Cellular Activation Therapy

sm

The ONLY Treatment Proven

to Stop, Retard, and/or Reverse the
Chronic Complications of Diabetes.
www.Diabetes.Net
Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

DIABETES a disease of
Improper Metabolism

Food: When food is eaten, the body metabolizes carbohydrates

sugars and releases insulin from the pancreas directly into the liver.
In non-diabetic people, the liver receives insulin in a unique pulsating
way which causes the liver to produce enzymes needed for proper
metabolism of all foods. This pulsating insulin to the liver is needed for
every normal person to activate their cells. Insulin is a primary hormone
that performs key functions in maintaining good health, at the cellular level.

Type 1 Results from the body's failure to produce insulin, the

hormone that "unlocks" the cells of the body, allowing glucose to enter
and fuel them. The body of a diabetic is unable to metabolize carbohydrates
sugars because they do not produce the needed insulin.

Type 2 Results from improper insulin release to the liver and

insulin resistance (a condition where cells fail to properly use insulin).
The bodys inability to properly metabolize carbohydrates, again, is the
core problem.
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Millions In Need

24 Mil cases of diabetes in USA alone

1 Mil new cases of diabetes each year
24%+ of diabetics, or 4 Mil Need CAT
One in three born after 2001, will become
diabetic during their life.

Native Americans are most inflicted.

The number of people diagnosed with diabetes worldwide has been consistently
on the rise for the last several decades and appears to continue to rise for the
foreseeable future. The number of children that are born with Type I diabetes
has increased from 1 in every 700 children in the 1970s to 1 in every 400
today. Diabetes is perhaps the largest worldwide treatable disease.
Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

Complications of Diabetes

Heart Disease:
Stroke:

Heart disease is the leading cause of diabetes related death.

The risk of stroke is 2 to 4 times greater among people with diabetes.

High Blood Pressure:

Blindness:

73% of adults with diabetes have high blood pressure.

Diabetic retinopathy is the most common cause of new blindness cases each year.

Kidney Disease:
Amputations:

Diabetes is the leading cause of renal disease, accounting for 43% cases.

Over 60% of non-traumatic amputations happen among diabetes patients.

Nervous System Disease:

60% to 70% of diabetes patients have mild to severe forms of

nervous system damage, depression and malaise.

In addition, many people experience fatigue, sleeping disorders, diabetes related

dementia, dental problems, poor wound healing, blackouts, as well as a general lack of
energy. Many people with diabetes lose the ability to sense when their glucose levels
are dropping. With Cellular Activation Therapysm given by the Bionica MicroDose,
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these and other symptomsCopyright
now
slow, stop and in many cases reverse.

Traditional Treatment Limitations

Insulin Injections:

Insulin Pumps:

Careful Diet:

Oral Medication:

Controlled Exercise Program:

The most common form of treatment for those who suffer from the effects

of diabetes.
For those want more flexible insulin delivery, these pumps replace shots and also
provide a background of insulin, which may be of some help. (These are not anything like the CAT pump.)

Every diabetic knows the difficulty in tightly controlling their daily diet.
For Type II diabetes patients, diet usually loses its effectiveness in avoiding symptoms.
Some diabetics take oral medications to stimulate production or increase

sensitivity to insulin.
Exercise is another way to help keep the body normal.

The lack of long term effectiveness of all the above methods is known by every
person who suffers from diabetes and is widely documented. Hospitals are filled
with diabetics who used all of the above methods which eventually loose their effect.
Unfortunately, the mortality rate among diabetics has continued to rise over the last
decade. Cellular Activation Therapy tm provides the only proven way to
impede, stop or reverse
the
chronic
complications
of permission
diabetes.
Copyright
Bionica
Inc. All rights reserved.
Confidential; no disclosure without
of Bionica Inc.

The Therapy and Background

Over 18 years of intensive research in leading Universities.

Insufficient insulin delivery to the liver plays a central role in
the pathophysiology (progression) of diabetes complications.

Even with Intensive Insulin therapy (tight control), many

diabetic patients will develop the many complications, because
tight control does not provide proper metabolism.

Poor carbohydrate metabolism results in improper lipid and

free fatty acid metabolism, the core problem of diabetes.

Every diabetic will eventually experience one or all of the symptoms of diabetes,
some become more ill due to their own genetic and physical makeup. The
progression of the disease complications have been irreversible by any other
treatment before Cellular Activation Therapy tm.
Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

Cellular Activation Therapy

sm

Before Activation, there has never been an effective body

wide metabolism treatment, so physicians were limited to
trying to regulate blood glucose (a symptom).

Cellular Activation Therapysm is clinically proven to be safe

and effective in shifting body wide metabolism toward
normal by reawakening enzyme pathways and providing
better cellular energy (ATP) production and use.

Cellular Activation Therapy sm reestablishes what is normal for

healthy human beings. In 2002, it was proven that
a normal persons liver receives pulses from the pancreas
on a 4 to 6 minute basis. This is what the Bionica
MicroDose delivers.
Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

Works on Young Pregnant & Elderly

From young to old, CAT works uniformly to normalize cellular metabolism,
and provide constant benefits.

This 7 year old girl was diagnosed at age 2, and was

chronically ill with hypoglycemic reactions hypoglycemic
unawareness, and many hospitalizations. She has now
been on the treatment for 16 years. The pump in the
foreground is the Bionica MicroDose with Cellular
Activation Therapy programmed into its memory. This
girl started on the Bionica MicroDose at age 6.

