Frontier Pharma: Ovarian Cancer - Identifying and

Commercializing First-in-Class Innovation Now

Available at iData Insights
Frontier Pharma: Ovarian Cancer - Identifying and Commercializing First-in-Class Innovation Summary
Ovarian cancer is the sixth most common cancer in females and it also has the highest mortality rate of
gynecological cancers. The five-year survival rate is approximately 45%, although the disease is
ultimately fatal in the majority of patients due to a high rate of recurrence. Surgery is generally
considered an effective treatment for localized tumors, however the management of recurrent and
later-stage disease is largely reliant on cytotoxic chemotherapy regimens. A highly active ovarian cancer
pipeline contains an array of diverse molecule types and molecular targets, in contrast to the market.
With the diversity in the pipeline, there is hope that innovative products can make it to market to
provide patients with greater therapeutic options, while meeting unmet needs within ovarian cancer.
There are 179 ovarian cancer pipeline products associated with a first-in-class molecular target
representing 52% of the total pancreatic cancer pipeline products that have a disclosed molecular
target. Such a diverse and innovative pipeline implies that approaches to ovarian cancer treatment are
changing and first-in-class development is playing a significant role in this. Scope Chemotherapy based
regimens continue to dominate the market, which has seen few new entrants over the past decade.
Lynparza (olaparib) is a key new entrant; however it is only effective in a small patient subset. - What
survival benefits do current therapies provide? - What are the current unmet needs that the pipeline
needs to address? The pipeline places increased focus on targeted therapies, including a large number
of therapies targeting common oncogenic pathways and signaling intermediates such as PI3K/Akt. What potential do mAbs have in ovarian cancer treatment? - Will pipeline diversity translate to clinically
and commercially successful therapies? - How are common target families, such as intracellular signal
transduction associated with pathophysiology? 52% of pipeline products act on a first-in-class target,
which is higher than the oncology and industry averages. - Do first-in-class products show strong
progression into the later stages? - Why is the greatest number of first-in-class products seen in signal
transduction? First-in-class products differ substantially in their clinical potential, based on their
alignment to disease causing pathways - How well are first-in-class targets, such as Notch, aligned to
known disease causing pathways? - Which targets are specifically found in early-stage development? What is the industry-wide interest in these targets? Co-development deals for first-in-class products are
typically higher value than non-first-in-class counterparts. - To what extent does first-in-class status
influence deal value and phase? - Can biologics command a greater deal value than other molecule
types? Reasons to buy This report will allow you to - - Understand the current clinical and commercial
landscape. This includes a comprehensive study of disease pathogenesis, diagnosis, prognosis and the
available treatment options available at each stage of diagnosis. - Visualize the composition of the
ovarian cancer market in terms of dominant molecule types and targets, highlighting what the current
unmet needs are and how they can be addressed. This knowledge allows a competitive understanding of
gaps in the current market. - Analyze the ovarian cancer pipeline, and stratify by stage of development,
molecule type and molecular target. There are promising signs in the pipeline that the industry is
seeking novel approaches the treating ovarian cancer. - Assess the therapeutic potential of first-in-class
targets. Using a proprietary matrix, first-in-class products have been assessed and ranked according to
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clinical potential. Promising early-stage targets have been further reviewed in greater detail. - Identify
commercial opportunities in the ovarian cancer deals landscape by analyzing trends in licensing and codevelopment deals and producing a curated list of ovarian cancer therapies that are not yet involved in
deals and may be potential investment opportunities.
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Table of Contents
1 List of Tables 3
1.2 List of Figures 3
2 Executive Summary 4
2.1 Significant Unmet Needs in the Ovarian Cancer Market 4
2.2 High Proportion of First-in-Class Innovation offers Promise in Ovarian Cancer 4
2.3 Deal Activity Varies with First-in-Class Status 4
3 The Case for Innovation 5
3.1 Growing Opportunities for Biologic Products 6
3.2 Diversification of Molecular Targets 6
3.3 Innovative First-in-Class Product Developments Remain Attractive 6
3.4 Regulatory and Reimbursement Policy Shifts Favor First-in-Class Product Innovation 7
3.5 Sustained Innovation 7
3.6 GBI Research Report Guidance 8
4 Clinical and Commercial Landscape 9
4.1 Disease Overview 9
4.2 Disease Symptoms 9
4.3 Epidemiology and Etiology 9
4.4 Pathophysiology 10
4.4.1 High-Grade Serous Subtype 10
4.4.2 Low-Grade Serous Subtype 11
4.4.3 Mucinous Carcinoma Subtype 11
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4.4.4 Endometrioid Carcinoma Subtype 11

