prerequisite none
Fundamentals of mass transfer: Diffusional mass transfer, mass transfer coefficients,
steady state and unsteady state theories of mass transfer, interphase mass transfer,
Whitmans two film theory and its variations, multiphase contacting equipments,
concept of transfer unit, unified approach to staged processes.

Distillation: Vapour-liquid Equilibria x-y, t-x-y, P-x-y and H-x-y diagrams;

Henrys, Raoults and Daltons Laws; Ideal and Non-ideal solutions Azeotropes;
Relative Volatility; Flash Vaporization; Differential Distillation; Steam Distillation;
Continuous Rectification Staged Calculation using Ponchon-Savarit and McCabeThiele Methods; Complex/Multi-draw Configuration; Packed Distillation Column;
Multicomponent Distillation; Azeotropic and Extractive Distillations; Performance
Evaluation of Distillation Columns including Reboilers and Condensers.
Absorption: solubility, choice of solvent, concept of rate approach and stage wise
approach, stage-wise and continuous contact absorbers; rich and lean gases;
absorption with chemical reaction. Counter-current and co-current multistage
operations, dilute and concentrated systems, process design and performance
evaluation of absorbers.
Crystallisation: Theory of solubility & crystallization, phase diagram (temp/solubility
relationship), crystal geometry; crystal nucleation and growth; equilibria and yields;
population balance analysis, method of moments for rate expressions for, volume,
area and length growth, CSD distribution, MSMPR operation, programmed
evaporative and cooling (rate expressions), most dominant size, ideal classified bed,
melt crystallization, process design of crystallisers and their operation, selection and
specification of crystallisers like OSLO, Swenson Walker, agitated type, etc.
performance evaluation of crystallisers
5. BT39001 Analytical Biochemistry Lab (0-0-3=2)
Visible, UV and Fluorescence spectroscopy; High performance thin layer
chromatography, High performance liquid chromatography, Fast protein liquid
chromatography, Gas chromatography, Poly acrylamide gel electrophoresis
6. BT31007 Environmental Biotechnology (3-0-0=3)
Introduction to environmental biotechnology, definitions and facts. Overview of
microbial transformations. Environmental monitoring: bioreporter, biomarker and
biosensor technology. Metagenomics/environmental genomics. Bioprospecting.
Biomicroelectronics and Nanobiotechnology. Bioremediation of inorganic (metal,
radionuclide, nitrate, phosphate) and organic pollutants. In situ and ex situ
remediation strategies. Biotechnology of sewage treatment. Clean technologies:
biofertilizers, biopesticides, microbial polymer production and bio plastic technology.
Biotechnology of fossil fuels: desulfurization of coal, oil shales, microbial enhanced
oil recovery (MEOR). Biofuels: biogas, biohydrogen, bioethahnol production.
Biotechnology of mineral processing. Ethical issues in environmental biotechnology.

SEMESTER 6
1. BT30006 Plant Cell and Tissue Culture
Fundamentals of plant tissue culture, plant regeneration: organogenesis. Somatic
embryogenesis; somaclonal variation, its genetic basis and application in crop
improvement. Cell/callus line selection for resistance to herbicide, stress and diseases.
Role of tissue culture in rapid clonal propagation, production of pathogen - free plants
and "synthetic seeds"; haploid production: advantages and methods. Protoplast
technology: isolation, culture and plant regeneration, protoplast fusion, identification
and characterization of somatic hybrids, applications of protoplast technology.
Specific gene transfer: indirect and direct methods, current status and limitations.
Automation in plant tissue culture. Field techniques for propagation of regenerated
plants.
2. BT 39006 Plant Cell and Tissue Culture Lab ( 0-0-3=2)
Explant selection, sterilization and inoculation; Various media preparations; MS, B5,
SH PC L-2; Callus and cell suspension culture; Induction and growth parameters;
Chromosomal variability in callus culture. Plant regeneration from embryo, meristem
and callus culture. Androgenesis: Anther and pollen culture; Isolation and culture of
protoplasts.
3. BT30008 Bioinformatics (3-1-0=4)
Introduction to Bioinformatics; Data bank: Protein and Nucleic acid; Data Bank for
different organisms. Sequence analysis, Analysis Tools for Sequence Data Bank;
Pairwise and Multiple sequence alignment, Secondary Structure predictions, Fold
recognition. Data analysis.
4. BT 39008 Bioinformatics Laboratory ( 0-0-3=2)
Understanding databases, understanding NCBI Entrez, Pairwise alignment and
multiple alignment, BLAST analysis of nucleotide and protein sequences, Gene
finding (Genescan, ORF finder, Translation etc.), Sequence analysis (restriction map,
repeat sequence identification, secondary structure prediction etc.), Primer design for
PCR, Genome analysis (ongoing and completed genome), Phylogenetic tree
constructions, protein structure prediction and functional analysis.
5.CH39018 Mass Transfer Laboratory (0-0-3=2):
Prerequisite CH30005 & CH30010
Experiments: Determination of Diffusion Co-efficient of Air-Acetone By Stefan's
method, T-X-Y equilibrium diagram for binary mixture, Batch Distillation, Sieve
Plate Distillation, Packed Bed Distillation Column, Flooding and Loading in Packed

