Professional Documents
Culture Documents
Subclass
Subclass
Virus
Enveloped?
Poliovirus
Coxsackie A virus
Enterovirus
Picornavirus
Coxsackie
virus
Non-enveloped
Coxsackie B virus
ECHO vruses
Enterovirus 70
Numbered
Rhinoviruses
Reovirus
Enterovirus 71
Enterovirus 72
(HepA)
Rhinovirus
Rotavirus
Non-enveloped
Adenoviruses
Adenovirus
Enteric
adenoviruses
Non-enveloped
Norwalk virus
(norovirus)
Calcivirus
Non-enveloped
Influenza A
Orthomyxoviruses
Influenza viruses
Enveloped
Influenza B
Influenza C
Parainfluenza (14)
Respiratory
syncytial virus
(RSV)
Paramyxoviruses
Mumps
Measles
Enveloped
Coronaviruse
s
SARS-associated
coronavirus
Enveloped
Other
coronaviruses
Hepadnavirus
Hepatitis B
Hepacivirus
Enveloped
Hepatitis C
St. Louis
Encephalitis Virus
Enveloped
Arboviruses
Dengue virus
[Deltavirus]
Hepatitis D
[Hepevirus]
Hepatitis E
Non-enveloped
Lymphocytic
Choriomeningitis
(LCMV)
(zoonoses
)
Arenaviruses
Enveloped
Marburg Virus
Filoviruses
African
Hemorrhagic (zoonoses
Fever
)
Viruses
Enveloped
Ebola Virus
Western Equine
Encephalitis Virus
Arboviruses
(zoonoses
)
Eastern Equine
Encephalitis Virus
Togavirus
Enveloped
Rubella
Parvovirus
Parvovirus B-19
Non-enveloped
HSV-1
HSV-2
VZV
CMV
Herpesviruses
Enveloped
EBV
HHV-6
HHV-7
HHV-8, KSHV
Papilloma virus
(HPV)
Papovaviruses
Non-enveloped
Polyomavirus (now its
own family apart from
Papovaviruses but this is
not in our notes)
JC Virus
Oncoviruses
Human T-cell
Leukemia Virus-1
and -2 (HTLV-1/2)
Retroviruses
Enveloped
Lentiviruses
HIV-1 (HIV-2 in
West Africa)
Smallpox virus
Poxviruses
Enveloped and
Non-enveloped
(can withstand
adverse
conditions
better)
Enveloped and
Non-enveloped
(can withstand
adverse
conditions
better)
Poxviruses
Molluscum
contagiosum virus
(MCV)
Rhabdovirus
Rabies virus
Enveloped
A-11 to A-12:
A7 for
AWESOME
characterization of
TABLE of
simple
characterization
(unenveloped
of viruses in
viruses)
course
Useful Pages
Pox viruses:
cytoplasmic
inclusions
Herpes
viruses:
nuclear
inclusions
Nucleic Acid/structure
Virion
Structure
icosahedral
(VP1/2/3,
CD155
binding sites)
icosahedral
dsRNA, 10 segments
icosahedral
icosahedral
ss+RNA
ss-RNA, 8 segments
helical
helical
helical
icosahedral
+ssRNA
icosahedral
circular -RNA
+RNA
-ssRNA
-ssRNA
Long cylinder
(longer than
rhabdoviruses
)
+ssRNA
icosahedral
linear ssDNA
icosahedral
linear dsDNA
icosahedral
icosahedral
circular dsDNA
No symmetry
(only virus
family like
this)
No symmetry
(only virus
family like
this)
-ssRNA
Helical
nucleocapsid,
bullet-shaped
vRNA functions as template for synthesis of mRNA, uses RdRp (packed with virion; hence, RNA
alone not infectious)
Viruses assembled in nucleus, have early mRNA (replication proteins) and late mRNA (structural;
virions)
Packaged with RdRp, HA binds sialic acid recptors, NA cleaves off for viral budding, infects cells
of respiratory tract to cause infleunza
Packaged with reverse transcriptase, viral DNA gaps filled in nucleocapsid on way to nucleus, late
in infection long RNA created (pregenomes) and packaged in nucleocapsid, are copied via RT into
DNA inside the nucleocapsid while RNA is degraded , virus buds thru plasma membrane
virion adsorbs to cell, fuses with PM, nucleocapsid goes to nucleus, synthesis of
proteins/DNA/mRNA, progeny nucleocapsids assembled in nucleus (nuclear inclusion bodies),
glycoproteins inserted into nuclear membrane that nucleocapsids bud through, glycoproteins in
PM can result in cell fusion (multinucleate giant cells like measles), also has tegument proteins
btw envelope and nucleocapsid
has early and late (capsid) genes early gene can bind promoter to recruit DNApol for genome
