Guidance for New and Existing Chemical

Substances Registration

()
Version 1

201508
August 2015

 Version 1

(Technical Guidance Documents, TGD)

 Version 1

................................................................................................................ 1
1.1 ....................................................................................................................... 1
1.2 ............................................................................................................... 2
1.2.1 ................................................................................ 2
1.2.2 ............................................. 3
1.3 ............................................................................................................... 4
1.4 ............................................................................................................... 4
1.5 ................................................................................................... 5
1.6 ........................................................................ 8
1.6.1 ................................................................................................... 8
1.6.2 .................................................................................... 8
1.6.3 ........................................................................................ 9
1.7 .............................................................................................. 10
.............................................................................................................. 11
2.1 ............................................................................................................. 11
2.2 ............................................................................................................. 11
2.2.1 ..................................................................................................... 11
2.2.2 .............. 11
2.2.3 ................................................................................................. 12
2.2.4 (Chemical Substance) ............................................................... 12
2.2.5 (Scientific Research and Development, SRD) ................... 13
2.2.6 (Product and Process Oriented Research and
Development, PPORD) ..................................................................................... 13
2.2.7 (Polymer) ..................................................................................... 14
2.2.8 (Polymer of Low Concern, PLC) ....................................... 14
2.2.9 (Intermediate)(On-Site Intermediate) ...... 15
2.2.10 (Nano-material) ...................................................................... 16
2.2.11 (Surface Treatment) ....................................................... 16
2.2.12 .......................... 17
2.2.13 .............................. 19
2.3 ..................................................................................................... 20
2.3.1 ................................................................................................. 20
2.3.2 ................................................... 20
2.3.3 .............................................................................. 20
2.3.4 .......................................................................... 21
II

 Version 1

2.3.5 .................................................................. 21
2.3.6 .................................................................................. 22
2.3.7 ..................................................................................................... 22
2.3.8 .......................................................................... 22
2.3.9 ..................................................................................................... 23
2.3.10 ....................................................................................................... 23
2.3.11 ...................................... 24
2.3.12 ...................... 24
2.4 .............................................................................................. 27
................................................................................................... 28
3.1 ...................................................................... 28
3.1.1 .................................................................................. 28
3.1.2 ...................................................................... 29
3.1.3 .................................................................................. 30
3.1.4 .................................................................................. 32
3.2 ............................................................... 32
3.2.1 ...................................................................... 32
3.2.2 ........................................................... 32
3.2.3 .................................................................................. 33
3.2.4 ...................................................................... 33
3.2.5 ............................................................... 34
3.2.6 .............................................................................. 34
3.2.7 ............. 35
3.2.8 (CMR) . 36
3.3 ..................................................................................................... 36
3.3.1 .................................................................. 36
3.3.2 .......................................................................... 37
3.3.3 ...................................................................................... 37
3.3.4 ......................................................................................... 38
3.3.5 .............................................................................. 38
3.3.6 ................................................................................................. 40
3.3.7 ......................................................................................... 46
3.3.8 ................................................................................................. 50
3.3.9 ................................................................................................. 51
3.4 ..................................................................................................... 52
3.4.1 ....................................... 52
3.4.2 ........................................................... 56
III

 Version 1

3.4.3 ................................................... 59
3.4.4 ................................................................................................. 62
3.4.5 ...................................................................... 67
3.4.6 .................................................................. 67
3.5 ...................................................... 68
3.5.1 ....................... 69
3.5.2 ................................... 69
3.5.3 .............................................................. 70
3.5.4 ................................................................. 72
3.6 ............................................................................................................ 72
........................................................................................... 73
4.1 ............................................................................................................. 73
4.1.1 .............................................................................. 73
4.1.2 .......................................................................... 75
4.2 .......................................................................................... 76
4.3 .......................................................................................... 76
4.4 .............................................................................. 77
4.5 .................................................................................. 77
4.6 ...................................................................................... 79
............................................................................... 80
5.1 ................................................................................................. 80
5.1.1 .............................................................................. 80
5.1.2 ...................................................................... 80
5.2 .......................................................................... 80
5.3 ................................................................... 81
5.4 ..................................................................................................... 82
5.5 ................................................... 82
................................................................................................................................... 84

PBT vPvB

IV

 Version 1

2.1.1 ............................................................................. 17
3.1.1 ...................................... 31
3.3.1 .............................................. 38
3.3.2 ................................................................. 40
3.3.3 ...................................... 42
3.3.4 .......................................................... 46
3.3.5 ...................................... 48
3.4.1 ................... 53
3.4.2 ...................................... 56
3.4.3 ............................... 59
3.4.4 ................................................................. 62
3.4.5 .................................................................................... 65
3.4.6 ............................................................................. 66
3.5.1 ..................................................................... 69

 Version 1

1 ...................................................... 6
2 .......................................... 7
3 ............................................................................... 74
4 ..................................... 75

VI

 Version 1

1.1

1.
2.
3.
4.
5.

