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Mitochondria are dynamic double-membrane-bound organelles that are involved in a wide range of cellular processes, including ATP
generation, calcium homeostasis, as well as the biosynthesis of amino acids, lipids and nucleotides. They differ with respect to size,
density, ROS production, respiratory/ Ca2 + regulatory activity and substrate preference in the immature compared with adult brain,
suggesting unique control mechanisms in the developing CNS.
Mitochondria are center stage in the regulation of cell death in the immature brain. They control apoptotic, necrotic/necroptotic and
autophagic events after injury and their dynamic properties seems critical for CNS development and maybe also cell fate. Mitochondrial
biogenesis, mitophagy and transcellular exchange can be important for repair processes in several tissues including the CNS. Mitochondria
are also, at least partly, responsible for induction of CNS tolerance in the immature brain. Mitochondria have recently been recognized
as an important scaffold for innate immune responses related to pattern recognition receptor regulation. We propose that mitochondria
are important in both anti-microbial defense as well as triggering of inammation after sterile insults.
Based on this knowledge, mitochondria-directed neuroprotective therapies (Mitoprotectants) such as caspase-2 inhibitors are being
developed to combat injurious events in the immature brain. We found recently that magnesium (Mg) in therapeutic concentrations given
as a bolus dose 12h-3days prior to hypoxia-ischemia (HI) provides marked preconditioning protection. This effects is different compared
with hypoxic preconditioning as it is unrelated to cerebral blood ow during the subsequent HI. We hypothesize that Mg induces
mitoprotection through regulation of mitochondrial Ca2 + uxes, mitochondrial ATP-sensitive K + channels and transient receptor potential
ion channels.
It is reasonable to believe that further insights into these basic and pathological aspects of mitochondria will be of paramount importance
for understanding brain development, neurologic disease and for finding new strategies for treatment.
CURRICULUM VITAE
Henrik Hagberg
Born: March 31, 1955, Stockholm, Sweden, two children
Professional preparation
1979-1985 Medicine doktor, (PhD)
Thesis: Electrolyte, pH and metabolic changes in skeletal muscle during ischemia
Supervisor: Hengo Haljame, PhD, Dept of Neurobiology, Gteborg, Sweden
1987
Registered Physician (Legitimerad lkare)
1976-1985 Lkarexamen (MD), Sahlgrenska Academy, Gteborg, Sweden
Appointments
2012-09 Professor in Perinatology and Obstetrics, Department of Clinical Sciences, Department of Obstetrics and Gynecology,
Sahlgrenska Academy, Gteborg and Professor, Chair in Fetal Medicine, Centre for the Developing Brain, Perinatal
Imaging & Health, Kings College London, London
2010-2012-08 Shared Professorship in Perinatology and Obstetrics, Department of Clinical Sciences, Department of Obstetrics and
Gynecology, Sahlgrenska Academy, Gteborg and Imperial College, Institute of Reproductive and Developmental
Biology, London.
2008-2010
Professor in Obstetrics, Imperial College, Institute of Reproductive and Developmental Biology, Queen Charlottes and
Chelsea Hospital, London
2000-2008
Professor in Perinatal Medicine and Obstetrics, Institute for the Health of Women and Children, Sahlgrenska Academy,
Gteborg University
2000-2001
Guest professor at the Neuroscience Lab, Kennedy Krieger Institute, Johns Hopkins School of Medicine, Baltimore, USA
1995-1999
Associate Professor and senior clinical consultant in Perinatal Medicine and Obstetrics
1993-1995
Assistant Professor (Docent) in Obstetrics and Gynecology, Gteborg and consultant physician at the Dept of Obstetrics
and Gynecology, Sahlgrenska University Hospital
1985Assistant Professorship (Docent) in Neurobiology
1994-1998
Research assistant, Swedish Medical Reasearch Council
1997
Associate Professor, (Docentur; Experimental Medicine)
1991-1993
Consultant in Obstetrics and Gynecology, Gteborg
1987-1991
Residency, Bors hospital, Mlndals hospital and Sahlgrenska University Hospital
1985-1987
Internship (AT-tjnstgring), Mlndals hospital, Mlndal
Commissions of trust
Abstracts for The 46th International Congress on Pathophysiology of Pregnancy
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