Now the same girl who was chronically ill, started

CAT at age 7; and now age 25 is a healthy mother
with 2 healthy children, and pregnant. She is no
longer ill, and her only hospitalization since
activating has been for childbirth. She has none
of her former complications, none of the signs of
being a diabetic for 23 years, and has no
hypoglycemic reactions.

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Annual Costs of Treatment

Outpatient Hospital
$20.2 (12%)
Office Visits
$15.5 (10%)

Cellular Activation
Therapy patients are
seldom hospitalized and
other symptoms are
dramatically reduced.

Drugs & DME

$14.0 (9%)

Home Healthcare
$7.4 (4%)

Emergency Room
$3.0 (1%)
Dental
$2.9 (1%)

$178 Billion

Inpatient Hospital
$115B (63%)

This hospital
cost is almost
the same
percentage
since 1992 !

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Savings by Cellular
Activation Therapy

sm

The $115B spent annually for inpatient hospital care

is an easy economic reason to support the
treatment. Just treating chronically hospitalized
patients would justify CAT treatments. Patients that
are on CAT are rarely hospitalized for diabetes
related complications.

Other areas such as dental, emergency room, etc will also be significantly
reduced due to the fact that patients on Cellular Activation Therapy sm do not
experience most or any of the side affects of diabetes.

Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

CAT Works With Type 1 & 2

Metabolism is the Problem for BOTH Type I and Type II Diabetics. Cellular Activation
Therapy sm works equally well for both Type I and Type II diabetic patients.

After the discovery of insulin, physicians were surprised to learn that insulin alone did not keep
diabetic people from developing the horrible complications of diabetes. At that point, the idea
of tight control of blood glucose was thought to be the answer. This proved wrong.
Tight control of was then studied in the DCCT, a 10 year NIH study, as well as the UKPDS
and other studies. These studies proved that tight control is better than not controlling blood
glucose, but it does not stop the complications of diabetes. Diabetics do not metabolize
properly, resulting in heart, liver, muscle, eye, kidney diseases, and a loss of energy, sleep,
sexual function, and all aspects of life are impacted. CAT is the only answer.
From the DCCT, it is understood that while not controlling glucose worsens complications, good
control will not keep 25 to 40 % of diabetics from developing overt secondary complications
within 10 years.
The reality is that all diabetics who are not on Cellular Activation Therapy sm will develop
some complications which reduce their lifespan, and complications should be treated with CAT.
Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

Pulses of Insulin

CAT simulates the normal pancreatic

delivery of insulin to the liver.
Peter Butler, professor of medicine and chair of the division of endocrinology and
diabetes, and research fellow Soon Song, received the Endocrine Society's first prize
for best clinical paper published in The Journal of Clinical Endocrinology and
Metabolism in the year 2002. The paper, "Direct Measurement of Pulsatile Insulin
Secretion from the Portal Vein in Human Subjects," reported that insulin is secreted
from beta cells in the pancreas almost exclusively in secretory bursts every four to
six minutes. The result: very large amplitude oscillations of insulin concentration in
the portal vein, which directly perfuses the liver, Butler said. Prior to this study, no
one had shown this effect in human beings. Subject was entrained to show
agreement between entrained frequency and portal vein insulin oscillations. We
conclude that insulin release in the human portal vein occurs at a mean periodicity
of 4.4 [plus minus] 0.2 min with a high signal-to-noise ratio (pulse amplitude 660%
of basal). This means that the pulses are about 7 times the base levels!
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Basic Clinic Structure

Chair

Chair

Chair

Chair

1 MD or NP Per Clinic

= 1 QUAD
24 Patients
160,000
Quads Needed
Operating 6 days per week, it will take 160,000
quads in the USA just to treat the extremely ill,
and many more for other conditions.

1 RN
Per 2 Quads

1 Technician
Per Quad

Training, Computerized Treatment

Oversight and Bionica Pumps
Complete the requirements

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Equipment Overview

One 6 hour treatment per week using

using the Metabolic Measurement (RQ)
machine to monitor metabolism.

Patients watch their metabolism
return to normal healthy levels.

Bionica Pump for Cellular Activation
Pulsed Insulin Release.
One of two
Models of
RQ Machines

Special treatment oversight

software ensures proper treatment
and tracks results.

The size of a video cassette

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Bionica Treatment Process

1
2

Measure weight and blood pressure.

Check blood sugar level.

Medical information reviewed and dosage determined for

programming Bionica pump.

Small IV inserted in arm or hand.

Breathe into RQ machine to measure resting metabolism.

Start 1 hour treatment session.
Blood sugar level checked and Glucola given as needed.

6
7
8
9

Breathe into RQ machine to measure metabolism levels.

Steps 5 8 repeated two more times equals 6 hour.
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Bionica MicroDose Pump

Mimics the Pancreas

The size of a video cassette

As can be seen, the Bionica pump delivers very accurate

pulses of insulin, at all levels of infusion. This is required to
stimulate the liver and reawaken dormant carbohydrate
Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.
metabolism.

Why Diabetics Need

Cellular Activation Therapy

sm

Notice that the Type 2 diabetic does not have early (first phase) insulin release, as does normal
man. This failure to stimulate the liver (and other tissue) is reversed by the Cellular Activation
Therapysm. This is why CAT works on Type 1 where there is no insulin release, and Type 2 where
Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.
the insulin is not released in pulses, as it is in normal person.

Cellular Activation Therapy

Clinical Results

sm

This slide shows the importance of early secretion. The Type II diabetic eats, and then shortly
thereafter is very hungry again
because
ofrights
the
highConfidential;
levelsnoof
insulin.
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Bionica Inc. All
reserved.
disclosure
without permission of Bionica Inc.