Professional Documents
Culture Documents
Physiology
Disorders
• PITUITARY DISEASES
• ADH DISEASES
• ADRENAL GLANDS DISEASES
• THYROID DISEASES
• PARATHYROID DISEASES
• PANCREAS DISEASES
“The Sequence”
Hypothalamus
↓
Pituitary Gland or Hypophysis
Anterior or Adenohypophysis
Posterior or Neurohypophysis
↓
Target Glands
The Hypothalamus
- This part of the DIENCEPHALON is located below the thalamus and is connected to the pituitary gland by a stalk
Physiology
- Secretes RELEASING HORMONES for the pituitary gland
- Releasing hormones= hypothalamus
APG
Adenohypophysis
- TSH - target thyroid gland
- ACTH - target adrenal gland
- ICSH - target testes (maturation of spermatozoa)
- GH - target epiphyseal plate (bone growth)
- FSH target ovary-estrogen (maturation of graafian follicles to release mature ovum)
- LH target graafian follicle (formation of corpus luteum to maturation of ova)
- MSH → skin (pigmentation)
- PROLACTIN → (maturation of mammary gland and production of milk)
PPG
Neurohypophysis
- ADH - target kidney tubules
(H2O reabsorption)
- OXYTOCIN – uterine contraction and ejection of milk
Target Glands
• Thyroid
• Adrenal
• Mammary
• Skin
• Bone plates
• Ovaries
• Testes
• Kidney tubules
• Uterus
Cortex
Mineralocorticoid:Aldosterone -Na & water reabsorption, K loss
Glucocorticoid: Cortisol - blood glucose regulation
Androgen: DHEA - sex hormones – testosterone
Medulla (catecholamines)
stress or sympathetic effect
Epinephrine and Nor-epinephrine
- neurotransmitters
• The GONADS
Anatomy
Ovaries
These two almond-shaped glands are found in the pelvic cavity attached to the uterus by the ovarian ligament
Testes
These two oval-shaped glands are found in the scrotum
Physiology
Ovary
- estrogen - affects devt of female sex organs and secondary sexual characteristics
- progesterone- influences menstrual cycle, stimulates the growth of uterine wall, and maintains pregnancy
Testes
- testosterone- affects the devt of male sex organs and secondary sexual characteristics
Pineal Gland
Melatonin (dec skin pigmentation, inhibit gonadotropic hormone)
• The Pancreas
- This retroperitoneal organ has both endocrine and exocrine functions
Anatomy
- The endocrine function resides in the ISLETS of Langerhans
- The islets have three types of cells- alpha, beta and delta cells
Physiology
- The ALPHA cells secrete GLUCAGON
- The BETA cells secrete INSULIN
- The DELTA cells secrete SOMATOSTATIN
Placenta
- HCG- maintains pregnancy
- estrogen, progesterone, human placental lactogen
Pancreas: Islet of langerhans
Alpha- glucagon- ↑blood sugar (hyperglycemia) by stimulating glycogenolysis & gluconeogenesis
Beta- insulin - ↓blood sugar (hypoglycemia) by facilitating transport of glucose across cell membranes of muscle, liver,
adipose tissue, inhibits breakdown of proteins
Caused by:
- trauma, tumor at the hypothalamus or pituitary gland
- complication from radiation therapy (head and neck)
- Panhypopituitarism (Simmonds’ Disease)- total absence of pituitary secretions
- Sheehan’s Syndrome – postpartum pituitary necrosis (bleeding)
Manifestations:
- Related to hypofunction of:
thyroid – hypometabolism
gonads – amenorrhea, impotence
adrenal glands - adrenal insufficiency
growth hormone – dwarfism, hypoglycemia
- Hemianopsia and headache – (if due to tumor)
- Increased ICP (if due to tumor)
Assessment Findings
- Retarded physical growth due to decreased GH dwarfism
- Low intellectual development
- poor development of secondary sexual characteristics
Management:
- Surgical removal of tumor
- Radiation
- HRT hormonal replacement therapy
• Pituitary Tumors
- Usually benign
- 3 Types
Eosinophilic Tumors
Basophilic Tumors
Chromophobic Tumors (most common)
Eosinophilic Tumors
- Gigantism (before puberty)
- Acromegaly (after puberty)
- Visual disturbance (compression from tumor)
• Hyperpituitarism
- hyper-secretion of the gland
- ACROMEGALY-after 15-16 yo
- Gigantism-before 15-16 yo
• Pituitary Tumors
Basophilic Tumors
- Cushing’s Syndrome
- Musculinization and amenorrhea (female)
