1.

Novomix
Manufacturer

Novo Nordisk

Contents

Insulin aspart 30%, protamine crystallised insulin aspart 70%

Indications

Treatment of DM.
Click to view NovoMix 30 FlexPen detailed prescribing information

Dosage

SC Individualized dosage. Usual dose: 0.5-1 u/kg/day.

Click to view NovoMix 30 FlexPen detailed prescribing information

Overdosage

View NovoMix 30 FlexPen overdosage for action to be taken in the event of an overdose.

Administration

Should be taken with food: Administer immediately before or soon after a meal.

Contraindications

Hypersensitivity. Hypoglycemia.
Click to view NovoMix 30 FlexPen detailed prescribing information

Special Precautions

Do not administer IV. Inadequate dosing & discontinuation of treatment may lead to hyperglycaemia &
ketoacidosis. Omission of meals or unplanned strenuous exercises may lead to hypoglycaemia;
disease or medication may delay food absorption &/or increase insulin requirement. Renal & hepatic
impairment. Transferring from other insulin products, Not to be used in insulin infusion pumps.
Combination w/ thiazolidinediones should be discontinued if any deterioration in cardiac symptoms
occurs. May impair ability to drive or operate machinery as a result of hypoglycaemia. Pregnancy &
lactation. Childn & adolescents <18 yr.
Click to view NovoMix 30 FlexPen detailed prescribing information

Adverse Drug Reactions

Hypoglycemia. Urticaria, rash, eruptions, anaphylactic reactions. Peripheral neuropathy. Refraction

disorder, diabetic retinopathy. Lipodystrophy. Inj site reaction, oedema.
View ADR Monitoring Form

Drug Interactions

Reduce insulin requirements w/ oral hypoglycemics, octreotide, MAOIs, nonselective -adrenergic

blockers, ACE inhibitors, salicylates, alcohol, anabolic steroids & sulfonamides; increase insulin
requirements w/ OCs, thiazides, glucocorticoids, thyroid hormones, sympathomimetics & danazol. blocking agents may mask the symptoms of hypoglycaemia. Alcohol may intensify & prolong the
glucose lowering effect of insulin.

Pregnancy Category (US

FDA)
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no
controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect
(other than a decrease in fertility) that was not confirmed in controlled studies in women in the
1sttrimester (and there is no evidence of a risk in later trimesters).
Caution For Usage

For caution against possible variation of physical aspect of medicine... click to view NovoMix 30
FlexPen detailed prescribing information

Storage

View NovoMix 30 FlexPen storage conditions for details to ensure optimal shelf-life.

Description

View NovoMix 30 FlexPen description for details of the chemical structure and excipients (inactive
components).

Mechanism of Action

View NovoMix 30 FlexPen mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Insulin Preparations

ATC Classification

A10AD05 - insulin aspart ; Belongs to the class of intermediate-acting combined with fast-acting

insulins and analogues. Used in the treatment of diabetes.

Drug Classification

2. Omeprazol
Manufacturer

Novo Nordisk

Contents

Insulin aspart 30%, protamine crystallised insulin aspart 70%

Indications

Treatment of DM.
Click to view NovoMix 30 FlexPen detailed prescribing information

Dosage

SC Individualized dosage. Usual dose: 0.5-1 u/kg/day.

Click to view NovoMix 30 FlexPen detailed prescribing information

Overdosage

View NovoMix 30 FlexPen overdosage for action to be taken in the event of an overdose.

Administration

Should be taken with food: Administer immediately before or soon after a meal.

Contraindications

Hypersensitivity. Hypoglycemia.
Click to view NovoMix 30 FlexPen detailed prescribing information

Special Precautions

Do not administer IV. Inadequate dosing & discontinuation of treatment may lead to hyperglycaemia &
ketoacidosis. Omission of meals or unplanned strenuous exercises may lead to hypoglycaemia;
disease or medication may delay food absorption &/or increase insulin requirement. Renal & hepatic
impairment. Transferring from other insulin products, Not to be used in insulin infusion pumps.
Combination w/ thiazolidinediones should be discontinued if any deterioration in cardiac symptoms
occurs. May impair ability to drive or operate machinery as a result of hypoglycaemia. Pregnancy &
lactation. Childn & adolescents <18 yr.
Click to view NovoMix 30 FlexPen detailed prescribing information

