Professional Documents
Culture Documents
Objectives:
Gross:
Name component parts
Review development & descent of testes
ID testis, epididymis & vas deferens
Understand course & components of spermatic cord
Describe prostate & relations (diseases)
Name & describe accessory glands
Describe penis & component parts
Trace pathway of sperm
Name layers of scrotum & counterparts
Describe vascularity, innervation & lymphatics
Histology:
Describe histologic organization of testes
Describe spermatogenesis (ploidy)
ID & describe Leydig cells
Describe histology of excretory ducts & accessory
glands
ID parts of the penis
EMBRYOLOGIC DEVELOPMENT
I. DEVELOPMENT OF MALE GONADS
UNDIFFERENTIATED GONADS
o found at the beginning of embryo life
o blind end of the hind gut expands to form the
cloaca
o At the 4mm stage, the cloaca expands and
divides into 2 compartments:
1.Ventral portion (urogenital sinus)
2.Dorsal portion (rectum)
o Urorectal Fold- - divides the cloacal into an anal
and urogenital orifice
o the division is completed by the seventh week
o Genital Tubercle
the mesoderm that passes around the cloacal
membrane proliferates and grows forming a
surface elevation
where the development of the gonads and
ductal system starts
January 12,2012
Dr.Bautista
Group 12 Chiu, Chua, Chuahiong, Cimagala, Cinco, Co, I., Co, K., Cocos
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1.
2.
3.
4.
Male Reproductive
Structure
Testis
Seminal Vesicle
Penis
Prostate Gland
Bulbourethral Gland
Scrotum
Group 12 Chiu, Chua, Chuahiong, Cimagala, Cinco, Co, I., Co, K., Cocos
Female Reproductive
Homologue
Ovary
Fallopian Tube
Clitoris
Paraurethral Gland
Bartholins Gland
Labia Majora
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II. SCROTUM
Houses the mature testes
Outpouching of the lower part of the ant abd wall
Develop from Labioscrotal swellings
Saccular appendages which house paired post-natal
testes
Female homologue= labia majora
Functions
1.Protection
2.Thermoregulation
Layers
1. Skin
Wrinkled in adults due to the contraction of
dartos muscle
Pigmented in gross appearance
Smooth in newborn
A slightly raised ridge in the midline indicating
fusion of the two lateral labioscrotal swellings
2. Superficial fascia
continuous with fatty & membranous layer of ant
abdominal wall
Campers/Fat
o becomes dartos muscle and fascia
sparse layer of smooth muscle tissue
important in the contraction of the
scrotum
during cold weather, the scrotum moves
close to the body
during warm weather, the scrotum
relaxes & descend farther away from the
body
Scarpas/Membranous
o becomes colles fascia
3. External Spermatic Fascia
derived from external oblique fascia/aponeurosis
4. Cremasteric Fascia
derived from internal oblique muscle
involves in contraction and relaxation of the
scrotal area
plays a role in thermoregulation
5. Internal Spermatic Fascia
derived from fascia transversalis fascia
6. Tunica Vaginalis
reflections of peritoneum
covers and almost adherent to the testis
tunica albuginea is the covering that is in
direct contact with the testis
Arterial Supply:
o Posterior scrotal branches of Perineal Artery
from Internal Pudendal Artery
o Anterior branches of Deep External Pudendal
Artery
from Femoral Artery
o Cremasteric Artery
from Inferior Epigastric Artery
Venous Drainage:
o Veins accompany arteries
Lymphatic Drainage:
o Superficial Inguinal Nodes
Nerve Supply:
o Anterolateral
Genital branch of Genitofemoral Nerve (L1L2)
o Anterior
Anterior Scrotal Nerves from Ilio-Inguinal N
(L1)
o Posterior
Posterior scrotal Nerves from Perineal branch
of Pudendal Nerve (S2-S4)
o Posteroinferior
Perineal branches from Posterior Cutaneous
Nerve to the Thigh
III. SPERMATIC CORD
Attached to the testes and come down with it during
descend
Suspends testes in scrotum
Group 12 Chiu, Chua, Chuahiong, Cimagala, Cinco, Co, I., Co, K., Cocos
Page 3 of
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Spermatic Cord
Skin
--------------------------External
Spermatic Fascia
Cremaster Ms.