Diagnostic:
- CT scan
- MRI
- Assessment Findings
Management:
- Drug
Bromocriptine (Parlodel) – to lower GH and Prolactin
- Radiation
- Surgery (transsphenoidal hypophysectomy)
Octreotide (Sandostatin) = preop drug to reduce tumor
Oral care
- Monitor LOC and neurologic status
- No activity that will increase ICP
- Watchout Diabetes Insipidus, Monitor I & O
- Observe for CSF leakage
- Administer prescribed medications
ASSESSMENT findings
- Signs of Hypervolemia
1. Mental status changes
2. Abnormal weight gain
3. DISORDERS OF the PITUITARY GLAND: Posterior gland
4. ASSESSMENT findings
5. Hypertension
6. Anorexia, Nausea and Vomiting
7. HYPOnatremia
Diagnostic Test
- Urine specific gravity is increased (concentrated)
- Hyponatremia
- CBC shows hemodilution
- SIADH
Management:
- FVE intervention
- Stop vasopressin
- Surgery (tumor excision)
Critical conditions:
- Pulmonary edema
- Cerebral edema
- Heart failure
- Hypertension
- Renal Failure
Nursing Interventions
1. Monitor VS and neurologic status
2. Provide safe environment
3. Restrict fluid intake (less than 500cc/day)
4. Monitor I and O and daily weight
5. Administer Diuretics and IVF carefully
6. Administer prescribed Demeclocycline to inhibit action of ADH in the kidney
• DI Diabetes Insipidus
- Decreased ADH secretion
- Decreased tubular reabsorption of water
= decreased blood volume
(high Hct, hyperosmolality, thrombosis)
- Increased urine output
= diluted urine (low S.G., clear urine)
- Watch out for manifestations of Fluid Volume Deficit
- Cause: trauma or injury to pituitary gland, resection of hypophysis, insensitivity of kidney to ADH
Assessment findings
1. Polyuria of more than 4 liters of urine/day
2. Polydipsia
3. Signs of Dehydration
4. Muscle pain and weakness
5. Postural hypotension and tachycardia
Diagnostic Test
1. Urinary Specific gravity very low, 1.006 or less
2. Serum Sodium levels high
Management:
- FVD intervention
- Synthetic ADH administration (vasopressin)
- Desmopressin (DDAVP) spray intranasal OD or BID
- Vasopressin tannate in oil = IM OD or every 4 days
Critical conditions:
- Thrombosis – thromboembolism – pulmonary embolism
- Ischemia
- Infarction
- Necrosis (CVA, MI, RF)
Nursing Interventions
1. Monitor VS, neurologic status and cardiovascular status
2. Monitor Intake and Output
3. Monitor urine specific gravity
4. Provide adequate fluids
5. Administer Chlorpropamide or Clofibrate as prescribed to increase the action of ADH if decreased
6. Administer VASOPRESIN. Desmopressin or Lypressin are given intranasal. Pitressin is given IM
Caused:
- tumor and trauma of the adrenal cortex
Conn’s Management:
- FVE intervention
- Stop sodium intake
- Critical conditions:
- Arrhythmias
- Hypertension
- Same with SIADH
Nursing Interventions
1. Monitor VS, I and O and urine sp gravity
2. Monitor serum K and Na
3. Provide Potassium rich foods and supplements
4. Administer prescribed diuretic- Spironolactone- K sparer
5. Maintain sodium-restricted diet
6. Prepare patient for possible surgical interventions
Pathophysiology
Assessment
1. Generalized muscle weakness and wasting
2. Truncal obesity
3. Moon-face
4. Buffalo hump
5. Easy bruisability
6. Reddish-purplish striae on the abdomen and thighs
7. Hirsutism and acne
8. Hypertension
9. Hyperglycemia
10. Osteoporosis
11. Amenorrhea
Management:
Diet: Low Sodium, High Potassium
FVE intervention
Replace potassium
Insulin administration
Hypertension
Surgery is adrenalectomy
Critical conditions:
Arrhythmias due to hypoK
Hypertensive crisis
Fluid overload
Hyperglycemia
• Addison’s Disease
- Adrenal cortex disorder/ tumor, idiopathic
- Hyposecretion of:
Mineralocorticoid: Aldosterone=Na and H2O excretion (hyponatremia, hypovolemia, hypotension), K reabsorption
(hyperkalemia)
Glucocorticoid=hypoglycemia
Androgen=decreased libido
↑ MSH=bronzing of the skin (primary)
Management
- FVD intervention
- Increase potassium excretion
- Glucagon or simple sugar administration
- Steroid medication
Nursing Interventions
- Monitor VS especially BP