Substance of Carcinogenic, Mutagenic, or Toxic for

Reproduction category 1, CMR 1

1.2

1.2.1

102 12 11
44

7 1

90

3 1
2 3

3 1 2 3
7 1

 Version 1

7
1
1 4

1.2.2

7 1

1.3

(Chemical Substance)

1.4
7 1

1
2./

1.
2.
3.
4.

5.

 Version 1

6.
7.

1.5

12

()

?
()

()
()

?
()

?
()

()

100?
()

 Version 1

CMR

1.

2.

3.
7

4.

5.

1.6
1.6.1

1.6.2

18 3 100
3 100
104 9 1 105 3 31
5

17
8

 Version 1

1.7

1.6.3

35 1 7 1 1
20 200
2

7 1 1
3 30
2

7 1 3 10 50

7 1 6

3 30
2

1.7

104 12
31 3

10

 Version 1

2.1

2.2
2.2.1
2

2.2.2
2

11

1./
2.

3.
4.
2.2.3

2.2.4 (Chemical Substance)

12

 Version 1

UVCB (Unknown or Variable composition, Complex reaction products

or Biological materials
)UVCB
/

CSNN

UVCB

(Gel permeation chromatography, GPC)

(Scanning electron microscope, SEM)

2.2.5 (Scientific Research and Development, SRD)

2.2.6 (Product and Process Oriented Research and

Development, PPORD)

13

1.
2.

3.
4.

2.2.7 (Polymer)

1. 1 (Monomers)

2. 3
50%
50%
3.
2.2.8 (Polymer of Low Concern, PLC)

1. (Number-average molecular
weight, Mn)
2.
3.

14

 Version 1

1. (number average molecular weight)

10,000 (Dalton, D) 500
2% 1,000
5%
2. 1,000~10,000
500 10%
1,000 25%
3.5.1
3.
4.
4
3 4
3.5.2
2.2.9 (Intermediate)(On-Site Intermediate)

1.
2.

15

2.2.10 (Nano-material)

50 %
1 100

2.2.11 (Surface Treatment)

substrate substance
substance used to coat the substance

16

 Version 1

2.2.12

2.1.1

2.1.1

1.1

1.2

1.3

1.4

1.5

1.6

17

C D

E F

1 1A1B1C

18

 Version 1

2A

1A

1B

1A

1B

1A

1B

2
1
2
1

1. 2.2.1 CNS15030

2.2.13

CNS15030

19

2.3

2.3.1

2.3.2

2.3.3

1.
2.
3.
4.

20

 Version 1

2.3.4

2.3.5

10% 20%

10%
20% UVCB
UVCB

10%

1%

21

2.3.6

2.3.7

2.3.8

2%

2%

2%
1.

2.

22

 Version 1

2.3.9

UVCB UVCB
UVCB

2.3.10

1.
2.

3.

23

2.3.11

(Chemical Abstracts Service Number,CAS No.)

1.(Glass, oxide, chemicals)CAS No.: 65997-17-3

2.(Frits, chemicals)CAS No.: 65997-18-4
3.(Ceramic materials and wares, chemicals)CAS No.
66402-68-4
4.(Steel manufacture, chemicals)CAS No. 65997-19-5
5.(Cement, alumina, chemicals)CAS No. 65997-16-2
6.(Cement, Portland, chemicals)CAS No. 65997-15-1

CAS No.
2.3.12
4

24

 Version 1

1.
2.
3.
4.

1.

2.
3.

6
1.

2.
3.
4.

1.
2.
25

3.

:
1.

2. 0.5%

20

90%

26

 Version 1

1.

2.

3.

2.4

CSNNhttp://csnn.osha.gov.tw

CAS No.
CAS No.

CAS No. > >

27

3.1

3.1.1

100
100 1
1

3.2

100
100 105
4 1 100

28

 Version 1

3.1.2

1 1 12 31

3.2

3.2 -
500
500

1.5 700
800
* 700
800

* 1.5
1.5 -
1.5
1.5

29

3.1.3

10
2.2.12
2.2.13
3.3.7 10
30

 Version 1

1,000
3.3.8

3.1.1

1.

2.
3.

1.1
1.2 /
1.3
1.4
1.5
1.6
1.7
1.8
1.9
1.10
1.11
1.12 1
1.13 2
2.1 CAS No. 3
3.1 4
3.2

1.
2.(EMS)
3.
CAS No.