Tower, Water Cooling Tower, Liquid-Liquid Extraction, Rotating Disk Contactor,

Liquid-Liquid Extraction in Sieve Plate Column, Drying Characteristics of Wet
Solids in Flowing Air, Rotary Drier (Hold-Up), Rotary Drier (Drying Characteristics
of Wet Solids), Gas-Solid Adsorption
6. BT31012 Protein Engineering (3-1-0=4)
Introduction : Design and construction of novel proteins and enzymes, Conformation
of proteins in general and enzymes in particular, Effect of amino acids on structure of
proteins, Energy status of a protein molecule, Structure function relations of enzymes,
Physical methods such as x-ray crystallography for determination of protein structure,
Site directed mutagenesis for specific protein function, Basic concepts for design of a
new protein/enzyme molecule, Specific examples of enzyme engineering.
7. BT31014 Immunology (3-0-0=3)
The origin of immunology; inherent immunity; humoral and cell mediated immunity;
primary and secondary lymphoid organ; antigen; B cell, T cell and macrophages;
major histocompatability complex (MHC); antigen processing and presentation;
synthesis of antibody and secretion; molecular basis of antibody diversity, polyclonal
and monoclonal antibody, complement; antigen-antibody reaction; regulation of
immune response, immune tolerance; hyper sensitivity; autoimmunity; graft versus
host reaction.

SEMESTER 7

1. BT40009 Bioprocess Technology (3-1-0=4)

Classification of bio-products; Bioprocesses for production of organic acids; solvents;
antibiotics, proteins; polysaccharides; lipids; pigments and aroma. Equipment and
accessories for industrial process. Stability of enzyme: Enzymes stabilization by
selection and genetic engineering, protein engineering. Reaction environment
rebuilding, chemical modification, intramolecular cross linking and immobilization.
Application of biocatalysts : group transfers redox, elemination, isomerisation and
rearrangements, C-C bond cleavage,formations. Application of enzymes in industry,
analytical purpose and medical therapy.
2. BT49001 Enzyme Technology Laboratory ( 0-0-3=2)
Immobilization of enzyme by physical entrapment and covalent binding Physical
characterization of immobilized enzyme beads Determination of Km , Vmax and
thermal stability of immobilized enzyme and comparison of these parameters with
free enzyme- Study of immobilized enzyme in CSTR and plug flow reactor
Enzyme catalyzed reaction in water- solvent interface

SEMESTER 8
1. BT31007 Neurophysiology (3-0-0=3)
Nerve-Muscle Physiology: Neuron structure and function; Regeneration of
nerve;;Axoplasmic flow and transport mechanism in the axons; Nature of nerve fibre
excitation and interpretation of action potential; Significance of different nerve fibre
types. Structural architecture of Neuro-Muscular Junction (NMJ); Neuro-muscular
transmission Electrical and Biochemical events; Drugs acting at NMJ. Protein
components and contraction mechanism of muscles. B. Nervous System :
Interpretative function of cerebral cortex. Aging and its effect on brain, Regulatory
function of cerebellum and structure activity relationship (neural circuitory) of
cerebellum, Vestibular apparatus, hypothalamus and its functions, basal ganglia,
thalamo cortical projections.
Non-specific sensory mechanism Sleep and
wakefulness. Behavioral functions of the brain emotion, memory, learning and
consciousness, Pharmacology and chemical transmission autonomic nervous system.
C. Special Sense: Sensory modalities, Sensory receptors, Sensory circuits, and
Sensory perception. Taste system , Olfactory system, Visual Sense and Auditory
Senses

