Hepatosplenomegaly - Wikipedia, the free encyclopedia

https://en.wikipedia.org/wiki/Hepatosplenomegaly

Hepatosplenomegaly
From Wikipedia, the free encyclopedia

Hepatosplenomegaly (commonly abbreviated HSM)

is the simultaneous enlargement of both the liver
(hepatomegaly) and the spleen (splenomegaly).
Hepatosplenomegaly can occur as the result of acute
viral hepatitis, infectious mononucleosis, and
histoplasmosis or it can be the sign of a serious and
life-threatening lysosomal storage disease. Systemic
venous hypertension can also increase the risk for
developing hepatosplenomegaly, which may be seen
in those patients with right-sided heart failure.

Hepatosplenomegaly
Classification and external resources
ICD-10

R16.2 (http://apps.who.int
/classifications/icd10/browse
/2015/en#/R16.2)

ICD-9

571.8 (http://www.icd9data.com
/getICD9Code.ashx?icd9=571.8)

MedlinePlus 003275 (http://www.nlm.nih.gov

/medlineplus/ency/article

Contents

/003275.htm)

1 Common causes
2 Rare disorders
3 References
4 External links

Common causes
Infection:
Acute viral hepatitis[1][2]
Infectious mononucleosis[1][2]
Cytomegalovirus[1][2]
Rubella[1]
Brucella infection[3]
Malaria[1]
Leishmaniasis[1]
Fasciolosis
Schistosomiasis or filariasis importants
Septicemic plague
Haematological disease:
Myeloproliferative disease[1][2]
Leukaemia[1][2]
Lymphoma[1][2]
Pernicious anaemia[2]
Sickle cell anaemia[2]

1 of 3

6/13/15, 14:43

Hepatosplenomegaly - Wikipedia, the free encyclopedia

https://en.wikipedia.org/wiki/Hepatosplenomegaly

Thalassaemia[2]
Myelofibrosis[1]
Metabolic disease:
Niemann-Pick disease
Gaucher's disease
Hurler's syndrome
Chronic liver disease and portal hypertension:
Chronic active hepatitis[2]
Amyloidosis[2]
Acromegaly[2]
Systemic lupus erythematosus[2]
Sarcoidosis
Human African trypanosomiasis

Rare disorders
Multiple sulfatase deficiency
Osteopetrosis

References
1. medcyclopaedia: Hepatosplenomegaly (http://www.medcyclopaedia.com/library/topics/volume_vii
/h/HEPATOSPLENOMEGALY.aspx) Retrieved on Nov 23, 2009
2. GPNotebook: hepatosplenomegaly (http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800)
Retrieved on Nov 23, 2009
3. Xavier, Mariana (2010). "Pathogenesis of Brucella spp.". The Open Veterinary Science Journal 4: 109118.

External links
National Niemann Pick Disease Foundation (http://www.nnpdf.org/)
Hide and Seek Foundation For Lysosomal Disease Research (http://www.hideandseek.org/)
1516961800 (http://www.gpnotebook.co.uk/simplepage.cfm?ID=1516961800) at GPnotebook
"Hepatosplenomegaly" (http://web.archive.org/web/20120205102047/http:
//www.medcyclopaedia.com/library/topics/volume_vii/h/HEPATOSPLENOMEGALY.aspx).
Medcyclopaedia. GE. Archived from the original (http://www.medcyclopaedia.com/library/topics
/volume_vii/h/HEPATOSPLENOMEGALY.aspx) on 2012-02-05.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Hepatosplenomegaly&oldid=645297813"

Categories: Symptoms and signs: Digestive system and abdomen Medical signs Diseases of liver
Medical sign stubs

2 of 3

6/13/15, 14:43

Hepatosplenomegaly - Wikipedia, the free encyclopedia

https://en.wikipedia.org/wiki/Hepatosplenomegaly

This page was last modified on 2 February 2015, at 12:32.

Text is available under the Creative Commons Attribution-ShareAlike License; additional terms
may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia is a
registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.

3 of 3

6/13/15, 14:43