replication, all genes essential for virus growth,
viral envelope glycoprotein gp120 binds host CD4, cellular CXCR4 or CCR5 (chemokine coreceptors) needed for absorption, gp41 mediates envelope fusion, HIV is a nondefective virus
Virus carries DdRp in virion to make mRNA (only DNA virus that encodes own RNApol), virus
multiplies in cytoplasm (forms inclusion body when histologically stained)
Virus carries DdRp in virion to make mRNA (only DNA virus that encodes own RNApol), virus
multiplies in cytoplasm (forms inclusion body when histologically stained)
Transmission Route
Disease(s) Caused
General Epidemiology
fecal-oral
colds
fecal-oral
rotavirus gastroenteritis
airborne
colds, conjunctivitis
fecal-oral
gastroenteritis, diarrhea
fecal-oral
adolescent/infant
gastroenteritis
airborne
non-systemic respiratory
disease, croup
non-systemic respiratory
disease, lower respiratory
infection, pneumonia,
induces giant cells
airborne
Measles, encephalitis,
pneumonia, otitis media,
rare giant-cell pneumonia
(w/o rash when cellmediated immunity is
defective), subacute
sclerosing panencephalitis
(SSPE), photophobia
SARS
airborne, others?
common cold
Hepatitis B, hepatocellular
carcinoma
Hepatitis C, hepatocellular
carcinoma
Encephalitis
requires multiplication in
arthropod host (usually 2
incubation periods; intrinsic 7
days in humans; extrinsic 14
days in arthropod), humans are
dead-end hosts b/c not high
enough viremia
Yellow fever
Hepatitis D
fecal-oral
Hepatitis E
fecal-oral
lymphocytic
choriomeningitis, aseptic
meningitis, fetal abortion,
congenital hydrocephaly
Encephalitis
airborne
airborne
saliva
chickenpox (primary
infection), zoster/shingles
(recurrent disease),
congenital varicella
syndrome
mononucleosis-like, most
frequent viral congenital
infection
none known
Kaposi's sarcoma
aerosols
progressive multifocal
leukoencephalopathy (PML)
Occurs in
immunocompromised, slow
virus
HIV, AIDS
airborne
Molluscum contagiosum
Rabies
Consuming brains
Kuru
Creutzfeld-Jacob Disease
(CJD)
Epidemiology
Pathogenesis
Incubation
Period
2-3 weeks
Acute onset
~ 30 days
0.1% mortality
poor growth at body temperature and low
pH, 80+ antigenic types
3-10 days
3-6 days
18-21 days
14 days
2-10 days
~ 70 days
(insiduous
onset)
~60 days
(insiduous
onset)
7 days
~ 30 days (acute
onset)
7 days
18 days
7 days
7-14 days
7-14 days
14-21 days
3-12 weeks
4-6 weeks
AIDS patients have increased susceptibility gradual depeltion of CD4+ cells, suppression
to opportunistic infections and tumors
of cell-mediated immunity (variable
(Kaposi's sacoma, B-cell lymphoma,
progression to AIDS), cytopathic effect, CTL
autoimmune thrombocytopenia, chronic
destruction of infected cells, apoptosis of
lymphadenopathy, dementia/diffuse brain CD4 cells, HIV also targets CD4 Th17 cells
disease in later stages of infection)
(imp for mucosal imm -- bacteria)
2-8 weeks
Spongiform encephalopathy
Weeks to
months
Lab Diagnostics
Vaccines
None
None
None
Diarrhea
Formaldehyde-killed vaccine
Live-attenuated vaccines
available (Rotarix, RotaTeq)
Hemagglutination
fever
Prodromal fever/malaise/anorexia
followed by uni/bilateral swelling of
parotid glands. Usual presenting
symptom is parotiditis.
No vaccines available
Hemagglutination
Live-attenuated vaccine
(MMR; twice)
Live-attenuated vaccine
(MMR; twice)
fever, malaise
live-attenuated (reduces
clinical infecions by 85%,
reduces severe infections by
97%, elderly should receive
booster
Pap smears
Chemotherapy
Passive immunization
Rehydration therapy
acyclovir
Passive immunization
(hyperimmune human serum; given
to delay symptoms)