Syllabi for Pre.PhD/Pre M.Phil/ Pre MS.

W.e.f. 2005-2006 Batch

PHARMACEUTICAL SCIENCES
[SPECILISATION CODE: 22]

PAPER- I
(Common paper)

S.NO
1

SUBJECT NAME
INSTRUMENTAL METHODS OF
PHARMACEUTICAL ANALYSIS

SUBJECT CODE
R52201

Syllabi for Pre.PhD/Pre M.Phil/ Pre MS.

W.e.f. 2005-2006 Batch

CHEMISTRY
[SPECILISATION CODE: 04]

PAPER II
(Choose Any ONE Subject)

S.NO

SUBJECT NAME

SUBJECT
CODE
R52251

1.

PHARMACEUTICAL BIOTECHNOLOGY

2.

ADVANCED PHARMACEUTICS (PHARMACY)

R52252

3.

ADVANCED PHARMACOGNOSY

R52253

4.

ADVANCED PHARMACEUTICAL CHEMISTRY

R52254

5.

ADVANCED PHARMACOLOGY

R52255

6.

ADVANCED PHARMACEUTICAL ANALYSIS

R52256

Syllabi for Pre.PhD/Pre M.Phil/ Pre MS.

W.e.f. 2005-2006 Batch

Subject Code: R52201

INSTRUMENTAL METHODS OF PHARMACEUTICAL ANALYSIS

Unit I
UV Visible spectroscopy: Introduction, Beers law and its limitations, molar extinction coefficient,
wood wards Fiesher rules for calculating absorption maximum, instrumentation design and
applications.
Unit II
IR Spectroscopy : Basic Principles Molecular vibrations, vibrational frequency and its
influencing factors, sampling techniques, instrumentation and applications of FT IR.
Unit III
NMR Spectroscopy : Principle, Chemical shifts, shielding and deshielding
signals, computing constants, instrumentations and applications (H&CNMR).

effects, splitting of

Unit IV
Mass spectroscopy : Principle, Ionization Techniques, Fragmentation pattern, Instrumentation and
applications.
Unit V
GLC and HPLC : Principles, instrumentation with special emphasis on different column and
detectors and applications.
Unit VI
HPTLC, Ion-exchange Chromatography and Gel filtration: Principle, instrumentation and
applications.
Unit VI
Potentiometry and Conductometry : Principle, instrumentation and applications.
Unit VIII:Polarimetry Fluorimetry and Refractometry : Principle, Instrumentation and applications with
suitable examples.
Books:
1.
2.
3.
4.

Instrumental Methods of Analysis

Scog and West
Instrumental Methods of Analysis
Willand, Dean and Merrit
Instrumental Methods of Analysis by B.K.Sarma
Introduction to Instrumental AnalysisRobert D.Braun.

Reference Books :
1.
2.

Vogels text book of Quantitative Chemical Analysis

A Text Book of Pharmaceutical Analysis
Kenneth A.Connors.

Syllabi for Pre.PhD/Pre M.Phil/ Pre MS.

W.e.f. 2005-2006 Batch

Subject Code: R52251

PHARMACEUTICAL BIOTECHNOLOGY
1.
2.

3.

Introduction to Proteins and Nucleic acids and their structure and features
Introduction to Genetic Engineering, enzymes and vectors in genetic engineering,
concepts of cloning, cDNA and genomic libraries, Cloning for production of
Biopharmaceuticals, Screening and detection methods for clones.
Recombinant DNA products and their applications

4.

Immune System Innate and acquired immunity, Monoclonal antibodies and

immunological techniques.

5.

Basic techniques of mammalian cell culture in vitro; disaggregation of tissue and

primary culture, maintenance of cell culture; cell separation, and applications of
mammalian cell culture.

6.

Different areas and applications of plant tissue culture. Nutritional components of

tissue culture media. Totipotency

7.

Transgenic Plants and animals and their applications.

8.

Introduction to Bioinformatics overview and applications.