- Monitor weight and I and O
- Monitor blood glucose level and K
- Administer hormonal agents as prescribed
- Observe for ADDISONIAN crisis
- Educate the client regarding lifelong treatment, avoidance of strenuous activities, stress and seeking prompt consult during
illness
- Provide a high-protein, high carbohydrate and increased sodium intake
Addisonian crisis
- A life-threatening disorders caused by acute severe adrenal insufficiency
Causes:
- Severe stress
- infection
- trauma or surgery
Pathophysiology
- Overwhelming stimuli mobilize body defense decreased stress hormones inadequate coping
ASSESSMENT Findings for Addisonian Crisis= “severe lahat”
- Severe headache
- Severe pain
- Severe weakness
- Severe hypotension
- Signs of Shock
- Addison’s Disease
Critical Conditions:
- Addisonian crisis – cyanosis, with signs of circulatory shock: pallor, apprehension, rapid and weak pulse,
- ↑ RR, and acute hypotension
- Dehydration
- Arrhythmias due to hyperkalemia
- Hypoglycemia
- Same with DI
Nursing Interventions
- Administer IV glucocorticoids, usually hydrocortisone
- Monitor VS frequently
- Monitor I and O, neurological status, electrolyte imbalances and blood glucose
- Administer IVF
- Maintain bed rest
- Administer prescribed antibiotics
Steroid
- Dose is variable
- Best time to give between 7-8 AM (active gland) to prevent side effects
- Steroid-induced adrenal insufficiency = TAPERING the DOSE
- Pituitary adrenal suppresion = DOSAGE CONTROL
- Steroid
- Hypertension, thromboembolism
- Prone to infection
- Glaucoma, corneal ulceration
- Muscle wasting, poor wound healing
- Osteoporosis,
- Hyperglycemia
- Weight gain, moon face, trunkal obesity, buffalo hump
- Acne
- MEDIC-ALERT CARD
• Addison’s Disease
Critical Conditions
- Dehydration
- Arrhythmias due to hyperK
- Hypovolemic shock
- Hypoglycemia
- Same with DI
- inc ACTH, inc cortisol = pituitary problem (benign tumor)
- normal ACTH, inc cortisol = adrenal problem (benign tumor)
- dec ACTH, dec cortisol = atrophy of the pituitary gland
- normal ACTH, dec cortisol = atrophy of the adrenal gland
• Pheochromocytoma
- Hyperfunction of adrenal medulla
- Cause: Tumor usually benign
- ↑catecholamines (nor E and E)
Diagnosis
- ↑VMA vanilly mandelic acid (urine specimen)
- ↑catecholamines (blood specimen)
- ↑blood sugar and glycosuria
- Monitor VS esp BP
- Give antihypertensive drugs:Phentolamine
- Provide high calorie foods
- Prepare pt forSurgical Intervention (adrenalectomy)
Abnormalities of the Thyroid Gland
• GOITER
- Iodine-deficient
- Goitrogenic = cabbage, beans
- Compensatory hypertrophy
- No s/sx, compression of the trachea
- SSKI to suppress pituitary’s TSH secretions
- Less than 40 fg/day of iodine = goiter
- Iodized salt = 1:100,000
- PREVENTION = iodized salt
Hypothyroidism
Hyperthyroidism
Note:
inc T3, inc T4, dec TSH = thyroid problem
inc T3, inc T4, inc TSH = pituitary tumor (benign)
• Hypothyroidism
Caused by:
- Autoimmune Disease (Hashimoto’s Thyroiditis)
- Use of radioactive iodine
- Destruction or removal of thyroid tissue
- Overtreatment of antithyroid drug
MYXEDEMA- Adults
CRETINISM- Children
3 Basic Concepts:
- Decreased metabolic rate due to hyposecretion of T3
- Decreased body heat production due to hyposecretion of T4
- Hypercalcemia due to hyposecretion of calcitonin
Assessment
1. Lethargy and fatigue
2. Weakness and paresthesia
3. COLD intolerance
4. Weight gain
5. Bradycardia, constipation
6. Dry hair and skin, loss of body hair
7. Generalized puffiness and edema around the eyes and face
Con’t of s/sx
- SQ swelling, puffy skin, puffy eyelids
- Thinning of hair, loss of lateral 1/3 of the eyebrow
- Menorrhagia or amenorrhea, decreased libido, abortions
- Myxedema = severe complication leads to coma
Management
- Symptomatic
- Monitor VS and daily weights
- Provide warm environment
- Diet: low calorie, high fiber
- Thyroid hormone replacement
- T4 Synthroid, Levothyroid
- T3 Cytomel
- T3 & T4 Proloid
- T3 given NGT, faster than T4
- T4 given parenterally(S.E. adrenal insuf.)
