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Prolongedduration
Howlongdoeschronicinflammationlast
3thingsassociatedwithchronicinflammation
ChronicInflammationsignificanttissue____,altered
____,andchangesto____
____abnormaltissueinfiltrationbycellsofimmune
systemsuchasmacrophagesandneutrophils
Continuousreleaseandactivitiesofgrowthfactors
andcytokinesfromdamagedtissuesandimmune
systemcells
Collagendepositsthatmakeupscartissuesand
fibrosis
Hypertrophy/plasiaareexamplesofwhatpartof
tissueremodeling
Chronicinflammationfollowsanepisodeofwhat
Chronicinflammationcanbegin____
TorF.Chronicinflammationbeginswith
manifestationofacutereactions.
Growthsignalforkeratinocytesandfibroblasts,
woundhealing
Signalforhepatocytesandepithelialcellreplication
Signalforonlyangiogenisisandwoundhealing
weeksormonths
prolongedduration
inflammation,tissueinjury,attemptsatrepair
remodeling,physiology,homeostasis
persistent
Tissueremodeling
fibroblasts
celladaptations
prolongedacuteinflammation
insidiously
Canbewithout,soF
EpidermalGrowthFactorAlpha(EGFa)
Transforminggrowthfactoraandb(TGFaandTGFb)
VEGF
Signalforchemotaxisforimmunesystemcells
Plateletderivedgrowthfactor(PDGF)
Signalforactivatingcellreplicationprocesses
Plateletderivedgrowthfactor
Signalforregulationofimmunefunctionsand
inflammation
TNF
Immunesystemmediators
MediatorsforWoundHealing
Mediatorsforangiogenesis
Scarringaka
4outcomesofchronicinflammation
outcomeofchronicinflammationthatcanleadto
emergenceofotherdisorders/diseases
Nearlyallchronicdiseasehassome
components/contributionsfromwhat
Proliferationoforiginalcellsandtissuestoreplace
lostones
Tissueregenerationoccurswhere
exof2selectedtissueswheretissueregeneration
occurs
Tissueregenerationdependentofavailabilityofwhat
Interleukins
EGFa,TGFa/b,VEGF,PDGF,TNF
VEGFandPDGF
fibrosis
Excessiveinflammation,Resolutionofinjury/cure,
Scarring/fibrosis,insufficient/defectiveremovalof
injuriousagents
excessiveinflammation
chronicinflammation
tissueregeneration
onlyinveryselectedtissues
bonemarrow,liver
adulttissuestemcells
Tissue____restoresfullfunctionoforiginaltissues
regeneration
Tissue____isideal,butrarelyoccurs
regeneration
Whatoccurswhentissueregenerationisnotpossible
Tissueregenerationcanoccurintheextracellular
matrix.TorF?
Wherecantissuerepairoccur?
Intissuerepair,whatisnecrotictissuereplacedwith?
repair
F
everywhereinbody
collagenthatresultsinscartissueformation
Tissue____doesNOTrestorefullfunctionoforiginal
tissues
Injuriousdamageremovedearly/promptly
persistenttissuedamage
Tissue____isnotideal,butcommonlyoccurs
repair
scarformation
fibrosis
repair
Atough,densemassofcollagen
Scartissue
Bridgeorcoveracrossdamagedarea
scartissue
Scartissueavascularorvascular
Scarringresultsinlossofwhat
avascular
normalphysiologicfunction
ECMremodelingalways____thetissuestructure
andnever____it
modifies,improves
Dotissueregenerationandtissuerepairinfluence
eachother?
theycan
Anattemptbytheimmunesystemtoisolateforeign
invadersbywallingorsealingthemoff
Purulentcollectionoffluid/pus
Granulomatousinflammationhaveinvolvementof
what
Whataremacrophagestransformedintoin
granulomatousinflammation
Whendogranulomatousinflammationsinclude
fibroblastsandconnectivetissue
Whatcellsinvolvedingranulomatousinflammation
(notoldones)
Restrictivelungdiseasecausedbyoccupational
exposure
abscessandgranuloma
abscess
Macrophages
epitheliumlikecells
oldergranuloma
macrophages,lymphocytes,plasmacells
Pneumoconiosis
Pneumoconiosisinvolveswhattypeofexposureto
offendingagent
chronic
Pneumoconiosisinvolveswhatkindofinflammation
chronic
Pneumoconiosiscauseswhattohappentolungs
Lossoflungtissueelasticityresultsinwhat
3examplesofaccumulations
Fattyliverisabnormalretentionofwhatwithinliver
cell
Isfattyliverreversible?
Wilson'sdiseaseisaccumulationofwhatwhere
Alzheimer'sdiseaseisaccumulationofwhatwhere
Inflammationoccursonwhichday
lossoflungtissueelasticity
chronicimpairmentofbreathing/oxygenchange
Fattyliver,Wilson'sdisease,Alzheimer's
lipids
yes
copperinliver
betaamyloidproteinsandpossiblyaluminuminbrain
0
Proliferationoccursonwhatday
34
Granulomatoustissuesoccuronwhichday
34
3stepsofwoundhealinginorder
4systemicfactorsthatcanhinderhealing
Exofnutritionalhinderance
inflammation,proliferation,remodeling
nutrition,metabolicstatus,impairedcirculatorystatus,
hormones/drugs
VitaminCorproteindeficiency
Exofmetabolicstatushinderance
Diabetes
Exofimpairedcirculatorystatushinderance
ischemia
3exofhormones/drugs
Glucocorticoidfrom
Exofsteroid
4localfactorsthatcanhinderhealing
glucocorticoid,steroids,sirolimus
adrenalhormone
prednisoneandsirolimus
infection,mechanicalfactors,presenceofforeign
bodies,size/type/locationofwounds
Worseoutcomesinsmallorlargewound
Moreorlessvascularizedleadtoworseoutcomes
andwhy
localizedexcavationattributedtoinflammation
generallydevelopafterthermal/traumaticinjurythat
involvesdeeplayersofdermis
Scartissuethatgrowsbeyondboundariesoforiginal
woundanddoesn'tregress
Keloidmorecommoninwhichrace
Woundhealinginexcesscancausewhattohappen
tomusclesandtendons
large
less,lessbloodsupply
ulcer
hypertrophicscars
keloid
AfricanAmerican
contraction