BREAST CANCER

Source: CDC/NHS Choices/NICE

Introduction
Cancer is a disease in which cells in the body grow out of control. When cancer starts in the breast, it is called breast
cancer. Except for skin cancer, breast cancer is the most common cancer in American women.
Breast cancer screening is checking a womans breasts for cancer before she has any symptoms. A mammogram is an
X-ray picture of the breast. Mammograms are the best way to find breast cancer early, when it is easier to treat and
before it is big enough to feel or cause symptoms.
A breast is made up of three main parts: glands, ducts, and connective tissue. The glands produce milk. The ducts are
passages that carry milk to the nipple. The connective tissue (which consists of fibrous and fatty tissue) connects and
holds everything together.
Lumps in the Breast
Many conditions can cause lumps in the breast, including cancer. But most breast lumps are caused by other medical
conditions. The two most common causes of breast lumps are fibrocystic breast condition and cysts. Fibrocystic
condition causes noncancerous changes in the breast that can make them lumpy, tender, and sore. Cysts are small
fluid-filled sacs that can develop in the breast.
What Is a Normal Breast?
No breast is typical. What is normal for you may not be normal for another woman. Most women say their breasts feel
lumpy or uneven. The way your breasts look and feel like can be affected by getting your period, having children,
losing or gaining weight, and taking certain medications. Breasts also tend to change as you age.
Kinds of Breast CA
There are different kinds of breast cancer. The kind of breast cancer depends on which cells in the breast turn into
cancer. Breast cancer can begin in different parts of the breast, like the ducts or the lobes.
Common Kinds of Breast Cancer
Common kinds of breast cancer are

Ductal carcinoma. The most common kind of breast cancer. It begins in the cells that line the milk ducts in
the breast, also called the lining of the breast ducts.
o Ductal carcinoma in situ (DCIS). The abnormal cancer cells are only in the lining of the milk ducts,
and have not spread to other tissues in the breast.
o Invasive ductal carcinoma. The abnormal cancer cells break through the ducts and spread into
other parts of the breast tissue. Invasive cancer cells can also spread to other parts of the body.

Lobular carcinoma. In this kind of breast cancer, the cancer cells begin in the lobes, or lobules, of the breast.
Lobules are the glands that make milk.
o Lobular carcinoma in situ (LCIS). The cancer cells are found only in the breast lobules. Lobular
carcinoma in situ, or LCIS, does not spread to other tissues.
o Invasive lobular carcinoma. Cancer cells spread from the lobules to the breast tissues that are close
by. These invasive cancer cells can also spread to other parts of the body.
Uncommon Kinds of Breast Cancer
There are several other less common kinds of breast cancer, such as Pagets disease and inflammatory breast cancer.
Signs and Symptoms
Different people have different warning signs for breast cancer. Some people do not have any signs or symptoms at all.
A person may find out they have breast cancer after a routine mammogram.
Some warning signs of breast cancer are

New lump in the breast or underarm (armpit).

Thickening or swelling of part of the breast.

Irritation or dimpling of breast skin.

Redness or flaky skin in the nipple area or the breast.

Pulling in of the nipple or pain in the nipple area.

Nipple discharge other than breast milk, including blood.

Any change in the size or the shape of the breast.

Pain in any area of the breast.

Risk Factors
The main factors that influence your risk for breast cancer include being a woman, being older (most breast cancers
are found in women who are 50 years old or older), and having changes in certain breast cancer genes (BRCA1 and
BRCA2). In addition, studies have shown that some other factors may also influence your risk.
Factors That Decrease Your Risk

Being older when you first had your menstrual period.

Starting menopause at an earlier age.

Giving birth to more children, being younger at the birth of your first child, and breastfeeding your children.

Getting regular exercise.

Maintaining a healthy weight.

Factors That Increase Your Risk

Long-term use of hormone replacement therapy.

Personal history of breast cancer or non-cancerous breast diseases.

Family history of breast cancer (on either your mothers or fathers side of the family).

Treatment with radiation therapy to the breast/chest.

Exposure to diethylstilbestrol (DES) (for example, if you took DES during pregnancy or your mother took DES
during her pregnancy with you).