Adverse Drug Reactions

Hypoglycemia. Urticaria, rash, eruptions, anaphylactic reactions. Peripheral neuropathy. Refraction

disorder, diabetic retinopathy. Lipodystrophy. Inj site reaction, oedema.
View ADR Monitoring Form

Drug Interactions

Reduce insulin requirements w/ oral hypoglycemics, octreotide, MAOIs, nonselective -adrenergic

blockers, ACE inhibitors, salicylates, alcohol, anabolic steroids & sulfonamides; increase insulin
requirements w/ OCs, thiazides, glucocorticoids, thyroid hormones, sympathomimetics & danazol. blocking agents may mask the symptoms of hypoglycaemia. Alcohol may intensify & prolong the
glucose lowering effect of insulin.

Pregnancy Category (US

FDA)
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no
controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect
(other than a decrease in fertility) that was not confirmed in controlled studies in women in the
1sttrimester (and there is no evidence of a risk in later trimesters).
Caution For Usage

For caution against possible variation of physical aspect of medicine... click to view NovoMix 30
FlexPen detailed prescribing information

Storage

View NovoMix 30 FlexPen storage conditions for details to ensure optimal shelf-life.

Description

View NovoMix 30 FlexPen description for details of the chemical structure and excipients (inactive
components).

Mechanism of Action

View NovoMix 30 FlexPen mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Insulin Preparations

ATC Classification

A10AD05 - insulin aspart ; Belongs to the class of intermediate-acting combined with fast-acting
insulins and analogues. Used in the treatment of diabetes.

Drug Classification

3. Furosemid
Manufacturer

Fahrenheit

Contents

Furosemide

Indications

Listed in Dosage.

Dosage

Tab Edema associated w/ CHF, hepatic cirrhosis, renal disease Adult 20-80 mg as a single dose,
increased by 20-40 mg 6-8 hrly until desired response is obtained. Childn 2 mg/kg body wt as a single
dose, increased by 1-2 mg/kg body wt 6-8 hrly, until desired response is obtained. In childn w/ nephrotic
syndrome dose may be increased to max 6 mg/kg body wt. Mild to moderate HTN, alone or in
combination w/ other antihypertensives & as adjunctive treatment in hypertensive crisisInitially 40
mg twice daily. Inj Initially 20-40 mg IV/IM. Increase at 2 hrly intervals by 20 mg. If necessary inject a
further 20-40 mg after 20 min. Acute pulmonary edema Initially 40 mg IV. An additional 20-40 mg may be
administered after 20 min.

Administration

May be taken with or without food: May be taken w/ meals to reduce GI discomfort.

Contraindications

Renal function impairment; oliguria, anuria; hypokalemia, hyponatremia; hypotension.

Special Precautions

DM; history of gout; hepatic function impairment; hyperuricemia; history of SLE; pancreatitis; pregnancy.

Adverse Drug Reactions

Hyperuricemia, hypokalemia, hyponatremia; anorexia; azotemia; hypersensitivity reaction; dermatologic

reaction; GI disturbances; irregular heart beat; thirst; hematologic reaction.
View ADR Monitoring Form

Drug Interactions

May potentiate antihypertensive action of d-tubocurarine. Hypoglycaemics, antigout medications. May

enhance toxicity of aminoglycosides, cephalosporins, salicylates, lithium & cardiac glycosides. Diuretic
effectiveness may be reduced by probenecid. Increased orthostatic hypotension may occur w/ alcohol,
narcotics, barbiturates. Adrenocorticoids, amphotericin B or ACTH may intensify electrolyte imbalance.

Pregnancy Category (US

FDA)
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or
embryocidal or other) and there are no controlled studies in women or studies in women and animals are
not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
MIMS Class

Diuretics

ATC Classification

C03CA01 - furosemide ; Belongs to the class of high-ceiling sulfonamide diuretics.

Drug Classification

4. Nephrosteril
Manufacturer

Fresenius Kabi

Contents

Per L L-isoleucine 5.1 g, L-leucine 10.3 g, L-lysine monoacetate 10.01 g (equiv to L-lysine 7.1 g), Lmethionine 2.8 g, acetylcysteine 0.5 g (equiv to L-cysteine 0.37 g), L-phenylalanine 3.8 g, L-threonine
4.8 g, L-tryptophan 1.9 g, L-valine 6.2 g, arginine 4.9 g, L-histidine 4.3 g, aminoacetic acid 3.2 g, Lalanine 6.3 g, L-proline 4.3 g, L-serine 4.5 g, L-malic acid 1.5 g, glacial acetic acid 1.38 g. Total amino
acids 70 g, total nitrogen content 10.8 g. Energy 280 kCal

Indications

Balanced supply of amino acids in acute & chronic renal failure eg malnutrition, hypoproteinemia, pre& post-op.

