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DRUG PROFILE
2. DRUG PROFILE
2.1. DRUG PROFILE OF DOMPERIDONE:
DOMPERIDONE31:
Domperidone is a medication developed by Janssen Pharmaceutical that is a
peripheral, specific blocker of dopamine receptors. It is administered orally, rectally,
or intravenously. Domperidone is given in order to relieve nausea and vomiting; to
increase the transit of food through the stomach (as a prokinetic agent through increase
in gastrointestinal peristalsis); and to increase lactation (breast milk production) by
release of prolactin. It is also used in the scientific study of the way dopamine (an
important neurotransmitter) acts in the body.
Structure32:
IUPAC name
: 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-
yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
Molecular formula
: C22H24ClN5O2
Molecular weight
Official in pharmacopeia :
Solubility
425.9
IP33, BP34, MARTINDALE, MERCK INDEX35
Melting Point
: 242.5 C
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DRUG PROFILE
MODE OF ACTION:
Domperidone
Brand Name
Domstal
Motilium
Molax
Abdopen
Motidon
Company
Torrent Pharmaceuticals
Janssen Pharmaceuticals
Janssen Pharmaceuticals
Health Saver Pharma
Abidi Pharmaceutical Co.
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DRUG PROFILE
Synonym
IUPAC name
Clofezone
InChI=1S/C18H21N3O3S/c1-13-16(19-9-8-17(13)24-
11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,
(H,20,21)
Molecular formula
: C18H21N3O3S
Molecular weight
Official in pharmacopeia :
Solubility
359.4
IP38, BP, MERCK INDEX
Melting Point
Category
: 140-141 C
: Anti-Ulcer Agents
Enzyme Inhibitors
MODE OF ACTION:
Rabeprazole is a selective and irreversible proton pump inhibitor.
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DRUG PROFILE
Rabeprazole Sodium
Brand Name
Kepreb 20
Elpizole
Rablet
Rabisiv 20
Rabeloc
Company
Kepler Healthcare
Orchid Chemicals &
Pharmaceuticals
Lupin Pharmaceuticals
Saharsh Biologicals
Duta Formulations
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DRUG PROFILE
2.3 COMBINATION:
Use:
Domperidone and Rabeprazole Sodium are used to help reduce the amount of acid
produced by the stomach and it may cause side effects, such as nausea, dizziness and
stomach pain.
2.4. Combination Formulations:
Table:-3
S.no
1.
Brand name
Generic name
Formulatio
Razol-D
n
Domperidone and Tablet
Company
Rabeprazole
2.
Acera
Sodium
Domperidone(SR)
and
3.
Atradom SR
Capsule
IPCA Laboratories
Rabeprazole
Sodium
Domperidone and Tablet
Atlas
Rabeprazole
Pvt. Ltd.
Laboratories
Sodium
4.
Comvine
Domperidone(SR)
and
Rabeprazole
Capsule
Alkem Laboratories
Ltd.
Sodium
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