Professional Documents
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Instituto de Ciencias de la Salud de Las Américas
Santo Domingo, República Dominicana
PURPOSE
The purpose of this course is to prepare students for the USMLE Step 1 exam
following a comprehensive overview of major subjects of Biomedical Basic
Sciences with a system approach and emphasizing the clinical relationships. At the
same time students are going to be trained in the computer based exams.
OBJECTIVES
By the end of the course students should be able to understand the basic principles
that control the human body organization and function as well as the mechanisms of
diseases production
PROGRAM
General principles 80 hours
Musculoskeletal system 40 hours
Central and peripheral nervous system 48 hours
Hematopoietic and Lymphoreticular system 8 hours
Respiratory system 16 hours
Cardiovascular system 32 hours
Gastrointestinal system 32 hours
Renal (urinary) system 16 hours
Endocrine system 24 hours
Reproductive system 16 hours
Skin and connective tissue 8 hours
FACULTIES
ASSESSMENTS
At the beginning of the course students will take a USMLE Step 1 like exam
every week students will take a comprehensive exam about topics covered in the
previous weeks. At the end of the course students will take another USMLE Step 1
like exam.
Calle Alma Mater, No. 103 entre Dr. Bernardo Correa y Cidrón e Independencia,
Zona Universitaria, Santo Domingo. República Dominicana
Phone: +1 809 221 6381 / web page: www: icsausmle.com / e‐mail: info@icsausmle.com
Instituto de Ciencias de la Salud de Las Américas
Santo Domingo, República Dominicana
COURSE OUTLINE
Calle Alma Mater, No. 103 entre Dr. Bernardo Correa y Cidrón e Independencia,
Zona Universitaria, Santo Domingo. República Dominicana
Phone: +1 809 221 6381 / web page: www: icsausmle.com / e‐mail: info@icsausmle.com
Instituto de Ciencias de la Salud de Las Américas
Santo Domingo, República Dominicana
Biology of cells
Calle Alma Mater, No. 103 entre Dr. Bernardo Correa y Cidrón e Independencia,
Zona Universitaria, Santo Domingo. República Dominicana
Phone: +1 809 221 6381 / web page: www: icsausmle.com / e‐mail: info@icsausmle.com
Instituto de Ciencias de la Salud de Las Américas
Santo Domingo, República Dominicana
Multisystem processes
• Nutrition
– Generation, expenditure, and storage of energy at the whole-body level
– Assessment of nutritional status across the life span, including calories, protein,
essential
Nutrients, hypoalimentation
– functions of nutrients, including essential, trans-fatty acids, cholesterol
– Protein-calorie malnutrition
– Vitamin deficiencies and/or toxicities
– Mineral deficiencies and toxicities
– Eating disorders: obesity, anorexia, bulimia, alternative diets and nutritional
supplements
• Temperature regulation
• Adaptation to environmental extremes, including occupational exposures
– Physical and associated disorders: temperature, radiation, burns, decreased
atmospheric pressure, high-altitude sickness, increased water pressure
– Chemical: gases, vapors, smoke inhalation, agricultural hazards, volatile organic
solvents, heavy metals, principles of poisoning and therapy
• Fluid, electrolyte, and acid-base balance and disorders: dehydration, acidosis,
alkalosis
Calle Alma Mater, No. 103 entre Dr. Bernardo Correa y Cidrón e Independencia,
Zona Universitaria, Santo Domingo. República Dominicana
Phone: +1 809 221 6381 / web page: www: icsausmle.com / e‐mail: info@icsausmle.com
Instituto de Ciencias de la Salud de Las Américas
Santo Domingo, República Dominicana
• General principles
– Pharmacokinetics: absorption, distribution, metabolism, excretion, dosage
intervals
– Mechanisms of drug action, structure-activity relationships
– Concentration- and dose-effect relationships: efficacy, potency, types of agonists
and antagonists and their actions
– Individual factors altering pharmacokinetics and pharmacodynamics: age,
gender, disease, tolerance, compliance, body weight, metabolic proficiency, and
pharmacogenetics
– Drug side effects, overdosage, and toxicology
– Drug interactions
– Regulatory issues: drug development, approval, scheduling
• General properties of autacoids, including peptides and analogs, biogenic
amines, prostanoids and their inhibitors, and smooth muscle/endothelial autacoids