Dosage

Adult Chronic renal failure 200 mL/day infused via a peripheral vein at 100 mL/hr (approx 25
drops/min) or 400 mL/day infused via central vein. Acute renal failure 600 mL/day infused via central
vein.

Contraindications

Impaired amino acid metabolism, advanced hepatic impairment, severe cardiac insufficiency,
hyperhydration, hypokalemia, hyponatremia. Hepatic coma, inherited abnormal amino acid
metabolism, severe renal impairment or azotemia, hyperammonemia.

Special Precautions

Supply sufficient K. Regularly monitor water-electrolyte metabolism, acid-base balance & serum urea.
Hyperammonemia or consciousness disorders (discontinue). Inadequate administration of calories. CV
dysfunction, hepatic disorders, GI bleeding, severe electrolyte imbalance, abnormal acid-base
balance, severe acidosis. Jaundice (childn). Pregnancy & lactation. Elderly, childn & infant.

Adverse Drug Reactions

Nausea, chills & vomiting (excessive drop rates). Eruption, skin rash (discontinue). Chest discomfort,
palpitations; increased SGOT, SGPT, total bilirubin, ammonia, BUN & creatinine; acidosis; fever,
headache, vascular pain, lower extremity edema, hyperkalemia, dry mouth.
View ADR Monitoring Form

MIMS Class

Parenteral Nutritional Products

ATC Classification

B05BA01 - amino acids ; Belongs to the class of solutions for parenteral nutrition used in I.V. solutions.

Drug Classification

5. Kalitake
Manufacturer

Dipa Pharmalab Intersains

Contents

Ca polystyrene sulfonate

Indications

Hyperkalemia due to acute & chronic renal failure.

Dosage

Adult 15-30 g daily orally, suspended in 30-50 mL water, in 3-4 divided doses. Childn adult dose.

Administration

Should be taken on an empty stomach.

Contraindications

Intestinal obstruction.

Special Precautions

Monitor K & Ca levels at regular intervals during therapy; intestinal stenosis, GI ulcers,
hyperthyroidism, multiple myeloma.

Adverse Drug Reactions

Intestinal perforation & obstruction, constipation, nausea, anorexia, stomach discomfort; hypokalemia.
View ADR Monitoring Form

Drug Interactions

Antacid & laxative containing Al, Mg or Ca, digitalis.

Pregnancy Category (US

FDA)

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or
embryocidal or other) and there are no controlled studies in women or studies in women and animals
are not available. Drugs should be given only if the potential benefit justifies the potential risk to the
foetus.
MIMS Class

Antidotes & Detoxifying Agents

ATC Classification

V03AE01 - polystyrene sulfonate ; Belongs to the class of drugs used in the treatment of hyperkalemia
and hyperphosphatemia.

Drug Classification

6. Simvastatin
Manufacturer

Kalbe Farma

Contents

Simvastatin

Indications

Hyperlipidemia, CHD.

Dosage

Initially 5-10 mg once daily at night. Max: 40 mg/day. Adjust at 4-wk intervals as required.

Administration

May be taken with or without food: Avoid excessive consumption (>1 L/day) of grapefruit juice.

Contraindications

Liver disease. Pregnancy & lactation.

Special Precautions

Persistent rise of transaminase level up to 3 times the upper limit of normal, history of liver disease,
high alcohol consumption. Muscle symptom & elevation of CPK.

Adverse Drug Reactions

Abdominal pain, flatulence, constipation, asthenia & headache. Rarely, hepatitis, hypersensitivity
syndrome.
View ADR Monitoring Form

Drug Interactions

Coumarin, cyclosporin, gemfibrozil, fibric acid derivatives & niacin.

Pregnancy Category (US

FDA)
Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is
evidence of foetal risk based on human experience or both, and the risk of the use of the drug in
pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who
are or may become pregnant.
MIMS Class

Dyslipidaemic Agents

ATC Classification

C10AA01 - simvastatin ; Belongs to the class of HMG CoA reductase inhibitors. Used in the treatment
of hyperlipidemia.