ELECTIVE SUBJECTS

ELECTIVE-1

1. CY50005 Drug Design and Development (3-0-0=3)

Approaches to Drug Design: Enzyme Inhibition, Molecular Recognition, Receptor
Based Molecular Modelling, QSAR, Agonist and Antagonist. Examples of Designed
Drugs: Antihypertensive, Antiviral, Anticancer and Antibiotic. Combinatorial Library
and Highthrouput Screening.
2. CY50007 Chemistry of natural Products (3-0-0=3)
Chemistry of selected natural products. Special emphasis on the synthesis of steroids,
terpenes, alkaloids, pheromones, prostaglandins, macrolides and polyether antibiotics.
Selected topics from the current literature.

3.CY50009 Spectroscopic Methods for Structure Determination (3-0-0=3)

Applications of UV, FT-IR Mass and NMR spectroscopy in organic, inorganic and
biological systems. Exercises on structure elucidation by joint applications.
4. BT31010 IPR in Biotechnology (3-1-0=4)
Juripredential definition and concept of property, rights, duties and their correlation;
History and evolution of IPR; Forms of IPR ? like patent, design and copyright;
Distinction among the various forms of IPR; Requirement of a patentable invention
likes novelty, inventive step, and prior art, state-of-art. Rights/protection,
infringement or violation, remedies against infringement ? civil and criminal; Indian
Patent Act 1970 and TRIPS; Major changes in Indian Patent system as post TRIPS
effects; Contents of patent specification and the procedure for patents; (a) Obtaining
patents; (b) Geographical indication; (c) WTO; Detailed information on patenting
biological products; Biodiversity; Budapest treaty; Appropriate case studies.

5. CS41009 Principles of Programming Languages (3-0-0=3)

The aim is to study and appreciate different types of languages and the underlying
mathematical theories. This may help to design and also to appreciate new language
features. Introduction : Overview of different programming paradigms e.g.
imperative, object oriented, functional , logic and concurrent programming. Syntax
and semantics of programming languages : A quick overview of syntax specification
and semiformal semantic specification using attribute grammar. Imperative and OO
Languages : Names, their scope, life and binding. Control-flow, control abstraction;
in subprogram and exception handling. Primitive and constructed data types, data
abstraction, inheritence, type checking and polymorphism. Functional Languages :
Typed -calculus, higher order functions and types, evaluation strategies, type
checking, implementation, case study. Logic Programming Languages : Computing
with relation, first-order logic, SLD-resolution, unification, sequencing of control,
negation, implementation, case study. Concurrency : Communication and
synchronization, shared memory and message passing, safety and liveness properties,
multithreaded program. Formal Semantics : Operational, denotational and axiomatic
semantics of toy languages, languages with higher order consstructs and types,
recursive type, subtype,semantics of nondeterminism and concurrency.
ELECTIVES-2 ( Flexible)
1.BT41013 Bioreactor Analysis and Design (3-0-0=3)
Types of reactors : batch, plug flow reactor (PFR), continuous stirred rank reactors
(CSTR), fluidized bed reactor, bubble column, air life fermenter, etc; concept of ideal
and non-ideal reactor; residence time distribution; Models of non-ideal reactors ? plug
flow with axial dispersion, tanks-n-series model; Chemostat model with cell growth

kinetics; Plug flow reactor for microbial processes; optimization of reactor systems;
Multiphase bioreactors ? packed bed with immobilized enzymes or microbial cells;
three ? phase fluidized bed trickling bed reactor; Design and analysis of the above
reactor systems; Gas liquid reactors; Unconventional bioreactors like Hollow fiber
reactor, membrane reactor, perfusion reactor for animal and plant cell culture.
2. BT41011 Transport Phenomena in Bioprocesses (3-0-0=3)
Unified approach to physical rate processes associated with momentum, mass and
energy transport. Differential and integral treatment on the conservation laws.
Momentum, mass and energy transfer in laminar and turbulent flow with applications
to interphase. Macroscopic balance. Molecular transport properties.

