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The effects of the toxin result from prevention of the release of neurotransmitters. The toxin has a
predominant effect on inhibitory neurones, inhibiting release of Glycine and Gammaaminobutyric Acid
(GABA). Interneurones inhibiting alpha motor neurones are first affected and the motor neurones lose
inhibitory control. Later (because of the longer path) preganglionic sympathetic neurones in the lateral
horns and the parasympathetic centres are also affected. Motor neurones are similarly affected and the
release of acetylcholine into the neuromuscular cleft is reduced. This effect is similar to the action of
the closely related botulinum toxin, which produces a flaccid paralysis. Uncontrolled disinhibited
efferent discharge from motor neurones in the cord and brainstem leads to intense muscular rigidity
and spasm, which may mimic convulsions. Disinhibited autonomic discharge leads to disturbances in
autonomic control, with sympathetic overactivity and excessive plasma Catecholamine levels
stimulation or a direct action of tetanus toxin on the myocardium. Altered myocardial function may be
because of persistently raised catecholamine levels but abnormal function may occur even in the
absence of sepsis or high catecholamine levels
DENTAL CARIES
Gum disease is clearly associated with heart disease and other health-related problems. This is not
necessarily due to bacterial spread from the mouth into the bloodstream, as many people think. In fact,
bacteria showers in the bloodstream are relatively common and occur in response to brushing teeth,
bowel movements, and other normal activities. These are rarely dangerous for people with healthy
immune systems. Rather, the link between gum disease and other systemic diseases appears to be due
to an increased inflammatory response occurring throughout the body and is triggered by inflammation
in the gums. Studies have shown an association between Periodontitis and cardiovascular disease and
suggest that Periodontitis is a risk factor for cardiovascular disease. Periodontitis is linked to heart
disease by inflammation. Other predictors are root remnants, Gingivitis, Dental Caries, and missing
teeth. But for the other predictors are only show that oral disease and coronary heart disease are
linked, but it does not show whether one cause another
http://bja.oxfordjournals.org/content/87/3/477.long
http://www.lef.org/protocols/dental/periodontitis_cavities_04.htm
http://jada.ada.org/content/135/4/416.1.full.pdf+html