• General principles of autonomic pharmacology
• General properties of antimicrobials, including mechanisms of action and
resistance
• General properties of antineoplastic agents and immunosuppressants, including
drug effects on rapidly dividing mammalian cells
Immune responses
Normal processes
Abnormal processes
Normal processes
Abnormal processes
Normal processes
Abnormal processes
Principles of therapeutics
• Mechanisms of action, use, and adverse effects of drugs for treatment of
disorders of the hematopoietic system
– Blood and blood products
– Treatment of anemia, drugs stimulating erythrocyte production: erythropoietin
– Drugs stimulating leukocyte production: G-CSF, GM-CSF
– Anticoagulants, thrombolytic drugs
– Antiplatelet drugs
– Antimicrobials: antimalarials, anti-HIV
– Antineoplastic and immunosuppressive drugs
– Drugs used to treat acquired disorders of immune responsiveness
• Other therapeutic modalities: splenectomy, chelating agents, radiation therapy for
lymphomas, plasmapheresis
Normal processes
Abnormal processes
Normal processes
Abnormal processes
• Neoplastic disorders
• metabolic and regulatory disorders: dysrhythmias, systolic and diastolic
dysfunction, low- and high-output heart failure, cor pulmonale, systemic
hypertension, ischemic heart disease, myocardial infarction, systemic hypotension,
and shock
• Vascular disorders: aneurysms, occlusions, varicosities, atherosclerosis
• Systemic diseases affecting the cardiovascular system: amyloidosis, aortic
dissection with Marfan syndrome, scleroderma
• Congenital disorders of the heart and central vessels
Principles of therapeutics
• Mechanisms of action, use, and adverse effects of drugs for treatment of
disorders of the cardiovascular system
– Coronary and peripheral vasodilators
– Antiarrhythmic drugs
– Antihypertensive drugs
– Measures used to combat hypotension and shock
– Drugs affecting cholesterol and lipid metabolism
– Drugs affecting blood coagulation, thrombolytic agents
– Inotropic agents and treatment of heart failure
– Immunosuppressive and antimicrobial drugs
– Drugs to treat peripheral arterial disease
• Other therapeutic modalities: pacemakers, angioplasty, valves, grafts, other
surgical procedures
Normal processes
Abnormal processes
Normal processes
Calle Alma Mater, No. 103 entre Dr. Bernardo Correa y Cidrón e Independencia,
Zona Universitaria, Santo Domingo. República Dominicana
Phone: +1 809 221 6381 / web page: www: icsausmle.com / e‐mail: info@icsausmle.com
Instituto de Ciencias de la Salud de Las Américas
Santo Domingo, República Dominicana
Abnormal processes
Normal processes
Calle Alma Mater, No. 103 entre Dr. Bernardo Correa y Cidrón e Independencia,
Zona Universitaria, Santo Domingo. República Dominicana
Phone: +1 809 221 6381 / web page: www: icsausmle.com / e‐mail: info@icsausmle.com
Instituto de Ciencias de la Salud de Las Américas
Santo Domingo, República Dominicana
Abnormal processes
Normal processes
Calle Alma Mater, No. 103 entre Dr. Bernardo Correa y Cidrón e Independencia,
Zona Universitaria, Santo Domingo. República Dominicana
Phone: +1 809 221 6381 / web page: www: icsausmle.com / e‐mail: info@icsausmle.com
Instituto de Ciencias de la Salud de Las Américas
Santo Domingo, República Dominicana
Abnormal processes
– Restoration of potency
• Other therapeutic modalities affecting the reproductive system: tampons
Normal processes
Abnormal processes
Calle Alma Mater, No. 103 entre Dr. Bernardo Correa y Cidrón e Independencia,
Zona Universitaria, Santo Domingo. República Dominicana
Phone: +1 809 221 6381 / web page: www: icsausmle.com / e‐mail: info@icsausmle.com
Instituto de Ciencias de la Salud de Las Américas
Santo Domingo, República Dominicana
BOOKS
High-Yield Lung
High-Yield Brain and Behavior
High-Yield Systems: Gastrointestinal Tract
High-Yield Heart
High-Yield Kidney
High-Yield Endocrine Organs
High-Yield Hematologic and Immune Systems
High-Yield Comprehensive USMLE Step I review
Lippincott's Illustrated Reviews Biochemistry
Medical Genetics for the Modem Clinician
MODALITIES
Calle Alma Mater, No. 103 entre Dr. Bernardo Correa y Cidrón e Independencia,
Zona Universitaria, Santo Domingo. República Dominicana
Phone: +1 809 221 6381 / web page: www: icsausmle.com / e‐mail: info@icsausmle.com