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AMINES
Amines are organic nitrogen compounds, formed by replacing one or more
hydrogen atoms of ammonia (NH3) with alkyi groups.
the amine nitrogen atom has a nonbonded electron pair, making it both a base
and a nucleophile. As a result, amines react with electrophiles to form quaternary
ammonium salts
Aromatic Amines
Nitrogen Heterocycles
Preparation of Amines
Three types of reactions are used to prepare an
amine:
[1] Nucleophilic substitution using nitrogen
nucleophiles
[2] Reduction of other nitrogen-containing
functional groups
[3] Reductive amination of aldehydes and
ketones
Examples
Problem
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Reactions of Amines
Amines react as nucleophiles with electrophilic carbon atoms.
Amines attack carbonyl groups to form products of nucleophilic
addition or substitution.
1. Reaction of 1o and 2o amines with aldehydes and ketones
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In the presence of acid, nitrous acid decomposes to +NO, the nitrosonium ion.
This electrophile then goes on to react with the nucleophile nitrogen atom of
amines to form diazonium salts (RN2+Cl-) from 1o amines and N-nitrosamines
(R2NN=O) from 2oamines.
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Quiz
Solution
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Example
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Quiz
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Solution
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Natural Dyes
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