3.CH42005 Project Engineering (3-0-0=3)

Origin of chemical project; Feasibility studies; Techno-economic report; Plant
location and site selection; Capital cost estimation; Working capital estimation;
Profitability indices, Discounted cash flow, Cost-benefit analysis, Sensitivity
analysis; Process development, Process Selection, Process Design, Utilities, Scale up;
Optimization; Project Construction, Project scheduling, Network analyses; Project
report; Plant and Equipment specification
ELECTIVE-3

1. CH42002 Non conventional Energy Engineering (3-0-0=3)

Renewable sources of energy and their potential. Low temperature application of
solar energy - solar hot water, solar drying, solar refrigeration, etc. Theory,
performance analysis and testing of liquid flat plate collectors. Solar air heater and
their design principles. Concentrating collectors ? application and their designs.
Thermal energy storage. Solar photovoltaic conversion. Biomass and their
characteristics. Physical, thermo-chemical and biological methods of their
conversion. Wind energy and their electric conversion. Tidal, geothermal and ocean
thermal energy conversion systems.
2. MM 6008 Cancer Biology (3-0-0=3)
Oncogenes and cancer, tumor suppressor genes, growth factors and signal
transduction, signal transduction mechanism, cell cycle and apoptosis, angiogenesis,
different important bio-markers and targets for targeting cancer e.g.: epidermal
growth factors and its receptors, vascular epidermal growth factor and its receptors,
PI3-K and AKT and others, different compounds for cancer therapy, monoclonal
antibodies, small tyrosine kinase inhibitors and others. Combination therapy with

antibody or small tyrosine kinase inhibitors in combination with chemotherapeutics

drugs alone or with radiation. Ionizing radiation: a genetic switch for cancer therapy.
3. BT41024 Bioresource Technology (3-0-0=3)
Availability of different organic wastes; Characteristics of the solid and liquid
wastes; Cell growth and product formation kinetics; Different bioenergy generation
processes: biomethanation, biohydrogen, bioethanol, biodiesel; Bioreactor design and
analysis, Different advanced bioreactors; Comparative analysis on different bioenergy
generation processes; Energy and material analysis of the process; Scaling up
problems; Economic analysis of the process.

ELECTIVE-4

1. BT41018 Metabolic Engineering (3-1-0=4)

Basic concepts of Metabolic Engineering. Overview of cellular metabolism. Different
models for cellular reactions. Metabolic regulation network at enzyme level and whole
cell level. Examples of metabolic pathway manipulations. Metabolic pathway synthesis
algorithms. Metabolic flux analysis and its applications. Methods for experimental
determination of metabolic fluxes by isotope labeling. Analysis of metabolic control and
the structure metabolic networks. Thermodynamics of cellular processes. New concepts
for quantitative bioprocess research and development.
2.MS41006 Biomaterials (3-0-0=3)
Introduction to biomaterials, Structure and properties (mechanical, thermal, and surface)
of biomaterials: metals and alloys, composites, ceramic materials, polymeric materials,
Biocompatibility and blood compatibility, Biomaterials: its foreign body response in a
body, Characterization: mechanical and thermal, Biological interface, interaction with
biomaterials and adhesion, Biological response to implants, 2D & 3D matrices (scaffolds)
of biomaterials for tissue engineering, Soft tissue and hard tissue replacement,
Biologically functional biomaterials, Testing and clearance of biomaterials, Evaluation of
biomaterials.

3.

CH 20004 Phase equilibrium thermodynamics (3-1-0=4)

Estimation of properties: real fluids and their mixtures, Computer aided algorithms
for property estimation and their applications to chemical engineering processes, Heat
effects of industrial reactions - theory and applications; Thermodynamic cycles and
their applications, Multiphase processes and equilibria. Chemical reaction equilibria;
Thermodynamic analysis of real processes.

