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Cell Cycle Control
6.2.2 Spindle
replication origins
at which DNA polymerases and other
proteins initiate synthesis of DNA.
centromere
attach any chromosome that
contains it to mitotic spindle during
M phase and guarantees the proper
separation of chromosomes.
telomeres
permit a linear chromosome to be
completely replicated.
Packing of Chromatin
Nucleosome
octamer of H2A, H2B, H3, H4.
146bp binding DNA and 0~80bp linker DNA
Linker DNA are bound by H1 histone and are
sensitive to endonuclease.
(2)
cyclin A~H
G1 phase cyclin
cyclin C,D,E are only synthesized at G1 phase and
degraded at S phase
S phase cyclin
cyclin A are only synthesized at G1 phase and
degraded at M phase
M phase cyclin
cyclin B synthesized at S phase and degraded at the
end of M phase
Activation of MPF