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Datasheet of AGN 190299

Description:.
The pharmacokinetics of AGN 190168, a novel synthetic retinoid, and its major metabolite, AGN 190299, in rat blood after
intravenous administration was investigated. Approximately 4.4 mg kg-1 (high dose) or 0.49 mg kg-1 (low dose) of AGN 190168
was administered to rats via the femoral vein. Blood was collected from the femoral artery at various time points during an 8 h
period. Blood concentrations of AGN 190168 and AGN 190299 were determined by a specific and sensitive high-pressure liquid
chromatographic (HPLC) method. AGN 190168 was rapidly metabolized in rats. The only detectable drug-related species in the
blood was AGN 190299. There Fore, only pharmacokinetics of AGN 190299 were calculated. Elimination of AGN 190299
appeared to be non-linear after administration of the high dose, and linear after administration of the low dose. The maximum
elimination rate (Vmax) and the concentration at half of the Vmax (km), as estimated by a Michaelis-Menten one-compartment
model, were 7.58 +/- 2.42 micrograms min-1 (mean +/- SD) and 6.10 +/- 1.58 micrograms mL-1, respectively. The value of the
area under the blood concentration time curve (AUC) was 9.54 +/- 1.68 micrograms h mL-1 after administration of the high dose
and 0.594 +/- 0.095 micrograms h mL-1 after administration of the low dose. The clearance value was 7.79 +/- 1.20 mL min-1
kg-1 after the high dose, statistically significantly different from that after the low dose (p < 0.05), 14.0 +/- 2.2 mL min-1 kg-1.
The terminal half-life (t1/2) was 1.25 +/- 0.74 h For the high-dose group and 0.95 +/- 0.16 h For the low-dose group. Study
results demonstrate rapid systemic metabolism of AGN 190168 to AGN 190299, non-linear pharmacokinetics of AGN 190299
after the 4.4 mg kg-1 dose, and the lack of difference in disposition profiles between sexes after intravenous administration of
AGN 190168 to rats.For the detailed information of Tazarotenic acid (AGN 190299), the solubility of Tazarotenic acid (AGN
190299) in water, the solubility of Tazarotenic acid (AGN 190299) in DMSO, the solubility of Tazarotenic acid (AGN 190299) in
PBS buffer, the animal experiment (test) of Tazarotenic acid (AGN 190299), the cell expriment (test) of Tazarotenic acid (AGN
190299), the in vivo, in vitro and clinical trial test of Tazarotenic acid (AGN 190299), the EC50, IC50,and Affinity of
Tazarotenic acid (AGN 190299), Please contact DC Chemicals.

Chemical Information
Catalog

DC7619

Purity of current batch:

>98%

Molecular Weight (MW)

323.40878

Molecular Formula

C19H17NO2S

CAS No.

118292-41-4

Solubility (25C)

DMSO

Storage

Store at -20C (desiccating conditions).

Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in
advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable
for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room
temperature for at least 1 hour.