Mount Saint Joseph University

School of Health Sciences, Department of Nursing

514 Gardner/Clephane

MEDICATION ADMINISTRATION SHEET

Generic and Product name of the drug ____Ampicillin Sodium and Sulbactam Sodium__/_____Unasyn_______
Classification & sub-classification (if applicable) of the drug ___Antibiotic____/___Aminopenicillin______

Child(1yorolder):IV300mg/
kg/day(200mg/kgampicillinand100mg/kgsulbactam)dividedq6h
Normal dose range specific for indication and patient population

PEDS: Safe dose range calculation for your patients weight in Kg (show work)

mg/dose =

mg/dose =

1500mg
______
kg/day
3000mg
_______
kg/day

22.8kg
_______ = 34200 mg
1
22.8kg
_______ = 68400 mg
1

Is the ordered dose on MAR safe for patient per dose (yes/no)?

YES

Is the ordered dose on MAR safe for patient per daily (24hr) total (yes/no)? YES

Mount Saint Joseph University

School of Health Sciences, Department of Nursing
1.

What are the patient specific indications and uses

of this medication?

2. What is the action of this medication in the body?

How would you evaluate its effectiveness?

514 Gardner/Clephane

ANTIBIOTIC FOR CELLULITIS. Treatmentofinfectionsdue

tosusceptibleorganismsinskinandskinstructures,intra
abdominalinfections,andgynecologicinfections.

Ampicillininhibitsthefinalstageofbacterialcellwall
synthesisbybindingtospecificpenicillinbindingproteins
(PBPs)locatedinsidethebacterialcellwall,thusdestroying
thecellwall.Sulbactaminhibitsbetalactamases,most
frequentlyresponsiblefortransferreddrugresistance.Thus
thespectrumofdrugsaffectedbythecombinationofthe
twoisincreased.

3. What are the major side effects/adverse effects of

this medication?

BodyasaWhole:Hypersensitivity(rash,itching,
anaphylactoidreaction),fatigue,malaise,headache,
chills,edema.GI:Diarrhea,nausea,vomiting,
abdominaldistention,candidiasis.Hematologic:
Neutropenia,thrombocytopenia.Urogenital:Dysuria.
CNS:Seizures.Other:Localpainatinjectionsite;
thrombophlebitis.

4. What are the important nursing considerations

related to administering this medication?

MONITOR I/OS, AND LAB TESTS. Determineprevious

hypersensitivityreactionstopenicillins,cephalosporins,
andotherallergenspriortotherapy.Reportpromptly
unexplainedbleeding(e.g.,epistaxis,purpura,
ecchymoses).Monitorpatientcarefullyduringthefirst30
minafterinitiationofIVtherapyforsignsof
hypersensitivityandanaphylactoidreaction

Mount Saint Joseph University

School of Health Sciences, Department of Nursing
5. Are there any other special considerations related
to administering this medication based on the
patient population? (i.e. if giving an IM injection to a
newborn, what size needle is needed. If giving a
medication to a pediatric patient, how will it be
given?)

Source: Wilson,

514 Gardner/Clephane
IntramuscularReconstitutesolutionwithsterilewaterfor
injectionbyadding6.4mLdiluenttoa3gvial.EachmL
contains250mgampicillinand125mgsulbactam.Intravenous
PREPARE:Direct/Intermittent:Reconstituteeach1.5gvial
with3.2mLofsterilewaterforinjectiontoyield375mg/mL
(250mgampicillin/125mgsulbactam);mustfurtherdilutewith
NS,D5W,D5/NS,D5W/0.45NS,orLRtoafinalconcentration
withintherangeof345mg/mL.ADMINISTER:Direct:Give
slowlyoveratleast1015min.Intermittent:Infusesolutionsof
lessthan50mLover1015minandsolutionsof50100mL
over1530min.

B. A., Shannon, M. T., & Shields, K. M. (2015). Pearson nurses drug

guide 2015. Upper Saddle River, NJ: Pearson Education.