Dense breasts by mammogram.

Drinking alcohol.

Night-shift work.
Some women will develop breast cancer even without any known risk factors. Having a risk factor does not mean you
will get the disease, and not all risk factors affect your risk to the same extent. Most women have some risk factors
and most women do not get breast cancer. If you have breast cancer risk factors, talk with your doctor about ways you
can lower your risk and about screening for breast cancer.
Screening Tests
Breast cancer screening means checking a womans breasts for cancer before there are signs or symptoms of the
disease. Three main tests are used to screen the breasts for cancer. Talk to your doctor about which tests are right for
you, and when you should have them.
Mammogram
A mammogram is an X-ray of the breast. Mammograms are the best way to find breast cancer early, when it is easier
to treat and before it is big enough to feel or cause symptoms. Having regular mammograms can lower the risk of
dying from breast cancer. The United States Preventive Services Task Force recommends that if you are 50 to 74 years
old, be sure to have a screening mammogram every two years. If you are 40 to 49 years old, talk to your doctor about
when to start and how often to get a screening mammogram.
Clinical Breast Exam
A clinical breast exam is an examination by a doctor or nurse, who uses his or her hands to feel for lumps or other
changes.
Breast Self-Exam
A breast self-exam is when you check your own breasts for lumps, changes in size or shape of the breast, or any other
changes in the breasts or underarm (armpit).
Diagnosis
Doctors often use additional tests to find or diagnose breast cancer.

Breast ultrasound. A machine uses sound waves to make detailed pictures, called sonograms, of areas
inside the breast.

Diagnostic mammogram. If you have a problem in your breast, such as lumps, or if an area of the breast
looks abnormal on a screening mammogram, doctors may have you get a diagnostic mammogram. This is a
more detailed X-ray of the breast.

Magnetic resonance imaging (MRI). A kind of body scan that uses a magnet linked to a computer. The MRI
scan will make detailed pictures of areas inside the breast.

Biopsy. This is a test that removes tissue or fluid from the breast to be looked at under a microscope and do
more testing. There are different kinds of biopsies (for example, fine-needle aspiration, core biopsy, or open
biopsy).
Staging
If breast cancer is diagnosed, other tests are done to find out if cancer cells have spread within the breast or to other
parts of the body. This process is called staging. Whether the cancer is only in the breast, is found in lymph nodes
under your arm, or has spread outside the breast determines your stage of breast cancer. The type and stage of breast
cancer tells doctors what kind of treatment you need.
Treatment
People with breast cancer often get more than one kind of treatment.

Surgery. An operation where doctors cut out cancer tissue.

Chemotherapy. Using special medicines to shrink or kill the cancer. The drugs can be pills you take or
medicines given in your veins, or sometimes both.

Hormonal therapy. Blocks cancer cells from getting the hormones they need to grow.

Biological therapy. Works with your body's immune system to help it fight cancer or to control side effects
from other cancer treatments. Side effects are how your body reacts to drugs or other treatments.

Radiation therapy. Using high-energy rays (similar to X-rays) to kill the cancer.
Doctors, from different specialties, often work together treat breast cancer. Surgeons are doctors who perform
operations. Medical oncologists are doctors who treat cancer with medicine. Radiation oncologists are doctors who
treat cancer with radiation.
NICE Guidelines
ADVANCED BREAST CA: Diagnosis and Treatment
1.1 Diagnosis and assessment
Imaging assessment
1.1.1 Assess the presence and extent of visceral metastases using a combination of plain radiography,
ultrasound, computed
tomography (CT) scans and magnetic resonance imaging (MRI). [2009]
1.1.2 Assess the presence and extent of metastases in the bones of the axial skeleton using bone windows on
a CT scan or MRI or
bone scintigraphy. [2009]
1.1.3 Assess proximal limb bones for the risk of pathological fracture in patients with evidence of bone
metastases elsewhere, using
bone scintigraphy and/or plain radiography. [2009]
1.1.4 Use MRI to assess bony metastases if other imaging is equivocal for metastatic disease or if more
information is needed (for
example, if there are lytic metastases encroaching on the spinal
canal). [2009]
1.1.5 Positron emission tomography fused with computed tomography (PET-CT) should only be used to make a
new diagnosis of
metastases for patients with breast cancer whose imaging is suspicious but not
diagnostic of metastatic disease. [2009]
Pathological assessment
1.1.6Patients with tumours of known oestrogen receptor (ER) status whose disease recurs should not have a
further biopsy just to
reassess ER status. [2009]