Scrotum
Skin
Dartos Ms. And
Fascia
External Spermatic
Fascia
Cremaster Ms.
Cremasteric
Fascia
Cremasteric Fascia
---------------------------
----------------------------
Transversalis
Fascia
Peritoneum
Internal Spermatic
Fascia
Vestige of
Procesus Vaginalis
Testis
Internal Spermatic
Fascia
Tunica Vaginalis
Testis (2 layers)
V. TESTIS
houses the seminiferous tubules
firm, mobile structure inside the scrotum
the left testis is lower that the right because the left
spermatic cord is longer
Female Homologue= Ovaries
Tunica Vaginalis
a serous sac carried by each testis when it
migrated from the abdominal cavity
derived from the peritoneum
consists of an outer parietal layer lining the
scrotum and an inner visceral layer covering the
tunica albuginea on the anterior and lateral sides
of the testis
Tunica Albuginea
o A capsule of dense connective tissue surrounding
each testes
o thickened on the posterior side of the testis to
form the mediastinum testis
from which fibrous septa penetrate the organ
and divide it into about 250 pyramidal
compartments or testicular lobules
Each lobule is occupied by 1-4 seminiferous
tubules
Functions
o Produce the male gametes or spermatozoa
o Produce testosterone which stimulates the
accessory male sexual organs and causes
development of the masculine extragenital sex
characteristics
Arterial Supply
o Testicular artery
Venous Drainage
o Testicular Vein (Pampiniform Plxus)
Right: Inferior Vena Cava
Left: Left Renal Vein
Lymphatic Drainage
o Lumba and para-aortic nodes at L1
Group 12 Chiu, Chua, Chuahiong, Cimagala, Cinco, Co, I., Co, K., Cocos
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A.
SERTOLI CELLS
Aka Sustentacular cells
Columnar or pyramidal cells that largely envelop
cells of the spermatogenic lineage
Function as:
o support, protection and nutritional regulation of
the developing spermatozoa
o Phagocytosis of cell membrane
o Secretion (fluid, androgen binding protein,
inhibin)
o Production of anti-mullerian hormone
Active sertoli cells : pyramidal in shape, with apex
directed towards the lumen and whose nucleus is
perpendicular to the base of the cell
Inactive sertoli cells: polygonal in shape, the
nucleus is directed parallel to the base of the cell
Bases of these cells adhere to the basal lamina
comes from basement membrane but extends to the
lumen for the maturing sperm cell
Apical ends frequently extend into the lumen of
seminiferous tubule
Contain abundant SER, RER, well-developed Golgi
complexes, numerous mitochondria and lysosomes.
VII. SPERMATOGENESIS
begins at puberty
Group 12 Chiu, Chua, Chuahiong, Cimagala, Cinco, Co, I., Co, K., Cocos
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2nd
meiotic
VIII. SPERMIOGENESIS
The final stage in sperm production and is the
process by which spermatids transform into
spermatozoa
Includes formation of acrosome
Condensation and elongation of the nucleus
Development of the flagellum
Loss of much of the cytoplasm
End result : mature spermatozoon
Has 3 phases:
o Early Golgi phase
Cytoplasm
of
spermatids
contains
a
prominent Golgi apparatus near the nucleus,
mitochondria,
a pair of centriole, free
ribosomes and tubules of SER
Small proacrosomal vesicles accumulate in
the Golgi apparatus and subsequently
coalesce to from a single membrane limited
acrosomal cap close to one end of the
nucleus
Centrioles migrate to a position near the the
cell surface and opposite the forming
acrosome.