Text Books:
1.
Bio-Chemistry
2.
Bio-Technology
3.
Molecular cell Biology
4.
Med.Plant Biotechnology

Stryer
Dr.U.Satyanarayana
Baltimore
Ciddi Veereshan.

Reference Books:
1.
Gene cloning
2.
Cell and Molecular Biology
3.
Essential immunology (1998) VII Edition
4.
Plant Tissue Culture
5.
Animal Cell Biotechnology methods & Protocols
6.
Bio Informatics Basics

T.A.Brown
Geral Corp
I.Roitt
J.Stewart
Negel Jenkins
Buelher.

Syllabi for Pre.PhD/Pre M.Phil/ Pre MS.

W.e.f. 2005-2006 Batch

Subject: Code: R52252
ADVANCED PHARMACEUTICS (PHARMACY)

Unit -1
Introduction to pharmacokinetics Pharmacokinetics models, physiological models,
one compartment open model drug disposition, plasma elimination half life, two compartment open
model drug disposition, Drug Distribution:- Apparent volume of distribution (one and two
compartment models), protein binding of drugs Implications of drug protein binding in
pharmacokinetics and therepy kinetics of drug protein binding.
Unit -2
Biotransformation of drugs:- Phase I and II biotransformation reactions, factors affecting,
Excretion of drugs renal and nonrenal drug excretion mechanism of renal excretion, clearancerenal clearance, hepatic clearance, kinetics of drug absorption- one compartment oper model,
evaluation of pharmacokinetic parameters.
Unit -3
Dosage form Evaluation-Bioavailability rate and extent of bioavailability, assessing
bioavailability, multiple dosing bioavailability, in vitro bioavailability studies (dissolution), Bio
equivalence General principles, criteria for establishing bioequivalence requirement, criteria for
waiver of evidence for bioequivalence requirement, methodology, pharmacokinetics parameters
logarithmic transformations.
Unit -4
Multiple dosage regimens drugs accumulation, i.v and oral regiment, loading
dosing, scheduling, Diseases-Dose adjustment hepatic disease dose adjustment, renal disease
dose adjustment, therapeutics drug monitoring, Non-compartment model-pharmacokinetics
statistical movement theory, pharmacokinetics parameters.
Unit -5
Concept & Models for NDDS: Classification of rate controlled drug delivery system
(DDS), rate programmed release, activation modulated & feedback regulated DDS, Fundamentals of
rate controlled drug delivery Introduction, mechanistic analysis of controlled release drug
delivery, effect of system parameters in controlled drug delivery, evaluation of controlled release drug
delivery systems.
Unit -6
Oral drug delivery and delivery systems: Development of novel drug delivery
systems for oral controlled release drug administration, modulation of gastrointestinal transit time,
overcome hepatic first pass elimination, Mucosal drug delivery: human mucosa, transmucosal
systemic delivery of drugs.
Unit -7
Transdermal Drug Delivery systems: Skin site for transdermal drug administration, recent
developments in transdermal drug delivery, fundamentals of skin permeabtion, technologies for
developing transdermal systems, Evaluation of transdermal systems, Particulate drug carriers
liposomes and nanoparticles Concepts, applications, preparation, and evaluation, in vivo barriers to
particulate distribution, selected examples of drug delivery.
Unit -8
Target Oriented Drug Delivery Systems: Rationale for targeted drug delivery, biological
processes and events involved in drug targeting, pharmacokinetics and pharmacodynamic
considerations, targeted drug delivery systems, targeting in the gastrointestinal tracts and other
mucosal surfaces.
Text Books :
1.
Y.W.Chein Novel Drug Deliuery Systems Vol 50 2nd Edition Marcel Deckker 2005
2.
Robinson & Lee, control Drug Delivery Systems, Vol-29, 2nd Edition, Marcel Deckker 2005
3.
Milo Gibaldi Biopharmaceutics & Clinical Pharmacokinetics, 4th Edition, PHarma syndicate,
Hyderabad (2005).
Reference Books:
1.
NK Jain Controlled Novel Drug Delivery, C.B.S.Publishers, New Delhi-2002
2.
Brahmankar & Jaiswal Bio pharmaceutics and Pharmacokinetics, Atreatise Vallabha
Prakashan, Delhi 2005.