4.

5.

31

3.1.4

3.3

3.2

3.2.1
1
1 10
10
-

3.2.2
1
1 10
10
-
32

 Version 1

3.2.3
1
1 10
10 -

3.5

3.2.4
1

3.5
4.1

33

3.2.4

3.2.5
1
1 10
10
-

3.2.6

(Organization for Economic Co-operation and

Development, OECD)

1./
34

 Version 1

2.

28
OECD WPMN(Working Party on Manufactured Nanomaterials)

OECD

3.5.3
3.2.7

10

PBT vPvB

35

3.2.8 (CMR)

CMR
CMR 1

CMR
1. 1 CMR
2.1 10 CMR
3.10 100 CMR
4.100 CMR

3.3
3.1.3 9

3.3.1

2.1

36

 Version 1

CAS No.

(1)(2)

3.5

3.3.2

3.3.3

27 /

CNS 15030

37

3.3.4

/
(SDS) 16
3.3.5

6
//
15
4
3.3.1
3.3.1

:/

pH

38

 Version 1

()(Test report)
1.(Full study report)

2.(Robust study summary)

()(SAR Estimation)

OECD QSAR Toolbox

39

3.3.6

9 4
3.3.2
3.3.2

()

:
()(Test report)
1.(Full study report)

40

 Version 1

2.(Robust study summary)

()(SAR Estimation)

OECD QSAR Toolbox

()(Testing proposal)

3.3.3

41

3.3.3

(Rat)(Albino rabbit)

(pH2.0)(pH11.5)

0.1 mmHg
10 m

(1)
(2)
(3)

(Albino rabbit)
/
/
/
/

(Albino rabbit)

(Guinea pig)(Mice)

42

 Version 1

DNA

CNS 15030 2
CNS 15030 2
CNS
15030 2

43

(Rat)(Albino rabbit)

28 90

28
(NOAEL,
No-observed-adverse-effect Level)
90

28 90
(NOAEL,
No-observed-adverse-effect Level)

(1)
(2)
(3)

44

 Version 1

(Rat)

28 90

(Mice)(Rat)

CNS 15030
12
/(pro-neoplastic lesion)

45

3.3.7

16 4

3.3.4
3.3.4

46

 Version 1

()(Test report)
1.(Full study report)

2.(Robust study summary)

()(Testing proposal)

3.3.5

47

3.3.5:

OECD TG 302

OECD TG 302/
/

CNS10530 1

1.
48

 Version 1

2.BCF>500 log Kow4

CNS15030 1

1.
2.BCF>500 log Kow4

OECD TG
207
OECD TG 220OECD TG 222

OECD TG
208
OECD TG 227

49

log Kow>3

OECD TG 218-

3.3.8

PBT vPvB

1.
2.
3.
4.

CNS 15030

50

 Version 1

(Derived No-Effect Concentrationl, DNEL)

(Derived Minimal Effect Level)

CNS15030

(Predict No-Effect Level, PNEC)

1.2. 3.

PBT vPvB PBT vPvB

3.3.9

2 :
1

51

(risk value) /
1
10-6

3.4

3.4.1

3.4.1(Testing Guideline, TG) OECD

(International Organization for St
andardization, ISO)(American Society for Testing
and Materials, ASTM)(UN Recommenda
52

 Version 1

tions on the Transport of Dangerous Goods, UN RTDG)

3.4.1
/

Endpoint

20 101.3 kPa

OECD TG 102

OECD TG 103

OECD TG 109

OECD TG 107

OECD TG 117

(HPLC)
OECD TG 123

OECD TG 105

OECD TG 104

ISO 1516:2002

ISO 1523:2002

ISO 3679:2004

ISO 3680:2004

UN RTDG: Manual of
Tests and Criteria Part III.
33.4 Test N.5 1

OECD TG 103
53

/
Endpoint

ISO 1516:2002

ISO 1523:2002

ISO 3679:2004

ISO 3680:2004

UN RTDG: Manual of
Tests and Criteria Part III.
33.2 Test N.1

UN RTDG: Manual of
Tests and Criteria Part II

A ~ H

UN RTDG: Manual of
Tests and Criteria Part III.
33.3 Test N.3

UN RTDG: Manual of
Tests and Criteria Part III.
33.3 Test N.2

UN RTDG: Manual of
Tests and Criteria Part III.
33.3 Test N.4

UN RTDG: Manual of
Tests and Criteria Part III.
33.4 Test N.5

UN RTDG: Manual of
Tests and Criteria Part II
54

 Version 1

/
Endpoint

A ~ H

UN RTDG: Manual of
Tests and Criteria Part I
1 ~ 8

UN RTDG: Manual of
Tests and Criteria Part III.
34.4 Test O.1

UN RTDG: Manual of
Tests and Criteria Part III.
34.4 Test O.2

pH

pH

OECD TG 122

ASTM E659-78(2005)