One centriole acts as a basal body, serving to
organize the axoneme of the flagellum
o Acrosome phase
Acrosome cap or acrosome spreads to cover
about half of the condensing nucleus
Acrosome is a specialized type of lysosome
containing
several
hydrolytic
enzymes
including hyaluronidase, neuraminidase, acid
phosphatase and trypsin like protease called
acrosin.
Spermatids become oriented toward the base
of the sertoli cells and the axonemes project
toward the lumen of the tubule
Nuclei become more elongated
The chromatin very highly condensed
The histones nucleosomes replaced by small
basic peptides called protamines.
Flagella growth continues
Mitochondria aggregate around the proximal
part of each flagellum forming the middle
piece ( source of ATP)
o Maturation phase
Unneeded cytoplasm is shed as a residual
body from each spermatozoon and is
phagocytosed by sertoli cells
Group 12 Chiu, Chua, Chuahiong, Cimagala, Cinco, Co, I., Co, K., Cocos
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A.
TUBULI
RECTI__________________________________________
Straight Tubules
Gradual loss of spermatogenic cells
Initial segment sertoli cells only
Main segment simple cuboidal epithelium
supported by a dense connective tissue
Empty into rete testis
B.
RETE
TESTIS____________________________________________
Interconnected network of channels
Net like structure
rete, means branching
Lining: simple cuboidal epithelium with microvilli and
a single cilium
o aid in progress of sperms that become motile
until after maturation at the epididymis
Surrounded by collagenous tissue with myoid cells
o contraction helps mix sperm and move them to
the epididymis
the channels of the rete testis are embedded within
the connective tissue of the mediastinum
Drains into about 20 efferent ductules
C. DUCTULI
EFFERENTES____________________________________
10-20 convoluted tubules
Lining: nonciliated cuboidal cells alternating with
cilated cells that beat in the direction of the
epididymis
o alternating tall & short columnar ciliated
epithelium
o scalloped appernace
Absorb most of the fluid secreted by the
seminiferous tubules
This absorption and the ciliary activity create
a fluid flow that sweeps sperm toward the
epididymis
Thin smooth muscle layer (SM) surrounds each
ductuli efferentes
Gradually fuse to form the head of ductus epididymis
or globus major
X. EXCRETORY GENITAL DUCTS
Responsible for transport of sperm from epididymis
to the penis during ejaculation
A.Ductus epididymidis
B.
Vas deferens
C.
Urethra
A. DUCTUS
EPIDIDYMIS____________________________________
Single highly coiled tube lying superior and posterior
to testis
Formed by minute convolutions of the duct if the
epididymis
Group 12 Chiu, Chua, Chuahiong, Cimagala, Cinco, Co, I., Co, K., Cocos
Page 7 of
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Cross
A.Seminal vesicles
B.
Prostate
C.
Bulbourethral glands
CLINICAL CORRELATION
EPIDIDYMO-ORCHITIS
Inflammation
May occur singly or in combo
Most commonly viral but may
bacterial (STD)
Tx: Ice bag to affected testis
cool down the testes,
preventing sterility)
analgesic; antibiotics as
necessary
Ceftriaxone 1g/IM
be
(to
B.
VAS
DEFERENS_________________________________________
a narrow lumen and a thick layer of smooth muscle
o Produce strong peristaltic contraction during
ejaculation which rapidly move sperm along this
duct from epididymis
Lining: pseudostratified columnar epithelium with
sparse stereocilia
45 cm long
A.
SEMINAL
VESICLES______________________________________
Page 8 of
Co, I., Co, K., Cocos
12
EJACULATORY DUCT
Slender tubes
Duct of vas deferens + duct of seminal vesicle
opens into Prostatic Urethra
Lining: Pseudostratified columnar epithelium with
stereocilia
Arises near the neck of the bladder, run close
together as they pass anteroinferiorly through
posterior part of the prostate and along the sides of
the prostatic utricle.
