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SPRING, 2009
In This Issue
The Beat Goes On-
• The Beat Goes On- 1
Estrogen and Weight Loss? Estrogen and Weight Loss
Yes! • Testimonials- 1
True or false: when you supplement with • What the Future
estrogen at menopause you gain weight. False. Holds-2
! In fact, recent research suggests that estrogen • Ask an Expert-2
has a crucial role to play in weight loss and
• Donate to the Study-3
weight maintenance. With increased life expectancy, women spend
more than a third of their life in menopause and with the loss of • Take Action-3
hormone protection, more likely to become obese. Obesity is • The Body Politic-4
increasing dramatically; about 66 percent of U.S adults 20 and
over are overweight or obese (National Center for Health Statistics, • The Greening of the
CDC, 2006). Wiley Protocol-4
A research team has tested the idea that estrogen deficiency in • Planetarium Corner-5
aged females may trigger the development of high blood pressure • Voters Booth-5
and obesity. Results? The estrogen-deprived animals gained twice • Resources-5
as much weight as the control animals and increased leptin levels
by 70 percent and blood glucose by 35 percent. Leptin is a fatty • Cont.Text- 6
tissue hormone associated with appetite and energy used by the • Cont.Text- 7
body (See What the Future Holds). Cont. on Page 7
• Cont.Text-
TESTIMONIALS
Check out our new blog - just go to the Wiley Protocol website (www.thewileyprotocol.com)
and click on the Wiley Protocol Blog. Don't forget to listen to the radio interviews with
practitioners and watch the videos in the Press Room.
In a YouTube video, Julie and Ola Stensland talk about how Julie got her life back and in her
words, “felt reconnected to everything and everyone” using bio-identical hormone replacement
therapy. Julie discusses the “mind fog” and how she felt like a ghost before starting the Wiley
Protocol™ and how after starting the Protocol she got a handle on the issues in her life. Ola
mentions the changes he’s seen in Julie, including in their sex life, from before to after starting
bio-mimetic hormone replacement therapy. Watch their video. Cont. on Page 6
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TAKE ACTION
Your voice can represent 1,000 to 13,000 people when
you email a letter to your senators and representative to
preserve our access to bio-identical hormones and
protect the right of the consumer to choose and the
practitioner to practice without unwarranted interference
! by the FDA. The FDA took action 01/09/2008 on behalf
of Wyeth, a major pharmaceuticals manufacturer, to
prohibit the use of estriol in compounded medicines and the use of the term “bio-
identical” in pharmacies’ hormone replacement formulas. There have been efforts to
extend the prohibition to all bio-identical hormones used for post-menopausal hormone
replacement therapy. For an already prepared letter objecting to the FDA’s actions that
you can send to your congress people, go to American Association for Health Freedom.
You can add your own points of interest. The web address is the “Save Bio-Identical
Hormones” page of the non-profit advocacy organization.
It’s time to do it again. TS Wiley has addressed the Senate on the validity of Compounded
Hormones, acquired not one, but two IRB numbers sanctioning studies on the Wiley Protocol
and is in discussion with representatives of the upcoming continuation of the WHI which
started in the fall of 2008.
NOW ALL WE HAVE TO DO IS PAY FOR IT. If you’d like to contribute to finding an answer to
the issues of safety and efficacy in hormone replacement for women sooner than later…Click
here .
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Planetarium Corner
In Roman mythology the Moon was represented by Diana, the hunter goddess. The Moon is the earth's
companion satellite, though some astrologers believe that it approaches being a planet in its own right. The Moon
is large enough for its gravity to affect the Earth, stabilizing its orbit and producing the regular ebb and flow of the
tides. The Moon is familiar to us for its different phases, waxing and waning in appearance in an unchanging
cycle. The Moon orbits the earth in about 28 days, spending a fleeting 2.33 days in each of the signs of the
zodiac. The lunar day syncs up with its orbit around Earth in such a manner that the same side of the moon
always faces the Earth and the other side, known as the "dark side of the moon" faces towards space.
VOTERS BOOTH
We believe that Quality Control starts with you, the consumer. We invite you to share your views
and make your voice heard. In every newsletter we will ask you to vote for your favorite Wiley
Protocol doctor, and the best Wiley Protocol pharmacist.
Dr Ching Chen from Capitola CA won last season as favorite physician and Abrams Pharmacy
in Dallas Texas won for favorite pharmacy. Send us an email with your votes and stay tuned!
RESOURCES
Sex Lies and Menopause | Lights Out: Sleep, Sugar,
A book of feminist medicine and Survival
In this revolutionary work -- a The light bulb put us out of sync
landmark that signals the true with nature. Way back when,
beginning of feminist medicine -- a people spent the summer sleeping
doctor, a philosopher, and a scientist less and eating heavily in
prove that by postponing marriage preparation for winter because light
and motherhood, women have triggers the hunger for
accelerated the aging process, carbohydrates. Now, with light
resulting in earlier menopause and, available 24 hours a day, we gulp
ultimately for thousands, earlier down food all year long.
death.