Drug Classification

7. Neforfit Fe
Brand::

Fahrenheit

Product Code::

Komposisi:

Vitamin B1 1.5 mg, vitamin B2 1.8 mg, pantothenic acid 10 mg, niacinamide 20 mg,
vitamin B6 10 mg, vitamin B12 6 mcg, vitamin C 60 mg, folic acid 1 mg, vitamin E 15
mg, biotin 300 mcg, Fe 100 mg

Indikasi:

Pra dan pasca hemodialis

Dosis:

1 tablet per hari

Pemberian Obat:

Dapat diberikan bersama makanan agar diabsorpsi lebih baik atau jika timbul rasa
tidak nyaman pada GI

Kemasan:

Tablet salut selaput 100's

8. Klonidin
Manufacturer

Boehringer Ingelheim

Contents

Clonidine HCl

Indications

HTN. Inj: Hypertensive crisis.

Click to view Catapres detailed prescribing information

Dosage

Tab Initially 0.075-0.15 mg daily. May be increased after 2-4 wk. Severe cases: 0.3 mg up to 3 times
daily. Inj 0.2 mcg/kg/min IV infusion at a rate not to exceed 0.5 mcg/kg/min. Max: 0.15 mg/infusion. If
required, 1 amp up to 4 times daily.
Click to view Catapres detailed prescribing information

Overdosage

View Catapres overdosage for action to be taken in the event of an overdose.

Administration

May be taken with or without food.

Contraindications

Sick sinus syndrome. 2nd or 3rd degree AV block.

Click to view Catapres detailed prescribing information

Special Precautions

Diseases affecting rhythmic & AV conduction system of the heart; renal failure, disorders of cerebral or
peripheral perfusion, depression, polyneuropathy, constipation. May impair ability to drive or operate
machinery. Reduce dose gradually over 2-4 days when discontinuing treatment.
Click to view Catapres detailed prescribing information

Adverse Drug Reactions

Initially dry mouth, sedation & fatigue; orthostatic complaints.

View ADR Monitoring Form

Side Effects

View Catapres side effects

Drug Interactions

Enhanced antihypertensive effects by diuretics, vasodilators & -blockers. Lower heart rate &
dysrhythmia w/ -blockers &/or cardiac glycosides. Reduction in BP-lowering effect w/ tricyclic
antidepressants.

Pregnancy Category (US

FDA)

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or
embryocidal or other) and there are no controlled studies in women or studies in women and animals
are not available. Drugs should be given only if the potential benefit justifies the potential risk to the
foetus.
Storage

View Catapres storage conditions for details to ensure optimal shelf-life.

Description

View Catapres description for details of the chemical structure and excipients (inactive components).

Mechanism of Action

View Catapres mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Other Antihypertensives

ATC Classification

C02AC01 - clonidine ; Belongs to the class of imidazoline receptor agonists, centrally-acting

antiadrenergic agents. Used in the treatment of hypertension.

Drug Classification

9. Amdixal
Manufacturer

Sandoz

Contents

Amlodipine maleate

Indications

Arterial HTN. Prophylactic treatment of angina pectoris.

Dosage

Adult Initially 5 mg once daily. Max: 10 mg.

Administration

May be taken with or without food.

Contraindications

Hypersensitivity to other dihydropyridines; cardiogenic shock, severe aortic stenosis, unstable angina
pectoris, acute MI, severe hypotension, severe hepatic dysfunction.

Special Precautions

Hepatic failure, renal insufficiency dependent on dialysis; hypotension (systolic BP <90 mmHg) & CHF.
Pregnancy & lactation. May impair ability to drive or operate machinery.

Adverse Drug Reactions

Nausea, abdominal pain, exanthema, headache, fatigue, drowsiness, somnolence, edema,

palpitations, dizziness, flushing.

View ADR Monitoring Form

Drug Interactions

Enhanced effect by other antihypertensive drugs & TCAs. Nitrates, -blockers, Ca-channel blockers.

Pregnancy Category (US

FDA)

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or
embryocidal or other) and there are no controlled studies in women or studies in women and animals
are not available. Drugs should be given only if the potential benefit justifies the potential risk to the
foetus.
MIMS Class

Anti-Anginal Drugs / Calcium Antagonists

ATC Classification

C08CA01 - amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel

blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.

Drug Classification