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e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 14, Issue 11 Ver. III (Nov. 2015), PP 17-19
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Post graduate, Department of Anaesthesiology and critical care, KIMS & RF, Amalapuram.
Senior Resident, Department of Anaesthesiology and critical care, KIMS & RF, Amalapuram.
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Prof & HOD of Anaesthesiology and critical care, KIMS & RF, Amalapuram.
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Prof & Dean, KIMS & RF, Amalapuram.
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Senior Resident, Department of Anaesthesiology and critical care, Andhra Medical College, Visakhapatnam.
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Abstract: The hemodynamic response during laryngoscopy and intubation is a unwanted side effect during
securing the airway for conducting safe anaesthesia. This study was done to compare the varying doses of
Intravenous Esmolol in attenuating the hemodynamic stress responses to laryngoscopy and endotracheal
intubation. 60 patients were enrolled in a prospective, randomized and double blind study. The three doses of
esmolol studies were 0.5mg/kg, 1.0mg/kg, 1.5mg/kg. We found that even though there was a rise in
hemodynamic parameters but the patients treated with esmolol showed greater resistance to abrupt excursions
of heart rate and blood pressure. The dosage of 1.5mg/kg was found to be the most efficacious in attenuating the
pressor response.
Keywords: Esmolol, Laryngoscopy, Intubation, Pressor response.
I. Introduction
The hemodynamic response during laryngoscopy and intubation should be abolished to balance the
myocardial oxygen supply and demand for the safe conduct of anaesthesia. Various pharmacological & non
pharmacological methods have been used to attenuate the hemodynamic response to laryngoscopy &
endotracheal intubation. Pharmacological methods like use of Inhalational anesthetics, topical and Intravenous
lidocaine, narcotics, -Blockers, calcium channel Blockers, vasodilators,have been tried. This study was done to
compare the varying doses of Intravenous Esmolol in attenuating the hemodynamic stress responses to
laryngoscopy and endotracheal intubation.
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VI. Conclusion
From our study it can be concluded that There is no statistical significance among the mean value of
heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure at the Pre-medication time(p
>0.05) in three groups A,B,C where they received 0.5mg/kg, 1mg/kg,1.5mg/kg of esmolol respectively. There is
DOI: 10.9790/0853-141131719
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DOI: 10.9790/0853-141131719
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