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Hyperalgesia
From Wikipedia, the free encyclopedia
Hyperalgesia
Classification and external resources
ICD-9
782.0
(http://www.icd9data.com/getICD9Code.ashx?
icd9=782.0)
DiseasesDB 30788
(http://www.diseasesdatabase.com/ddb30788.htm)
MeSH
Contents
D006930
(https://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?
field=uid&term=D006930)
1 Types
2 Causes
3 Treatment
4 See also
5 References
Types
Hyperalgesia can be experienced in focal, discrete areas, or as a more diffuse, body-wide form. Conditioning
studies have established that it is possible to experience a learned hyperalgesia of the latter, diffuse form.
The focal form is typically associated with injury, and is divided into two subtypes:
Primary hyperalgesia describes pain sensitivity that occurs directly in the damaged tissues.
Secondary hyperalgesia describes pain sensitivity that occurs in surrounding undamaged tissues.
Opioid-induced hyperalgesia may develop as a result of long-term opioid use in the treatment of chronic pain.[2]
Various studies of humans and animals have demonstrated that primary or secondary hyperalgesia can develop
in response to both chronic and acute exposure to opioids. This side effect can be severe enough to warrant
discontinuation of opioid treatment.
Causes
Hyperalgesia is induced by platelet-activating factor (PAF) which comes about in an inflammatory or an allergic
response. This seems to occur via immune cells interacting with the peripheral nervous system and releasing
pain-producing chemicals (cytokines and chemokines).[3]
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Treatment
Hyperalgesia is similar to other sorts of pain associated with nerve
irritation or damage such as allodynia and neuropathic pain, and
consequently may respond to standard treatment for these conditions,
Look up hyperalgesia in
Wiktionary, the free
dictionary.
See also
Allodynia
References
http://en.wikipedia.org/wiki/Hyperalgesia
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