Syllabi for Pre.PhD/Pre M.Phil/ Pre MS.

W.e.f. 2005-2006 Batch

Subject Code: R52253
ADVANCED PHARMACOGNOSY

Unit I
General methods and Principles of extraction methods, types of extraction and their merits and
demerits for Crude Drugs; Selection and purification of solvents for extraction; screening of the plant
extracts for chemicals. General methods of isolation of different classes of phytochemical.
Unit II
Screening of plant extracts / phytochemicals for analgesic, anti-inflammatory, anti-diabetic,
diuretic, anti-fertility, anti-epileptic, hepatoprotective, immunomodulatory, anticancer cardiovascular
and antimicrobial activity.
Unit III
Techniques employed in elucidation of bio synthetic pathway. Study of basic metabolic
pathways (Shikkinic, Acetatemerolonate pathway 2 calvins cycle) Biogenesis of tropane, quinoline,
Imidazole, Isoquinoline and Indole alkaloids; sterols, anthraquinone, saponin glycosides and
flavonoids compounds of pharmaceutical significance.
Unit IV
Current status of anti-cancer, anti-HIV, anti-diabetic and Immunomodulatory herbal drugs. A
review of Bio medicinals of recent discovery. Current status of plants used in alternative systems of
medicines.
Unit V
Application of various chromatographic techniques and spectrometry to natural products :
TLC, GC, HPLC and HPTLC; Flourimetry and colorimetry. Uses of UV, IR, NMR and mass
spectrometry in the structural elucidation of natural products.
Unit VI
Herbal formulations : Types of herbal formulations preparation of standardized extracts
suitable for incorporation into solid dosage form like tablets capsules etc. Recent trends in polyherbal medicines. Herbal cosmetics and herbal teas. Manufacture, packaging and approach to quality
control of herbal formulations. GMP for herbal drug formulations.
Unit VII
World Health Organisation guide lines for herbal drugs including standards for pesticide
residue / aflatoxins. Current status of regulatory affairs for herbal formulations. Patents, Intellectual
property rights.
Unit VIII
Current trends in tissue culture and its applications in Pharmaceutical and allied fields.
Immobilized cell systems and techniques of immobilization, Biotransformation resulting into
pharmaceutically important secondary metabolites, using tissue cultures.
Micro propagation, Hairy-root cultures and their applications in Pharmacy.
Text Books:
1.
Text Book of Pharmacognosy by Trease & Evans
2.
Phytochemical methods by J.B.Heraborne
3.
Instrumental methods of Analysis B.K.Sharma
4.
Pharmacognosy and Phytochemistry- Vinod Rangari
5.
Plant Tissue culture by Razdawn.
Reference Books:
1.
Text Book of Pharmacogonsy by Brady & Tyler
2.
Instrumental Analysis by Chatwal & Anand
3.
Pharmacognosy and Pharmacobiotechnology Aushthoskar

Syllabi for Pre.PhD/Pre M.Phil/ Pre MS.

4.
5.
6.

W.e.f. 2005-2006 Batch

Pharmacognosy Gene Bruneton

Quality control of Herbal Drugs and approach to evaluation of Botanicals by Dr.Paulok
K.Mukarjee
Aromatic Planats cultivation of process and uses H.Panda
7.
Meidcinal plant Biotechnology By ciddi Veeresham.

Syllabi for Pre.PhD/Pre M.Phil/ Pre MS.