4.4.5 Clear Cell Carcinoma Subtype 11
4.5 Diagnosis 12
4.6 Prognosis 12
4.7 Treatment Algorithm 12
4.7.1 Surgery 12
4.7.2 First-Line Therapy 12
4.7.3 Maintenance Therapy 14
4.7.4 Recurrent Disease and Second-Line Therapy 15
4.8 Overview of Marketed Products in Ovarian Cancer 18
4.8.1 Molecule Type and Target Analysis 18
4.8.2 Innovative Products in Ovarian Cancer Market 19
4.8.3 Unmet Needs 20
5 Assessment of Pipeline Product Innovation 21
5.1 Ovarian Cancer Pipeline by Molecule Type, Phase and Therapeutic Target 21
5.2 Comparative Distribution of Programs between Ovarian Cancer Market and Pipeline by Therapeutic
Target Family 25
5.3 First-in-Class Pipeline Programs Targeting Novel Molecular Targets 26
6 Signaling Network, Disease Causation and Innovation Alignment 32
6.1 Complexity of Signaling Networks in Oncology 32
6.2 Signaling Pathways and First-in-Class Molecular Target Integration 33
6.3 First-in-Class Matrix Assessment 33
7 First-in-Class Target Evaluation 37
7.1 Pipeline Programs Targeting Mucin 16 and Mucin 1 37
7.2 Pipeline Programs Targeting Notch 38
7.3 Pipeline Programs Targeting 3-Phosphoinositide-Dependent Protein Kinase 1 39
7.4 Pipeline Programs Targeting G2/Mitotic-Specific Cyclin B1 40
7.5 Pipeline Programs Targeting Cell Division Cycle 7-Related Protein Kinase 40
7.6 Pipeline Programs Targeting X-Linked Inhibitor of Apoptosis Protein 41
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7.7 Pipeline Programs Targeting Cyclin-Dependent Kinase 2 42

7.8 Pipeline Programs Targeting PIK3CA 43
7.9 Pipeline Products Targeting HDAC 10, 4, 5 and 7 44
7.10 Conclusion 45
8 Deals and Strategic Consolidations 46
8.1 Industry-Wide First-in-Class Deals 46
8.2 Licensing Deals 47
8.2.1 Licensing Deals by Molecule Type 51
8.2.2 Licensing Deals by Molecular Target 52
8.2.3 Conclusion 52
8.3 Co-development Deals 53
8.3.1 Co-development Deals by Molecule Type 55
8.3.2 Co-development Deals by Molecular Target 56
8.3.3 Conclusion 56
8.4 First-in-Class Programs Not Involved in Licensing or Co-development Deals 56
9 Appendix 60
9.1 References 60
9.2 Abbreviations 62
9.3 Research Methodology 63
9.4 Secondary Research 64
9.4.1 Marketed Product Heatmaps and Treatment Algorithm 64
9.4.2 Pipeline Analysis 64
9.4.3 First-in-Class Matrix Assessment 64
9.4.4 First-in-Class Target Profiles 65
9.4.5 Licensing and Co-Development Deals 65
9.5 Contact Us 65
9.6 Disclaimer 65

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