ELECTIVE-5
1.CE31218 Biomechanics (3-0-0=3)
Human body : musculo-skeletal system; Physical properties of bones and muscles;
Idealization of musculo-skeletal system; Kinematics and kinetics of rigid bodies;
Eulers equation; Lagranges equation; spring, mass, dashpot system; Sports
mechanics; Computer simulation of different atheletic activities; Design of
prosthetics and other accessories; Introduction to mechanics of other improtant limbs
: lungs, heart & kidney.
2.CS41022 Artificial Intelligence (3-0-0=3)
This course will cover basic ideas and techniques underlying the design of intelligent
computer systems. Topics include: Introduction to AI and intelligent agents. Problem
Solving : Solving Problems by Searching, heuristic search techniques, constraint
satisfaction problems, stochastic search methods. Game Playing : minimax, alphabeta pruning. Knowledge and Reasoning: Building a Knowledge Base: Propositional
logic, first order logic, situation calculus. Theorem Proving in First Order Logic.
Planning, partial order planning. Uncertain Knowledge and Reasoning, Probabilities,
Bayesian Networks. Learning : Overview of different forms of learning, Learning
Decision Trees, Neural Networks Introduction to Natural Language Processing.
Suggested Text Book: Artificial Intelligence: A Modern Approach Stuart Russell and
Peter Norving Prentice Hall, 1995
3.CS23005 Design and Analysis of Algorithms (3-0-0=3)
Algorithms and Complexity. asymptotic notations, orders, worst-case and averagecase, amortized complexity. Basic Techniques divide & conquer, dynamic
programming, greedy method, backtracking, branch and bound, randomization. Data
Structures heaps, search trees, union-find problems. Applications sorting &
searching, combinatorial problems, optimization problems, computational geometric
problems, string matching. Graph Algorithms BFS and DFS, connected
components, spanning trees, shortest paths, max-flow. NP-completeness.
Approximation algorithms.

Laboratory: The laboratory component will emphasize two areas:

.Implementation of algorithms covered in class: This will involve running the
algorithms under varying input sets and measuring running times, use of different
data structures for the same algorithm (wherever applicable) to see its effect on time
and space, comparison of different algorithms for the same problem etc.
Design of Algorithms: This will involve design and implementation of algorithms for
problems not covered in class but related to a topic covered in class. The exact set of
algorithms to design and implement is to be decided by the instructor. In addition,
there will be at least one significantly large design project involving some real world

application. An efficient design of the project should require the use of multiple data
structures and a combination of different algorithms/techniques.

ELECTIVE-6 (Flexible)
1. BT40016 Downstream Processing (3-0-0=3)
Introduction; An overview of bioseparation. Separation of cells and other insolubles
from fermented broth. Filtration and microfiltration, centrifugation (batch,
continuous, basket). Cell disruption: Physical methods (osmotic shock, grinding with
abrasives, solid shear, liquid shear), Chemical methods (alkali, detergents),
Enzymatic methods Products isolation: Extraction and adsorption method,
precipitation (ammonium sulphate. Organic solvents, high molecular weight
polymers), column chromatography; ultrafiltration., Products polishing:
Crystallization and drying.
2. BT41020 Food Biotechnology (3-0-0=3)
Microbial role in food process operation and production: new protein foods. SCP;
mushroom; food yeasts, algal proteins. Fermentation as a method of preparing and
preserving foods. Food additives like colouring, flavours and vitamins. Organisms
and their use of pickling; alcoholic beverages and other products. Mechanism of
enzyme functions and reactions in process techniques. starch and sugar conversion
processes or baking by amylases; de-oxygenation and desugaring by glucose oxidase;
beer mashing and chill-proofing or cheese making by proteases and various other
enzyme catalytic actions in food processing. Process wastes, whey; molasses; starch
substrates and other food wastes for bioconversion to useful products
3. CE31302 Environmental Engineering (3-0-0=3)
Man, environment and ecosystems. Their inter relationships. Types of environmental
pollutants, their sources and effects. Indoor pollution, Air pollution, sources,
quantities, effects and controls technologies. Noise pollution. Industrial wastes, and
their treatment. Solid wastes, generation, collection, processing and
disposal.Environmental impact assessment and auditing. Introduction to
Environmental laws and policies. Global issues on environment.