W.e.f. 2005-2006 Batch

Subject Code: R52254
ADVANCED PHARMACEUTICAL CHEMISTRY

UNIT-I:
Structural Elucidation: Structural Elucidation of some important Natural, Synthetic and
Semi synthetic drugs by using spectroscopic data.
[UV, IR, H1NMR, C13 NMR, Mass].
UNIT-II :
Reaction Mechanisms: Generation, Stability, structure and reactivity of free radicals,
Carbocations and Carbenes. Mechanism of free radical, electrophitic, Nucleophitic (Addition and
substitution) reactions, eliminaton reactions with examinable
UNIT-III
Basic Principles and strategies to plan synthetic reactions schemes by using different reagents.
UNIT-IV:
Molecular Boric of Being Action: Concept of receptors and receptor theories. The role of
functional groups in drying receptors, interactions with specific reference to Opiod, thiotaminergic ,
Dorpaminergic, Adrenergic, Cholinergic, GABA nergic receptors.
UNIT-V :
Recent advances in the treatment of Diabetes Mellitub, Cardiovasenlan disease, CNS diseases,
Viral, Cancer, Malaria and Tuberculosis.
UNIT-VI:
New drug development and lead approach: Identification of lead molecule for natural
products. Lead optimization for the New drying development with suitable example from CNS, CNS,
Chemotherapeutic. Agents.
UNIT-VII:
Drying Resign:- History and development of QSAR, physicochemical parameters. Hansch
analysis., free klison analysis.
Molecular modeling: Molecular mechanics quantum mechanism.
UNIT-VIII:

Design and application of prodrugs.

Structure based drug design.
Combinational chemistry: Combinational approached chemical peptide and small molecule
librarian.
Assays and Screening combinational libraries introduction to high through puts. Screening
(HTS)

Text Books:
1.
2.
3.
4.

Organic Chemistry
Advanced Organic Chemistry
Medicinal Chemistry Vol I to V
Organic Medicinal & Pharmaceutical Chemistry

Reference Books:
1.
Identification of Organic Compounds
2.
Principles of Medicinal Chemistry
3.
Organic Synthesis

Vol I & II I.L.Finar

Jerry March
Barger
Willon and Gisword

Silverstain
Foye
Lednicer.

Syllabi for Pre.PhD/Pre M.Phil/ Pre MS.

W.e.f. 2005-2006 Batch

Subject Code: R52255

ADVANCED PHARMACOLOGY
UNIT I
Receptor Pharmacology & Mechanisms :
Types of Receptors, theories of receptors, G-protein coupled receptors, NMDA receptors,
Kinase linked receptors, ion channels, second messengers, DNA linked receptors, signal transduction
mechanism, proliferation and apoptosis.
UNIT II
Pharmacogenetics, Drug Interactions invitho (biopharmaceutical)
Pharmacodynamic interaction, Adverse drug reactions.

Pharmacokinetic

and

UNIT III
Neurohumoral transmission in CNS, ANS and somatic various system
a.
Molecular basis, underlying mechanism of action of adrenergic, Cholinergic,
Dopaminergie, Serotoninergie and GBA ergie system.
b.
Pharmacological actions and possible physiological role of serotononin, Noradrenalene,
Adrenaline. Acetylcholine and Dopamine.
UNIT IV
Chemotherapy :
a.
Molecular and bio chemical mechanisms Pharmacology involved in the activity of various
antiviral and anticancer drugs.
b.
Concepts on free radicle mediated injury, TAT inhibitors and its role in HIV.
UNIT IV
Cardiovascular Pharmacology :
Cardiotonics, Antiarrhythonics, Antihypertensive, antianginal & anti hyperlipidemic agents.
UNIT V
Organisation of screening for the pharmacological activity of new substances with emphasis on
the evaluation of antihypertensives, Cardiac, Psychopharmacological, analgesic, anti inflammatory anti
diabetic, hepatoprotective, antistress and nootropic agents.
UNIT VI
a
b.
c.
d.
UNIT VII
a.
b.

Biotransformation of drugs : Phase I & II biotransformation reactions

Excretion of drugs : Renal & nonrenal Mechanisms and factors affecting.
Clearance : Renals & hepatic clearance.
Kinetics of drug absorption compartment models evaluation of Pharmacokinetic
parameters.
Design & testing of drugs in humans clinical trials bio equivalence studies.
Acute and Chronic toxicity studies in animals models.