- Note: 3-12 wks S/Sx must disappear
• Hyperthyroidism
Caused by:
Grave’s Disease: Autoimmune
TSAb thyroid stimulating antibody duplicate
TSH, which increases thyroid hormone secretion ( ↑T3 and T4)
Toxic nodular goiter (benign, hot spot)
Overmedication of thyroid hormone
Severe emotional stress
3 Basic Concepts:
Increased metabolic rate due to hypersecretion of T3
Increased body heat production due to hypersecretion of T4
Hypocalcemia due to hypersecretion of calcitonin
Manifestations:
Nervousness, tremors, emotional lability
Weight loss, emaciated
Flushed skin, warm and moist
Increased temp and palpitation to atrial fibrillation
Heat intolerance
Hypertension
Difficulty in sitting quietly
Thyroid gland may be palpable and a (+) bruit
Diarrhea
Bulging eyes (exophthalmus), startled expression
Amenorrhea, oligomenorrhea, decreased libido
Delirium, disorientation, extreme nervousness
Arrhythmias
Thyroid storm = hyperpyrexia, diarrhea, dehydration,
tachycardia, arrhythmias, delirium, coma, shock, death
Exophthalmus
Thyroid Scan
MANAGEMENT
Beta blockers- Metoprolol: Inderal
to control tachycardia and hypertension
Thiomides- PTU (propylthiouracil) and Tapazole ( Methimazole)
to inhibit synthesis of thyroid hormone side effects: Agranulocytosis and neutrpenia
Radioactive Iodine – isolation for a few days, body secretions are radioactive contaminated
Surgery:Thyroidectomy: 5/6 of the gland is removed
SSKI (Lugol’s) is given preop to dec thyroid vascularity & to inhibit release of thyroid hormone
Given with juice to disguise taste
Given with straw to prevent staining of teeth
Postop:
Position: Semi-fowlers, neck at the midline
Monitor for bleeding, prevent hemorrhage by placing ice collar over the neck
Monitor blood pressure- to assess for TROUSSEAU’S Sign ( hypocalcemia)
Check for tetany and monitor for signs of hypocalcemia (parathyroid gland is severed)
give calcium gluconate
Hoarseness of voice-laryngeal nerve damage- ask the client to speak every hour
Watchout thyroid crisis
THYROIDECTOMY
Removal of the thyroid gland
NURSING INTERVENTIONS
1. Provide adequate rest periods in a quiet room
2. Administer anti-thyroid medications that block hormone synthesis- Methimazole and PTU
3. Provide a HIGH-calorie diet, HIGH protein
4. Manage diarrhea
5. Provide a cool and quiet environment
6. Avoid giving stimulants
7. Provide eye care
Hypoallergenic tape for eyelid closure
8. Administer PROPRANOLOL for tachycardia
9. Administer IODIONE preparation- Lugol’s solution and SSKI to inhibit the release of T3 and T4
10. Prepare clients for Radioactive iodine therapy
11. Prepare patient for thyroidectomy
12. Manage thyroid storm appropriately
Thyroid storm
An acute LIFE-threatening condition characterized by excessive thyroid hormone
CAUSE: Manipulation of the thyroid during surgery causing the release of excessive hormones in the blood
Hypoparathyroidism
Hyperparathyroidism
Parathyroid Gland
- produce parathyroid hormone/parathormone which regulates calcium and phosphorus balance
dec serum Ca level
↓
PTH release
↓
withdraws Ca from bones
↓
↑ serum Ca levels
Diagnostic:
- Decreased PTH
- Decreased serum Ca (7.5 mg/100 ml)
- Increased PO4
Manifestation:
- Hypocalcemia
- Tetany
- Numbness of fingers
- +Chvostek’s sign
- +Trousseau’s sign
- +Laryngeal spasm
- Severe anxiety and apprehension
- Muscle cramps
- Cardiac dysrhythmias
Management:
- Treat the cause
- IV calcium gluconate -Syringe and ampule of Ca sol. on bedside
- Oral Ca with Vit. D
• Hyperparathyroidism
Caused:
Primary
Tumor/adenoma
hyperplasia
Diagnostic:
- Increased vit D
- Increased PTH
- Increased serum Ca (11 mg/100 ml)
- Decreased PO4
Manifestation:
- Hypercalcemia
- Decalcification of bone
- Fracture
- Deep bone pain
- Depression of neuromuscular function
- Generalized fatigue
- Memory loss
- Dec LOC, stupor coma
Management:
- Treat the cause
- Hydration (IV saline)
- Diuretics (Ca excretion)
- Calcitonin (inhibits bone resorption)
- Dietary Ca restriction
- Avoid thiazide and vit D (may increase Ca)
- Dialysis
- Digitalis is withdrawn (may increase Ca)
Beta- insulin- ↓blood sugar (hypoglycemia) by facilitating transport of glucose across cell membranes of muscle, liver, adipose
tissue, inhibits breakdown of proteins, requires Na for transport of CHO and requires K for production
• Diabetes Mellitus
- DM is a disorder of glucose intolerance caused by a deficiency in insulin production and action resulting
in hyperglycemia and abnormal CHO, CHON and fat metabolism.