1.1.7Patients with tumours of known human epidermal growth factor receptor 2 (HER2) status whose disease
recurs should not
have a further biopsy just to reassess HER2 status. [2009]
1.1.8 Assess ER and HER2 status at the time of disease recurrence if receptor status was not assessed at the
time of initial diagnosis.
In the absence of tumour tissue from the primary tumour, and if feasible,
obtain a biopsy of a metastasis to
assess ER and HER2 status. [2009]
Monitoring disease status
1.1.9 Do not use bone scintigraphy to monitor the response of bone metastases to treatment. [2009]
1.1.10 Do not use PET-CT to monitor advanced breast cancer. [2009]
1.2 Providing information and support for decision making
1.2.1 Assess the patient's individual preference for the level and type of information. Reassess this as
circumstances change. [2009]
1.2.2 On the basis of this assessment, offer patients consistent, relevant information and clear explanations,
and provide
opportunities for patients to discuss issues and ask questions. [2009]
1.2.3 Assess the patient's individual preference for how much they wish to be involved in decision making.
Reassess this as
circumstances change. [2009]
1.2.4Be aware of the value of decision aids and the range available. Make the most appropriate decision aid
available to the
patient. [2009]
1.3 Systemic disease-modifying therapy
1.3.1Offer endocrine therapy as first-line treatment for the majority of patients with ER-positive advanced
breast cancer. [2009]
1.3.2Offer chemotherapy as first-line treatment for patients with ER positive advanced breast cancer whose
disease is imminently
life-threatening or requires early relief of symptoms because of significant
visceral organ involvement, providing they
understand and are prepared to accept the
toxicity. [2009]
1.3.3For patients with ER-positive advanced breast cancer who have been treated with chemotherapy as their
first-line treatment,
offer endocrine therapy following the completion of chemotherapy. [2009]
Endocrine therapy
1.3.4Offer an aromatase inhibitor (either non-steroidal or steroidal) to:

postmenopausal women with ER-positive breast cancer and no prior history of endocrine therapy

postmenopausal women with ER-positive breast cancer previously treated with tamoxifen. [2009]
1.3.5Offer tamoxifen and ovarian suppression as first-line treatment to premenopausal and perimenopausal
women with ERpositive advanced breast cancer not previously treated with tamoxifen. [2009]
1.3.6 Offer ovarian suppression to premenopausal and perimenopausal women who have previously been
treated with tamoxifen
and then experience disease progression. [2009]
1.3.7Offer tamoxifen as first-line treatment to men with ER-positive advanced breast cancer. [2009]
Chemotherapy
1.3.8 On disease progression, offer systemic sequential therapy to the majority of patients with advanced
breast cancer who have
decided to be treated with chemotherapy. [2009]
1.3.9Consider using combination chemotherapy to treat patients with advanced breast cancer for whom a
greater probability of
response is important and who understand and are likely to tolerate the
additional toxicity. [2009]
1.3.10For patients with advanced breast cancer who are not suitable for anthracyclines (because they are
contraindicated or
because of prior anthracycline treatment either in the adjuvant or metastatic
setting), systemic chemotherapy should be
offered in the following sequence:

first line: single-agent docetaxel

second line: single-agent vinorelbine or capecitabine

third line: single-agent capecitabine or vinorelbine (whichever was not used as second-line
treatment). [2009]
1.3.11Gemcitabine in combination with paclitaxel, within its licensed indication, is recommended as an option
for the treatment of
metastatic breast cancer only when docetaxel monotherapy or docetaxel plus
capecitabine are also considered
appropriate[4]. [2009]
Biological therapy
1.3.12For patients who are receiving treatment with trastuzumab [5] for advanced breast cancer, discontinue
treatment with
trastuzumab at the time of disease progression outside the central nervous system. Do
not discontinue trastuzumab if
disease progression is within the central nervous system alone. [2009]
1.4 Supportive care
1.4.1Healthcare professionals involved in the care of patients with advanced breast cancer should ensure that
the organisation and
provision of supportive care services comply with the recommendations made
in Improving outcomes in breast cancer:
manual update (NICE cancer service guidance [2002])
and Improving supportive and palliative care for adults with
cancer (NICE cancer service guidance
[2004]), in particular the following two recommendations:

