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Georg C. Terstappen*
Angelo Reggiani
Biology Dept,
GlaxoWellcome
Medicines Research
Centre, Via A. Fleming 4,
37135 Verona, Italy.
*e-mail: gct66554@
glaxowellcome.co.uk
http://tips.trends.com 0165-6147/01/$ see front matter 2001 Elsevier Science Ltd. All rights reserved. PII: S0165-6147(00)01584-4
Review
24
Target
Target
Lead
Lead
identification validation identification optimization
Target discovery
Lead discovery
Preclinical
evaluation
Clinical
evaluation
Market
Enzymes
(3500)
Nuclear hormone
receptors (>150)
TRENDS in Pharmacological Sciences
http://tips.trends.com
Review
25
Review
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Acknowledgements
We thank A.M. Capelli
(Chemistry Dept) and
F. Caldara (Dept Biology)
for helpful discussions
and comments on the
manuscript.
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