ASTM G72/
G72M-09

OECD TG 114

UN RTDG: Manual of
Tests and Criteria Part III.
37.4 Test C.1

1. UN RTDG Recommendations on the Transport of Dangerous Goods

Manual of Tests and Criteria

2. OECD

55

3.4.2

3.4.2 OECD TG
3.4.2

/
(LD50)

OECD TG 420
OECD TG 423
OECD TG 425

(LC50)

OECD TG 403
OECD TG 436

(LD50)

OECD TG 402

OECD TG 430
OECD TG 431
OECD TG 435

OECD TG 439

OECD TG 404

OECD TG 437

OECD TG 438

OECD TG 405

OECD TG 406
OECD TG 429
56

 Version 1

OECD TG 442A
DA
OECD TG 442B

BrdU-ELISA

OECD TG 471

OECD TG 473

OECD TG 476

OECD TG 487

OECD TG 474

OECD TG 475

OECD TG 486
DNA
OECD TG 488

OECD TG 417

28

OECD TG 407
28

90

OECD TG 408
90

OECD TG 452
OECD TG 453

28

57

OECD TG 41228

/
90

OECD TG 41390

OECD TG 452
OECD TG 453

21/28

OECD TG 41021/28

90

OECD TG 41190

OECD TG 452
OECD TG 453

OECD TG 415

OECD TG 421

OECD TG 422

OECD TG 414

OECD TG 416

OECD TG 443

OECD TG 451
OECD TG 453

1 OECD

58

 Version 1

3.4.3

3.4.3
OECD
3.4.3

Endpoint
(EC50)

OECD TG 202

(EC50)

(LOEC)

(NOEC)

OECD TG 201

OECD TG 203

OECD TG 301
OECD TG 301ADOC
OECD TG 301BCO2
Sturm
OECD TG 301C
MITII
OECD TG 301D
OECD TG 301E OECD

OECD TG 301F
OECD TG 302
OECD TG 302A
(SCAS)
OECD TG 302B
Zahn-Wellens/EMPA
OECD TG 302C
(MITI)II
OECD TG 310
CO2
OECD TG 311

(LC50)
59

Endpoint

(LOEC)

(NOEC)

(NOEC)

(EC50)

OECD TG 204
14
OECD TG 111

OECD TG 209

20%
(EC20)
80%
(EC80)

(NOEC)

(EC50)

OECD TG 224

(Koc)

OECD TG 106

OECD TG 121
(HPLC)

(ECx)

(LOEC)

(NOEC)

(NOEC)

(LOEC)

(NOEC)
(LC50)
(EC50)

OECD TG 211 Daphnia magna

OECD TG 204
14
OECD TG 210

OECD TG 212 -

(LOEC)
60

 Version 1

Endpoint

(NOEC)
(ECx )

(LOEC)

(NOEC)
(LC50)
( ) (LC50)

(ECx )

OECD TG 215

OECD TG 207
OECD TG 220

(NOEC)
(ECx)

(LOEC)

(NOEC)
(ECx)

OECD TG 222
OECD TG 208

OECD TG 227

OECD TG 216

OECD TG 217

OECD TG 303A-

OECD TG 303B-

OECD TG 306

OECD TG 308-

OECD TG 309

OECD TG 304A

OECD TG 307

OECD TG 305-

61

Endpoint

OECD TG 305A-

OECD TG 305B-

OECD TG 305C-

OECD TG 305D-

OECD TG 218-

(ECx)

(LOEC)

OECD TG 219-

(NOEC)

OECD TG 225-

1 OECD

3.4.4

3.4.4 3.4.5 3.4.6

3.4.4

/-20
300

62

 Version 1

pH 47 9
12

300

200 300

100 200

-200

500 J/g
500 5.1
15%
I II
30% III

800J/g

63

pH

200
160
400

64

 Version 1

3.4.5

(pH2.0)(pH11.5)

(2000 mg/kg b.w)

(pH2.0)(pH11.5)

(pH2.0)(pH11.5)

28 90

90

28

(1) 1000 mg/kg

bw/day
(2))
20000 ppm/6h/day
20 mg/l/6h/day
5 mg/l/6h/day
(3) 1000 mg/kg
bw/day

65

3.4.6

1mg/L 1

1mg/L 1

1mg/L 1

1mg/L 1

1mg/L

/
3(log Kow <3)
2

(
)