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Testimonials- continued
Marylove Thrall: Prior to being introduced to the Wiley Protocol, I had been experiencing
debilitating hot flashes for several years. I had been put on Premarin following a partial
hysterectomy more than 15 years ago, but after reading about the origin of this hormone
replacement drug (the urine of pregnant mares) and the horrific conditions in which
these pitiful animals were kept, as well as the fact that the drug had undergone initial
testing on male prison volunteers, I advised my doctor that I would not continue with this
drug. It took a year or so before the effects of low estrogen began to seriously affect me,
but when they did, they hit hard. I would experience extreme and sudden sensations of
feeling so terribly ill that it would stop me in my tracks. Day and night. Five or ten times
a day. Read more...
In a YouTube video, Dr. Patricia Ryan talks about her extensive research on hormone
replacement therapy prior to talking to T.S. Wiley. When T.S. Wiley began to answer her
questions, “I was very impressed and I wanted to learn more” she said. Since learning
about the Protocol, she has taken her patients off the linear dosing and switched to the
Wiley Protocol’s rhythmic, cyclical bio-mimetic hormone replacement therapy program.
She has seen no weight gain, reversal of osteoporosis, and restoration of libido in her
patient population. Watch her video.
In a YouTube video, Dr. Bob Mathis says that most of the women coming to see him
who present with brain fog, insomnia, loss of libido, depression and other symptoms find
that most of their symptoms resolve after about a month using bio-identical hormone
replacement on the Wiley Protocol. One of his patients spent three years looking for a
practioner and he describes her success on the protocol. He sees his patients become
more resilient in the face of stress. Watch his video.
What the Future Holds- continued
As 75 to 95 percent of previously obese individuals regain their lost weight, many researchers
are interested in developing treatments to help individuals maintain their weight loss. Leptin
therapy after weight loss might improve weight maintenance by overriding this fat-loss
defense. Other research in mice indicates that sensitivity to leptin, reduced in obese
individuals, may be regained with the use of existing oral drugs that are already FDA-approved
and considered safe.
The Body Politic- continued
About 40,000 women die of metastatic breast cancer each year, and estrogen therapy
potentially could help thousands of women with hormone receptor-positive disease, the
study suggests.
It's too early to know why estrogen has a negative effect on metastatic breast cancer
tumors. One clue — estrogen reduces the amount of a tumor-promoting hormone called
insulin-like growth factor-1 (IGF1). Ellis says “In theory, when you give estrogen back,
IGF1 decreases and cancer cells die as a consequence. But surviving cancer cells
prefer to switch back to living on estrogen — to them it's like eating out at McDonald's
every day instead of foraging on roots and berries. These cells eventually reappear as
estrogen dependent tumors and the cycle starts over.”
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Back Story- continued
All the hormonal and metabolic effects were completely abolished with estrogen
replacement. Bio-identical, biomimetic hormone replacement therapy in women would
have similar effects. The Wiley Protocol addresses the issue of weight loss through its
biomimetic hormone replacement protocol, otherwise known as bioidentical hormone
replacement.
Estrogen – even in men – may weigh in as a component in the regulation of obesity,
along with other well-known risk factors such as food indulgence and lack of exercise,
according to researchers. In a study of this premise, male mice genetically altered to
lack one type of estrogen receptor became obese, expended less energy and built up
larger stores of fat, even though they were fed the same as normal mice. The findings
suggest that estrogen may be important for regulating fat in men as well as women. The
lack of estrogen led to an increase in white adipose tissue, as well as insulin resistance
and glucose intolerance. Such a relationship was known to occur in female mice and
post-menopausal women, but it had not been shown in males. “In light of the metabolic
results of our study, it appears that estrogen enhances one’s ability to burn excess fat in
both males and females”, one of the researchers said. “We don’t know yet if the lack of
estrogen is merely decreasing the basal metabolic rate, or if it is also decreasing the
activity level of mice.”
Research on the mechanism of estrogen activity in the brain indicates that estrogen
regulates the brain's energy metabolism in the same way as leptin. Researchers found
that estrogen suppresses appetite using the same pathways in the brain as leptin.
Estrogen's effect on feeding and obesity was shown to be independent from leptin or
the leptin receptor. Researchers theorized that impaired estrogen signaling in the brain
may be the cause of metabolic changes during menopause. Brain-selective mimics of
estrogen could be a viable approach to tackle obesity in the case of leptin resistance.
Obese people are generally leptin-resistant.
Estrogen has been found to help the body use fat and glucose as energy in the same
way that exercise does. It activates pathways that regulate metabolism and also directly
regulates the expression of certain genes. In an animal model, estrogen replacement
was found to reduce fats by promoting the use of fat as fuel. The three mechanisms
include: inhibiting fat storage in liver, muscle and fat tissue; activating the pathways that
promote burning the fat in muscles; and breaking down stored fats used for energy
reserves in fat cells. When estrogen was present in muscle, liver and fat cells, the
expression of genes that control manufacturing and storing fat was reduced, and the
expression of genes that promote burning fat in muscle cells was increased. Always
ahead of her time, T.S. Wiley concluded menopausal and post-menopausal obesity
could be avoided with biomimetic hormone supplementation in a rhythmic manner in her
2003 book Sex, Lies, and Menopause. It seems that mainstream research is catching
up.
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