Blood Supply
arteries to the ductus deferens (usually branch of
superior(but frequently inferior) vesical arteries.
Venous drainage
o Veins join the prostatic and vesical venous
plexuxes
C. PROSTATE
GLAND_______________________________________
dense, fibromuscular organ surrounding the urethra
below the bladder
About 3 cms long
Lies between the neck of bladder and urogenital
diaphragm
Has a base and apex
collection of 30-50 branched tubuloalveolar gland
that empty into prostatic urethra
produces prostatic fluid containing glycoproteins and
stores it in the interior
With Corpora Amylacea
o prostatic concretions
o increases with age
o contains deposited glycoproteins and sulfated
glycosaminoglycans
(GAGs),
particularly
Keratan sulfate
Lining:
simple
to
psuedostratified
columnar
epithelium
Female Homologue = Paraurethral Gland/Skenes
Gland
Surrounded by fibroelastic capsule rich in smooth
muscle
glands are arranged in concentric layers around
urethra:
1.mucosal glands: inner layer
2.submucosal glands: intermediate layer
3.main glands: peripheral layer
Incompletely divided into 5 lobes
1.Anterior: devoid of glands
2.Middle/median: rich in glands
3.Posterior
4.Right lateral lobe
5.Left lateral lobe
Zones:
o Anterior
non-glandular
o Transition
5%
of
prostates
volume
surrounds
prostatic
urethra (BPH)
contains
mucosal glands emptying directly into the
urethra
o Central
25% of prostates volume
surrounds ejaculatory duct
contains submucosal glands with longer
ducts
o Peripheral
bulk (70%) of gland (prostatic CA)
contains main glands
Group 12 Chiu, Chua, Chuahiong, Cimagala, Cinco, Co, I., Co, K., Cocos
Page 9 of
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diff in urination
surgically treated
D.
URETHRA
____________________________________________
Intramural
Prostatic
Intermediate
Spongy
INTRAMURAL
o Inside the wall of the bladder
o Pre-prostatic/ Bladder neck
o Size depends on bladder distension
PROSTATIC
o Urethral Crest
o Prostatic sinuses(openings of prostatic ducts)
o Prostatic
Utricle
remnant
of
female
counterparts
o Ejaculatory ducts
INTERMEDIATE
o From apex of prostate, thru external urethral
sphincter (narrowest portion) to bulb of penis
SPONGY
o Bulb to tip
o 5mm diameter
o Dilates at bulb where ducts of bulbourethral
glands open Interbulbar Fossa
E.
BULBOURETHAL
GLAND__________________________________
Cowpers Gland
3-5 mm in diameter
Lining: simple columnar epithelium
located in the urogenital diaphragm
adjacent to intermediate urethra
Located proximal to membranous urethra
Tubulo-alveolar glands
o Secretes clear mucus clear containing various
small carbohydrates which acts as lubricant
Together with urethral glands
o secrete mucus to coat & lubricate urethra for
sperm during erection
Female Homologue= Great Vestibular/Bartholins
Gland
Ducts open into the proximal part of the spongy
urethra through minute apertures
Group 12 Chiu, Chua, Chuahiong, Cimagala, Cinco, Co, I., Co, K., Cocos
Page 10 of
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Arterial Supply
o Internal pudendal arteries
deep artery of the penis
dorsal artery of the penis
bulbourethral artery
Venous Drainage
o superficial dorsal vein (external to bucks)
o deep dorsal vein (within bucks)
Both connect with pudendal plexus which drains
into the internal pudendal vein
Lymphatic Drainage
o Skin of penis
superficial inguinal and subinguinal LN
o Glans penis
Group 12 Chiu, Chua, Chuahiong, Cimagala, Cinco, Co, I., Co, K., Cocos
Page 11 of
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Group 12 Chiu, Chua, Chuahiong, Cimagala, Cinco, Co, I., Co, K., Cocos
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