/ log Kow <3

2
66

 Version 1

1.: 1 mg
2.(readily biodegradation): 28
(lag phase) 10 (10-day
windows) OECD TG
(Dissolved
organic carbon, DOC) 70%(Theoretical oxygen demand, ThOD) 60%

3.4.5

1.
2.
a.

b.

c.
3.4.6

1. (Good
Laboratory Practice, GLP
2. ISO17025

67

3.(in-house test)

1.(Good
Laboratory Practice, GLP)
2.TAF) GLP
3.
100
06 29 16
(Institutional Animal Care and Use Committee, IACUC)

1.
2.

3.5

68

 Version 1

3.5.1

2.2.5 2.2.6

3.5.2

3.5.1

4.4
2.2.8

1,000 10,000
(high concern
reactive functional group) 3.5.1

3.5.1
69

Acrylates or methacrylates
Amines
Aziridine
Carbodiimides
Epoxides
Hydrazines
Isocyanates or isothiocyanates
(Alpha- or beta-) lactones
Phenolic hydroxyl
(Halo-, Hydro- or Alkoxy-) silanes
Sulfo
Vinyl sulfones

5
2000 mg/L 35~40 1
252 24
40
2%

3.5.3

/(Aggregation /
Agglomeration )

70

 Version 1

71

3.5.4

(Gel permeation chromatography, GPC)

: MALDI-TOFMALS

1.2.11

3.6

300 800

1100

72

 Version 1

4.1
4.1.1

1.
2.
3.
3.2

73

()

()

3
74

 Version 1

4.1.2

1.
2.

75

4.2

OECD

4.3

1.
2.
1.3

76

 Version 1

4.4

4.5

4.5.1

77

78

 Version 1

4.6

http://tcscachemreg.epa.gov.tw/

79

5.1

5.1.1

5.1.2

30
2

5.2

30

80

 Version 1

1.
2.
3.

5.3

1.
2.
3.
4.
5.
6.
7.
8.
9.

1.
2.
3.
4.
81

5.
6.

5.4

1.
2.
3.

1.
2.
3.
4.

5.5
5

5

1.
2.
3.
82

 Version 1

1.
2.
3.
4.
5.

83

PBT vPvB

84

 Version 1

UVCB

-
-
-
-

85

IUPAC (International Union of Pure and

Applied Chemistry name(s), IUPAC name(s))(CAS)
(Chemical Abstracts (CA) Preferred Index name(s))
PCPC CIFA INCI
(SDC) C.I. Index (IUBMB)

REACH

86

 Version 1

118

2015 (CAS) CAS No.

IUPAC CA Index

(IR)(UV)(NMR)(MS)
X (XRD)X (XRF)
(AA)(GC)(HPLC)

87

(International Union for Pure

and Applied Chemistry name(s), IUPAC name(s) )
(Chemical Abstracts (CA) Preferred Index name(s)
(SDC)
C.I. Index

(1)(IUPAC)

(2)
DLRS
(3)

(4)

(5)

a. (NaCl)
b.
(MgSO47H2O)
c.

88

 Version 1

d.
e.
(6)

a.
b.
c.
d.
e.
f.
g.
(7)
a.
b.
c.
d.
e.
(8)

(9)

89

1.

2.

(%)(50%)
3. (%)
(50%)

1. (structure-based)

2. (process-based)

90

 Version 1

(International Union of Pure

and Applied Chemistry name(s)IUPAC name(s))
(Chemical Abstracts (CA) Preferred Index name(s))
PCPC CIFA
INCI
IUPAC
CAS

(structure-based)
(process-based)
1.

2.

3. ABABAB

4.

5.

6.

91

7.

8.
9.
a. (cis-)(trans-)

b. (tacticity)
(isotactic)(syndiotactic)(atactic)
c.

92

 Version 1

UVCB

(Unknown or Variable composition)

(Complex reaction products)
(Biological materials, other than a whole animal or a whole plant)
UVCB
IUPAC

UVCB

UVCB
1.

2.

3.

93

UVCB
(1)(2)
(1)(2)

UVCB

68308-36-1

Soybean meal

UVCB

94

 Version 1

UVCB

2,4-

2,4-

2 -2,5-

68131-74-8

Ashes,

residues

UVCB

8028-48-6

Citrus

aurantium,
ext.

95

1.

pH

2.

UVCB
3.

4.

96

 Version 1

1.

a.
b
c.
d.

68937-77-9

C14-18 Fatty acids,C14-18

branched and linear

14 ~18

97

2.