Types
Type I or IDDM
no insulin
diseased pancreas (beta cell)
Type II NIDDM
decreased insulin
inadequate insulin
Management
- Diet
- Activity/Exercise
- Insulin
Manifestations
- Polyuria- glucose exert high osmotic pressure w/in the renal tubules, osmotic diuresis occurs,
hypovolemia, ECF/ICF dehydration
- Polydipsia- results from ECF/ICF dehydration
- Polyphagia- the cells are starved
- Glycosuria- glucose level exceed renal threshold (180mg/dl)
- Inc Blood Viscosity- sluggish circulation, microorganism proliferation, infection
- Ketonuria
- Tissue wasting
- Weight Loss
Complications
- Macroangiopathies
brain: CVA
heart: Myocardial Infarction
peripheral arteries: peripheral vascular disease
- Microangiopathies
kidneys: renal failure
eyes: retinopathy/cataract
- Neuropathy
spinal cord/ ANS
paralysis
peripheral neuropathy
numbness/tingling sensation
neurogenic bladder
Management
- Diet
- Activity/Exercise
- Oral Hypoglycemic Agents
- Insulin- in case of stress, surgery, infection, pregnancy---these conditions trigger stress response and
stimulate the secretion of epi, norepi, glucocorticoids thereby causing hyperglycemia
- DIET- CHO 50%, Fats 30%, CHON 20%
- ↓ calorie specially if obese
- ACTIVITY/EXERCISE- ↑ CHO uptake by the cells, ↓ insulin requirements, maintains ideal body weight
done 1-2 hours after meals to prevent hypoglycemia
regular pattern
- MEDICATIONS: Oral Hypoglycemic Agents- indicated only in type II DM
- INSULIN
TYPES OF INSULIN
About Insulin!
Nursing Interventions
- Site – abdomen (best site), upper arms,
upper buttocks- rotate the site of injection
- Route – SQ, only REGULAR insulin can be given as IV bolus esp in case of DKA
(flush the line first it will absorb insulin)
- IV bolus – mixed with D5W if hypoglycemic, or PNSS ideal for DKA and HONKS
- Subcutaneous-Pinch or 45° for thin patient, 90° for regular client
- Good site must be supple skin.
- Mixed Insulin – regular (clear) first to be drawn followed by NPH (cloudy)
- Administer at room temp- cold insulin leads to lipodystrophy
- Refrigerate after use.
Diagnostic Evaluation
- Fasting Blood Sugar –80-120mg/dl
≥ 140 mg/dl for 2 readings
- 2H Postprandial Blood Sugar Test –
≥ 200 mg/dl
100 gm of sugar orally
then check after 2H
- OGTT -≥ 200 mg/dl
blood is withdrawn initially
150-300 gm of CHO/sugar PO
every hour bloos specimen is taken (1H,2H,3H after)
done when results of FBS and 2H PPBS are borderline
- Random Blood Sugar –
≥ 200 mg/dl for 2x + 3 P’s blood is withdrawn anytime
- Glycosylated Hg A1C -
can detect average serum
glucose level over preceding
2-3 months (most reliable)
Adult 2.2%-4.0%
Children 1.8%-4.0%