Professional Documents
Culture Documents
Drug name
Penicillins
Natural Penicillins
Penicillin V
Penicillin G
Aminopenicillins
Amoxicillin
Ampicillin
Amoxicillin + Clavulanate
Aminopenicillins plus lactamase inhibitors
Penicillinase resistant
penicillins
Ampicillin+Sulbactam
Nafcillin
Oxacillin
Dicloxacillin
1st Generation
Cefazolin
Cephalexin
Cefadroxil
2A Generation
Cefuroxime
Cefaclor
Cefprozil
2B Generation
Cefoxitin
Ceftibuten
Cefdinir
Cefpodoxime
Ceftriaxone
Cefotaxime
Cefixime
Ceftazidime
3rd Generation
Ceftaroline
4th Generation
Cefepime
Monobactam
Aztreonam
Carbapenems
Imipenem/Cliastatin
Meropenem
Doripenem
Ertapenem
Glycopeptides
Vancomycin
Fosfomycins
Fosfomycin
Inhibitors of DNA/RNA
Synthesis
Sulfa Drugs
Trimethoprim+Sulfamethoxazole
Rifampin
Rifampin
Fidaxomicin
Fidaxomicin
Ciprofloxacin
Fluoroquinolones
Levofloxacin
Moxifloxacin
Inhibitors of Protein Synthesis
Aminoglycosides
Gentamicin
Tobramycin
Amikacin
Azithromycin
Macrolides
Clarithromycin
Tetracycline
Tetracyclines
Doxycycline
Minocycline
Glycylcycline
Tigecycline
Lincosamide
Clindamycin
Oxazolidinone
DNA Damaging Agents
Linezolid
Nitrofurantoin
Metronidazole
Cell Membrane Damaging
Agents
Lipopeptides
Polymyxins
Daptomycin
Polymyxin B
Colistin
Routes of administration
Mechanism of action
PO
IM, IV
inhibition of peptidoglycan
cross linking
PO
IV
inhibition of peptidoglycan
cross linking
IV
IV
IV
PO
PO
IV
PO
PO
IV, PO
PO
PO
IV
inhibition of peptidoglycan
cross linking
inhibition of peptidoglycan
cross linking
same
PO
PO
PO
same
same
IV
IV
PO
IV
IV
IV
same
IV
IV
IV
IV
IV
PO - suspension
IV and PO
in combination act
synergistically to inhibit
nucleic acid synthesis,
inhibition of 2 enzymes in
DNA synthesis pathway
IV and PO
PO only
inhibits transcription of
bacterial RNA polymerase
IV and PO
IV and PO
IV only
PO
PO
IV and PO
PO
IV
IV and PO
IV and PO
blocks initiation of
translation at 50S ribosome
PO
IV and PO
anaerobic nitro-reduction to
radicals that damage DNA
IV
IV
IV
Gram +
Gram -
none
MSSA, streptococci
MSSA, streptococci
MSSA, streptococci
same as 2A
MSSA, streptococci
poor
MSSA, streptococci
none
MSSA, strep
NONE
none
H. influenzae, N. gonorrhea, M.
catarrhalis, Campylobacter, H.
pylori
H. influenzae, M. catarrhalis,
S. pneumoniae, Enterococcus, MRSA
Campylobacter, E. coli, Klebsiella,
and MSSA
some N. gonorrheae
none
none
none
H. pylori
none
Anaerobes
Atypicals
Renal adjustment
mouth anaerobes
mouth anaerobes
T. pallidum, B.
burgdorferi
yes
good anaerobic
coverage including B.
fragilis
T. pallidum, B.
burgdorferi
yes
none
none
NO**
good anaerobic
coverage including B.
fragilis
T. pallidum
yes
mouth anaerobes
none
yes
none
yes
mouth anaerobes
moderate B. fragilis
none
yes
none
mouth anaerobes
only
yes
mouth anaerobes
only
CA-meningitis, N.
gonorrhea, B.
burgdorferi
NO***
yes
none
mouth anaerobes
only
none
yes
none
none
yes
yes
none
yes
none
none
yes
none
Nocardia,
Pneumocystis
jiroveci, Toxoplasma
gondii
yes
none
M. tuberculosis
**NO
Primary use is to
treat C. dif, active
against Gram +
anaerobes
none
yes
yes
poor anaerobic
activity
Chlamydia,
Mycoplasma,
Legionella
better anaerobic
coverage, incl. B.
fragilis
**NO
none
none
Legionella,
Mycoplasma,
Chlamydia, M.
avium (MAC)
good anaerobic
coverage
B. burgdorferi,
Rickettsia
good anaerobic
coverage, including
B. fragilis
yes
good anaerobic
coverage but some B.
fragilis are resistant none
yes
**NO
yes
***NO
no but needs
hepatic
adjustment
***NO
none
none
yes
none
none
yes
Extensive anaerobic
activity including C.
diff, B.fragilis
Trichomonas,
Giardia
yes
none
none
yes
none
none
yes
Toxicities
Pharmacodynamics
Cidal/Static
hypersensitivities common,
seizures at high doses
Time Dependent
Cidal
hypersensitivity, seizures
time dependent
cidal
hypersensitivity, seizures,
diarrhea
Time Dependent
cidal
hypersensitivity, seizures,
hepatotoxicity, interstitial
nephritis
time dependent
cidal
hypersensitivity, seizures,
diarrhea
Time Dependent
cidal
hypersensitivities common,
seizures at high doses
Time Dependent
cidal
hypersensitivity, seizures
Time Dependent
cidal
hypersensitivity, seizures
Time Dependent
cidal
hypersensitivity, seizures
time dependent
cidal
time dependent
cidal
hypersensitivity, seizures
hypersensitivity, seizures
Time Dependent
cidal
time dependent
cidal
time dependent
cidal
cidal
well tolerated
exposure dependent
cidal
time dependent
components static
but together cidal
cidal
well tolerated
cidal
concentration dependent
cidal
concentration dependent
cidal
some GI symptoms,
Clarithromycin - drug interactions
common, also torsades de
pointes (V-Tach)
exposure dependent
static
exposure dependent
static
GI symptoms including
esophageal ulceration,
photosensitivity, in childrendiscoloration of teeth
exposure dependent
static
exposure dependent
static
myelosuppression,
thrombocytopenia, serotonin
syndrome
time dependent
static
nephrotoxicity, neuromuscular
blockade, paresthesias
cidal (?)
Other notes
ceftaroline = cetriaxone +
MRSA coverage
ceftaroline = cetriaxone +
MRSA coverage