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Structure
Nicardipine is a calcium ion increase inhibitor (sluggish stations blocker or
calciumstationsblocker).
Nicardipine hydrochloride injection By Manusaktteva for intravenous
administration contains 2.5 mg/mL of nicardipine hydrochloride.
Nicardipine hydrochloride is a dihydropyridine byproduct with IUPAC
(International Union of Pure and Applied Chemistry) chemical name ( )2
(benzylmethylamino)ethylmethyl1,4dihydro2,6dimethyl4(mnitrophenyl)
3,5pyridinedicarboxylatemonohydrochlorideandalsohasthecomplyingwith
framework:
Nicardipinehydrochlorideisagreenishyellow,odorless,crystallinepowderthat
thawsatabout169C.Itisopenlysolubleinchloroform,methanol,aswellas
glacialaceticacid,moderatelysolubleinanhydrousethanol,slightlysolublein
nbutanol, water, 0.01M potassium dihydrogen phosphate,acetone, and also
dioxane,extremelyslightlysolubleinethylacetate,andalsovirtuallyinsoluble
inbenzene,ether,andalsohexane.Ithasamolecularweightof515.99.
Nicardipinehydrochlorideshotisreadilyavailableasacleanandsterile,non
pyrogenic, clear, yellow option in 10 mL vials for intravenous mixture after
dilution.
Avoidwidespreadhypotensionwhenprovidingthedrugtopeoplethathave
sustainedasevereanalyticalinfarctionorhemorrhage.
UsageinClientswithDamaged Hepatic Function:Giventhat nicardipineis
metabolizedintheliver,thinkaboutlowerdosesaswellasverycloselymonitor
responses in clients with impaired liver function or decreased hepatic blood
flow.