West Visayas State University

COLLEGE OF NURSING
La Paz, Iloilo City

DRUG STUDY
Name of Patient:
Age:
Name of Drug
Generic:
phytonadione

Brand:
Vit. K

Ward/Bed Number:
Dosage,
Route,
Frequency
and Timing
Dosage:
0.5 ml
Route:
IM

Frequency:

Timing:

Classification

Attending Physician:
Impression/Diagnosis:

Mechanisms of
Action
Promotes hepatic
formation of
coagulation
factors II, VII, IX,
X. Essential for
normal clotting of
blood. Readily
absorbed from GI
tract (duodenum)
after IM,
subcutaneous
administration.
Metabolized in
liver. Excreted in
urine; eliminated
by biliary system.
Onset
of action
(increased
coagulation
factors

Indication

Prevention,
treatment of
hemorrhagic
states in
neonates.
Antidote for
hemorrhage
induced by oral
anticoagulants,
hypoprothrombi
nemic states
due to vitamin K
deficiency.
Hypoprothrombi
nemia caused
by
malabsorption
or inability to
synthesize
vitamin K.

Contraindication

Adverse
Reactions
Newborns (esp.
premature
infants) may
develop
hyperbilirubinemi
a. Severe
reaction
(cramp-like pain,
chest pain,
dyspnea,
facial flushing,
dizziness,
rapid/weak
pulse, rash,
diaphoresis,
hypotension
progressing
to shock, cardiac
arrest) occurs
rarely,
immediately
after IV
administration.
Side Effects

Special
Precautions

Nursing Responsibilities
Monitor PT, international
normalized ratio (INR)
routinely in those taking
anticoagulants.
Assess skin for
ecchymoses, petechiae.
Assess gums for gingival
bleeding,
Erythema.
Assess urine for
hematuria.
Assess Hct, platelet count,
urine/stool culture
for occult blood.
Assess for decrease
in B/P, increase in pulse rate,
complaint of abdominal/back
pain, severe headache (may
be evidence of hemorrhage).
Assess for increase in
amount of discharge
during menses.
Assess peripheral pulses.
Check for excessive

Functional:
antihemorrhagi
c

Chemical:
Fat-soluble
vitamin.

Students Name:
Clinical Instructor:

s
None known.
Cautions:
Renal
impairment,
newborns (esp.
premature):
Risk of
hemolysis,
jaundice,
hyperbilirubine
mia.

bleeding from minor cuts,

scratches
Pain, soreness,
swelling at IM
injection site,
pruritic erythema
(with
repeated
injections), facial
flushing, altered
taste.