(>10%)

64741-97-5

Distillates

(petroleum),

100

solvent-refined

SUS/100F (19 cSt/ 40C)

light naphthenic

C15~C30

98

 Version 1

3.

UVCB

IUBMB (International Union of

Biochemistry and Molecular Biology)IUBMB
4

9014-01-1

IUBMB

[]

Subtilisin

3.4.21.62

99

alkyl or alkane

alkenyl or alkene

alkynyl or alkyne

(
)

carbomonocyclic or
carbomonocycle (e.g.,
cyclohexane or benzene)
carbopolycyclic or

carbopolycycle (e.g.,

[3.4])

naphthalene or
spiro[3.4]octane)

100

 Version 1

heteromonocyclic or
heteromonocycle (e.g.,

()
furan)

heteropolycyclic or
heteropolycycle (e.g.,

()
purine)

metal

CH3C(NO2)HCH2CHBr2
1,1--3-
1,1-dibromo-3-nitrobutane

1.
1,1--3-
1,1-dihalosubstituted-3-nitrobutane
2.
-3-
polybromo-3-nitrobutane
3.-

dibromonitroalkane

101

IUPAC

CAS No.

INCI

PCPC

International Union of Pure and

Applied Chemistry name(s)

Chemical Abstracts Service

Registry Number

International Nomenclature of

Cosmetic Ingredients

Personal Care Products Council

IUBMB

International Union of

Biochemistry and Molecular

Biology
SDC

Society of Dyers and Colourists

UVCB

Unknown or Variable

composition, Complex reaction

products, Biological materials,

other than a whole animal or a

whole plant

102

 Version 1

CAS No.

Reactant

Monobasic Acids and Natural Oils

65-85-0

Benzoic acid

120962-03-0

Canola oil

8001-31-8

Coconut oil

8001-30-7

Corn oil

8001-29-4

Cottonseed oil

143-07-7

Lauric acid

128952-11-4

anchovy fats and glyceridic oils

91078-92-1

babassu fats and glyceridic oils

68153-06-0

herring fats and glyceridic oils

8002-50-4

menhaden fats and glyceridic oils

93334-41-9

sardine fats and glyceridic oils

8016-35-1

oiticica fats and glyceridic oils

67701-08-0

C16-18 C18-

C16-18 and C18-unsaturated fatty acids

61789-44-4

castor-oil fatty acids

61788-47-4

Coco fatty acids

61789-45-5

dehydrated castor-oil fatty acids

68424-45-3

Linseed oil fatty acids

93165-34-5

safflower oil fatty acids

68308-53-2

Soya fatty acids

84625-38-7

Sunflower-oil fatty acids

68953-27-5

sunflower-oil, conjugated fatty acids

61790-12-3

tall-oil fatty acids

tall-oil, conjugated fatty acids

61788-66-7

vegetable oil fatty acids

67701-30-8

C16-18 C18-

C16-18 and C18-unsaturated Glycerides

111-14-8

Heptanoic acid

142-62-1

Hexanoic acid

3302-10-1

3,5,5-

3,5,5-trimethyl hexanoic acid

8001-26-1

Linseed oil

68649-95-6

oxidized linseed oil

()

