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has developed a new generation of mycotoxin binder to face the challenges of modern animal production.
Binding of mycotoxins
FEATURE
the gut lumen and the animals blood stream. Several studies have
shown that mycotoxins such as DON and OTA reduce the protective
function of the gut wall. A meta-analysis published by Grenier and
Applegate (2013) reviews how mycotoxins can modulate intestinal
functions. In terms of morphology of the intestinal villi, studies show
that feeding poultry low or moderate levels of deoxynivalenol (DON)
alone or combined with other fusariotoxins leads to a reduction in
villi height in both the duodenum and jejunum. Practical implications
can range from diarrhoea, inflammation and fever to reduced feed
efficiency. In a series of trials, the plant based ingredients in AntaFerm
MT FlavoMax have shown to act as an anti-inflammatory agent along
the digestive tract, having a positive effect on the integrity of the intestinal epithelium resulting in an improved feed conversion ratio (fig 2).
Some mycotoxins (ie, OTA, FB1, AFB1, DON, and T2) have been
known to produce damages by increasing oxidative stress. The animal
has to detoxify mycotoxins, which is called xenobiotic metabolisation.
During this detoxification process, free radicals are produced that
increase levels of oxidative stress resulting in DNA damage, lipid
peroxidation and inflammation or cell death. Practical implications can
be reduced health status, increased incidence and severity of inflammations or skin disorders. The flavonoids in AntaFerm MT FlavoMax
have shown to reduce oxidative stress by deactivating reactive radicals
in the body (Gessner et al 2013).