TEXT BOOKS:
1. Bio Pharmaceutics and Pharmacokinetics an introduction by Robert E.Notari
2. The Pharmacological basics of Therapeutics by Goodman and Gillmans
3. Pharmacology by M.M.Ranga and H.D.Dale
4. Screening Methods in Pharmacology by Robert A.Turner
Reference Books:
1.
Drug Metabolism by Bernard Testa and Peter Jenner
2.
Remingtons Pharmaceutical Sciences

Syllabi for Pre.PhD/Pre M.Phil/ Pre MS.

3.
4.
5.
6.
7.

W.e.f. 2005-2006 Batch

Drug Evaluation by voges

Methods in Pharmacology by Swarbrick
Basic and Clinical Pharmacology by Bertram G.Katzung
Clinical Pharmacology by Molmon and Morelli
Essentials of Medical Pharmacology by Tripathi.

Syllabi for Pre.PhD/Pre M.Phil/ Pre MS.

W.e.f. 2005-2006 Batch

Subject Code: R52256
ADVANCED PHARMACEUTICAL ANALYSIS

UNIT I
Interpretation of FTIR spectra, Raman Spectroscopy 1Hz13CMR and its significance uses of
2D NMR techniques in the characterization of organic compounds.
UNIT II
Analysis of drugs and excipients in solid state particle size analysis, DTA, DSC, DGA
Principles, instrumentation, applications, X-ray diffraction applications in Pharmacy, Powered
XRD, single crystal x ray crystallography.
UNIT III
Multi component analysis using uv spectro photometric method, radio immunoassay
principle, theory application and methods.
UNIT IV
Principles and procedures involved in the use of the following reagents in Pharmaceutical
analysis.
i.
N, 1-naphthyl ethylene diamine
ii
P-dimethylamine benzaldehyde (DDNB)
iii
2,6 Dichloro quinine chlorimide
iv
2,3,5, Triphenyl tetrazolium salt
v
FC ragent
vi
P dimethylamine cinnamaldehyde
vii
3-Methyl, 2-benzothiazoline hydrazone
viii
2,4 dinitrophenyl hydrazine
ix
DPPH
UNIT V
Quality control and in process quality control of tablets, capsules, liquid dosage forms,
pasenteral and sterile preparations.
UNIT VI
Validation and calibration of various instruments used for drug analysis such as uv-visible
spectrophotometer, IR spectro photometer, HPLC, GC, and HPTLC.
UNIT VII
Study of principles and procedures involved in the following biological tests and assays tests
for effectiveness of antimicrobial preservatives, absorbed diphtheria vaccine, adsorbed diphtheria,
Microbiological assays of cyanocobalamine neomycin sulphate, oxytocin and tetanus toxoid.
UNIT VIII
Quality Control Laboratory Responsibilities, good laboratory practices, routine controls,
instruments, protocol non clinical testing, stability testing of pharmaceuticals and shelf life
predictions, ICH guidelines.
Text Books:
1.
2.
3.
4.
5.

Instrumental Analysis
Instrumental method of Analysis
B.K.Sharma
Quantitative Analysis of Drugs
Introduction of Instrumental Analysis

Eving
Skog & West
Jenkin
Robert D.Braun

Syllabi for Pre.PhD/Pre M.Phil/ Pre MS.

Reference Books:
1.
A Text Book of Pharmaceutical Analysis
2.
Instrumental Methods of Analysis
3.
Quantitative Analysis of Drugs
4.
Quantitative Analysis of Drugs
5.
Pharmaceutical Analysis Modern Methods Part-A&B
Dekker)
6.
IP, BP, USP
7.
Vogel Quantitative Analysis.

W.e.f. 2005-2006 Batch

-

Kenneth A.Connors
Willad, Dean & Merrit
P.D.Sethi
D.C.Garret
J.W.Munson(Marcel