103

112-05-0

Nonanoic acid

Cannabis oils

8023-79-8

palm kernel oils

68132-21-8

Perilla oils

8024-09-7

Walnut oils

8001-23-8

Safflower oil

8001-22-7

Soybean oil

8001-21-6

Sunflower oil

8001-20-5

Tung oil
Di and Tri Basic Acids

88-99-3

1,2-Benzenedicarboxylic acid

121-91-5

1,3-Benzenedicarboxylic acid

1459-93-4

1,3-Benzenedicarboxylic acid, dimethyl ester

100-21-0

1,4-Benzenedicarboxylic acid

636-09-9

1,4-Benzenedicarboxylic acid, diethyl ester

120-61-6

1,4-Benzenedicarboxylic acid, dimethyl ester

528-44-9

1,2,4-

1,2,4-Benzenetricarboxylic acid

110-15-6

Butanedioic acid

123-25-1

Butanedioic acid, diethyl ester

106-65-0

Butanedioic acid, dimethyl ester

110-17-8

(E)-2-

(E)-2-Butenedioic acid

111-20-6

Decanedioic acid

110-40-7

Decanedioic acid, diethyl ester

106-79-6

Decanedioic acid, dimethyl ester

693-23-2

Dodecanedioic acid

61788-89-4

C18 C18-unsaturated fatty acids, dimers

111-16-0

Heptanedioic acid

1732-08-7

Heptanedioic acid, dimethyl ester

124-04-9

Hexanedioic acid

627-93-0

Hexanedioic acid, dimethyl ester

141-28-6

Hexanedioic acid, diethyl ester

123-99-9

Nonanedioic acid

1732-10-1

Nonanedioic acid, dimethyl ester

624-17-9

Nonanedioic acid, diethyl ester

104

 Version 1

505-48-6

Octanedioic acid

1732-09-8

Octanedioic acid, dimethyl ester

110-94-1

Pentanedioic acid

1119-40-0

Pentanedioic acid, dimethyl ester

818-38-2

Pentanedioic acid, diethyl ester

1852-04-6

Undecanedioic acid
Polyols

107-88-0

1,3-

1,3-Butanediol

110-63-4

1,4-

1,4-Butanediol

105-08-8

1,4-

1,4-Cyclohexanedimethanol

107-21-1

1,2-

1,2-Ethanediol

111-46-6

2,2-

2,2-oxydiethanol

629-11-8

1,6-

1,6-Hexanediol

144-19-4

2,2,4--1,3- 2,2,4-trimethyl-1,3-Pentanediol

57-55-6

1,2-

115-77-5

2,2-()-1,3- 2,2-bis(hydroxymethyl)- 1,3-Propanediol

126-30-7

2,2--1,3- 2,2-dimethylpropane-1,3-diol

77-99-6

2--2-()-1,3- 2-ethyl-2-(hydroxymethyl)- 1,3-Propanediol

77-85-0

2-()-2 -1,3- 2-(hydroxymethyl)-2-methyl-1,3-Propanediol

2163-42-0

2--1,3-

2-methyl-1,3-propanediol

56-81-5

1,2,3-

1,2,3-Propanetriol

25618-55-7

1,2,3- 1,2,3-Propanetriol, homopolymer

25119-62-4

1,2-Propanediol

2-Propen-1-ol, polymer with ethenylbenzene

Modifiers

2,2--

2,2-oxybis- Acetic acid

1-

1-Butanol

108-93-0

Cyclohexanol

80-04-6

4,4-(1-) 4,4-(1-methylethylidene) bis Cyclohexanol

110-99-6
71-36-3

105

112-34-5

2-(2-)- 2-(2-butoxyethoxy)- Ethanol

111-27-3

1-Hexanol

72318-84-4

-1,4a-
-7-(1-)-1-

Methanol, hydrolysis products with trichlorohexylsilane

13393-93-6

and trichlorophenylsilane
tetradecahydro-1,4a-dimethyl-7-(1-methylethyl)1-Phenanthrenemethanol

25036-25-3

4,4'-(1-) Phenol, 4,4-(1-methylethylidene)bis-, polymer with

2,2'-[(1- 2,2-[(1-methylethylidene)bis(4,1-phenyleneoxymethyl
)(4,1- ene)]bis[oxirane]
)]()

68440-65-3

(
)

,(
)

()

Siloxanes and Silicones, dimethyl, diphenyl, polymers

Silsesquioxanes, phenyl propyl

68957-04-0

68957-06-2

68037-90-1

with phenyl silsesquioxanes, methoxy-terminated

Siloxanes and Silicones, dimethyl, methoxy phenyl,

polymers with phenyl silsesquioxanes,
methoxy-terminated
Siloxanes and Silicones, methyl phenyl, methoxy
phenyl, polymers with phenyl silsesquioxanes,
methoxy- and phenyl-terminated

1.(71-36-3)1-

106

 Version 1

PBT vPvB

1.PBTPersistent, Bioaccumulative and Toxic

2.vPvBvery Persistent and very Bioaccumulative

PBT
PBT vPvB
vPvB
PBT

-T1/2 > 60 days in marine water, or

-T1/2 > 40 days,or in fresh- or estuarine
water, or
-T1/2 > 180 days in marine sediment, or
-T1/2 > 120 days in fresh- or estuarine
sediment, or

vPvB

-T1/2 > 60 days in marine, fresh- or estuarine

water, or
-T1/2 > 180 days in marine, fresh- or estuarine
sediment, or
-T1/2 > 180 days in soil.

-T1/2 > 120 days in soil.