'Assessment and discussion of patients' needs for physical, psychological, social, spiritual and
financial support should be undertaken at key points (such as diagnosis; at commencement,
during, and at the end of treatment; at relapse; and when death is approaching).'

'Mechanisms should be developed to promote continuity of care, which might include the
nomination of a person to take on the role of "key worker" for individual patients.' [2009]
1.5 Managing complications
Lymphoedema
1.5.1 Discuss with people who have or who are at risk of breast-cancer related lymphoedema that there is no
indication that
exercise prevents, causes or worsens lymphoedema. [new 2014]
1.5.2Discuss with people who have or who are at risk of breast cancer related lymphoedema that exercise may
improve their
quality of life. [new 2014]
1.5.3Assess patients with lymphoedema for treatable underlying factors before starting any lymphoedema
management
programme. [2009]
1.5.4 Offer all patients with lymphoedema complex decongestive therapy (CDT) as the first stage of
lymphoedema
management. [2009]

1.5.5 Consider using multilayer lymphoedema bandaging (MLLB) for volume reduction as a first treatment
option before
compression hosiery. [2009]
1.5.6 Provide patients with lymphoedema with at least two suitable compression garments. These should be of
the appropriate
class and size, and a choice of fabrics and colours should be available. [2009]
1.5.7Provide patients with lymphoedema with clear, written information and the contact details of local and
national lymphoedema
support groups. [2009]
Cancer-related fatigue
1.5.8Offer all patients with advanced breast cancer for whom cancer related fatigue is a significant problem an
assessment to
identify any treatable causative factors, and offer appropriate management as
necessary. [2009]
1.5.9Provide clear, written information about cancer-related fatigue, organisations that offer psychosocial
support and patient led
groups. [2009]
1.5.10 Provide information about and timely access to an exercise programme for all patients with advanced
breast cancer
experiencing cancer-related fatigue. [2009]
Uncontrolled local disease
1.5.11A breast cancer multidisciplinary team should assess all patients presenting with uncontrolled local
disease and discuss the
therapeutic options for controlling the disease and relieving
symptoms. [2009]
1.5.12A wound care team should see all patients with fungating tumours to plan a dressing regimen and
supervise management
with the breast care team. [2009]
1.5.13A palliative care team should assess all patients with uncontrolled local disease in order to plan a
symptom management
strategy and provide psychological support. [2009]
Bone metastases
1.5.14Consider offering bisphosphonates to patients newly diagnosed with bone metastases to prevent
skeletal-related events and
reduce pain. [2009]
1.5.15The choice of bisphosphonate for patients with bone metastases should be a local decision, taking into
account patient
preference and limited to preparations licensed for this indication. [2009]
1.5.16 Use external beam radiotherapy in a single fraction of 8Gy to treat patients with bone metastases and
pain. [2009]
1.5.17An orthopaedic surgeon should assess all patients at risk of a long bone fracture, to consider
prophylactic surgery. [2009]
Brain metastases
1.5.18Offer surgery followed by whole brain radiotherapy to patients who have a single or small number of
potentially resectable
brain metastases, a good performance status and who have no or well
controlled other metastatic disease. [2009]
1.5.19 Offer whole brain radiotherapy to patients for whom surgery is not appropriate, unless they have a very
poor
prognosis. [2009]
1.5.20 Offer active rehabilitation to patients who have surgery and/or whole brain radiotherapy. [2009]
1.5.21 Offer referral to specialist palliative care to patients for whom active treatment for brain metastases
would be
inappropriate. [2009]