- 60

- 60

- 180

- 40
- 180

- 180

- 120

- 120

BCF > 2000 L/Kg

BCF > 5000 L/Kg

(BCF) 2000 L/Kg

(BCF) 5000 L/Kg

107

-NOEC < 0.01 mg/L for marine or

freshwater organisms

(NOEC) 0.01 mg/L

-substance is classified as carcinogenic

(category 1A or 1B) ,germ cell mutagenic
(category 1A or 1B) or toxic for
reproduction (category 1A,1B or 2 )
- 1A 1B
1A1B
2 ( 1A1B 2B)

-there is other evidence of chronic

toxicity, as identified by the
classificationsSTOT(repeated
exposure),category 1 (oral,dermal,
inhalation of gases/vapours, inhalation of
dust/mist/fume)or category 2 (oral,dermal,
inhalation of gases/vapours,inhalation of
dust/mist/fume)according to the CLP
Regulation.
- CLP

1 /
// 2
///

(1) 90 (BCF) 300 L/Kg

(NOEC) 0.005 mg/L PBT
(2) 100 (BCF) 7000 L/Kg
vPvB
(3) 90 PBT
PBT vPvB
vPvB

108

 Version 1

1.
2.
3.
4.

<100 nm 100 nm

1-100 nm 100 nm

(nano-object)
(nano-structured material)
109

(nanocomposite)(assembled nanomaterial)
(shell structures)

1-100 nm
50%

50%
50% 1-100nm
(nanomaterial)

1-100nm (nanoscale)
(1)
(2)

(3)

1. (nanoscale)
1 100 nm
2.
//
/

3. OECD 13
2010 OECD
110

 Version 1

(1).(fullerenes (C60)) CAS No. 99685-96-8

(2).(single-walled carbon nanotubes (SWCNTs)) CAS
No.99685-96-8
(3).(multi-walled carbon nanotubes (MWCNTs))CAS
No.308068-56-6
(4). (silver nanoparticles) CAS No. 7440-22-4
(5).(Iron nanoparticles) CAS No. 7439-89-6
(6). (Titanium dioxide) CAS No. 13463-67-7
(7). (Aluminum oxide) CAS No. 1344-28-1
(8). (Cerium oxide) CAS No. 1306-38-3
(9).(Zinc oxide) CAS No. 1314-13-2
(10).(silicon dioxide)CAS No. 7631-86-9 (15468-32-3)
(11).(dendrimers)
(12).(nanoclays)
(13).(Gold nanoparticles)(2010 ) CAS No. 7440-57-5

1. (Nanomaterial)

2. (Nanoscale)<100 nm
3. (Nanostructure)<100nm

4. (Nanotube)<100nm()
()
111

5. (agglomeration)

6. (aggregation)

1.
CAS No.
CAS No. CAS No.
CAS No.
//
/

(International Union forof

Pure and Applied Chemistry Name(s)IUPAC Name(s))
(Chemical Abstracts (CA)Preferred Index Name(s))

2.
Particle size

(primary particle size)

(scale bar)
(SEMTEMAFM)
SEMTEMAFMDLS

112

 Version 1

Sci. Technol. Adv. Mater. 14 (2013) 023001

Particle size distribution

: DLSqNano TEMAFMSEM

J. Braz. Chem. Soc., Vol. 17, No. 8, 1679-1682, 2006

Agglomeration

(surface
energy)

113

DLS SEM TEM

DLS
Aggregation

DLS
SEM TEM DLS
Shape

SEM TEM : SEMTEM

http://scimonth.blogspot.tw/2011/01/2011.html

Specific surface area

m2/g m2/m3

114

 Version 1

BET
Inverse GCNMR particle surface analyzer
Crystal structure

XRDTEM
Surface charge
(stern
layer)
(diffuse layer)
(slipping plane)

pH
pH

Surface properties

Porosity

: ISO 15901
Part 1~3

115

1.

(particle size) *
nm

1.1

3.

SEM TEM
AFM DLS

SEM TEM
AFM DLS

1.2

2.

(Agglomeration) *
2.1

nm

SEM TEM
DLS

2.2

nm

SEM TEM
DLS

(Shape) *
3.1

SEM TEM

3.2
4.

m2/g

(Specific surface area)

*

5.

(Crystal structure) *
XRD

5.1

116

 Version 1

5.2

XRD

5.3

nm

6.

(Surface charge)

mV

7.

(Surface properties)
7.1 /

7.2
8.

(Porosity)

117

XRD

1. (Scanning Electron Microscopy, SEM)

2. (Transmission Electron Microscopy, TEM)

3. (Atomic Force Microscopy, AFM)

10-10m

4. (Dynamic Light Scattering, DLS)

(Brownian motion)

118

 Version 1

(interference)

(correlator)

(self-correlation function)

5. X (X-Ray Diffractometer, XRD)

X-ray

X
(Diffraction Pattern)

6. ISO 15901 Part 1~3

Part 1: Mercury Porosimetry
Part 2: Analysis of Mesopores by Gas Adsorption
Part 3: Analysis of Micropores by Gas Adsorption

119

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120